کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1371969 | 981863 | 2009 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pyrrole[2,3-d]azepino compounds as agonists of the farnesoid X receptor (FXR)
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Pyrrole[2,3-d]azepino compounds as agonists of the farnesoid X receptor (FXR) Pyrrole[2,3-d]azepino compounds as agonists of the farnesoid X receptor (FXR)](/preview/png/1371969.png)
چکیده انگلیسی
Pyrrole[2,3-d]azepines have been identified as potent agonists of the farnesoid X receptor (FXR). Based on the planar X-ray crystal structure of WAY-362450 1 in the ligand binding domain and molecular modeling studies, non-planar reduced compounds were designed which led to agonists that exhibit high aqueous solubility and retain moderate in vitro potency.
The rational design and discovery of a new series of pyrrole[2,3-d]azepino FXR agonists with aqueous solubility and improved pharmaceutical properties is reported.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 18, 15 September 2009, Pages 5289–5292
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 18, 15 September 2009, Pages 5289–5292
نویسندگان
John F. Mehlmann, Matthew L. Crawley, Joseph T. Lundquist IV, Ray J. Unwalla, Douglas C. Harnish, Mark J. Evans, Callain Y. Kim, Jay E. Wrobel, Paige E. Mahaney,