کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5622710 1579256 2014 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Featured ArticleAfrican-American TOMM40'523-APOE haplotypes are admixture of West African and Caucasian alleles
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Featured ArticleAfrican-American TOMM40'523-APOE haplotypes are admixture of West African and Caucasian alleles
چکیده انگلیسی

BackgroundSeveral studies have demonstrated a lower apolipoprotein E4 (APOE ε4) allele frequency in African-Americans, but yet an increased age-related prevalence of AD. An algorithm for prevention clinical trials incorporating TOMM40'523 (Translocase of Outer Mitochondria Membrane) and APOE depends on accurate TOMM40'523-APOE haplotypes.MethodsWe have compared the APOE and TOMM40'523 phased haplotype frequencies of a 9.5 kb TOMM40/APOE genomic region in West African, Caucasian, and African-American cohorts.ResultsAfrican-American haplotype frequency scans of poly-T lengths connected in phase with either APOE ε4 or APOE ε3 differ from both West Africans and Caucasians and represent admixture of several distinct West African and Caucasian haplotypes. A new West African TOMM40'523 haplotype, with APOE ε4 connected to a short TOMM40'523 allele, is observed in African-Americans but not Caucasians.ConclusionThese data have therapeutic implications for the age of onset risk algorithm estimates and the design of a prevention trial for African-Americans or other mixed ethnic populations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Alzheimer's & Dementia - Volume 10, Issue 6, November 2014, Pages 592-601.e2
نویسندگان
, , , , , , , , , , , , ,