کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1905086 1534693 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nuclear bile acid receptor FXR in the hepatic regeneration
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Nuclear bile acid receptor FXR in the hepatic regeneration
چکیده انگلیسی

The liver can fully regenerate itself by a compensatory regrowth in response to partial hepatectomy or injury. This process consists of a variety of well-orchestrated phases and is mediated by many signals. Farnesoid X receptor (FXR) is a member of the nuclear hormone receptor superfamily of ligand-activated transcription factors. Bile acids are FXR physiological ligands. As a metabolic regulator, FXR plays key roles in regulating metabolism of bile acids, lipids and glucose. Recently, bile acid/FXR signaling pathway is shown to be required for normal liver regeneration. Furthermore, FXR promotes liver repair after injury and activation of FXR is able to alleviate age-related defective liver regeneration. These novel findings suggest that FXR-mediated bile acid signaling is an integrated component of normal liver regeneration machinery, and also highlight the potential use of FXR ligands to promote liver regeneration after segmental liver transplantation or resection of liver tumors. This article is part of a Special Issue entitled: Translating nuclear receptors from health to disease.

Research Highlights
► FXR mediates bile acid signaling in promoting liver regeneration.
► FXR promotes liver repair after injury.
► FXR promotes the regeneration of aged liver.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1812, Issue 8, August 2011, Pages 888–892
نویسندگان
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