کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3299453 | 1209929 | 2006 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Bile Acids Induce Ileal Damage During Experimental Necrotizing Enterocolitis
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
EGFCHOLDOCNECFXRIBABPfarnesoid X receptor - Farnesoid X گیرندهAsbt - آزبستDeoxycholic acid - اسید DeoxycholicBile acid - اسید صفراویNecrotizing enterocolitis - انتروکولیت نکروزانapical sodium-dependent bile acid transporter - اپوکسی سدیم وابسته به پروتئین اسید صفراepidermal growth factor - عامل رشد اپیدرمیileal bile acid binding protein - پروتئین متصل به اسید صفراوی ایلئالCholestyramine - کلستیآمینین
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Background & Aims: Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency of premature infants. While the effect of bile acids (BAs) on intestinal mucosal injury is known, we investigated the contribution of BAs during the development of NEC in neonatal rats. Methods: Premature rats were fed with cow's milk-based formula and subjected to asphyxia and cold stress to develop NEC. Jejunal and ileal luminal BAs, portal blood BAs, and messenger RNA and protein for the apical sodium-dependent bile acid transporter, the ileal bile acid binding protein, and the heteromeric organic solute transporter (Ostα/Ostβ)were evaluated. Results: Ileal luminal BAs levels were increased significantly during disease development and the removal of ileal BAs significantly decreased the incidence and severity of disease. Furthermore, when NEC was reduced via treatment with epidermal growth factor (EGF), BA levels were reduced significantly. Jejunal luminal BA levels were similar between animals with NEC and controls, but portal/ileal luminal BA ratios were decreased significantly in animals with NEC. The apical sodium-dependent bile acid transporter was up-regulated at the site of injury in animals with NEC and decreased after EGF treatment; however, the ileal bile acid binding protein was up-regulated only in the NEC and EGF group. Ostα/Ostβ expression was low in all groups, and only slightly increased in the NEC group. Conclusions: These data strongly suggest that BAs play a role in the development of ileal damage in experimental NEC and that alterations in BA transport in the neonatal ileum may contribute to disease development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastroenterology - Volume 130, Issue 2, February 2006, Pages 359-372
Journal: Gastroenterology - Volume 130, Issue 2, February 2006, Pages 359-372
نویسندگان
Melissa D. Halpern, Hana Holubec, Tara A. Saunders, Katerina Dvorak, Jessica A. Clark, Sarah M. Doelle, Nazzareno Ballatori, Bohuslav Dvorak,