Keywords: پمپ صادرات نمک صفر; NAFLD; nonalcoholic fatty liver disease; NASH; nonalcoholic steatohepatitis; FC; free cholesterol; VLDL; very low density lipoprotein; LDL; low density lipoprotein; mTOR; mechanistic target of rapamycin signaling; AMPK; AMP-activated protein kinase; TG; t
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Keywords: پمپ صادرات نمک صفر; neonatal cholestasis; ABCC2; MRP2; black liver; molecular genetic analysis; ABCC2; ATP-binding cassette sub-family C member 2; BSEP; Bile salt export pump; D Bil; Direct bilirubin; GGT; γ-glutamyltransferase; MRP2; Multidrug resistance-associated protein
Keywords: پمپ صادرات نمک صفر; 2D-sw; 2D-sandwich; AMI; amiodarone; APAP; acetaminophen; BA; bile acid; BC; bile canaliculi; BOS; bosentan; BSEP; bile salt export pump; CPZ; chlorpromazine; CSA; cyclosporine A; CYP450; cytochrome P450; DIC; drug-induced cholestasis; DICI; drug-induced
Keywords: پمپ صادرات نمک صفر; BS; bile salts; BSEP; bile salt export pump; MRP2; multidrug resistance-associated protein 2; E17G; estradiol 17 β-d-glucuronide; EE; 17α-ethynylestadiol; IRHC; isolated rat hepatocyte couplets; CME; clathrin mediated endocytosis; MDC; monodansylcadaver
Development of a rapid and sensitive multiple reaction monitoring proteomic approach for quantification of transporters in human liver tissue
Keywords: پمپ صادرات نمک صفر; BCRP; breast cancer resistance protein; BSEP; bile salt export pump; CE; collision energy; HSA; human serum albumin; LLOQ; lower limit of quantification; MRP; multidrug resistance-associated protein; NTCP; sodium-taurocholate cotransporting polypeptide; O
Keywords: پمپ صادرات نمک صفر; Acss2; Acyl-CoA synthetase short-chain 2; Akt; Protein kinase B; ALP; Alkaline phosphatase; ALT; Alanine aminotransferase; Bsep; Bile salt export pump; Creb-Pgc-1α; cAMP regulator element binding-peroxisome proliferator-activated receptor γ coactivator
Keywords: پمپ صادرات نمک صفر; ADME; absorption, distribution, metabolism, and excretion; AUC; area under concentration-time curve; BCRP; breast cancer resistance protein; BSEP; bile salt export pump; CFTR; cystic fibrosis transmembrane conductance regulator; Cmax; maximal plasma conce
Keywords: پمپ صادرات نمک صفر; Drug interactions; Hepatic transport; Transporters; ABC transporters; Bile acid transporters; BSEP; bile salt export pump; DILI; drug-induced liver injury; FXR; farnesoid X receptor; MDR; multidrug resistance protein; MRP; multidrug resistance-associated
Keywords: پمپ صادرات نمک صفر; transporters; metabolism; drug-metabolizing enzymes; pharmacokinetics; hepatic transport; hepatic metabolism; organic anion-transporting polypeptide transporters; ALT; alanine aminotransferase; AST; aspartate aminotransferase; ATP; adenosine triphosphate;
Keywords: پمپ صادرات نمک صفر; DILI; drug-induced liver injury; ALT; alanine aminotransferase; ALP; alkaline phosphatase; BBW; black box warning; WDN; withdrawn; BC; bile canalicular; BSEP; bile salt export pump; MRP2; multidrug resistance-associated protein 2; SCHs; sandwich cultured
Keywords: پمپ صادرات نمک صفر; ABCB; ATP-binding cassette sub-family B; Apo; apolipoprotein; ASBT; apical sodium dependent bile acid transporter; BDL; bile duct ligation; BSEP; bile salt export pump; CA; cholic acid; CDCA; chenodeoxycholic acid; C/EBP; CCAAT-enhancer-binding protein; C
Keywords: پمپ صادرات نمک صفر; BA; bile acid; BEI; biliary excretion index; BSEP/Bsep; bile salt export pump; CsA; cyclosporine A; DILI; drug-induced liver injury; DMSO; dimethyl sulfoxide; E217βG; estradiol-17β-D-glucuronide; FBS; fetal bovine serum; GFP; green fluorescent protein;
Keywords: پمپ صادرات نمک صفر; [3H]-TC; [3H]-Taurocholate; 4PB; 4-Phenylbutyrate; ALT; Alanine aminotransaminase; AST; Aspartate aminotransaminase; ATP; Adenosine triphosphate; BSEP; Bile salt export pump; cDNA; Complementary DNA; D-Bil; Direct bilirubin; EV; Empty vector; GAPDH; Glyce
Keywords: پمپ صادرات نمک صفر; ABC; ATP-binding cassette; AE2 (SLC4A2); anion exchanger 2; ALT; alanine aminotransferase; AMPK; AMP-activated protein kinase; ALP; alkaline phosphatase; ASBT (SLC10A2); apical sodium-dependent bile acid transporter; ASCOM; activating signal cointegrator-
Keywords: پمپ صادرات نمک صفر; PBC; primary biliary cirrhosis; CMVs; canalicular membrane vesicles; mAb1F9; monoclonal antibody 1F9; mAb1F9-Ag; mAb1F9 antigen; UDCA; ursodeoxycholic acid; MALDI-TOF/TOF; matrix assisted laser desorption/ionization-tandem time-of-flight analysis; MS; mas
Keywords: پمپ صادرات نمک صفر; AL; ad libitum; Asbt; apical sodium-dependent bile acid transporter; BA; bile acid; BAL; bile acid-CoA ligase; BAT; bile acid-CoA: amino acid N-acyltransferase; Bsep; bile salt export pump; CA; cholic acid; CDCA; chenodeoxycholic acid; CR; calorie restric
Keywords: پمپ صادرات نمک صفر; BCRP; breast cancer resistance protein; BSEP; bile salt export pump; BSP; bromosulfophtalein; CYP; cytochrome P450; day 29 or 36; hepatocyte cultures 29 or 36 days respectively after start of the hepatic differentiation protocol; E17βG; estradiol-17β-d-
N-(4-[18F]fluorobenzyl)cholylglycine, a novel tracer for PET of enterohepatic circulation of bile acids: Radiosynthesis and proof-of-concept studies in rats
Keywords: پمپ صادرات نمک صفر; Bile acids; Bile Salt Export Pump; Enterohepatic circulation; Fluorine-18 labelling; Metabolism; Positron emission tomography;
Reduced Hepatocellular Expression of Canalicular Transport Proteins in Infants with Neonatal Cholestasis and Congenital Hypopituitarism
Keywords: پمپ صادرات نمک صفر; cholestasis; congenital hypopituitarism; septo-optic dysplasia; canalicular ectoenzymes; canalicular transport proteins; ACTH; Adrenocorticotropic hormone; BSEP; Bile salt export pump; CD13; Alanyl aminopeptidase; FIC1; Familial intrahepatic cholestasis t
Alisma orientale extract exerts the reversing cholestasis effect by activation of farnesoid X receptor
Keywords: پمپ صادرات نمک صفر; Alisma orientale; Cholestasis; Proteomics; Farnesoid X receptor; AOE; Alisma orientale extract; ANIT; α-naphthylisothiocyanate; FXR; farnesoid X receptor; AST; aspartate aminotransferase; ALT; alanine aminotransferase; TBIL; total bilirubin; TBA; intrahe
The ileum-liver Farnesoid X Receptor signaling axis mediates the compensatory mechanism of 17α-ethynylestradiol-induced cholestasis via increasing hepatic biosynthesis of chenodeoxycholic acids in rats
Keywords: پمپ صادرات نمک صفر; Asbt; apical sodium-dependent bile acids transporter; ALP; alkaline phosphatase; ALT; alanine transaminase; AST; aspartate transaminase; BAs; bile acids; Bsep/BSEP; bile salt export pump; β-MCA; β-muricholic acid; CA; cholic acid; CDCA; chenodeoxycholic
Assessment of ATP8B1 Deficiency in Pediatric Patients With Cholestasis Using Peripheral Blood Monocyte-Derived Macrophages
Keywords: پمپ صادرات نمک صفر; Pediatric liver disease; Diagnosis; Progressive familial intrahepatic cholestasis; ACTB; β-actin; BSEP; bile salt export pump; GGT; gamma-glutamyl transferase; HA; hemagglutinin; HBV; hepatitis B virus; HCV; hepatitis C virus; HMDM; human peripheral bloo
Dysregulation of Î4-3-oxosteroid 5β-reductase in diabetic patients: Implications and mechanisms
Keywords: پمپ صادرات نمک صفر; AKR1D1; Diabetes; Bile acid synthesis; Steroid hormone metabolism; PPARα signaling; AKR1D1; aldo-keto reductase family 1, member D1; BMI; body mass index; BSEP; bile salt export pump; CA; cholic acid; CDCA; chenodeoxycholic acid; CPT1A; carnitine palmito
Endoplasmic reticulum stress precedes oxidative stress in antibiotic-induced cholestasis and cytotoxicity in human hepatocytes
Keywords: پمپ صادرات نمک صفر; Ac-DEVD-AMC; N-acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin; AKT; protein kinase B; AMP; ampicillin; ATB; antibiotic; ATF6; activating transcription factor 6; BC; bile canaliculi; BSEP; bile salt export pump; CDF; 5(6)-carboxy-2,7-dichlorofluorescein;
Nuclear receptor FXR, bile acids and liver damage: Introducing the progressive familial intrahepatic cholestasis with FXR mutations
Keywords: پمپ صادرات نمک صفر; NR; nuclear receptor; FXR; farnesoid X receptor; RXR; retinoid X receptor; PXR; pregnane X receptor; VDR; Vitamin D receptor; TGR5; G protein-coupled bile acid receptor; Lrh1; liver receptor homolog 1; Mdr; multidrug resistance protein; Abcb4; ATP Bindi
Activation of PPARα decreases bile acids in livers of female mice while maintaining bile flow and biliary bile acid excretion
Keywords: پمپ صادرات نمک صفر; Biliary excretion; PPARα; Bile acids; Gender difference; 1oBAs; Primary bile acids; 2oBAs; secondary bile acids; 12-OH; 12-hydroxylated bile acid; Asbt; apical sodium-dependent bile acid transporter; BA; bile acid; Baat; bile acid CoA:amino acid N-acyltr
Transhepatic bile acid kinetics in pigs and humans
Keywords: پمپ صادرات نمک صفر; Bile acids; TGR5; Porcine; Postprandial; Portal concentrations; BAs; bile acids; ASBT; apical sodium-dependent bile acid transporter; OST; organic solute transporter; NTCP; taurocholate cotransporting polypeptide; OATP; organic anion transporting polypept
Maternal fructose induces gender-dependent changes in both LXRα promoter methylation and cholesterol metabolism in progeny
Keywords: پمپ صادرات نمک صفر; RCT; Reverse cholesterol transport; LXRα; Liver X-receptor alpha; CpG islands; CG-dinucleotide-rich regions in the gene promoter; HDL; High-density lipoproteins; PPAR; Peroxisome proliferator-activated receptor; SRB-1; Scavenger Receptor class B, member
Individual serum bile acid profiling in rats aids in human risk assessment of drug-induced liver injury due to BSEP inhibition
Keywords: پمپ صادرات نمک صفر; ALT; alanine amino transferase; AST; aspartate amino transferase; AUClast; area under the plasma time curve from time 0 to the last measured concentration (24Â h); BSEP; Bile Salt Export Pump; CL; clearance; C0; highest initial plasma concentration of dru
Comparative hepatic transcriptome analyses revealed possible pathogenic mechanisms of fasiglifam (TAK-875)-induced acute liver injury in mice
Keywords: پمپ صادرات نمک صفر; Fasiglifam (TAK-875); Drug-induced liver injury (DILI); Microarray; Comparative hepatic transcriptome analysis; Gene set enrichment analysis; ALT; Alanine aminotransferase; Bsep; Bile salt export pump; CCl4; Carbon tetrachloride; ConA; Concanavalin A; DAM
Post-transplant cholangiopathy: Classification, pathogenesis, and preventive strategies
Keywords: پمپ صادرات نمک صفر; AE2; Anion exchanger 2 (cholangiocyte Clâ/HCO3â transporter); ATP; Adenosine triphosphate; BSEP; Bile salt export pump; CFTR; Cystic fibrosis transmembrane conductance regulator; CIT; Cold ischemia time; CMV; Cytomegalovirus; DBD; Donation after brain
Aryl hydrocarbon receptor (AhR) mediated short-term effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on bile acid homeostasis in mice
Keywords: پمپ صادرات نمک صفر; Aryl hydrocarbon receptor; TCDD; Bile acids; Biliary excretion; Taurodeoxycholic acid; Cyp8b1; 1°BAs; Primary bile acids; 2°BAs; Secondary bile acids; 6-OH; 6-hydroxylated (6-OH); 12-OH; 12α-hydroxylated; Abc; ATP-binding cassette; AhR; Aryl hydrocarbo
Intake of stigmasterol and β-sitosterol alters lipid metabolism and alleviates NAFLD in mice fed a high-fat western-style diet
Keywords: پمپ صادرات نمک صفر; ABCA1; ATP binding cassette transporter A1; ABCG5; ATP binding cassette transporter 5; ALT; alanine aminotransferase; ASBT; ileal apical sodium-dependent bile acid transporter; BA; bile acid(s); BSEP; bile salt export pump; CD36; Cluster of Differentiatio
Disruption of TFGβ-SMAD3 pathway by the nuclear receptor SHP mediates the antifibrotic activities of BAR704, a novel highly selective FXR ligand
Keywords: پمپ صادرات نمک صفر; CDCA; chenodeoxycholic acid; CA; cholic acid; DCA; deoxycholic acid; LCA; litocholic acid; BAs; bile acids; BARS; bile acid activated receptors; GPBAR1; G protein coupled bile acid receptor; TGR5; Takeda G protein receptor 5; FXR; farnesoid x-receptor; PX
Natural products as modulators of the nuclear receptors and metabolic sensors LXR, FXR and RXR
Keywords: پمپ صادرات نمک صفر; Natural products; Nuclear receptors; Liver X receptor; Farnesoid X receptor; Retinoid X receptor; Metabolic syndrome; Precision medicine; 6-ECDCA; 6α-ethyl-chenodeoxycholic acid (obeticholic acid); AA; arachidonic acid; ABC; ATP-binding cassette transpor
Metabolic preconditioning protects BSEP/ABCB11â/â mice against cholestatic liver injury
Keywords: پمپ صادرات نمک صفر; Bile salt export pump; Polyhydroxylated bile acids; Intrahepatic cholestasis;
The role of Ntcp, Oatp2, Bsep and Mrp2 in liver injury induced by Dioscorea bulbifera L. and Diosbulbin B in mice
Keywords: پمپ صادرات نمک صفر; Dioscorea bulbifera L.; Diosbulbin B; Na+-taurocholate co-transporting polypeptide; Organic anion transporting polypeptide 2; Bile salt export pump; Multidrug resistance associated protein 2;
Anti-hyperlipidemic effects of Rhizoma Coptidis alkaloids are achieved through modulation of the enterohepatic circulation of bile acids and cross-talk between the gut microbiota and the liver
Keywords: پمپ صادرات نمک صفر; ASBT; apical sodium-dependent bile salt transporter; BSEP; bile salt export pump; COX2; cyclooxygenase 2; CYP7A1; cholesterol 7α-hydroxylase; FXR; farnesoid X receptor; HFHC; high fat and high cholesterol; HMGCR; 3-hydroxy-3-methyl glutaryl coenzyme A re
Dihydroartemisinin protects against alcoholic liver injury through alleviating hepatocyte steatosis in a farnesoid X receptor-dependent manner
Keywords: پمپ صادرات نمک صفر; ALD; alcoholic liver disease; ALP; alkaline phosphatase; ALT; alanine aminotransferase; AST; aspartate aminotransferase; BSEP; bile salt export pump; CPT1; carnitine palmitoyltransferase I; CYP7A1; cholesterol 7-alpha hydroxy-lase; DHA; dihydroartemisinin
Myotoxicity of statins: Mechanism of action
Keywords: پمپ صادرات نمک صفر; AKT; protein kinase B; AMPK; AMP-activated protein kinase; Bax; Bcl-2-associated X; Bcl-2; B-cell lymphoma 2; BCRP; breast cancer resistance protein; BSEP; bile salt export pump; CaMKII; calmodulin kinase II; CaMKK; Ca2Â +/calmodulin-dependent kinase kina
The interrelationship between bile acid and vitamin A homeostasis
Keywords: پمپ صادرات نمک صفر; ATGL; Adipose triglyceride lipase; ADH; Alcohol dehydrogenase; ALD; Alcoholic liver disease; atRA; All-trans retinoic acid; ASBT/SLC10A2; Apical sodium-dependent bile salt transporter; ABCA1; ATP-binding cassette transporter member 1; BCMO1; Beta-carotene
Identification of Bile Acids Responsible for Inhibiting the Bile Salt Export Pump, Leading to Bile Acid Accumulation and Cell Toxicity in Rat Hepatocytes
Keywords: پمپ صادرات نمک صفر; biliary excretion; in vitro models; toxicology; bile acid transporters; efflux pumps; BA; bile acid; BSEP; bile salt export pump; CA; cholic acid; CDCA; chenodeoxycholic acid; CsA; cyclosporin A; DCA; deoxycholic acid; DILI; drug-induced liver injury; DM
Rifampicin-induced injury in HepG2 cells is alleviated by TUDCA via increasing bile acid transporters expression and enhancing the Nrf2-mediated adaptive response
Keywords: پمپ صادرات نمک صفر; RFP; rifampicin; TUDCA; tauroursodeoxycholic acid; Nrf2; nuclear factor erythroid 2-related factor; DILI; drug-induced liver injury; ALF; acute liver failure; TB; tuberculosis; INH; isoniazid; GSH; glutathione; BAs; bile acids; ER; endoplasmic reticulum;
Targeted pharmacotherapies for defective ABC transporters
Keywords: پمپ صادرات نمک صفر; 4-PBA; 4-phenylbutyrate; ABC; ATP-Binding Cassette; BRIC2; Benign Recurrent Intrahepatic Cholestasis type 2; BSEP; Bile Salt Export Pump; CF; Cystic Fibrosis; CFTR; Cystic Fibrosis Transmembrane conductance Regulator; CsA; Cyclosporin A; DMSO; DiMethylSul
Progressive Familial Intrahepatic Cholestasis (PFIC) in Indian Children: Clinical Spectrum and Outcome
Keywords: پمپ صادرات نمک صفر; BD; biliary diversion; BSEP; bile salt export pump; DDLT; deceased donor liver transplantation; ESLD; end stage liver disease; GGT; gamma glutamyl transferase; HE; hepatic encephalopathy; ICP; intrahepatic cholestasis of pregnancy; LFT; liver functions te
Comparative study of CYP2B1/2 induction and the transport of bilirubin and taurocholate in rat hepatocyte-mono- and hepatocyte-Kupffer cell co-cultures
Keywords: پمپ صادرات نمک صفر; B; bilirubin; Bsep; bile salt export pump; CYP; cytochrome P-450; GdCl3; gadolinium(III) chloride; H/KC; hepatocyte-Kupffer-cell co-culture; HBSS; Hanks' balanced salt solution; HPLC; high-performance liquid chromatography; KC; Kupffer-cell; LPS; lipopoli
Dioscin protects against ANIT-induced cholestasis via regulating Oatps, Mrp2 and Bsep expression in rats
Keywords: پمپ صادرات نمک صفر; ALT; alanine amiotransferase; ANIT; alpha-naphthylisothiocyanate; AST; aspartate transaminase; BIL; bilirubin; Bsep; bile salt export pump; CMC-Na; carboxymethylcellulose sodium; E3S; estrone-3-sulfate; FXR; Farnesoid X receptor; IS; hydrochlorothiazide;
Alpha-naphthylisothiocyanate impairs bile acid homeostasis through AMPK-FXR pathways in rat primary hepatocytes
Keywords: پمپ صادرات نمک صفر; ANIT; alpha-naphthylisothiocyanate; A1AR; A1 adenosine receptor; FXR; farnesoid X receptor; SHP; small heterodimer partner; Bsep; bile salt export pump; Mrp2; multidrug resistance-associated protein 2; Ntcp; Na+-dependent taurocholate cotransporter; Oatp2
Inhibition of bile salt transport by drugs associated with liver injury in primary hepatocytes from human, monkey, dog, rat, and mouse
Keywords: پمپ صادرات نمک صفر; Bile salt export pump; BSEP; ABCB11; Drug-induced liver injury; DILI; Bile salts; Hepatocytes; Species differenceBSEP, bile salt export pump; CA, cholic acid; CDCA, chenodeoxycholic acid; DILI, drug-induced liver injury; GCA, glycocholic acid; GCDCA, glyc
Conformational modulation of the farnesoid X receptor by prenylflavonoids: Insights from hydrogen deuterium exchange mass spectrometry (HDX-MS), fluorescence titration and molecular docking studies
Keywords: پمپ صادرات نمک صفر; FXR; farnesoid X receptor; HDX-MS; hydrogen deuterium exchange mass spectrometry; MetS; metabolic syndromes; SHP; small heterodimer partner; BSEP; bile salt export pump; LBD; ligand binding domain; XN; xanthohumol; IX; isoxanthohumol; 8-PN; 8-prenylnarige