کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1371969 981863 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pyrrole[2,3-d]azepino compounds as agonists of the farnesoid X receptor (FXR)
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Pyrrole[2,3-d]azepino compounds as agonists of the farnesoid X receptor (FXR)
چکیده انگلیسی

Pyrrole[2,3-d]azepines have been identified as potent agonists of the farnesoid X receptor (FXR). Based on the planar X-ray crystal structure of WAY-362450 1 in the ligand binding domain and molecular modeling studies, non-planar reduced compounds were designed which led to agonists that exhibit high aqueous solubility and retain moderate in vitro potency.

The rational design and discovery of a new series of pyrrole[2,3-d]azepino FXR agonists with aqueous solubility and improved pharmaceutical properties is reported.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 18, 15 September 2009, Pages 5289–5292
نویسندگان
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