Keywords: Polychlorinated biphenyls; Signalling disruption; Secondary necrosis; Casein kinase 2; AKT; Serine/Threonine kinase 1; CAR; Constitutive androstane receptor; CASP3; Caspase-3; CD; Control diet; CD+; Control diet + Aroclor 1260 exposure; CDK; Cyclin depend
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Keywords: Hyperlipidemia; Hybrids; FXR; SREBP-1c; 3T3-L1 adipocytes;
Keywords: NAFLD; nonalcoholic fatty liver disease; NASH; nonalcoholic steatohepatitis; FC; free cholesterol; VLDL; very low density lipoprotein; LDL; low density lipoprotein; mTOR; mechanistic target of rapamycin signaling; AMPK; AMP-activated protein kinase; TG; t
Keywords: ACAT; acyl-coenzyme A:cholesterol acyltransferases; BSH; bile salt hydrolase; CFU; colony-forming unit; FAS; fatty acid synthase; FXR; farnesoid X receptor; GA; gum Arabic; GLP; glucagon-like peptides; HDL-C; high density lipoproteins cholesterol; HFD; hi
Keywords: α; 7nAChRAlpha7 nicotinic acetylcholine receptor; α; -CGRPAlpha-calcitonin gene-related peptide; AT; 1/2Angiotensin 1/2 receptor; AVP; Arginine vasopressin; BDL; Bile duct ligation; CLR; Calcitonin-like receptor; CNS; Central nervous system; cAMP; Cycli
Keywords: AHR; aryl hydrocarbon receptor; ALD; alcoholic liver disease; BAs; bile acids; CAR; constitutive androstane receptor; CARM1; coactivator associated arginine methyltransferases 1; CBP/P300; CREB-binding protein/p300; CYP27A1/Cyp27a1; sterol 27α-hydroxylas
Keywords: Sex differences; Steroids; Gut microbiota; Metabolic disease; Cardiovascular disease; ApoE; apolipoprotein E; BAs; bile acids; CVD; cardiovascular diseases; E1; estrone; E2; estradiol; E3; estriol; ER; estrogen receptor; FCG; four core genotypes; FMO3; fl
Keywords: ATP; Adenosine 5c-triphosphate; ALT; Alanine aminotransferase; aa; Amino acid; ASK1; Apoptosis signal- regulating kinase 1; AST; Aspartate aminotransferase; BASH; Both alcoholic and non-alcoholic liver disease; CCR2/CCR5; C-C chemokine receptor types 2 an
Keywords: Liver; Proliferation; Cancer; Tumor-Suppressor Proteins; Progenitor Cells; BrdU; bromodeoxyuridine; cDNA; complementary DNA; C/EBP; CCAAT/enhancer binding protein; Co-IP; co-immunoprecipitation; CUGBP1; CUG triplet repeat binding protein 1; DEN; diethylni
Keywords: AMPK; adenosine 5â²-monophosphate (AMP)-activated protein kinase; ANGPTL4; angiopoietin-like protein 4; AX; arabinoxylan; CAZymes; carbohydrate active enzymes; CBMs; carbohydrate-binding modules; CVD; cerebrobascular disease; ERs; estrogen receptors; IL;
Keywords: ADME; absorption, distribution, metabolism and excretion; AFND; allele frequency net database; ALT; alanine aminotransferase; AOP; adverse outcome pathway; AOP-KB; AOP knowledge base; AST; aspartate aminotransferase; BSEP; bile salt export protein; CAR; c
Keywords: RDC; reactive ductular cell; DAMPs; danger associated molecular patterns; PAMPs; pathogen associated molecular patterns; cAMP; cyclic adenosine monophosphate; NOS; nitric oxide synthase; RNOS; reactive nitrogen oxide species; CFTR; cystic fibrosis transme
Keywords: Cholestasis; FXR; Bile acids; Hepatic inflammation; Yangonin;
Keywords: ASBT; apical sodium-dependent bile acid transporter; BMI; body mass index; CA; cholic acid; CA-D4; cholic acidâ2,2,4,4âD4; CARB; Carbohydrate and Related Biomarkers; CDCA; chenodeoxycholic acid; CRP; C-reactive protein; CV; coefficient of variation; D
Keywords: Serotonin; Stress; Irritable Bowel Syndrome; Intestinal Permeability; ANS; autonomic nervous system; ASD; autism spectrum disorder; BBB; blood-brain barrier; BGM; brain-gut-microbiome; CNS; central nervous system; ECC; enterochromaffin cell; EEC; enteroen
Keywords: Steatohepatitis; Liver; Intestine; Nuclear receptors; FXR; GPBAR1; PPARs; Lipids; Fibrosis; Apoptosis; Inflammation;
Keywords: BA; bile acids; BSH; bile salt hydrolase; CA; cholic acid; CDCA; chenodeoxycholic acid; DCA; deoxycholic acid; LCA; litocholic acid; MCA; muricholic acid; CYP7A1; cholesterol 7-αhydroxylase; L.; Lactobacillus; B.; Bifidobacterium; EPS; exopolysaccharide;
Keywords: ERK; extracellular signal regulated kinase; FXR; farsenoid X receptor; HCC; hepatocellular carcinoma; HSCs; hepatic stellate cells; IL1β; Interleukin 1 beta; IL18; Interleukin 18; IKKβ; inhibitor of nuclear factor kappa-B kinase subunit beta; JAK; Janus
Keywords: ASBT; apical sodium-dependent bile acid transporter; ASDs; amorphous solid dispersions; BACS; bile acid-CoA synthase; BAT; bile acid-amino acid transferase; BCS; biopharmaceutics classification system; BSH; bile salt hydrolase; C4; 7α-hydroxy-4-cholesten
Keywords: ACC; acetyl CoA carboxylase; ACYL; ATP citrate lyase; Akt2; rac-β-serine-threonine kinase; ALA; α-linolenic acid; ALT; alanine aminotransferase; ARA; arachidonic acid, 20:4,Ï6; AST; aspartate aminotransferase; ATGL; adipocyte triglyceride lipase; CD36;
Keywords: Oxysterols; Cancer; Polymorphism; Risk; Genetics; Cholesterol; 25(OH)D; 25-hydroxyvitamin D; ABC; ATP-binding cassette; AEBS; antiestrogen-binding site; BC; breast cancer; BCR; biochemical recurrence; CETP; cholesteryl ester transfer protein; CH25H; chole
Keywords: CCl4; carbon tetrachloride; CDCA; chenodeoxycholic acid; ERK; extracellular regulated protein kinase; FXR; farnesoid X receptor; IkB; inhibitor of kB; IL; interleukin; KC; keratinocyte-derived chemokine; MAPK; mitogen-activated protein kinase; MCP-1; mono
Keywords: NASH; nonalcoholic steatohepatitis; NAFD; nonalcoholic fatty liver disease; FXR; farnesoid X receptor; FGF19; fibroblast growth factor; DMSO; dimethyl sulfoxide; CYP; cytochrome P450; Liver; Flow; FXR; NASH; Transcriptomics; Obeticholic;
Keywords: 5-HT(2B); 5-hydroxytryptamine 2B receptor; ACE; angiotensin-converting enzyme; AMPK; AMP-activated protein kinase; ARB; AT1R blocker; ASK1; apoptosis signal-regulating kinase 1; AT1R; angiotensin II type 1 receptor; ATX; autotaxin; BDL; bile duct ligation
Keywords: Genetic variability; Postnatal development; Brown adipocytes; Inguinal white fat; Interscapular brown fat; Reduced ambient temperature; Thermoneutrality; Gut microbiota; Bile acids; AMPK; AMP-activated protein kinase; BA; bile acid; BAP; brown adipocyte p
27-hydroxycholesterol: A novel player in molecular carcinogenesis of breast and prostate cancer
Keywords: 27-OHC; 27-hydroxycholesterol; ADT; androgen deprivation therapy; AR; androgen receptor; ATF4; Activating Transcription Factor 4; ATF6; Activating Transcription Factor 6; C/EBP; CCAAT / Enhancer binding proteins; CHOP; C/EBP homologous protein; CIP2A; can
Keywords: Parenteral nutrition; Liver disease; Steatosis; FXR; Bile salt signaling; PNALD; parenteral nutrition-associated liver disease; FXR; farnesoid X receptor; SHP; small heterodimer partner; FGF; fibroblast growth factor; ALT; alanine aminotransferase; AST; a
Keywords: Gut Microbiota; Obesity; Diabetes; Fecal Transplantation; BMI; body mass index; CDI; Clostridium difficile infection; FMT; fecal microbiota transplantation; FXR; farnesoid X receptor; GF; germ-free; RYGB; roux-en-Y gastric; SCFA; short chain fatty acids;
Keywords: NAFLD; nonalcoholic fatty liver disease; ALD; alcoholic liver disease; TLRs; Toll-like receptors; NLRs; Nod-like receptors; NASH; nonalcoholic steatohepatitis; BT; bacterial translocation; HE; hepatic encephalopathy; ACLF; acute on chronic liver failure;
Keywords: Bariatric Surgery; Metabolic Surgery; Weight Loss; Type 2 Diabetes; Mortality; AGB; adjustable gastric banding; BMI; body mass index; BPD; biliopancreatic diversion; DS; duodenal-switch; FXR; farnesoid-x receptor; GLP1; glucagon-like peptide 1; HbA1c; hem
Keywords: Drug interactions; Hepatic transport; Transporters; ABC transporters; Bile acid transporters; BSEP; bile salt export pump; DILI; drug-induced liver injury; FXR; farnesoid X receptor; MDR; multidrug resistance protein; MRP; multidrug resistance-associated
Keywords: ATGL; adipose triglyceride lipase; CE; cholesterol ester; CESD; cholesterol ester storage disease; CMA; chaperone-mediated autophagy; CREB; cAMP response element binding protein; FA; fatty acid; FOXO; forkhead box O proteins; FXR; farsenoid X receptor; HS
Keywords: transporters; metabolism; drug-metabolizing enzymes; pharmacokinetics; hepatic transport; hepatic metabolism; organic anion-transporting polypeptide transporters; ALT; alanine aminotransferase; AST; aspartate aminotransferase; ATP; adenosine triphosphate;
Keywords: Bile Acids; FXR; TGR5; Meta-Inflammation; apo; apolipoprotein; ASBT; apical sodiumâdependent bile acid transporter; BA; bile acid; BAS; bile acid sequestrant; BAT; brown adipose tissue; BSH; bile salt hydrolase; CA; cholic acid; CCK; cholecystokinin; CD
Keywords: 3-BC; 3-benzylidene camphor; 4-MBC; 4-methylbenzylidene camphor; Aβ; amyloid-β; ABAD; Aβ-binding alcohol dehydrogenase; AD; Alzheimer's disease; AI; aromatase inhibitor; AKR; aldo-keto reductase; AME; apparent mineralocorticoid excess; AR; androgen r
Keywords: ADH; alcohol dehydrogenase; AH; acute alcoholic hepatitis; ALD; alcoholic liver disease; ALT; alanine aminotransferase; ARIC; Atherosclerosis Risk in Communities; ASH; alcoholic steato-hepatitis; AST; aspartate aminotransferase; ATM; ataxia-telangiectasis
Keywords: FGF21; Biliary atresia; Hepatic fibrosis; FXR; FGF21; fibroblast growth factor 21; BA; biliary atresia; DCD; donation after cardiac death; PPARα; peroxisome proliferator-activated receptors α; FXR; farnesoid X receptor; BDL; bile duct ligation;
Keywords: GBT; gut bacterial translocation; TJ; tight junction; ZO-1; zonula occludens-1; FXR; farnesoid X receptor; MLN; mesenteric lymph nodes; OCA; obeticholic acid; SHP; small heterodimer partner; OTU; operational taxonomic units; TNF; tumor necrosis factor; IL
Keywords: LPS; lipopolysaccharide; TLR4; toll-like receptor 4; BA; bile acid; FXR; farnesoid x receptor; PHx; partial hepatectomy; PCoA; Principal Coordinates Analysis; PICRUSt; Phylogenetic Investigation of Communities by Reconstruction of Unobserved States; STEM;
Keywords: Apo; apolipoprotein; BMI; body mass index; BPD; biliopancreatic diversion; FGF21; fibroblast growth factor 21; FXR; farnesoid X receptor; GB; gastric bypass; GBd; gastric banding; GLP-1; glucagon-like peptide-1; HDL-C; high-density lipoprotein cholesterol
Keywords: Dysbiosis; Diabetes; Metagenomics; Translocation; Intestinal Permeability; ALD; alcoholic liver disease; ALT; alanine aminotransferase; AST; aspartate aminotransferase; CDR; cirrhosis dysbiosis ratio; DHA; docosahexaenoic acid; FXR; farnesoid X receptor;
Keywords: ABCB; ATP-binding cassette sub-family B; Apo; apolipoprotein; ASBT; apical sodium dependent bile acid transporter; BDL; bile duct ligation; BSEP; bile salt export pump; CA; cholic acid; CDCA; chenodeoxycholic acid; C/EBP; CCAAT-enhancer-binding protein; C
Keywords: Liver regeneration; Bile acid; FXR; TGR5; FGF15;
Keywords: ADMA; asymmetric dimethylarginine; DDAH-1; dimethylarginine dimethylaminohydrolase 1; eNOS; endothelial nitric oxide synthase; FXR; farnesoid X receptor; HVPG; hepatic venous pressure gradient; MAP; mean arterial pressure; NO; nitric oxide; OA; obeticholi
Keywords: IF; intestinal failure; PN; parenteral nutrition; IFALD; intestinal failure associated liver disease; IL-6; interleukin-6; TNF-α; tumor necrosis factor-α; FGF19; fibroblast growth factor 19; FXR; farnesoid nuclear receptor X; NAFLD; nonalcoholic fatty l
Keywords: ADCYAP1R1 (PACAPR); adenylate cyclase activating polypeptide 1 (pituitary) receptor type I; B2M; beta-2-microglobulin; CCKAR; cholecystokinin A receptor; CCKBR; cholecystokinin B receptor; FXR; farnesoid X receptor; CRP; C-reactive protein; GAPDH; glycera
Keywords: apo; apolipoprotein; HDL; high-density lipoprotein; HNF-1α,4α; hepatocyte nuclear factor-1α,4α; LRH-1; liver receptor homolog-1; Foxa2; forkhead box A2; PAF; platelet activating factor; LXR; liver X receptor; RXR; retinoid X receptor; FXR; farnesoid X
Keywords: ALT; alanine aminotransferase; AST; aspartate aminotransferase; BMI; body mass index; EGD; esophagoduodenoscopy; FXR; farnesoid X receptor; HCC; hepatocellular carcinoma; LDL; low-density lipoprotein; MRE; magnetic resonance elastography; NAFL; nonalcohol
Keywords: AR; androgen receptor; CAR; constitutive androstane receptor; DBD; DNA-binding domain; EDC; endocrine disrupting chemical; ER; estrogen receptor; FXR; farnesoid X receptor; GR; glucocorticoid receptor; HRE; hormone responsive elements; LBD; ligand-binding
Keywords: ACS; acyl-coenzyme A synthase; adipoR; adiponectin receptor; ADP; adenosine diphosphate; AP2diph; attenuated P2 diphtheria toxin; AOX; acyl-coenzyme A oxidase; ApoE; apolipoprotein E; ATP; adenosine triphosphate; CBS; cystathionine-β-synthase; CD36; clus