Keywords: Mouse Model; Regeneration; Signal Transduction; CYP7A; BAC; bacterial artificial chromosome; BDL; bile duct ligation; FAH; fumarylacetoacetate hydrolase; FGF; fibroblast growth factor; FXR; farnesoid X receptor; NPC; nonparenchymal cell; PCR; polymerase c
مقالات ISI (ترجمه نشده)
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Keywords: ASBT; apical sodium dependent transporter; AKT; protein kinase B; BSEP; bile salt export protein (ABCB11); CA; cholic acid; CCA; cholangiocarcinoma; CDCA; chenodeoxycholic acid; CYP7A1; cholesterol 7α-hydroxylase; CYP7B1; oxysterol 7α-hydroxylase; CYP27
Keywords: Liver; Nuclear receptor; FXR; SHP; CYP7A1; CYP8B1All-trans retinoic acid (Pubchem CID: 444795)
Keywords: GC; glucocorticoid; BA; bile acid; GR; glucocorticoid receptor; FXR; farnesoid X receptor; SHP; short heterodimer partner; Asbt; Apical sodium-dependent bile acid transporter; CA; cholic acid; DCA; deoxycholic acid; α-MCA; α-muricholic acid; β-MCA; β-
Keywords: bile acid sequestrant; type 2 diabetes; glucose homeostasis; FXR; TGR5
Keywords: Bile acids; FXR; TGR5; Obesity; Insulin resistance
Keywords: ABCA1; ATP binding cassette transporter A1; Actb; beta-actin; ApoA-I; apolipoprotein A-I; B2m; beta-2 microglobulin; Cyp2E1; cytochrome P450 2E1; FXR; farnesoid X receptor; Gapdh; glyceraldehyde-3-phosphate dehydrogenase; GLUT1; glucose transporter 1; HDL
Keywords: AMP; antimicrobial peptides; APC; antigen-presenting cell; BDL; bile duct ligation; BT; bacterial translocation; CCl4; carbon-tetrachloride; DC; dendritic cell; FxR; Farnesoid X receptor; GALT; gut-associated lymphoid tissue; GI; gastrointestinal; GNB; gr
Keywords: ABC; ATP-binding cassette; AE2 (SLC4A2); anion exchanger 2; ALT; alanine aminotransferase; AMPK; AMP-activated protein kinase; ALP; alkaline phosphatase; ASBT (SLC10A2); apical sodium-dependent bile acid transporter; ASCOM; activating signal cointegrator-
Keywords: ACAA2; 3-oxoacyl-CoA thiolase; ADIPOR; adiponectin receptor; AF1,2; activation function 1,2; AMPK; AMP-activated protein kinase; ATF4; activating transcription factor 4; ATGL; adipose triglyceride lipase; CaMK; calcium/calmodulin-dependent kinase; CD36; f
Keywords: ACAT; acyl-CoA cholesterol acyltransferase; ACC; acetyl CoA carboxylases; ACLY; ATP citrate lyases; ACSL; acyl CoA synthetases long chain family; ADRP; adipose differentiation related protein; AGP; advanced glycation end products; AGPAT; acylglycerophosph
Keywords: Cholesterol; Oxysterol; CYP46A1; CYP27A1; CYP3A4; CYP39A1; CYP7B1; CH25H; Cholesterol 7α-hydroxylase; Sterol 27-hydroxylase; Cholesterol 24-hydroxylase; Cholesterol 25-hydroxylase; Oxysterol 7α-hydroxylase; 24-hydroxycholesterol 7α-hydroxylase; Epigene
Keywords: BH; Bcl-2 homology; CA; cholic acid (3α,7α,12α-trihydroxy-5β-cholanoic acid); CDCA; chenodeoxycholic acid (3α,7α-dihydroxy-5β-cholanoic acid); DCA; deoxycholic acid (3α,12α-dihydroxy-5β-cholanoic acid); EGFR; epidermal growth factor receptor; ER
Keywords: ROS; reactive oxygen species; NR; nuclear receptor; FA; fatty acid; TAG; triacylglycerol; MCD; malonyl-CoA decarboxylase; ACC; acetyl-CoA carboxylase; FAS; fatty acid synthase; SCD1; stearoyl-CoA desaturase-1; G-3-P; glycerol 3-phosphate; CPT-1; carnitine
Alisma orientale extract exerts the reversing cholestasis effect by activation of farnesoid X receptor
Keywords: Alisma orientale; Cholestasis; Proteomics; Farnesoid X receptor; AOE; Alisma orientale extract; ANIT; α-naphthylisothiocyanate; FXR; farnesoid X receptor; AST; aspartate aminotransferase; ALT; alanine aminotransferase; TBIL; total bilirubin; TBA; intrahe
Significance of A-to-I RNA editing of transcripts modulating pharmacokinetics and pharmacodynamics
Keywords: ABC; ATP-binding cassette transporter; ADAR; adenosine deaminase acting on RNA; ADH; alcohol dehydrogenase; AhR; aryl hydrocarbon receptor; AKR; aldo-keto reductase; ALS; amyotrophic lateral sclerosis; AZIN1; antizyme inhibitor 1; AMPA; α-amino-3-hydroxy
Differential effects of FXR or TGR5 activation in cholangiocarcinoma progression
Keywords: BA; bile acid; CCA; cholangiocarcinoma; DMEM; Dulbecco's modified Eagle's medium; FBS; fetal bovine serum; FXR; farnesoid X receptor; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GPBAR1 (or TGR5); G protein-coupled bile acid receptor 1; MRI; magnetic
Protective effect of dioscin against doxorubicin-induced cardiotoxicity via adjusting microRNA-140-5p-mediated myocardial oxidative stress
Keywords: AMPK; adenosine 5'-monophosphate (AMP)-activated protein kinase; CK; creatine kinase; DAPI; 4',6'-Diamidino-2-phenylindole; DOX; doxorubicin; ECG; electrocardiograms; FOXO3a; Forkhead box O3; FXR; farnesoid X receptor; GCLM; glutamatecysteine ligase mod
Takeda G Protein-Coupled Receptor 5-Mechanistic Target of Rapamycin Complex 1 Signaling Contributes to the Increment of Glucagon-Like Peptide-1 Production after Roux-en-Y Gastric Bypass
Keywords: BAs; Bile acids; Cyp7a1; Cytochrome P450 family 7 subfamily A member 1; DCA; Deoxycholic acid; FXR; Farnesoid X receptor; GLP-1; Glucagon-like peptide-1; ip; Intraperitoneal; mTOR; mechanistic target of rapamycin; mTORC1; mechanistic target of rapamycin c
Intestinal Farnesoid X Receptor Activation by Pharmacologic Inhibition of the Organic Solute Transporter α-β
Keywords: Fluorescence Resonance Energy Transfer (FRET); FXR; OSTα-OSTβ; Bile Acids; ASBT; apical sodium-dependent bile acid transporter; BAS; bile acid sensor; FACS; fluorescence-activated cell sorting; FDA; Food and Drug Administration; FGF15/19; fibroblast gro
Ablating both Fabp1 and Scp2/Scpx (TKO) induces hepatic phospholipid and cholesterol accumulation in high fat-fed mice
Keywords: 3αHSD; 3alpha-hydroxysteroid reductase; ABCA1; ATP-binding cassette sub-family A member 1; ABCG1; 4, 5 or 8, ATP-binding cassette sub-family G member 1,4, 5 or 8; ACAT2; acetyl-CoA acetyltransferase (Soat2 gene); ACC1; acetyl-CoA carboxylase (Acaca gene)
Ubiquitination/sumoylation: An alternative pathway to modify gene regulation directed by xenosensors
Keywords: Epigenetic regulation; Post-translational modifications; Nuclear receptors; Xenobiotics metabolism; AHR; aryl hydrocarbon receptor; AHRR; aryl hydrocarbon receptor repressor; ARNT; aryl hydrocarbon receptor nuclear translocator; CAR; constitutive androsta
An FXR Agonist Reduces Bile Acid Synthesis Independently of Increases in FGF19 in Healthy Volunteers
Keywords: Liver; CYP7A1; Nuclear Receptor Subfamily 1 Group H Member 4; NR1H4; BA; bile acid; C4; 7α-hydroxy-4-cholesten-3-one; CDCA; chenodeoxycholic acid; CYP7A1; cholesterol 7α-hydroxylase; FGF; fibroblast growth factor; FXR; farnesoid X receptor; LDL; low-den
Cyp7a1 is continuously increased with disrupted Fxr-mediated feedback inhibition in hypercholesterolemic TALLYHO/Jng mice
Keywords: TALLYHO/Jng; Hypercholesterolemia; BAs metabolism; Cyp7a1; Fxr;
Cholestatic Alterations in the Critically Ill
Keywords: bile acids; bilirubin; cholestasis; critical illness; liver; sepsis; ALP; alkaline phosphatase; ALT; alanine aminotransferase; AST; aspartate aminotransferase; BA; bile acid; FXR; farnesoid X receptor; γ-GT; γ-glutamyl transpeptidase; INR; international
Synbiotics Bifidobacterium infantis and milk oligosaccharides are effective in reversing cancer-prone nonalcoholic steatohepatitis using western diet-fed FXR knockout mouse models
Keywords: ALT; alanine transferases; ALP; alkaline phosphatase; BA; bile acid; bcoA; butyryl-coenzyme-A-CoA transferase; buk; butyrate kinase; B. infantis; Bifidobacterium longum subsp. infantis; CA; cholic acid; CDCA; chenodeoxycholic acid; DCA; deoxycholic acid;
Farnesoid X receptor agonist obeticholic acid inhibits renal inflammation and oxidative stress during lipopolysaccharide-induced acute kidney injury
Keywords: OCA; FXR; Inflammation; Oxidative stress; Acute kidney injury;
FXR deletion in hepatocytes does not affect the severity of alcoholic liver disease in mice
Keywords: Alcoholic liver disease; Bile acid metabolism; Ethanol toxicity; FXR; Lipid metabolism; Tissue specific knockout;
Bioactive Lipid Species and Metabolic Pathways in Progression and Resolution of Nonalcoholic Steatohepatitis
Keywords: Nonalcoholic Fatty Liver Disease; Triglycerides; Fatty Acids; Therapy; AA; arachidonic acid; ACC; acetyl-coenzyme A carboxylase; ASMase; acid sphingomyelinase; CeS; ceramide synthase; CoA; coenzyme A; COX; cyclo-oxygenase; DES; dihydro-ceramide desatura
Interaction of glucocorticoids with FXR/FGF19/FGF21-mediated ileum-liver crosstalk
Keywords: BA; bile acid; C4; 7α-hydroxy-4-cholesten-3-one; DEX; dexamethasone; DHP; 16-dehydropregnenolone; FGF; fibroblast growth factor; FXR; farnesoid-X-receptor; GC; glucocorticoids; GR; glucocorticoid receptor; GRE; glucocorticoid response element; MFS; mifep
Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR
Keywords: Farnesoid X receptor; TGR5; Atherosclerosis; Obesity; NAFLD; α-Sma; alpha smooth muscle actin (α-Sma); BA; bile acid; BAT; brown adipose tissue; CEBPα; CCAAT/enhancer-binding protein α; Col1α1; collagen type 1 α1; DIO; diet-induced obesity; FXR; far
Nuclear receptor FXR, bile acids and liver damage: Introducing the progressive familial intrahepatic cholestasis with FXR mutations
Keywords: NR; nuclear receptor; FXR; farnesoid X receptor; RXR; retinoid X receptor; PXR; pregnane X receptor; VDR; Vitamin D receptor; TGR5; G protein-coupled bile acid receptor; Lrh1; liver receptor homolog 1; Mdr; multidrug resistance protein; Abcb4; ATP Bindi
Activation of Farnesoid X Receptor impairs the tumor-promoting function of breast cancer-associated fibroblasts
Keywords: CAFs; FXR; Tumor microenvironment; Breast cancer; Nuclear receptors;
Microcystin induction small Maf protein involve in transcriptional regulation of GST from freshwater mussel Cristaria plicata
Keywords: Maf; musculoaponeurotic fibrosarcoma; GST; glutathione S-transferase; ARE; antioxidant response element; EpRE; electrophile response element; CNC; cap “n” collar; bZIP; basic region leucine zipper; Nrf2; nuclear factor erythroid-2p45-related factor 2;
Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer
Keywords: FXR; Obeticholic Acid; S-Adenosylmethionine; Ursodeoxycholic Acid; AP-1; activator protein-1; ARE; antioxidant response element; BDL; bile duct ligation; BrdU; 5-bromo-2'deoxyuridine; CCA; cholangiocarcinoma; FXR; farnesoid X receptor; GSH; reduced glut
Transhepatic bile acid kinetics in pigs and humans
Keywords: Bile acids; TGR5; Porcine; Postprandial; Portal concentrations; BAs; bile acids; ASBT; apical sodium-dependent bile acid transporter; OST; organic solute transporter; NTCP; taurocholate cotransporting polypeptide; OATP; organic anion transporting polypept
Activation of PPARα decreases bile acids in livers of female mice while maintaining bile flow and biliary bile acid excretion
Keywords: Biliary excretion; PPARα; Bile acids; Gender difference; 1oBAs; Primary bile acids; 2oBAs; secondary bile acids; 12-OH; 12-hydroxylated bile acid; Asbt; apical sodium-dependent bile acid transporter; BA; bile acid; Baat; bile acid CoA:amino acid N-acyltr
Cholemic nephropathy - Historical notes and novel perspectives
Keywords: AKI; acute kidney injury; CBDL; common bile duct ligation; CKD; chronic kidney disease; CN; cholemic nephropathy; FXR; farnesoid X receptor; GFR; glomerular filtration rate; IL-18; interleukin 18; iNOS; inducible nitric oxide synthase; KDIGO; Kidney Disea
Human-based systems: Mechanistic NASH modelling just around the corner?
Keywords: Elafibranor (PubChem CID: 9864881); Obeticholic acid (PubChem CID: 447715); Pioglitazone (PubChem CID: 4829); Rosiglitazone (PubChem CID: 77999); Fenofibrate (PubChem CID: 3339); Serine (PubChem CID: 5951); ACC1; acetyl-coenzyme A carboxylase 1; AdipoR; a
Lipotoxicity and the gut-liver axis in NASH pathogenesis
Keywords: Free fatty acids; Ceramides; Apoptosis; JNK; Fibrosis; Inflammasome; Microbiota; Fibroblast growth factor; FXR; Inflammation;
Aryl hydrocarbon receptor (AhR) mediated short-term effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on bile acid homeostasis in mice
Keywords: Aryl hydrocarbon receptor; TCDD; Bile acids; Biliary excretion; Taurodeoxycholic acid; Cyp8b1; 1°BAs; Primary bile acids; 2°BAs; Secondary bile acids; 6-OH; 6-hydroxylated (6-OH); 12-OH; 12α-hydroxylated; Abc; ATP-binding cassette; AhR; Aryl hydrocarbo
Disruption of TFGβ-SMAD3 pathway by the nuclear receptor SHP mediates the antifibrotic activities of BAR704, a novel highly selective FXR ligand
Keywords: CDCA; chenodeoxycholic acid; CA; cholic acid; DCA; deoxycholic acid; LCA; litocholic acid; BAs; bile acids; BARS; bile acid activated receptors; GPBAR1; G protein coupled bile acid receptor; TGR5; Takeda G protein receptor 5; FXR; farnesoid x-receptor; PX
Non-alcoholic fatty liver disease and its treatment with n-3 polyunsaturated fatty acids
Keywords: NAFLD; Omega-3 fatty acids; Fish oil; Algal oil; Insulin resistance; Metabolic syndrome; ALA; alpha-linolenic acid; ALT; alanine aminotransferase; Apo; apolipoprotein; AST; aspartate aminotransferase; BMI; body mass index; ChREBP; carbohydrate response el
Farnesoid X receptor: A “homeostat” for hepatic nutrient metabolism
Keywords: Bile acids; FXR; Nutrient metabolism; Autophagy; Proliferation; Inflammation;
Tithonia diversifolia (Hemsl.) A. Gray as a medicinal plant: A comprehensive review of its ethnopharmacology, phytochemistry, pharmacotoxicology and clinical relevance
Keywords: ABTS; 2,2â²-Azinobis (3-ethylbenzothiazoline-6-sulphonate); Ach; acetyl choline; ALP; alkaline phosphatase; ALT; alanine aminotransferase; AMPK; 5' adenosine monophosphate-activated protein kinase; AST; Aspartate transaminase; CAs; chlorogenic acids; CC5
Insights into hepatic and renal FXR/DDAH-1/eNOS pathway and its role in the potential benefit of rosuvastatin and silymarin in hepatic nephropathy
Keywords: Cirrhosis; DDAH-1; FXR; Kidney; Rosuvastatin; Silymarin; ADMA; asymmetric dimethylarginine; ALK; Alkaline phosphatase; ALT; alaninetransaminase; AST; aspartate transaminase; CRD; Chronic Renal Disease; DDAH; dimethylarginine dimethylaminohydrolase-; ED; E
Autophagy in ischemic stroke
Keywords: 3-MA; 3-methyladenine; Aβ; amyloid β; AIF; apoptosis-inducing factor; Akt; protein kinase B; AMPK; AMP-activated protein kinase; ATF6; activating transcription factor 6; Atg; autophagy-related genes; ATP; adenosine 5â²-triphosphate; BBB; blood-brain ba
Natural products as modulators of the nuclear receptors and metabolic sensors LXR, FXR and RXR
Keywords: Natural products; Nuclear receptors; Liver X receptor; Farnesoid X receptor; Retinoid X receptor; Metabolic syndrome; Precision medicine; 6-ECDCA; 6α-ethyl-chenodeoxycholic acid (obeticholic acid); AA; arachidonic acid; ABC; ATP-binding cassette transpor
Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)
Keywords: NASH; Nrf2; TBE-31; ACACA; acetyl-CoA carboxylase alpha; ACLY; ATP citrate lyase; ACOT7; acetyl-CoA thioesterase 7; ACOX2; acetyl-CoA oxidase 2; ADRP; adipose differentiation-related protein; AP-1; activator protein 1; ApoB; apolipoprotein B; ATF4; activa
Cyp3a11 is not essential for the formation of murine bile acids
Keywords: P450 enzymes; Mouse models; FXR; 6-Hydroxylation;