FXR agonist activity of conformationally constrained analogs of GW 4064
Keywords: Farnesoid X receptor; FXR; Nuclear receptor
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Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis
Keywords: FXR; farnesoid X receptor; SHP; small heterodimer partner; BSEP; bile salt export pump; MCD; methionine- and choline-deficient; NASH; nonalcholic steatohepatitis; NAFLD; non-alcoholic fatty liver disease; CYP7A1; cholesterol 7α-hydroxylase; CYP8B1; stero
The farnesoid X receptor regulates transcription of 3β-hydroxysteroid dehydrogenase type 2 in human adrenal cells
Keywords: FXR; HSD3B2; Adrenal gland; Bile acids
The role of herbal PPAR modulators in the treatment of cardiometabolic syndrome
Keywords: Herbal; Natural Ligands; PPAR; LXR; FXR; Peroxisome proliferator-activated receptors; Liver X receptors; Farnesoid X receptor
EASL Clinical Practice Guidelines: Management of cholestatic liver diseases
Keywords: Primary biliary cirrhosis; Primary sclerosing cholangitis; Overlap syndrome; Immunoglobulin G4-associated cholangitis; Drug-induced cholestatic liver disease; Genetic cholestatic liver disease; Cholestatic liver diseases in pregnancy; Intrahepatic cholest
Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064
Keywords: Farnesoid X receptor agonist; FXR; Nuclear receptor modulator; FXR X-ray co-crystal structure; GW 4064; GSK8062; Naphthoic acid; Bile acid receptor; NR1H4
Upregulation of decorin by FXR in vascular smooth muscle cells
Keywords: FXR; Decorin; Smooth muscle cells; Vascular; Regulation
The farnesoid X receptor (FXR) as a new target in non-alcoholic steatohepatitis
Keywords: FXR; Bile acids; Liver steatosis; Liver regeneration; Lipogenesis; ReviewFXR; Acides biliaires; Stéatose hépatique; Régénération hépatique; Lipogenèse; Revue
Fluctuation of lipoprotein metabolism linked with bile acid-activated liver nuclear receptors in Alagille syndrome
Keywords: Cholestasis; HDL; Apolipoprotein E; FXR; LXR; SR-BI; CETP
Activation of the farnesoid X receptor represses PCSK9 expression in human hepatocytes
Keywords: BA; bile acid; CA; cholic acid; CDCA; chenodeoxycholic acid; DCA; deoxycholic acid; FXR; farnesoid X receptor; IHH; immortalized human hepatocytes; LA; lithocholic acid; LDL-c; low density lipoprotein cholesterol; LDLr; low density lipoprotein receptor; P
Immunolocalization of farnesoid X receptor (FXR) in mouse tissues using tissue microarray
Keywords: FXR; Tissue microarray; Immunohistochemistry; Localization; Nuclear receptor
Genetic factors of susceptibility and of severity in primary biliary cirrhosis
Keywords: PBC; primary biliary cirrhosis; CTLA-4; cytotoxic T-lymphocyte antigen 4; TNFα; tumor necrosis factor α; SNP; single nucleotide polymorphism; Ht SNP; haplotype-tagging single nucleotide polymorphism; MDR1; multidrug resistance 1; UDCA; ursodeoxycholic a
FXR signaling in metabolic disease
Keywords: FXR; Bile acid; Lipid; Glucose
ReviewGallstone disease: From genes to evidence-based therapy
Keywords: ABC; ATP-binding cassette; ERC; endoscopic retrograde cholangiography; ESWL; extracorporeal shock-wave lithotripsy; FXR; farneosid X receptor; GT; glutamyltransferase; MRC; magnetic resonance cholangiography; RCT; randomised controlled trial; UDCA; ursode
Bile acids and signal transduction: Role in glucose homeostasis
Keywords: CDCA; chenodeoxycholic acid (3α,7α-dihydroxy-5β cholan-24-oic acid); CA; cholic acid (3α,7α,12α-trihydroxy-5β cholan-24-oic acid); DCA; deoxycholic acid (3α,12α-dihydroxy-5β cholan-24-oic acid); LCA; lithocholic acid (3α-monohydroxy-5β cholan-
3D-QSAR studies with the aid of molecular docking for a series of non-steroidal FXR agonists
Keywords: Farnesoid x receptor; FXR; Agonist; 3D-QSAR; Molecular docking; Bile acid; Non-steroidal agonist; Fexaramine;
3D QSAR comparative molecular field analysis on nonsteroidal farnesoid X receptor activators
Keywords: Nuclear receptors; FXR; QSAR; CoMFA
Human constitutive androstane receptor mediated methotrexate induction of human dehydroepiandrosterone sulfotransferase (hSULT2A1)
Keywords: SULT; sulfotransferase; hSULT; human sulfotransferase; mSULT; mouse sulfotransferase; rSULT; rat sulfotransferase; SULT2A1; dehydroepiandrosterone sulfotransferase; SULT1A1; simple phenol sulfotransferase; DHEA; dehydroepiandrosterone; MTX; methotrexate;
Functional Variants of the Central Bile Acid Sensor FXR Identified in Intrahepatic Cholestasis of Pregnancy
Keywords: DBD; DNA-binding domain; EcR; ecdysone receptor; FXR; farnesoid X receptor; GGT; γ-glutamyl transpeptidase; ICP; intrahepatic cholestasis of pregnancy; PCR; polymerase chain reaction; SHP; short heterodimer partner; USP; ultraspiracle;
Functional analysis on the 5â²-flanking region of human FXR gene in HepG2 cells
Keywords: ChIP; Chromatin Immunoprecipitation; EMSA; Electrophoresis Mobility shift and Supershift Assay; FXR; Farnesoid X Receptor; HNF1α; Hepatic Nuclear Factor 1α; RACE; Rapid Amplification of cDNA Ends; BA; bile acid.; Farnesoid X receptor; Hepatic nuclear fa
Design, synthesis, and evaluation of non-steroidal farnesoid X receptor (FXR) antagonist
Keywords: FXR; Farnesoid X receptor; FXR antagonist; Non-steroidal; Corepressor
Diphenylmethane skeleton as a multi-template for nuclear receptor ligands: Preparation of FXR and PPAR ligands
Keywords: Nuclear receptor ligands; FXR; PPAR; Drug design; Diphenylmethane
¿Existen aún nuevas dianas terapéuticas en la arteriosclerosis? LXR y FXR
Keywords: Arteriosclerosis Receptores nucleares; LXR; FXR; Dianas terapéuticas; Arteriosclerosis; Nuclear receptors; LXR; FXR; Therapeutic targets;
The region of CQQQKPQRRP of PGC-1α interacts with the DNA-binding complex of FXR/RXRα
Keywords: Nuclear receptor; FXR; PGC-1α; DNA binding; EMSA
3α-6α-Dihydroxy-7α-fluoro-5β-cholanoate (UPF-680), physicochemical and physiological properties of a new fluorinated bile acid that prevents 17α-ethynyl-estradiol-induced cholestasis in rats
Keywords: Cholestasis; UPF-680; Bile acids; FXR; UDCA;
Screening of novel nuclear receptor agonists by a convenient reporter gene assay system using green fluorescent protein derivatives
Keywords: FXR; RAR; Reporter assay; Fluorescence; GFP; Caffeic acid; Ginkgolic acid; Grifolin
Bile Acids Induce Ileal Damage During Experimental Necrotizing Enterocolitis
Keywords: ASBT; apical sodium-dependent bile acid transporter; BA; bile acid; Chol; cholestyramine; DF; dam fed; DOC; deoxycholic acid; EGF; epidermal growth factor; FXR; farnesoid X receptor; IBABP; ileal bile acid binding protein; NEC; necrotizing enterocolitis;
Reconstitution of functional nuclear receptor proteins using high pressure refolding
Keywords: Steroid receptor; Estrogen receptor; FXR; LRH-1; Orphan receptor; Nuclear receptor; Bile acid; Protein expression;
Nuclear Receptor Ligands: Rational and Effective Therapy for Chronic Cholestatic Liver Disease?
Keywords: ABCG5/8; cholesterol export pump; BSEP; bile salt export pump; CAR; constitutive androstane receptor; CYP; cytochrome P-450; FTF; fetal transcription factor; FXR; farnesoid X receptor; GST; glutathione-S-transferase; LXR; liver X receptor; MDR; multidrug
Potential regulatory role of the farnesoid X receptor in the metabolic syndrome
Keywords: FXR; Insulin resistance; SHP; Gluconeogenesis; Metabolic syndrome;
Identification of the promoter elements involved in the stimulation of ASCT2 expression by glutamine availability in HepG2 cells and the probable involvement of FXR/RXR dimers
Keywords: Transporter; Hepatoma; Glutamine; FXR; RXR; Promoter;
Hologram quantitative structure–activity relationships for a series of farnesoid X receptor activators
Keywords: HQSAR; Drug design; Nuclear receptors; FXR
5β-Cholane activators of the farnesol X receptor
Keywords: FXR; Bile acids; 5β-Cholane;
Xanthohumol, the chalcone from beer hops (Humulus lupulus L.), is the ligand for farnesoid X receptor and ameliorates lipid and glucose metabolism in KK-Ay mice
Keywords: Xanthohumol; FXR; Selective bile acid receptor modulator; Anti-diabetes; Beer hops;
Regulation of ileal bile acid-binding protein expression in Caco-2 cells by ursodeoxycholic acid: Role of the farnesoid X receptor
Keywords: CDCA; chenodeoxycholic acid; Cyp7a; cholesterol 7α-hydroxylase; DCA; deoxycholic acid; FCS; fetal calf serum; FXR; farnesoid X receptor; IBABP; ileal bile-acid binding protein; LDH; lactate dehydrogenase; RLU; relative light units; UDCA; ursodeoxycholic
The gene encoding the human ileal bile acid-binding protein (I-BABP) is regulated by peroxisome proliferator-activated receptors
Keywords: ASBT; apical sodium-dependent bile acid transporter; I-BABP; ileal bile acid-binding protein; CYP7A1; cholesterol 7α-hydroxylase; CYP27A1; sterol 27-hydroxylase; CYP8B1; sterol 12α-hydroxylase; PPAR; peroxisome proliferator-activated receptors; RXR; ret
Characterization of organic anion transporter regulation, glutathione metabolism and bile formation in the obese Zucker rat
Keywords: Glutathione; Bile acids; Glutathione conjugates; Organic anion transport; Isolated rat liver perfusion; Steatosis; BCRP; breast cancer resistance protein; BDBF; bile salt-dependent bile flow; BIBF; bile salt-independent bile flow; Bsep; bile salt export p
Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR
Keywords: Nuclear receptors; Drug-induction; Lipids; Bile acids; Cholesterol; CAR; PXR; LXR; FXR; Cytochrome P450;
Bile acids reduce SR-BI expression in hepatocytes by a pathway involving FXR/RXR, SHP, and LRH-1
Keywords: SR-BI; Liver; Bile acids; FXR; LRH-1; SHP;
Polymorphisms affecting gene regulation and mRNA processing: Broad implications for pharmacogenetics
Keywords: 5-FU; 5-fluorouracil; 5-HTT; serotonin transporter; 5-HTTLPR; serotonin gene-linked polymorphic region; 6-MP; 6-mercaptopurine; 6-TG; 6-thioguanine; ABCB; ATP-binding cassette (ABC), subfamily B; ACE; angiotensin I converting enzyme (peptidyl-dipeptidase
Modulation of hepatic and renal drug metabolizing enzyme activities in rats by subchronic administration of farnesol
Keywords: AHMC; 3-[2-(diethylamino)ethyl]-7-hydroxy-4-methylcoumarin hydrochloride; AMMC; 3-[2-(N,N-diethyl-N-methylammonium)ethyl]-7-methoxy-4-methylcoumarin; BHT; butylated hydroxytoluene; CAR; constitutive androstane receptor; CYP or P450; cytochrome P450; DCPIP
C. elegans DAF-12, Nuclear Hormone Receptors and human longevity and disease at old age
Keywords: AR; Androgen Receptor; BLAST; Basic Local Alignment Search Tool; CAR; Constitutive Androstane Receptor; CETP; Cholesterol Ester Transfer Protein; COUP-TF1/COUP-TF2; Chicken Ovalbumin Upstream Promoter Transcription Factor 1/2; CYP7A1; cholesterol-7-alpha-