Keywords: AT، آنتی ترومبین; ACE, affinity capillary electrophoresis; AT, antithrombin; BGE, background electrolyte; CE, capillary electrophoresis; DE-ACE, dynamic equilibrium-ACE; EOF, electroosmotic flow; FA, frontal analysis; HEK, human embryonic kidney; K, binding constant; Kd, d
مقالات ISI AT، آنتی ترومبین (ترجمه نشده)
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Keywords: AT، آنتی ترومبین; AT, antithrombin; CSF, cerebrospinal fluid; CT, computed tomography; MRI, magnetic resonance imaging; PC, protein C; PS, protein SVentriculomegaly; Heritable thrombophilia; Perinatal stroke
Development of a novel, rapid assay for detection of heparin-binding defect antithrombin deficiencies: the heparin-antithrombin binding (HAB) ratio
Keywords: AT، آنتی ترومبین; AT, antithrombin; FXa, activated factor X; HAB, heparin-antithrombin binding; HBD, heparin-binding defect; HCII, heparin co-factor II; HIP, heparin incubation period; PE, pleiotropic effect; RS, reactive siteAntithrombin deficiency; Heparin binding defect
Low endogenous thrombin potential in trained subjects
Keywords: AT، آنتی ترومبین; aPTT, activated partial thromboplastin time; AT, antithrombin; CaCl2, calcium chloride; CAT, calibrated automated thrombography; ELISA, enzyme-linked immunosorbent assay; ETP, endogenous thrombin potential; F1 + 2, prothrombin fragments 1 + 2; FII, prothr
Molecular basis and thrombotic manifestations of antithrombin deficiency in 15 unrelated Chinese patients
Keywords: AT، آنتی ترومبین; SERPINC1, AT gene; AT, antithrombin; TE, thromboembolism; VTE, venous thromboembolism; DVT, deep venous thrombosis; FXa, activated factor X; MVT, mesenteric venous thrombosis; PROC, protein C gene; PE, pulmonary embolism; PROS, protein S gene; AT:A, activ
The control of the complement lectin pathway activation revisited: Both C1-inhibitor and antithrombin are likely physiological inhibitors, while α2-macroglobulin is not
Keywords: AT، آنتی ترومبین; Complement lectin pathway; MBL-associated serine proteases; Serpins; Antithrombin; α2-Macroglobulin; HeparinMBL, mannose-binding lectin; MASP, MBL-associated serine protease; C1-inh, C1-inhibitor; AT, antithrombin; α2M, α2-macroglobulin; ka, association r
Decreased procoagulant phospholipids in patients treated by vitamin K antagonists
Keywords: AT، آنتی ترومبین; APTT, activated partial thromboplastin time; AT, antithrombin; BMI, body mass index; DVT, deep vein thrombosis; FC, flow cytometry; INR, index normalised ratio; PC, protein C; PE, pulmonary embolism; PS, Protein S; MPs, microparticles; PMN, polymorphonucl
Treatment responses for disseminated intravascular coagulation in 25 children treated with recombinant thrombomodulin: A single institution experience
Keywords: AT، آنتی ترومبین; ALL, acute lymphocytic leukemia; AML, acute myelocytic leukemia; APL, acute promyelocytic leukemia; AT, antithrombin; DIC, disseminated intravascular coagulation; FDP, fibrin and fibrinogen degradation product; FEL, familial erythrohemophagocytic lymphohi
Efficacy and bleeding risk of antithrombin supplementation in septic disseminated intravascular coagulation: A prospective multicenter survey
Keywords: AT، آنتی ترومبین; DIC, disseminated intravascular coagulation; AT, antithrombin; OR, odds ratio; JAAM, Japanese Association for Acute Medicine; ISTH, International Society on Thrombosis and Haemostasis; SIRS, systemic inflammatory response syndrome; SOFA, Sepsis-Related Or
Molecular basis of type I antithrombin deficiency in two women with recurrent venous thromboembolism in the first trimester of pregnancy
Keywords: AT، آنتی ترومبین; AT, antithrombin; VTE, venous thromboembolism; WT, wild-type; HEK293T, Human embryonic kidney 293T; CHO, Chinese hamster ovary; ER, endoplasmic reticulumAntithrombin; Gene mutation; Pregnancy; Venous thromboembolism
Sepsis, thrombosis and organ dysfunction
Keywords: AT، آنتی ترومبین; APC, activated protein C; AT, antithrombin; DIC, disseminated intravascular coagulation; ECs, endothelial cells; EPCR, endothelial protein C receptor; HMGB-1, High Mobility Group Box-1; MODS, multiple organ dysfunction syndrome; PAI-1, plasminogen activat
A moderate aseptic local inflammation does not induce a significant systemic inflammatory response
Keywords: AT، آنتی ترومبین; Alb, albumin; ALT, alanine aminotransferase; AP, alkaline phosphatase; APC, activated protein C; aPTT, activated partial thromboplastin time; AT, antithrombin; CK, creatine kinase; Crea, creatinin; CRP, C-reactive protein; Eos, eosinophils; FVIII, factor
Comparison of a fluorogenic anti-FXa assay with a central laboratory chromogenic anti-FXa assay for measuring LMWH activity in patient plasmas
Keywords: AT، آنتی ترومبین; AMC, 7-amino-4-methylcoumarin; ACT, Activated clotting time; aPTT, Activated partial thromboplastin time; AT, Antithrombin; FXa, Factor Xa; Hepes, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; INR, International Normalized Ratio; LMWH, Low molecular
Comparison of the anticoagulant response of a novel fluorogenic anti-FXa assay with two commercial anti-FXa chromogenic assays
Keywords: AT، آنتی ترومبین; AMC, 7-amino-4-methylcoumarin; ACT, Activated clotting time; aPTT, Activated partial thromboplastin time; AT, Antithrombin; AU, Arbitrary units; CV, Coefficient of variation; FXa, Factor Xa; Hepes, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; LMWH,
The impact of coagulation parameters on the outcomes of patients with severe community-acquired pneumonia requiring intensive care unit admission
Keywords: AT، آنتی ترومبین; APACHE II, The Acute Physiology and Chronic Health Evaluation II; ATS, American Thoracic Society; AT, antithrombin; AUROC, area under the receiver operating curve; CAP, community-acquired pneumonia; CRP, C-reactive protein; ICU, intensive care unit; ICU-L
Inter-individual variability of effect of 7 low molecular weight antithrombin-dependent anticoagulants studied in vitro with Calibrated Automated Thrombography
Keywords: AT، آنتی ترومبین; CAT, calibrated automated thrombogram; LMWH, low-molecular-weight heparin; AT, antithrombin; aPTT, activated prothrombin time; PDP, platelet-depleted plasma; ETP, endogenous thrombin potential; TF, tissue factor; UFH, unfractionated heparinLow-molecular-w
Mortality and recurrence after treatment of VTE: Long term follow-up of patients with good life-expectancy
Keywords: AT، آنتی ترومبین; AT, antithrombin; DVT, deep venous thrombosis; FV, factor V; HR, hazard ratio; INR, international normalised ratio; OA, oral anticoagulation; PE, pulmonary embolism; PC, protein C; PS, protein S; SMR, standardised mortality ratio; VTE, venous thromboembol
Safety Assessment and Pharmacodynamics of a Novel Ultra Low Molecular Weight Heparin (RO-14) in Healthy Volunteers – A First-Time-In-Human Single Ascending Dose Study
Keywords: AT، آنتی ترومبین; APTT, Activated partial thromboplastin time; AE, Adverse event; AEMPS, Agencia Espanola de Medicamentos y Productos Sanitarios; AT, Antithrombin; AUC0-24, Area under the anti-FXa activity-time curve in the 24 hours after drug administration; AUC0-∞, Area
The mechanism of action of rivaroxaban – an oral, direct Factor Xa inhibitor – compared with other anticoagulants
Keywords: AT، آنتی ترومبین; ACS, acute coronary syndrome; aPTT, activated partial thromboplastin time; AT, antithrombin; AUC, area under the curve; bid, twice daily; Cmax, maximum plasma concentration; CrCl, creatinine clearance; CYP, cytochrome P450; IC50, inhibitory concentration
Evaluation of a Post-operative Thrombin Inhibitor Replacement Protocol to reduce Haemorrhagic and Thrombotic Complications after Paediatric Liver Transplantation
Keywords: AT، آنتی ترومبین; OLT, Orthotopic Liver Transplantation; HAT, Hepatic Artery Thrombosis; PVT, Portal Vein Thrombosis; PT, Prothrombin Time; APTT, Activated Partial Thromboplastin Time; RCH, Royal Children's Hospital; AT, Antithrombin; TG, Thrombin Generation; TAT, Thrombin
A Novel Mutation (G2172→C) in the Factor V Gene in a Chinese Family with Hereditary Activated Protein C Resistance
Keywords: AT، آنتی ترومبین; APC-R, Activated protein C resistance; VTE, venous thromboembolism; FV, factor V; APC, activated protein C; AT, antithrombin; PC, protein C; PS, protein S; aPTT, activated partial thromboplastin time; ACL, anticardiolipin antibodies; LA, lupus anticoagula
Randomized, Controlled Trial of Individualized Heparin and Protamine Management in Infants Undergoing Cardiac Surgery With Cardiopulmonary Bypass
Keywords: AT، آنتی ترومبین; anticoagulation; cardiopulmonary bypass; congenital heart diseaseACT, activated clotting time; AT, antithrombin; CCCU, cardiac critical care unit; CPB, cardiopulmonary bypass; F1.2, prothrombin fragments 1 + 2; HMS, hemostasis management system; PRBCs, pa
Protein C inhibitor regulates both cathepsin L activity and cell-mediated tumor cell migration
Keywords: AT، آنتی ترومبین; PCI, protein C inhibitor; AT, antithrombin; serpins, serpin protease inhibitors; SI, stoichiometry of inhibition; RCL, reactive center loop; DTT, dithiothreitolSerpins; Protein C inhibitor; siRNA; Cathepsins; Heparin; Breast cancer cells; Cell migration
In vivo age dependency of unfractionated heparin in infants and children
Keywords: AT، آنتی ترومبین; UFH, Unfractionated Heparin; ETP, Endogenous Thrombin Potential; AT, Antithrombin; APTT, Activated Partial Thromboplastin TimeUnfractionated Heparin; Children; Anti-Xa; ETP; APTT
Regulation of thrombin generation by TFPI in plasma without and with heparin
Keywords: AT، آنتی ترومبین; APTT, activated partial thromboplastin time; AT, antithrombin; BSA, bovine serum albumin; CAT, calibrated automated thrombography; CV, coefficient of variation; dPT, diluted prothrombin time; ETP, endogenous thrombin potential; FVIIa, factor VIIa; FXa, fa
Implementation of the ISTH classification of non-overt DIC in a thromboplastin induced rabbit model
Keywords: AT، آنتی ترومبین; ISTH, International Society on Thrombosis and Hemostasis; DIC, disseminated intravascular coagulation; FDP, fibrin degradation product; PT, prothrombin time; AT, antithrombin; TAT, thrombin-antithrombin; PC, protein C; TEG, thromboelastography; FVIIa, act
The Critical Role of Hinge-Region Expulsion in the Induced-Fit Heparin Binding Mechanism of Antithrombin
Keywords: AT، آنتی ترومبین; AT, antithrombin; RCL, reactive centre loop; PEG, polyethylene glycol; SI, stoichiometry of inhibition; HEK, human embryonic kidney; EBNA, Epstein–Barr nuclear antigen 1; H5, heparin pentasaccharideallosteric; antithrombin; heparin; pentasaccharide; serpi
Heparin-induced thrombocytopenia: A stoichiometry-based model to explain the differing immunogenicities of unfractionated heparin, low-molecular-weight heparin, and fondaparinux in different clinical settings
Keywords: AT، آنتی ترومبین; UFH, unfractionated heparin; LMWH, low-molecular weight heparin; HIT, heparin-induced thrombocytopenia; PF4, platelet factor 4; AT, antithrombin; PCS, photon correlation spectroscopy; aXaU, anti-factor Xa units; MW, molecular weight.Heparin-induced thromb
A Structural Basis for Loop C-Sheet Polymerization in Serpins
Keywords: AT، آنتی ترومبین; AT, antithrombin; RCL, reactive center loop; s1C, first strand of the C β-sheet; PAI-1, plasminogen activator inhibitor 1; FENIB, familial encephalopathy with neuroserpin inclusion bodies; vdW, van der Waals; EDTA, ethylenediaminetetraacetic acidserpin; p
A loop of coagulation factor VIIa influencing macromolecular substrate specificity
Keywords: AT، آنتی ترومبین; AT, antithrombin; FIX(a), factor IX(a); FVIIa, factor VIIa; FVIIaIIa, FVIIa variant Val158{21}Asp/Glu296{154}Val/Met298{156}Gln; FVIIaDIK, FVIIa variant Val158{21}Asp/Glu296{154}Ile/Met298{156}Lys; FVIIaDTSIK, FVIIa variant Val158{21}Asp/Leu287{144}Thr/Al
Mutation of the H-helix in antithrombin decreases heparin stimulation of protease inhibition
Keywords: AT، آنتی ترومبین; AT, antithrombin; PCI, protein C inhibitor; TM, thrombomodulinThrombin; Factor Xa; Thrombomodulin; Coagulation; Serpin
Effect of oversulfated dermatan sulfate derivatives on platelet aggregation
Keywords: AT، آنتی ترومبین; DS, dermatan sulfate; GAGs, glycosaminoglycans; AT, antithrombin; HCII, heparin cofactor II, GlcA, glucuronic acid; IdoA, iduronic acid; GalNAc, N-acetyl-galactosamine.Dermatan sulfate; Platelets; Aggregation; Heparin cofactor II; Antithrombin; Coagulatio
Differential effects of conventional and low dose oral hormone therapy (HT), tibolone, and raloxifene on coagulation and fibrinolysis
Keywords: AT، آنتی ترومبین; AT, antithrombin; BMI, body mass index; CEE, conjugated equine estrogen; CI, confidence interval; Factor VIIa, activated factor VII; Free PS, free protein S antigen; HT, hormone therapy; NETA, norethisterone acetate; PAI-1, plasminogen activator inhibitor
Evaluation and performance characteristics of the automated coagulation analyzer ACL TOP
Keywords: AT، آنتی ترومبین; Anti-FXa, anti-activated factor X; APC, activated protein C; aPTT, activated partial thromboplastin time; AT, antithrombin; CV, coefficient of variation; FV, (coagulation) factor V; FVIII, (coagulation) factor VIII; INR, international normalized ratio; OD
Antithrombin replacement in neonates: Is there any indication?
Keywords: AT، آنتی ترومبین; AT, Antithrombin; ICH, Intracranial hemorrhage; RCT, Randomised controlled trial; RDS, Respiratory distress syndromeAntithrombin; Infant newborn; Respiratory distress syndrome; Intraventricular hemorrhage; Sepsis
Thrombin inhibition by antithrombin in the presence of oversulfated dermatan sulfates
Keywords: AT، آنتی ترومبین; AT, antithrombin; HC II, heparin cofactor II; DS, dermatan sulfateHeparin; Dermatan sulfate; Oversulfation; Antithrombin; Thrombin; Anticoagulant mechanism
Evaluation of the automated coagulation analyzer Sysmex® CA-7000
Keywords: AT، آنتی ترومبین; APTT, activated partial thromboplastin time; AT, antithrombin; CV, coefficient of variation; INR, international normalized ratio; PT, prothrombin time; vWF:Ag, von Willebrand factor antigenAnalyzer; Coagulation; Evaluation; Sysmex® CA-7000
A combination of a thrombin inhibitor and dexamethasone prevents the development of experimental disseminated intravascular coagulation in rats
Keywords: AT، آنتی ترومبین; ADP, adenosine diphosphate; ANOVA, analysis of variance; AT, antithrombin; cpm, counts per minute; CPU, carboxypeptidase U; DIC, disseminated intravascular coagulation; F, factor; Hb, haemoglobin; IL, interleukin; LMWH, low-molecular-weight heparin; LPS,
Thromboembolic complications in children with cancer
Keywords: AT، آنتی ترومبین; ALL, acute lymphoblastic leukemia; AML, Acute myeloid leukemia; AT, antithrombin; BFM, Berlin–Frankfurt–Munster; CNS, central nervous system; CT, computerized tomogram; CVL, central venous line; DFCI, Dana-Farber Cancer Institute; DVT, deep venous thrombo
The anticoagulant protein C pathway
Keywords: AT، آنتی ترومبین; APC, activated protein C; AT, antithrombin; CCP, complement control protein; C4BP, C4b-binding protein; EPCR, endothelial protein C receptor; EGF, epidermal growth factor; FV, factor V; Gla, γ-carboxy glutamic acid; LamG, laminin G-type; PCI, protein C in
Synthesis of per-sulfated flavonoids using 2,2,2-trichloro ethyl protecting group and their factor Xa inhibition potential
Keywords: AT، آنتی ترومبین; DMF, dimethyl formamide; DMSO, dimethyl sulfoxide; TCE-Cl, 2,2,2-trichloroethylsulfuryl chloride; RP-HPLC, Reverse Phase HPLC; DCC, dicyclohexylcarbodiimide; ESI-MS, electrospray ionization mass spectrometry; fXa, factor Xa; AT, antithrombin; DMAP, Nâ²,N