Diphenylmethane skeleton as a multi-template for nuclear receptor ligands: Preparation of FXR and PPAR ligands

Novel, potent farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor α (PPARα) agonists were obtained by using a diphenylmethane skeleton as a substitute for a steroid skeleton.

Design and preparation of novel ligands for FXR, DPPF-01, and for PPARα, DPHK-01, were described.Figure optionsDownload as PowerPoint slide