Keywords: BBB، مانع خونریزی مغزی; Nasal drug delivery; Nose to brain; Formulation; Drug targeting; Brain delivery; Nasal devicesCNS, central nervous system; BBB, blood-brain barrier; CSF, cerebrospinal fluid; IGF-I, insulin growth factor-I; AUC, area under the curve; DTE, direct targeting
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Keywords: BBB، مانع خونریزی مغزی; AJs, adherens junctions; ANOVA, analysis of variance; BBB, blood-brain barrier; CTEE, control exposed to environmental enrichment; CTSE, control maintained in standard environment; EE, environmental enrichment; GFAP, glial fibrillary acidic protein; GLUT1
Keywords: BBB، مانع خونریزی مغزی; AD, Alzheimer’s disease; ALS, amyotrophic lateral sclerosis; APP, amyloid precursor protein; BBB, blood-brain barrier; BSB, blood-spinal cord barrier; C1-Inh/C1-INH, C1 complex inhibitor; CNS, central nervous system; CR1, complement receptor 1; CR2, compl
Keywords: BBB، مانع خونریزی مغزی; BBB, blood-brain barrier; RANTES, regulated upon activation normal T cells; expressed and secreted; CCRs, C–C chemokine receptorsCCR5; Complement; Anti-ccr5 antibody; Glutamate; Human cortex; Mouse cortex
Keywords: BBB، مانع خونریزی مغزی; hepatic encephalopathy; acute liver failure; neuroinflammation; microglial activation; intracranial hypertensionALF, acute liver failure; ATP, adenosine triphosphate; BBB, blood-brain barrier; CCL2, chemokine ligand-2; CMRO2, cerebral metabolic rate for o
Keywords: BBB، مانع خونریزی مغزی; AIS, acute ischemic stroke; aPC, activated protein C; ATC, acute traumatic coagulopathy; BBB, blood-brain barrier; CPB, cardiopulmonary bypass; DAMP, damage-associated molecular pattern; DIC, disseminated intravascular coagulation; FDP, fibrin/fibrinogen
Keywords: BBB، مانع خونریزی مغزی; Biomarker; Pathophysiology; Spinal cord injury; TreatmentAIS, American Spinal Injury Association Impairment Scale; BBB, Blood-brain barrier; BDP, Breakdown product; CNS, Central nervous system; CSF, Cerebrospinal fluid; GFAP, Glial fibrillary acidic prote
Keywords: BBB، مانع خونریزی مغزی; BBB, blood-brain barrier; CDK4, cyclin-dependent kinase 4; CDKN2A, cyclin-dependent kinase inhibitor 2A; c-KIT, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; EGFR, epidermal growth factor receptor; FT, farnesyl transferase; FTI, FT inhibi
Keywords: BBB، مانع خونریزی مغزی; GBM, Glioblastoma multiforme; Doxo, Doxorubicin; Aldoxo, Aldoxorubicin; HPLC, High-performance liquid chromatography; MTD, Maximum tolerated dose; TMZ, Temozolomide; BBB, Blood-brain barrier
Keywords: BBB، مانع خونریزی مغزی; aCL, anti-cardiolipin-antibodies; AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; aPL, antiphospholipid antibodies; APS, antiphospholipid syndrome; aPS, anti-phosphatidylserine-antibodies; BBB, blood-brain barrier; beta2-GPI, beta2-glycoprotei
Keywords: BBB، مانع خونریزی مغزی; BBB, blood-brain barrier; CA, cornu ammonis; CNS, central nervous system; IL, interleukin; iPS, induced pluripotent stem; MRI, magnetic resonance imaging; NPs, nanoparticles; LPS, lipopolysaccharide; PEG, polyethylene glycol; PBCA, polybutyl-cyanoacrylate
Keywords: BBB، مانع خونریزی مغزی; BBB, blood-brain barrier; EB, Evans blue; TEM, transmission electron microscopy; HPLC, high-performance liquid chromatography; Glu, glutamate; GABA, gamma aminobutyric acid; GABAAR, gamma aminobutyric acid type A receptor; GABABR, gamma aminobutyric acid
In vitro and in vivo evaluations of the P-glycoprotein-mediated efflux of dibenzoylhydrazines
Keywords: BBB، مانع خونریزی مغزی; P-glycoprotein; Dibenzoylhydrazines; MDR1-LLCPK1 cells; Bidirectional transport assay; Quinidine transport inhibition; Brain to plasma concentration ratioAP, apical; BBB, blood-brain barrier; BCRP, breast cancer resistance proteins; BL, basolateral; R2, c
Histone deacetylase inhibition is cytotoxic to oligodendrocyte precursor cells in vitro and in vivo
Keywords: BBB، مانع خونریزی مغزی; BBB, blood-brain barrier; BSA, bovine serum albumin; CC3, cleaved caspase 3; CICI, chemotherapy-induced cognitive impairment; CNPase, 2′3′-cyclic-nucleotide phosphodiesterase; CNS, central nervous system; DMSO, dimethyl sulfoxide; EGFP, enhanced green flu
Sodium butyrate exerts neuroprotective effects by restoring the blood-brain barrier in traumatic brain injury mice
Keywords: BBB، مانع خونریزی مغزی; TBI, traumatic brain injury; BBB, blood-brain barrier; SB, sodium butyrate; ZO-1, zonula occludens-1; EB, Evans Blue; NSS, Neurological Severity Score; PBS, Phosphate-buffered saline; TBS, Tris-buffered saline; H&E, hematoxylin and eosin; SEM, Standard Er
Regional c-Fos expression induced by peripheral oxytocin administration is prevented by the vasopressin 1A receptor antagonist SR49059
Keywords: BBB، مانع خونریزی مغزی; ADP, anterodorsal preoptic area; ANOVA, analysis of variance; AVP, arginine vasopressin; BBB, blood-brain barrier; BNST, bed nucleus of the stria terminalis; CEA, central amygdala; CNS, central nervous system; CRH, corticotrophin-releasing hormone; DMSO,
Effects of realgar on GSH synthesis in the mouse hippocampus: Involvement of system XAG−, system XC−, MRP-1 and Nrf2
Keywords: BBB، مانع خونریزی مغزی; TCMs, traditional Chinese medicines; BBB, blood-brain barrier; ORT, object recognition task; γ-GCS, γ-glutamylcysteine synthetase; EAATs, excitatory amino acid transporters; MRP-1, multidrug resistance-associated protein 1; γ-GT, γ-glutamyl transpeptidase
Cellular uptake of lead in the blood-cerebrospinal fluid barrier: Novel roles of Connexin 43 hemichannel and its down-regulations via Erk phosphorylation
Keywords: BBB، مانع خونریزی مغزی; Pb, lead; BBB, blood-brain barrier; CSF, cerebrospinal fluid; BCB, blood-CSF barrier; CP, choroid plexus; Cx43, Connexin 43Lead; Choroid plexus; Connexin 43; Src; Erk; iZCx43
Neuropharmacological effects of Phoneutria nigriventer venom on astrocytes
Keywords: BBB، مانع خونریزی مغزی; Arthropod venom; Astrocytes; Ca2+ responses; Stress fibers; TLR4; GlutamateAUC, area under the curve; BBB, blood-brain barrier; Cx43, connexin 43; GFAP, glial fibrillary acidic protein; IL-1β, interleukin-1β; IP3, inositol 1,4,5-trisphosphate; IP3R, inosi
Post-ischemic treatment of WIB801C, standardized Cordyceps extract, reduces cerebral ischemic injury via inhibition of inflammatory cell migration
Keywords: BBB، مانع خونریزی مغزی; A3AR, A3 adenosine receptor; APP, amyloid precursor protein; BBB, blood-brain barrier; CBF, cerebral blood flow; EB, evans blue; MBP, myelin basic protein; MCAO, middle cerebral artery Occlusion; MCP-1, monocyte chemoattractant protein-1; PFA, paraformald
“Targeting astrocytes in CNS injury and disease: A translational research approach”
Keywords: BBB، مانع خونریزی مغزی; AD, Alzheimer’s disease; AEG-1, astrocyte-elevated gene 1; ALS, amyotrophic lateral sclerosis; ApoE, apolipoprotein E; BBB, blood-brain barrier; BDNF, brain-derived neurotrophic factor; BLBP, brain lipid binding protein; BMP, bone morphogenetic protein; C
Neuroprotective action of resveratrol
Keywords: BBB، مانع خونریزی مغزی; Aβ, beta-amyloid; AD, Alzheimer's disease; AIF, Apoptosis Inducing Factor; AMPK, AMP-activated protein kinase; AP-1, activator protein-1; BBB, blood-brain barrier; COX, cyclooxygenase; APP, amyloid precursor protein; ERK1/2, extracellular signal-regulated
Increasing pro-survival factors within whole brain tissue of Sprague Dawley rats via intracerebral administration of modified valproic acid
Keywords: BBB، مانع خونریزی مغزی; Intracerebral administration; Phospho-proteins; Pro-survival; Brain injury; Valproic acidAkt, v-Akt Murine Thymoma Viral Oncogene Homolog; APP, amyloid precursor protein; BAD, Bcl-2-associated death promoter; BBB, blood-brain barrier; BCSFB, blood-CSF bar
Oligonol improves memory and cognition under an amyloid β25-35–induced Alzheimer's mouse model
Keywords: BBB، مانع خونریزی مغزی; Amyloid beta; Alzheimer's disease; Memory; Oxidative stress; Oligonol; MouseAD, Alzheimer's disease; Aβ, amyloid β peptide; Aβ25-35, amyloid β25-35; BBB, blood-brain barrier; NO, nitric oxide; TBA, Thiobarbituric acid; MDA, Malondialdehyde
Erythropoietin prevents cognitive impairment and oxidative parameters in Wistar rats subjected to pneumococcal meningitis
Keywords: BBB، مانع خونریزی مغزی; BBB, blood-brain barrier; CAT, catalase; CNS, central nervous system; CSF, cerebrospinal fluid; DTNB, 5,5-dithiobis (2-nitrobenzoic acid); EPO, erythropoietin; MPO, myeloperoxidase; NF-κB, nuclear transcription factor kappa B; ROS, reactive oxygen species
Stanniocalcin 1 is important for poststroke functionality, but dispensable for ischemic tolerance
Keywords: BBB، مانع خونریزی مغزی; BBB, blood-brain barrier; CBF, cerebral blood flow; EB, Evans Blue dye; HLV, hemispheric lesion volume; HPC, hypoxic preconditioning; HT, hemorrhagic transformation; IL-6, interleukin-6; LDF, laser Doppler flow; MCAO, middle cerebral artery occlusion; STC
A simple method to quickly and simultaneously purify and enrich intact rat brain microcapillaries and endothelial and glial cells for ex vivo studies and cell culture
Keywords: BBB، مانع خونریزی مغزی; aCSF, artificial cerebrospinal fluid; BSA, bovine serum albumin; BBB, blood-brain barrier; CsA, cyclosporine A; DAPI, 4′,6-Diamidino-2-phenylindole dihydrochloride; FGF-2, fibroblast growth factor-2; GFAP, glial fibrillary acidic protein; ICC, immunocytoc
Intranasal delivery of nerve growth factor attenuates aquaporins-4-induced edema following traumatic brain injury in rats
Keywords: BBB، مانع خونریزی مغزی; TBI, traumatic brain injury; NGF, nerve growth factor; AQP4, aquaporins-4; BBB, blood-brain barrier; IL-1β, interleukin-1β; TNF-α, tumor necrosis factor-α; NF-κB, nuclear factor-κB; Bcl-2, B cell lymphoma/lewkmia-2; RIPA, radio immunoprecipitation assay;
Expression and functional role of metallothioneins I and II in the spinal cord in inflammatory and neuropathic pain models
Keywords: BBB، مانع خونریزی مغزی; ANOVA, analysis of variance; BBB, blood-brain barrier; BSCB, blood-spinal cord barrier; CCI, chronic constriction injury; CFA, complete Freund's adjuvant; COX-2, cyclooxygenase-2; GLT1, glucose transporter 1; ICAMs, intercellular adhesion molecules; IL, i
MicroRNAs in multiple sclerosis and experimental autoimmune encephalomyelitis
Keywords: BBB، مانع خونریزی مغزی; BBB, blood-brain barrier; CNS, central nervous system; EAE, experimental autoimmune encephalomyelitis; HV, healthy volunteers; miRNA, microribonucleic acid; MS, multiple sclerosis; PBMC, peripheral blood mononuclear cells; PPMS, primary progressive multip
Novel model for the mechanisms of glutamate-dependent excitotoxicity: Role of neuronal gap junctions
Keywords: BBB، مانع خونریزی مغزی; BBB, blood-brain barrier; CNS, central nervous system; CREB, Ca2+/cAMP response element binding protein; Cx36, connexin 36; DIV, day in vitro; GABA, γ-aminobutyric acid; GABAAR, GABAA receptor; mGluR, metabotropic glutamate receptor; NMDA, N-methyl-d-aspa
Long-term evolution of diffusion tensor indices after temporary experimental ischemic stroke in rats
Keywords: BBB، مانع خونریزی مغزی; λ║, axial diffusivity; λ┴, radial diffusivity; BBB, blood-brain barrier; DTI, diffusion tensor imaging; DWI, diffusion-weighted imaging; EPI, echo-planar imaging; FA, fractional anisotropy; GM, gray matter; MCAO, middle cerebral artery occlusion; MD, mean
Elevated Plasma Levels of Neuropeptide Proenkephalin A Predict Mortality and Functional Outcome in Ischemic Stroke
Keywords: BBB، مانع خونریزی مغزی; biomarker; blood-brain barrier; proenkephalin; protachykinin; strokeAUC, area under the curve; BBB, blood-brain barrier; CI, confidence interval; CT, computed tomography; HR, hazards ratio; LAA, large-artery atherosclerosis; MACCE, major adverse cerebro/c
Lipopolysaccharide potentiates polychlorinated biphenyl-induced disruption of the blood–brain barrier via TLR4/IRF-3 signaling
Keywords: BBB، مانع خونریزی مغزی; BBB, blood-brain barrier; IRF-3, interferon regulatory factor-3; LPS, lipopolysaccharide; PCB, polychlorinated biphenyl; TLR4, toll-like receptor 4; ZO, zonula occludensBlood–brain barrier; Inflammation; Interferon regulatory factor-3; Polychlorinated bip
Pathogenesis of pre-eclampsia: marinobufagenin and angiogenic imbalance as biomarkers of the syndrome
Keywords: BBB، مانع خونریزی مغزی; preE, Preeclampsia; MBG, marinobufagenin; RBG, resibufogenin; IUGR, intrauterine growth restriction; DOCA, desoxycorticosterone acetate; MAPK, mitogen activated protein kinase; BBB, blood-brain barrier; CTB, cytotrophoblast; ECF, extracellular fluid; RLME
Preclinical studies of potential amyloid binding PET/SPECT ligands in Alzheimer's disease
Keywords: BBB، مانع خونریزی مغزی; Aβ, amyloid β; AD, Alzheimer's disease; APP, amyloid precursor protein; BBB, blood-brain barrier; BTA, benzothiazole; CSF, cerebrospinal fluid; CT, computed tomography; MOM, methoxymethyl; MRI, magnetic resonance imaging; NSAID, nonsteroidal anti-inflamma
Gene delivery by pullulan derivatives in brain capillary endothelial cells for protein secretion
Keywords: BBB، مانع خونریزی مغزی; BBB, blood-brain barrier; RBE4, rat brain endothelial cells 4; HBMEC, human brain microvascular endothelial cells; hGH1, human growth hormone 1; ASGPR, asialoglycoprotein receptor; PICs, polyion complexes; BDNF, brain-derived neurotrophic factor; FGF, fib
Amelioration of dementia induced by Aβ 22-35 through rectal delivery of undecapeptide-hEGF to mouse brain
Keywords: BBB، مانع خونریزی مغزی; DMEM, Dulbecco modified Eagle's medium; FBS, fetal bovine serum; BBB, blood-brain barrier; hEGF, humam epidermal growth factor; P11, undecapeptide (YGRKKRRQRRR); IV, intravenous injection; Aβ 22-35, beta-amyloid peptide 22-35; PTD, protein transduction do
Targeting the neurovascular unit for treatment of neurological disorders
Keywords: BBB، مانع خونریزی مغزی; Blood-brain barrier; Alzheimer's disease; Stroke; Astrocyte; Drug deliveryCNS, central nervous system; BBB, blood-brain barrier; NVU, neurovascular unit; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; MS, multiple sclerosis; Da, Dalton; SNpc
Opioid receptor agonists reduce brain edema in stroke
Keywords: BBB، مانع خونریزی مغزی; NKCC, Na, K, 2Cl cotransporter; BBB, blood-brain barrier; MCAO, middle cerebral artery occlusion; OGD, oxygen glucose deprivation; aCSF, artificial cerebral spinal fluid; TTC, 2,3,5-triphenyltetrazolium chloride; ANOVA, One-way Analysis of Variance; CCA,
Amyloid and Tau accumulate in the brains of aged hydrocephalic rats
Keywords: BBB، مانع خونریزی مغزی; Aβ40, amyloid-beta peptide 1-40 amino acids; Aβ42, amyloid-beta peptide 1-42 amino acids; AD, Alzheimer's disease; AβPP, amyloid precursor protein; BBB, blood-brain barrier; ELISA, enzyme-linked immunosorbent assay; IMHC, immunohistochemistry; pTau, hyper
Higher order structure of aquaporin-4
Keywords: BBB، مانع خونریزی مغزی; aquaporins; AQP4; BN–SDS/PAGE; NMO; NMO-IgG; OAPsAQP, aquaporin; AQP4, aquaporin-4; BBB, blood-brain barrier; BNE, blue native electrophoresis; CNS, central nervous system; DAPs, dystrophin associated proteins; DDM, dodecyl-beta-d-maltoside; DMD, Duchenne
New mass spectrometric tools in brain research
Keywords: BBB، مانع خونریزی مغزی; ALS, Amyotrophic lateral sclerosis; AD, Alzheimer’s disease; BBB, Blood-brain barrier; BCB, Blood-cerebrospinal fluid barrier; BrainMet, Bioimaging of Metals in Brain and Metallomics; CSF, Cerebrospinal fluid; ESI-MS, Electrospray ionization mass spectrom
Nanotechnology applications for improved delivery of antiretroviral drugs to the brain
Keywords: BBB، مانع خونریزی مغزی; ABC transporter, ATP-binding cassette membrane transporter; AIDS, acquired immunodeficiency syndrome; apoE, apolipoprotein E; ARVs, antiretroviral drugs; BBB, blood-brain barrier; BCSFB, blood-cerebro spinal fluid barrier; CD4, cluster of differentiation
Therapy of MS
Keywords: BBB، مانع خونریزی مغزی; AHSCT, autologous hematopoietic stem cell transplantation; ARR, absolute risk reduction; BBB, blood-brain barrier; CDMS, clinically definite multiple sclerosis; CIS, clinically isolated syndrome; CNS, central nervous system; CHF, congestive heart failure;
Barometric changes in patients with intracranial lesions: can they dive and fly?
Keywords: BBB، مانع خونریزی مغزی; AVM, arteriovenous malformation; BBB, blood-brain barrier; CT, computed tomography; MRI, magnetic resonance imagingBarometric; Air travel; Diving; Brain tumor; Unruptured aneurysm; Colloid cyst; Hydrocephalus
A case of an intraventricular inflammatory pseudotumor presumably caused by Epstein-Barr virus infection
Keywords: BBB، مانع خونریزی مغزی; ALK, Anaplastic lymphoma kinase; ANCA, antineutrophil cytoplasmic antibody; BBB, blood-brain barrier; CNS, central nervous system; CT, computed tomography; DNA, deoxyribonucleic acid; EA, early antigen; EBNA, Epstein-Barr nuclear antigen; EBV, Epstein-Bar
Increased expression of serum matrix metalloproteinase-9 in patients with moyamoya disease
Keywords: BBB، مانع خونریزی مغزی; BBB, blood-brain barrier; CNS, central nervous system; MMP, matrix metalloproteinase; TIMP, tissue inhibitor of metalloproteinasesMoyamoya disease; Matrix metalloproteinase; Enzyme-linked immunosorbent assay; Immunohistochemistry
Decreased serum BDNF levels in chronic institutionalized schizophrenia on long-term treatment with typical and atypical antipsychotics
Keywords: BBB، مانع خونریزی مغزی; ANOVA, analysis of variance; BBB, blood-brain barrier; BDNF, brain-derived neurotrophic factor; BMI, body mass index; DA, dopamine; ELISA, enzyme-linked immunosorbent assay; PANSS, Positive and Negative Syndrome Scale; TD, tardive dyskinesia; 5-HT, seroto
Incidence and risk factors for symptomatic cerebral hyperperfusion after superficial temporal artery-middle cerebral artery anastomosis in patients with moyamoya disease
Keywords: BBB، مانع خونریزی مغزی; BBB, blood-brain barrier; CBF, cerebral blood flow; CT, computed tomography; DWI, diffusion-weighted images; EDMS, encephalo-duro-myo-synangiosis; ICH, intracerebral hemorrhage; 123I-IMP-SPECT, N-isopropyl-p-[123I]iodoamphetamine single-photon emission co