Keywords: ASIC، کانال یون سنجش اسید; Symmetric protein oligomers; Asymmetric activation; Ion channels; Transporters; Biophysical structural techniques; Symmetry-asymmetry distinctionAA, alternating access; ABC, ATP-binding cassette; ASIC, acid-sensing ion channel; β2AR, β2-adrenergic recepto
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Keywords: ASIC، کانال یون سنجش اسید; Ion channels; Prostacyclin; Endothelin receptor antagonists; Soluble guanylate cyclase stimulators; Sympathetic neurotransmitter; Pulmonary hypertension5-HT, 5-hydroxytryptamine, i.e. serotonin; ADM, adrenomedullin; ASIC, acid-sensing ion channel; BKCa, l
Epithelial sodium channel (ENaC) family: Phylogeny, structure–function, tissue distribution, and associated inherited diseases
Keywords: ASIC، کانال یون سنجش اسید; ASIC, acid-sensing ion channel; ASL, airway surface liquid; CF, cystic fibrosis; CFTR, cystic fibrosis transmembrane conductance regulator; ENaC, epithelial sodium channel; ECF, extracellular fluid; ICF, intracellular fluid; PHA, pseudohypoaldosteronism;
2-Guanidine-4-methylquinazoline acts as a novel competitive antagonist of A type γ-aminobutyric acid receptors
Keywords: ASIC، کانال یون سنجش اسید; GMQ; GABA; GABAA receptor; Competitive antagonist; ASICGMQ, 2-guanidine-4-methylquinazoline; GABA, γ-aminobutyric acid; GABAAR, A type γ-aminobutyric acid receptor; ASIC, acid-sensing ion channel; HBSS, Hank's Buffered Salt Solution; DMEM, Dulbecco's Modi
Multiple interacting cell death mechanisms in the mediation of excitotoxicity and ischemic brain damage: A challenge for neuroprotection
Keywords: ASIC، کانال یون سنجش اسید; AIF, apoptosis inducing factor; Ambra1, activating molecule in beclin1-regulated autophagy; Apaf-1, adapter protein apoptotic protease-activating factor-1; ASIC, acid-sensing ion channel; atg, autophagic related genes; Bad, Bcl-2-associated death promoter
Targeting ASIC3 for pain, anxiety, and insulin resistance
Keywords: ASIC، کانال یون سنجش اسید; ABR, auditory brainstem response; APETx2, Anthopleura elegantissima toxin 2; ASIC, acid-sensing ion channel; BVE, blood volume expansion; CFA, complete Freund's adjuvant; CFTR, cystic fibrosis transmembrane conductance regulator; CNS, central nervous syst
Acid-sensing ion channel (ASIC) 1a undergoes a height transition in response to acidification
Keywords: ASIC، کانال یون سنجش اسید; ASIC, acid-sensing ion channel; AFM, atomic force microscopy; CHAPS, 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate; HBS, HEPES-buffered salineAcid-sensing ion channel; Atomic force microscopy; Ion channel structure; Channel activation
Alterations in subcellular expression of acid-sensing ion channels in the rat forebrain following chronic amphetamine administration
Keywords: ASIC، کانال یون سنجش اسید; ACSF, artificial cerebrospinal fluid; AMPH, amphetamine; ASIC, acid-sensing ion channel; BS3, bis(sulfosuccinimidyl)suberate; CPu, caudate putamen; i.p., intraperitoneal; mPFC, medial prefrontal cortex; NAc, nucleus accumbensDopamine; Striatum; Caudate; N
Distribution of acid-sensing ion channel 3 in the rat hypothalamus
Keywords: ASIC، کانال یون سنجش اسید; ASIC3; hypothalamus; RT-PCR; Western blot; immunohistochemistryARC, arcuate nucleus; ASIC, acid-sensing ion channel; AVP, vasopressin; DMN, dorsomedial nucleus; DRG, dorsal root ganglion; ir, immunoreactive; PVN, paraventricular nucleus; RT-PCR, reverse t
Proteomics of the neurotoxic fraction from the sea anemone Bunodosoma cangicum venom: Novel peptides belonging to new classes of toxins
Keywords: ASIC، کانال یون سنجش اسید; amu, atomic mass unit; ASIC, acid-sensing ion channel; CAPs, compound action potentials; CH3CN, acetonitrile; ESI-Q-TOF MS/MS, Electrospray ionisation quadrupole tandem mass spectrometry; HERG, human ether-a-gogo related gene potassium channel; Kv, voltag
Activation of Extracellular Signal-Regulated Protein Kinase in Sensory Neurons After Noxious Gastric Distention and Its Involvement in Acute Visceral Pain in Rats
Keywords: ASIC، کانال یون سنجش اسید; ASIC, acid-sensing ion channel; DRG, dorsal root ganglion; EMG, electromyography; ERK, extracellular signal-regulated protein kinase; FG, fluorogold; GD, gastric distention; IR, immunoreactive; MAPK, mitogen-activated protein kinase; MEK, mitogen-activate
Crystal Structure of a Core Domain of Stomatin from Pyrococcus horikoshii Illustrates a Novel Trimeric and Coiled-Coil Fold
Keywords: ASIC، کانال یون سنجش اسید; PhStoCD, residues 56–234 of PH1511p; ASIC, acid-sensing ion channel; stopp, stomatin operon partner protein; 1510-N, residues 16–236 of PH1510p; PDB, Protein Data Bank; MAD, multiwavelength anomalous dispersion; SeMet, selenomethionine; BSA, buried surfac
Functional characterization of acid-sensing ion channels in cultured neurons of rat inferior colliculus
Keywords: ASIC، کانال یون سنجش اسید; inferior colliculus; acid-sensing ion channel; whole-cell patch-clamp; cell cultureAP, action potential; APV, d-2-amino-5-phosphonopentanoic acid; ASIC, acid-sensing ion channel; [Ca2+]i, intracellular Ca2+ concentration; CNQX, 6-cyano-7-nitroquinoxaline-
Proton binding sites involved in the activation of acid-sensing ion channel ASIC2a
Keywords: ASIC، کانال یون سنجش اسید; ASIC, acid-sensing ion channel; CHO, Chinese hamster ovary cell line; GFP, green fluorescent protein; pH0.5, pH for half maximal activationASIC; Acid; Ion channel; Pain; Channel gating
Modulation of acid-sensing ion channels by Cu2+ in cultured hypothalamic neurons of the rat
Keywords: ASIC، کانال یون سنجش اسید; acid-sensing ion channels; Cu2+; hypothalamus; patch clamp; membrane excitabilityANOVA, analysis of variance; ASIC, acid-sensing ion channel; C, drug concentration; EC50, agonist concentration inducing half-maximal response; EDTA, ethylenediaminetetraacet
Arachidonic acid potentiates acid-sensing ion channels in rat sensory neurons by a direct action
Keywords: ASIC، کانال یون سنجش اسید; arachidonic acid; ASIC; sensory neuron; acid; painAA, arachidonic acid; AEA, anandamide; Ara-C, cytosine β-d-arabinofuranoside; ASIC, acid-sensing ion channel; CHO, Chinese hamster ovary; COX, cyclooxygenase; DRG, dorsal root ganglion; EA, cis-11-eicoseno
BcIV, a new paralyzing peptide obtained from the venom of the sea anemone Bunodosoma caissarum. A comparison with the Na+ channel toxin BcIII
Keywords: ASIC، کانال یون سنجش اسید; amu, atomic mass unit; Arg-EP, arginylendopeptidase; ASIC, acid-sensing ion channel; BcIII and BcIV, Bunodosoma caissarum toxins III and IV, respectively; CAPs, compound action potentials; CD, circular dichroism; CH3CN, acetonitrile; DTT, dithiothreitol;
Synaptic plasticity impairment and hypofunction of NMDA receptors induced by glutathione deficit: Relevance to schizophrenia
Keywords: ASIC، کانال یون سنجش اسید; hippocampus; LTP; cell excitability; paired-pulse facilitation; redox stateACF, artificial cerebrospinal fluid; AP5, dl-2-amino-5-phosphonopentanoic acid; ASIC, acid-sensing ion channel; BSO, l-buthionine-(S,R)-sulfoximine; CNQX, 6-cyano-7-nitroquinoxalin