The emerging role of acyl-CoA thioesterases and acyltransferases in regulating peroxisomal lipid metabolism

► ACOTs regulate acyl-CoA metabolism in peroxisomes. ► Peroxisomes produce glycine and taurine-conjugated fatty acids. ► BAAT is involved in the inheritance of familial hypercholanemia. ► New insights into acyl-CoA thioesterase structure and function. ► ACOTs structurally belong to the α/β hydrolase and HotDog fold protein superfamilies.