Keywords: مهار کننده BACE1; Click reaction; BACE1 inhibitor; Metal chelator; Molecular modeling; Neuroprotective assay; Synthesis;
مقالات ISI مهار کننده BACE1 (ترجمه نشده)
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Lodopyridones B and C from a marine sediment-derived bacterium Saccharomonospora sp.
Keywords: مهار کننده BACE1; Lodopyridone; Saccharomonospora; BACE1 inhibitor; Marine natural products;
Featured ArticlePrevention of tau increase in cerebrospinal fluid of APP transgenic mice suggests downstream effect of BACE1 inhibition
Keywords: مهار کننده BACE1; Alzheimer's disease; Biomarker; CSF; Tau; BACE1 inhibitor; Treatment;
Design and synthesis of 5-cyclopropyl substituted cyclic acylguanidine compounds as BACE1 inhibitors
Keywords: مهار کننده BACE1; Alzheimer's disease; BACE1 inhibitor; β-Secretase; Drug discovery; Cyclic acylguanidine;
Design and synthesis of cyclic acylguanidines as BACE1 inhibitors
Keywords: مهار کننده BACE1; Alzheimer's disease; BACE1 inhibitor; Cyclic acylguanidine
Synthesis and evaluation of aminopyridine derivatives as potential BACE1 inhibitors
Keywords: مهار کننده BACE1; Sonogashira coupling; Glaser coupling; Amino pyridine; BACE1 inhibitor; Alzheimer's disease;
Structure-activity relationship study of BACE1 inhibitors possessing a chelidonic or 2,6-pyridinedicarboxylic scaffold at the P2 position
Keywords: مهار کننده BACE1; Alzheimer's disease; β-Secretase; BACE1; BACE1 inhibitor;
Amplified voltammetric characterization of cleavage of the biotinylated peptide by BACE1 and screening of BACE1 inhibitors
Keywords: مهار کننده BACE1; Voltammetry; Biotinylated peptide substrate; Fc-capped gold nanoparticle/streptavidin conjugates; BACE1 activity; BACE1 inhibitor;
Design and synthesis of thiophene dihydroisoquinolines as novel BACE1 inhibitors
Keywords: مهار کننده BACE1; BACE1 inhibitor; Structural based drug design; SAR; Selectivity;
Hydroxyethylamine-based inhibitors of BACE1: P1-P3 macrocyclization can improve potency, selectivity, and cell activity
Keywords: مهار کننده BACE1; Conformational constraint; Alzheimer's disease; BACE1 inhibitor; Macrocycle; β-Secretase;
Phenylimino-2H-chromen-3-carboxamide derivatives as novel small molecule inhibitors of β-secretase (BACE1)
Keywords: مهار کننده BACE1; Alzheimer disease; BACE1 inhibitor; Phenylimino-2H-chromen-3-carboxamide
Novel BACE1 inhibitors possessing a 5-nitroisophthalic scaffold at the P2 position
Keywords: مهار کننده BACE1; Alzheimer’s disease; β-Secretase; BACE1; BACE1 inhibitor
Tripeptidic BACE1 inhibitors devised by in-silico conformational structure-based design
Keywords: مهار کننده BACE1; Alzheimer's disease; β-Secretase; BACE1; BACE1 inhibitor;
Triazolyl tryptoline derivatives as β-secretase inhibitors
Keywords: مهار کننده BACE1; BACE1; BACE1 inhibitor; JJCA-140; Tryptoline; Docking; Binding mode; Enzyme assay; Cathepsin-D
Significance of interactions of BACE1–Arg235 with its ligands and design of BACE1 inhibitors with P2 pyridine scaffold
Keywords: مهار کننده BACE1; Alzheimer’s disease; BACE1; β-Secretase; BACE1 inhibitor
BACE1 inhibitors: Optimization by replacing the P1′ residue with non-acidic moiety
Keywords: مهار کننده BACE1; Alzheimer’s disease; BACE1; β-Secretase; BACE1 inhibitor
Design and synthesis of BACE1 inhibitors containing a novel norstatine derivative (2R,3R)-3-amino-2-hydroxy-4-(phenylthio)butyric acid
Keywords: مهار کننده BACE1; Alzheimer’s disease; BACE1 inhibitor; Norstatine; Hydroxymethylcarbonyl isostere
β-Secretase inhibitors: Modification at the P4 position and improvement of inhibitory activity in cultured cells
Keywords: مهار کننده BACE1; Alzheimer’s disease; BACE1 inhibitor; Cultured cells
Design and synthesis of potent β-secretase (BACE1) inhibitors with P1′ carboxylic acid bioisosteres
Keywords: مهار کننده BACE1; Alzheimer’s disease; BACE1 inhibitor; β-Secretase; Bioisostere
Design and synthesis of highly active Alzheimer's β-secretase (BACE1) inhibitors, KMI-420 and KMI-429, with enhanced chemical stability
Keywords: مهار کننده BACE1; Alzheimer's disease; BACE1 inhibitor; β-Secretase; Bioisostere;