Clinical and pathologic presentation in Parkinson's disease by apolipoprotein e4 allele status
Keywords: آپو; Parkinson's disease; APOE; Neuropathology; Clinical symptoms;
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Gene-gene interaction between CETP and APOE polymorphisms confers higher risk for hypertriglyceridemia in oldest-old Chinese women
Keywords: آپو; Hypertriglyceridemia; Gene-gene interaction; CETP; APOE; Longevity;
GGA1 overexpression attenuates amyloidogenic processing of the amyloid precursor protein in Niemann-Pick type C cells
Keywords: آپو; Aβ; amyloid beta peptide; AD; Alzheimer's disease; ADAM; A disintegrin and metalloproteinase; APOE; apolipoprotein E; APP; amyloid precursor protein; BACE1; beta-secretase; CHO; Chinese hamster ovary; CTF; C-terminal fragment; DN; dominant negative; FA
APOE modulates the effect of estrogen therapy on Aβ accumulation EFAD-Tg mice
Keywords: آپو; Alzheimer's disease; Estrogen; Amyloid-β; APOE; Soluble Aβ; AD transgenic mouse model; Aβ; amyloid-β; apoE; apolipoprotein E; AD; Alzheimer's disease; ET; estrogen therapy; FAD; familial AD; Thio-S; thioflavin S; HRT; hormone replacement therapy; OVX;
Short CommunicationAssociation of APOE, GCPII and MMP9 polymorphisms with common diseases and lipid levels in an older adult/elderly cohort
Keywords: آپو; AD; Alzheimer's disease; APOE; apolipoprotein E; BMI; body mass index; CI; confidence interval; CVD; cardiovascular disease; GCPII; glutamate carboxipeptidase II; HWE; Hardy Weinberg Equilibrium; MMP9; matrix metalloproteinase; OR; odds ratio; RFLP-PCR; R
An apolipoprotein E modified liposomal nanoparticle: Ligand dependent efficiency as a siRNA delivery carrier for mouse-derived brain endothelial cells
Keywords: آپو; siRNA; short interference RNA; ApoE; apolipoprotein E; NVU; neurovascular unit; BBB; blood brain barrier; pDNA; plasmid DNA; MEND; multi-functional envelop-type nano device; LDLR; low-density lipoprotein receptor; LRP1; LDLR-related protein 1; VLDLR; very
Birth cohort differences in the prevalence of longevity-associated variants in APOE and FOXO3A in Danish long-lived individuals
Keywords: آپو; APOE; apolipoprotein E; FOXO3A; forkhead box O3A; LSDC; Longitudinal Study of Danish Centenarians; DCRS; Danish Civil Registration System; 5-COOP; 5-Country Oldest Old Project; Human longevity; Genetics; Cohort effects; Selection; Apolipoprotein E (APOE);
CR1, ABCA7, and APOE genes affect the features of cognitive impairment in Alzheimer's disease
Keywords: آپو; Alzheimer's disease; ABCA7; APOE; CR1; Single nucleotide polymorphism; Phenotype;
Gene sequences regulating the production of apoE and cerebral palsy of variable severity
Keywords: آپو; APOE; Severity of CP; APOE regulator genes
NPC1, intracellular cholesterol trafficking and atherosclerosis
Keywords: آپو; NPC1; Niemann-Pick type C1; LE/LY; late endosome/lysosome; LDL; low-density lipoprotein; LDL-C; LDL-cholesterol; ER; endoplasmic reticulum; SSD; sterol-sensing domain; NTD; N-terminal domain; apoE; apolipoprotein E; LXR; liver X receptor; OSBP; oxysterolÂ
Research PaperAnti-atherosclerotic effects of Polygonum aviculare L. ethanol extract in ApoE knock-out mice fed a Western diet mediated via the MAPK pathway
Keywords: آپو; HASMC; human aortic smooth muscle cell; TNF-α; tumor necrosis factor-α; ApoE; apolipoprotein E; VCAM; vascular cell adhesion molecule; ICAM; intercellular adhesion molecule; NF-κB; nuclear factor-κB; KIOM; Korea Institute of Oriental Medicine; Atheros
Apolipoprotein E genotype influences spatial distribution of cerebral microbleeds
Keywords: آپو; Cerebral microbleeds; Epidemiology; Risk factor; APOE; Population-based; MRI; Imaging marker; Cerebrovascular disease;
Retinoids as potential targets for Alzheimer's disease
Keywords: آپو; Retinoids; ApoE; Alzheimer's disease; Amyloid; Oxidative stress
Serial F-18-FDG PET/CT distinguishes inflamed from stable plaque phenotypes in shear-stress induced murine atherosclerosis
Keywords: آپو; Atherosclerosis; Shear-stress; Plaque inflammation; Positron emission tomography; ApoE; apolipoprotein E; CCA; common carotid artery; DS; downstream; FDG; fluorodeoxyglucose; P/B-ratio; plaque to background ratio; PET/CT; positron emission tomography with
The interaction between sleep-disordered breathing and apolipoprotein E genotype on cerebrospinal fluid biomarkers for Alzheimer's disease in cognitively normal elderly individuals
Keywords: آپو; Alzheimer's disease; Sleep-disordered breathing; Elderly; Biomarkers; CSF; Amyloid beta 42; p-tau; Cerebral amyloid angiopathy; ApoE;
Hippocampus-specific deficiency in RNA editing of GluA2 in Alzheimer's disease
Keywords: آپو; RNA editing; ADAR; Glutamate; Alzheimer's disease; ApoE; Neurodegeneration; AMPA; GluA2; Postmortem; Hippocampus; Caudate; Primer extension;
Research reportAPOE and BDNF Val66Met polymorphisms combine to influence episodic memory function in older adults
Keywords: آپو; APOE; BDNF; Aging; Episodic memory; Polymorphism; Older adult;
25(OH) vitamin D suppresses macrophage adhesion and migration by downregulation of ER stress and scavenger receptor A1 in type 2 diabetes
Keywords: آپو; CVD; cardiovascular disease; T2DM; type 2 diabetes mellitus; 25(OH)D; 25-hydroxy vitamin D; MCP-1; monocyte chemotactic protein 1; CCR2; chemokine (C-C motif) receptor 2; ER; endoplasmic reticulum; SR-A1; scavenger receptor class A type 1; M-CSF; macropha
The TOMM40 poly-T rs10524523 variant is associated with cognitive performance among non-demented elderly with type 2 diabetes
Keywords: آپو; Alzheimer׳s disease; Cognition; TOMM40; APOE; Type 2 diabetes;
Association of cerebrospinal fluid Aβ42 with A2M gene in cognitively normal subjects
Keywords: آپو; Alzheimer's disease; Cerebrospinal fluid; Aβ42; alpha-2-Macroglobulin; A2M; APOE;
Disentangling the effects of age and APOE on neuropathology and late life cognitive decline
Keywords: آپو; Age; APOE; Neuropathologies; Alzheimer's disease; Cognitive decline; Path analysis;
Interaction of APOE genotype and testosterone on episodic memory in middle-aged men
Keywords: آپو; APOE; Testosterone; Episodic memory; Middle-age; Gene-hormone interaction;
ApoE gene and exceptional longevity: Insights from three independent cohorts
Keywords: آپو; Centenarians; ApoE; Genetics; Longevity; Case-control study
Additive genetic effect of APOE and BDNF on hippocampus activity
Keywords: آپو; BDNF; APOE; fMRI; Hippocampus; Gene-gene effect; Imaging genetics;
Featured ArticleGenetic interaction of PICALM and APOE is associated with brain atrophy and cognitive impairment in Alzheimer's disease
Keywords: آپو; Alzheimer's disease; PICALM; APOE; Genetic interaction; Brain atrophy;
ATP-binding cassette transporter A1: From metabolism to neurodegeneration
Keywords: آپو; Abca1; HDL; apoE; apoA-I; Alzheimer's disease; Amyloid beta; Cardiovascular disease; LXR; RXR;
In vivo type 1 cannabinoid receptor availability in Alzheimer's disease
Keywords: آپو; Alzheimer's disease; Cannabinoid receptor; Amyloid; PET scan; MMSE; ApoE
Featured ArticleEstrogen receptor polymorphisms and incident dementia: The prospective 3C study
Keywords: آپو; Alzheimer's disease; Dementia; Estrogen receptor polymorphisms; ESR1; ESR2; Gender-specific; APOE; Epidemiology; Cohort study;
Detection and quantification of plasma amyloid-β by selected reaction monitoring mass spectrometry
Keywords: آپو; Aβ; amyloid-β; SRM; selected reaction monitoring; RPLC; reversed-phase liquid chromatography; LOQ; limit of quantification; CSF; cerebrospinal fluid; AD; Alzheimer's disease; APP; amyloid precursor protein; ApoE; apolipoprotein E; ApoJ; apolipoprotein J
Alzheimer's disease susceptibility genes APOE and TOMM40, and brain white matter integrity in the Lothian Birth Cohort 1936
Keywords: آپو; White matter; Cognitive ageing; Diffusion MRI; Tractography; APOE; TOMM40; Alzheimer's disease;
Cerebrospinal fluid apolipoprotein E and phospholipid transfer protein activity are reduced in multiple sclerosis; relationships with the brain MRI and CSF lipid variables
Keywords: آپو; ApoE; apolipoprotein E (protein); APOE; apolipoprotein E (gene); BBB; blood-brain barrier; BH; black hole lesion load (BH); CSF; cerebrospinal fluid; EDSS; Expanded Disability Status Scale; GAD; gadolinium-enhancing lesions; GC-MS; gas chromatography
Validation of association of the apolipoprotein E ε2 allele with neurodevelopmental dysfunction after cardiac surgery in neonates and infants
Keywords: آپو; 19; 20; AIC; Akaike's information criterion; ApoE; apolipoprotein E; BSID-II; Bayley Scales of Infant Development-II; CHD; congenital heart defects; CNS; central nervous system; CP; cerebral palsy; CPB; cardiopulmonary bypass; DHCA; deep hypothermic circu
The apolipoprotein E epsilon 4 allele is associated with ventricular expansion rate and surface morphology in dementia and normal aging
Keywords: آپو; ApoE; Ventricular expansion; Dementia; Neuroimaging genetics; Structural MRI;
Cognitive and neural signatures of the APOE E4 allele in mid-aged adults
Keywords: آپو; Alzheimer's disease; Imaging; Memory; Attention; APOE; Aging;
Research ReportNeuroprotective effect against axonal damage-induced retinal ganglion cell death in apolipoprotein E-deficient mice through the suppression of kainate receptor signaling
Keywords: آپو; ApoE; Apolipoprotein E; NC; nerve crush; KA; kainic acid; WT; wild-type; IOP; intraocular pressure; POAG; primary open angle glaucoma; NTG; normal tension glaucoma; RGCs; retinal ganglion cells; LDL; low density lipoprotein; OH; ocular hypertension; IHC;
Beta-Amyloid Associated Differential Effects of APOE ε4 on Brain Metabolism in Cognitively Normal Elderly
Keywords: آپو; APOE; glucose metabolism; beta-amyloid protein; FDG-PET; cognitively normal elderly;
Strong Improvement of Apolipoprotein E/Low-Density Lipoprotein Receptor Signals by Telmisartan in Poststroke Spontaneously Hypertensive Stroke Resistant
Keywords: آپو; Alzheimer disease; spontaneously hypertensive rat; telmisartan; ApoE; LDL-R
Properties of apolipoprotein E derived peptide modulate their lipid-binding capacity and influence their anti-inflammatory function
Keywords: آپو; ApoE; apolipoprotein E; CD spectroscopy; circular dichroism spectroscopy; COX-2; cyclooxygenase-2; DMPC; 1,2-dimyristoyl-sn-glycero-3-phosphocholine; ELISA; enzyme-linked immunosorbent assay; IL-8; interleukin 8; KOdiA-PC; 1-palmitoyl-2-(5-keto-6-octendio
Human apolipoprotein E4 modulates the expression of Pin1, Sirtuin 1, and Presenilin 1 in brain regions of targeted replacement apoE mice
Keywords: آپو; AD; Alzheimer's disease; apoE; apoliporpotein E; apoE TR mice; human apoE3- and apoE4-targeted replacement mice; APP; amyloid precursor protein; Aβ; amyloid beta peptide; BDNF; Brain-derived Neurotrophic Factor; DDCt; Delta-Delta Ct; EDTA; ethylenedi
Identification of a novel partial agonist of liver X receptor α (LXRα) via screening
Keywords: آپو; ABC; ATP-binding cassette; ApoE; apolipoprotein E; DRIP205; vitamin D receptor-interacting protein 205; FAS; fatty acid synthase; GAPDH; glyceraldehyde-phosphate dehydrogenase; HDL; high-density lipoprotein; LBD; ligand-binding domain; LXR; liver X recept
Clinical ScienceInfluence of apolipoprotein E gene polymorphism on development of type 2 diabetes mellitus in Chinese Han population: A meta-analysis of 29 studies
Keywords: آپو; DM; diabetes mellitus; T2DM; type 2 diabetes mellitus; ApoE; apolipoprotein E; PRISMA; Preferred Reporting Items for Systematic Reviews and Meta-analyses; ORs; odds ratios; CI; confidence interval; HWE; Hardy-Weinberg equilibrium; NOS; Newcastle-Ottaw
Featured ArticleAPOE ε4 and risk for Alzheimer's disease: Do regionally distributed white matter hyperintensities play a role?
Keywords: آپو; APOE; Alzheimer's disease; White matter hyperintensities;
Featured ArticleAfrican-American TOMM40'523-APOE haplotypes are admixture of West African and Caucasian alleles
Keywords: آپو; Phased Sanger sequencing; Phylogenetic analysis; Population admixture; APOE; TOMM40; haplotypes; African-American; Alzheimer's disease; Yoruban; Caucasian; Complex disease genetics; age of onset;
Strong Reduction of Low-Density Lipoprotein Receptor/Apolipoprotein E Expressions by Telmisartan in Cerebral Cortex and Hippocampus of Stroke Resistant Spontaneously Hypertensive Rats
Keywords: آپو; Alzheimer's disease; spontaneously hypertensive rat; telmisartan; ApoE; LDL-R
The ApoE4 genotype modifies the relationship of long-term glycemic control with cognitive functioning in elderly with type 2 diabetes
Keywords: آپو; ApoE; Glycemic control; HbA1c; Cognition; Type 2 diabetes;
Agile delivery of protein therapeutics to CNS
Keywords: آپو; Aβ; amyloid β; Ab-InsR; antibodies against insulin receptor; Ab-TfR; antibodies against transferrin receptor; AD; Alzheimer's disease; Aerosol OT; bis-(2-ethylhexyl) sulfosucciate; ALS; amyotrophic lateral sclerosis; ApoB; apolipoprotein B; ApoE; apolip
Influence of Alzheimer's disease genes on cognitive decline: the Guangzhou Biobank Cohort Study
Keywords: آپو; Cognitive decline; Alzheimer's disease; ACE; APOE; Joint effect;
Apolipoprotein E: Structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases
Keywords: آپو; Alzheimer's disease; ApoE; Lipid metabolism; Mouse model;
ApoE isoform-related behavioral defects. Is chronic cholesterol loss-driven membrane disorganization behind?
Keywords: آپو; ApoE; Cholesterol; Raft; Neuron; Behavior; BDNF; trkB;
PerspectiveTOMM40 and APOE: Requirements for replication studies of association with age of disease onset and enrichment of a clinical trial
Keywords: آپو; Alzheimer's disease; Genotype-phenotype correlations; Age of disease onset; Biomarkers; TOMM40; APOE;