دانلود مقالات ISI درباره Fxr + ترجمه فارسی

The potential of microRNAs in liver fibrosis

Keywords: miRNA; microRNA; ECM; extracellular matrix; HSC; hepatic stellate cell; α-SMA; α-smooth muscle actin; TGF-β; transforming growth factor-β; 3'UTR; 3'untranslated region; PDGF; platelet-derived growth factor; HCC; hepatocellular carcinoma; ACSL1; acyl-C

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Farnesoid X Receptor Targeting for Hepatitis C: Study Protocol for a Proof-of-concept Trial

Keywords: clinical trial; farnesoid X receptor; hepatitis C; proof of concept; essai clinique; récepteur nucléaire des acides biliaires; hépatite C; preuve de concept; Afssaps; french Agency for the Safety of Health Products (currently ANSM); BA; bile acid; CBC;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Complement factor C5 deficiency significantly delays the progression of biliary fibrosis in bile duct-ligated mice

Keywords: α-SMA; alpha-smooth muscle actin; BA; bile acid; BDL; bile duct ligation; Col; collagen; FXR; farnesoid X receptor; HE; Hematoxilin&Eosin; Ntcp; Na-dependent taurocholate transporter; MMP; matrix metalloproteinase; Mrp; multidrug resistance associated pr

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Discovery of new non-steroidal FXR ligands via a virtual screening workflow based on Phase shape and induced fit docking

Keywords: FXR; Phase shape; Docking; Ligands; Virtual screening;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Human UDP-glucuronosyltransferases: Feedback loops between substrates and ligands of their transcription factors

Keywords: AhR; Ah receptor; CAR; constitutive androstane receptor; CYP; cytochrome P450; FXR; farnesoid receptor; GST; glutathione S-transferase; HETE; hydroxyeicosatetraenoic acid; LATF; ligand-activated transcription factor; LTB4; leucotriene B4; PPAR; peroxisome

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Research ArticleLack of Abcc3 expression impairs bile-acid induced liver growth and delays hepatic regeneration after partial hepatectomy in mice

Keywords: BA; bile acids; PH; partial hepatectomy; Mrp3; multi drug resistance-associated protein 3; CA; cholic acid; FXR; farnesoid X receptor; EGF; epidermal growth factor; Cyp7a1; cholesterol 7-alpha hydroxylase; Ntcp; Na+-taurocholate cotransporting protein; Bs

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Research ArticleMouse organic solute transporter alpha deficiency alters FGF15 expression and bile acid metabolism

Keywords: BA; bile acid(s); Asbt; apical sodium-dependent bile acid transporter; Ost; organic solute transporter; FXR; farnesoid X receptor; FGF15; fibroblast growth factor 15; Cyp7a1; cholesterol 7α-hydroxylase; FGFR4; fibroblast growth factor receptor 4; CA; cho

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

FXR agonist GW4064 increases plasma glucocorticoid levels in C57BL/6 mice

Keywords: Glucocorticoid; Corticosterone; Cholesterol; FXR; GW4064; SR-BI

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Research ArticleEffect of ursodeoxycholic acid on bile acid profiles and intestinal detoxification machinery in primary biliary cirrhosis and health

Keywords: UDCA; ursodeoxycholic acid; PBC; primary biliary cirrhosis; ASBT; apical sodium-dependent bile acid transporter; FXR; farnesoid X receptor; PXR; pregnane X receptor; VDR; vitamin D receptor; CA; cholic acid; CDCA; chenodeoxycholic acid; DCA; deoxycholic a

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Research ArticleSRC-3 is required for CAR-regulated hepatocyte proliferation and drug metabolism

Keywords: SRC; steroid receptor co-activator; NR; nuclear receptor; CAR; constitutive androstane receptor; TCPOBOP; 1,4-bis-[2-(3,5-dichloropyridyloxy)] benzene; ASC-2; activating signal cointegrator 2; FXR; farnesoid X receptor; PCNA; proliferating cell nuclear an

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Effects of bile duct ligation and cholic acid treatment on fatty liver in two rat models of non-alcoholic fatty liver disease

Keywords: Bile acids; CYP7A1; Fatty liver; FXR; LXR

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Research ArticleDeletion of IFNγ enhances hepatocarcinogenesis in FXR knockout mice

Keywords: HCC; hepatocellular carcinoma; FXR; farnesoid X receptor; DEN; diethylnitrosamine; AST; aspartate aminotransferase; ALT; alanine aminotransferase; ROS; reactive oxygen species; FXR; HCC; STAT3; JNK; NF-κB; p53;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Dancing with the sterols: Critical roles for ABCG1, ABCA1, miRNAs, and nuclear and cell surface receptors in controlling cellular sterol homeostasis

Keywords: ABC; ATP Binding Cassette; AICAR; Aminoimidazole Carboxamide Ribonucleotide; ApoE; Apolipoprotein E; ApoER2; ApoE receptor 2 (LRP8); AR; Androgen Receptor; BAC; Bacterial Artificial Chromosome; CETP; Cholesterol Ester Transfer Protein; eNOS; endothelial N

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Alpha-linolenic acid increases cholesterol efflux in macrophage-derived foam cells by decreasing stearoyl CoA desaturase 1 expression: evidence for a farnesoid-X-receptor mechanism of action

Keywords: ALA; SCD1; FXR; SREBP1C; Cholesterol efflux; Foam cell;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Anti-inflammatory and metabolic actions of FXR: Insights into molecular mechanisms

Keywords: AF1; activation function 1; ANIT; α-naphthylisothiocyanate; AR; androgen receptor; BA; bile acids; BDL; bile duct ligation; ChIP-seq; chromatin immunoprecipitation-sequencing; DBD; DNA binding domain; DR; direct repeat; ER; estrogen receptor; FXR; farnes

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Retinoid metabolism and its effects on the vasculature

Keywords: ADH; alcohol dehydrogenase; ADMA; asymmetric dimethylarginine; AP-1; activated protein-1; apo14; β-apo-14′-carotenal; ARVM; adult rat ventricular myocytes; ATBC; Alpha-tocopherol Beta-carotene Cancer Prevention Study; atRA; all-trans retinoic acid; BCO

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

The genus Commiphora: A review of its traditional uses, phytochemistry and pharmacology

Keywords: ABTS; 2,2′-azino-di-[3-ethylbenzthiazoline sulphonate]; ALP; alkaline phosphatase; ALT; alanine aminotransferase; AST; aspartate aminotransferase; COX; cyclooxygenase; CNS; central nervous system; DPPH; 2,2-diphenyl-1-picrylhydrazyl; FXR; farnesoid X re

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

The emerging role of acyl-CoA thioesterases and acyltransferases in regulating peroxisomal lipid metabolism

Keywords: ACNAT; acyl-CoA:amino acid N-acyltransferase; ACOT; acyl-CoA thioesterase; ACOX3; acyl-CoA oxidase 3; BAAT; bile acid-CoA:amino acid N-acyltransferase; CA; cholic acid; CoASH; coenzyme A; CDCA; chenodeoxycholic acid; DMN-CoA; dimethylnonanoyl-CoA; FAAH; f

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

Farnesoid X Receptor Protects Hepatocytes From Injury by Repressing miR-199a-3p, Which Increases Levels of LKB1

Keywords: Nuclear Receptor; Noncoding RNA; Mitochondrial Protection; Fibrotic Liver Injury; AA; arachidonic acid; AMPK; AMP-activated protein kinase; ASO; antisense oligonucleotide; CAB39; calcium binding protein 39; CDCA; chenodeoxycholic acid; DCFH-DA; 2′,7′-

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2012 سفارش ترجمه

Glucocorticoids Promote Hepatic Cholestasis in Mice by Inhibiting the Transcriptional Activity of the Farnesoid X Receptor

Keywords: Bile Acid Metabolism; Small Heterodimer Partners; Liver Disease; Nuclear Receptor; ALT; alanine aminotransferase; BA; bile acid; BMI; body mass index; ChIP; chromatin immunoprecipitation; CtBP; C-terminal binding protein; Cyp7A1; cytochrome P450, family 7

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2012 سفارش ترجمه

Features, Diagnosis, and Treatment of Nonalcoholic Fatty Liver Disease

Keywords: Diagnosis; Epidemiology; Cancer Risk; Mechanisms; ALT; alanine aminotransferase; APOC3; apolipoprotein C3; ARFI; acoustic radiation force impulse elastography; AST; aspartate aminotransferase; ATF6; activating transcription factor-6; AUROC; area under the

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2012 سفارش ترجمه

Anti-obesity and anti-hyperglycemic effects of the dietary citrus limonoid nomilin in mice fed a high-fat diet

Keywords: FXR; Limonoid; Nomilin; TGR5

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Nuclear bile acid receptor FXR in the hepatic regeneration

Keywords: FXR; Nuclear receptor; Bile acid; Liver regeneration; Liver repair

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Novel molecular targets for prevention of obesity and osteoporosis

Keywords: AHR; aryl hydrocarbon receptor; ARNT; AHR nuclear translocator; BAs; bile acids; cAMP; cyclic adenosine monophosphate; CRE; cAMP response element; CYP24; cytochrome P450 enzyme 24-hydroxylase; CYP27B1; 1 α-hydroxylase; D2; type 2 iodothyronine deiodinase

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Proteomics for the discovery of nuclear bile acid receptor FXR targets

Keywords: NR, nuclear receptor; FXR, farnesoid X receptor; BA, bile acid; FXR−/−, FXR loss-of-functionNuclear receptor; FXR; Proteomic analysis; Expression profiling; Post-transcriptional modification; Mitochondrial

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties

Keywords: Farnesoid X receptor agonist; FXR; Nuclear receptor; Lead optimization; ADME; X-ray structure

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Post-translational modification of pregnane x receptor

Keywords: PXR; pregnane x receptor; NR; nuclear receptor; PCN; pregnenalone 16α-carbonitrile; Rif; rifampicin; G6Pase; glucose-6-phosphatase; PEPCK; phosphoenolpyruvate carboxykinase; CYP3A; cytochrome P450 3A; CREs; cyclic AMP response elements; PKA; cyclic AMP-d

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Nuclear receptors in renal disease

Keywords: Diabetes; Nuclear hormone receptors; Renal disease; VDR; FXR; PPAR

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Conformationally constrained farnesoid X receptor (FXR) agonists: Alternative replacements of the stilbene

Keywords: Farnesoid X receptor; FXR; Nuclear receptor modulator; FXR X-ray co-crystal structure; GW 4064; GSK8062; GSK2324; Bile acid receptor; NR1H4

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Conformationally constrained farnesoid X receptor (FXR) agonists: Heteroaryl replacements of the naphthalene

Keywords: Farnesoid X receptor; FXR; Nuclear receptor modulator; FXR X-ray co-crystal structure; GW 4064; GSK8062; Bile acid receptor; NR1H4 GSK2324

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Extending SAR of bile acids as FXR ligands: Discovery of 23-N-(carbocinnamyloxy)-3α,7α-dihydroxy-6α-ethyl-24-nor-5β-cholan-23-amine

Keywords: FXR; Bile acid; Carbamate; RMDS; Allosteric site

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

The nuclear receptor FXR regulates hepatic transport and metabolism of glutamine and glutamate

Keywords: Glutamine; Glutamate; Urea cycle; NAGS; FXR; Hyperammonemia

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

ReviewThe bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation

Keywords: Bile acids; Diabetes; Energy homeostasis; FXR; GLP-1; G-protein coupled receptor; Nuclear receptors; TGR5;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

The role of lithocholic acid in the regulation of bile acid detoxication, synthesis, and transport proteins in rat and human intestine and liver slices

Keywords: Lithocholic acid; VDR; FXR; PXR; GR; Intestinal slices; Liver slices; Cytochrome P450; Transporters; Bile acid; Induction

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Research ArticleInsufficient bile acid signaling impairs liver repair in CYP27−/− mice

Keywords: Liver repair; CYP27; Cerebrotendinous xanthomatosis; Bile acids; BA; bile acid; CTX; cerebrotendinous xanthomatosis; PH; partial hepatectomy; CCl4; carbon tetrachloride; FXR; farnesoid X receptor; CYP27; sterol 27-hydroxylase; CYP7A1; cholesterol-7α-hydr

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Role of nuclear receptors for bile acid metabolism, bile secretion, cholestasis, and gallstone disease

Keywords: Bile acids; Nuclear receptors; FXR; Cholestasis; Gallstone; Bile acid transport

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Pharmacophore-based discovery of FXR-agonists. Part II: Identification of bioactive triterpenes from Ganoderma lucidum

Keywords: AAJIHHYEPHRIET-XEFAKFPISA-N; DNVPQKQSNYMLRS-AWYZMFRDSA-N; AZPOACUDFJKUHJ-KRDQJDFUSA-N; LVGCWXNRZNCAJG-AMKDLFIQSA-N; SNZQBBATMLGADX-VVUVUVSISA-N; KASALCUNLBTNAA-LIPCCPSCSA-N; JVGJXXNUVVQEIG-MCKXIFHVSA-N; INIPQDKLXQHEAJ-NCQSLMINSA-N; YTVGSCZIHGRVAV-YQKBFJOX

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

Pharmacophore-based discovery of FXR agonists. Part I: Model development and experimental validation

Keywords: TUOXXRMLFZBSTB-UHFFFAOYSA-N; JTRRVYQZHXAOGI-UHFFFAOYSA-N; QMDSMBFIKFKGBD-MDZDMXLPSA-N; WPHVYHBQJIXGIJ-UHFFFAOYSA-N; FCSGTZIUJUNGAC-UHFFFAOYSA-N; GKTSXRHLYUJTSU-QHCPKHFHSA-N; SPFSVEKWCKWVLI-DEOSSOPVSA-N; SUHGVDRUULOBLM-ZXVVBBHZSA-N; CPEYWROBUIDLPI-UHFFFAOY

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

Hepatic Free Cholesterol Accumulates in Obese, Diabetic Mice and Causes Nonalcoholic Steatohepatitis

Keywords: Lipotoxicity; LRH-1; Bsep; Liver Damage; ABC; adenosine triphosphate-binding cassette; ACAT; acyl-CoA cholesterol/cholesteryl transferase; BA; bile acid; Bsep; bile salt export pump; CE; cholesteryl ester; Cyp; cytochrome P450; FC; free cholesterol; FFA

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2011 سفارش ترجمه

Farnesoid X Receptor Activation Improves Erectile Function in Animal Models of Metabolic Syndrome and Diabetes

Keywords: Erectile Dysfunction; FXR; Metabolic Syndrome;

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2011 سفارش ترجمه

Research ArticleBile acids modulate glucocorticoid metabolism and the hypothalamic-pituitary-adrenal axis in obstructive jaundice

Keywords: HPA; hypothalamic-pituitary-adrenal; ACTH; adrenocorticotropic hormone; 3αHSD; 3α-hydroxysteroid dehydrogenase; FXR; farnesoid X receptor; Cyp7a1; cholesterol 7α-hydroxylase; 11βHSD; 11β-hydroxysteroid dehydrogenase; BDL; bile duct ligation; THB;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Activation of the nuclear receptor PPARγ by metabolites isolated from sage (Salvia officinalis L.)

Keywords: DCM; dichloromethane; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; EtOAc; ethyl acetate; FXR; farnesoid X receptor; HDL; high-density lipoprotein; HPLC; high performance liquid chromatography; LBD; ligand binding domain; LDL; low-de

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

The nuclear receptor FXR is expressed in pancreatic β-cells and protects human islets from lipotoxicity

Keywords: BA; bile acids; BSA; bovine serum albumin; FGF; fibroblast growth factor; GSCN; guanidinium thiocyanate; FXR; farnesoid X receptor; GSIS; glucose-stimulated insulin secretion; IAPP; islet amyloid polypeptide; IPGTT; intraperitoneal glucose tolerance test;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Research ArticleRegulation of the human bile acid UDP-glucuronosyltransferase 1A3 by the farnesoid X receptor and bile acids

Keywords: BA; bile acid; CDCA; chenodeoxycholic acid; CA; cholic acid; DCA; deoxycholic acid; LCA; lithocholic acid; CYP; cytocrome P450; PXR; pregnane X receptor; CAR; constitutive androstane receptor; FXR; farnesoid X receptor; JNK; c-Jun N-terminal kinase; UGT;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Getting the mOST from OST: Role of organic solute transporter, OSTα-OSTβ, in bile acid and steroid metabolism

Keywords: ABC; ATP-binding cassette; ASBT; apical sodium-dependent bile acid transporter; DHEA; dehydroepiandrosterone; DHEAS; dehydroepiandrosterone-3-sulfate; ER; endoplasmic reticulum; Endo H; endoglycosidase H; FGF; fibroblast growth factor; FGFR; fibroblast gr

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

Pathogenesis of Gallstones

Keywords: Bilirubin; Bile salt; Cholesterol; Crystallization; FXR; Gallbladder; Motility;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2010 سفارش ترجمه

Suppression of interleukin-6-induced C-reactive protein expression by FXR agonists

Keywords: FXR; farnesoid X receptor; SHP; small heterodimer partner; CRP; C-reactive protein; SAP; serum amyloid P component; SAA; serum amyloid A; APP; acute-phase protein; IL-6; interleukin-6; IL-1; interleukin-1; PPAR-α; peroxisome proliferator-activated recept

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2009 سفارش ترجمه

Pyrrole[2,3-d]azepino compounds as agonists of the farnesoid X receptor (FXR)

Keywords: FXR; Nuclear hormone receptor; Rational design

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2009 سفارش ترجمه

Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064

Keywords: Farnesoid X receptor agonist; FXR; Nuclear receptor modulator; FXR X-ray co-crystal structure; GW4064; Bile acid receptor; NR1H4

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

A New Mechanism for Bile Acid Diarrhea: Defective Feedback Inhibition of Bile Acid Biosynthesis

Keywords: ASBT; apical sodium-dependent bile acid transporter; BA; bile acid; BAM; bile acid malabsorption; C4; 7α-hydroxy-4-cholesten-3-one; CYP7A1; cholesterol 7α hydroxylase; ELISA; enzyme-linked immunosorbent assay; FGFR4; fibroblast growth receptor 4; FGF15;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه