Cell-based Therapies: Current Issues and Future Directions
Keywords: بیولوژیک; Mesenchymal stem cells; Biologics; Efficacy; Clinical trials;
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The Addition of Lysostaphin Dramatically Improves Survival, Protects Porcine Biomesh from Infection, and Improves Graft Tensile Shear Strength
Keywords: بیولوژیک; lysostaphin; hernia; porcine mesh; biologics; infection; antimicrobials
The therapeutic equivalence of complex drugs
Keywords: بیولوژیک; Biologics; Biosimilars; Immunogenicity; LMWH; Liposomes; Iron-carbohydrate complexes; Glatiramoids; Bioequivalence; Therapeutic equivalence;
Immune response to pneumococcal polysaccharide vaccine in adults with chronic plaque psoriasis treated with alefacept
Keywords: بیولوژیک; alefacept; biologics; pneumococcal polysaccharide vaccine; psoriasis; T cells; vaccinesAE, adverse event; CI, confidence interval; IL, interleukin; PPV, pneumococcal polysaccharide vaccine; PSO, chronic plaque psoriasis; TNF, tumor necrosis factor
Mycoplasma testing of cell substrates and biologics: Review of alternative non-microbiological techniques
Keywords: بیولوژیک; Mycoplasma; Cell substrates; Biologics; Detection; NAT assays
Costimulatory signals potently modulate the T cell inhibitory capacity of the therapeutic CD11a antibody Efalizumab
Keywords: بیولوژیک; T cell activation;; Costimulation;; Immunomodulation;; CD11a;; Biologics
Comparative assessment of vascular function in autoimmune rheumatic diseases: Considerations of prevention and treatment
Keywords: بیولوژیک; Atherosclerosis; Cardiovascular disease; Autoimmune rheumatic diseases; Endothelial dysfunction; Biologics
Measurement and Rates of Persistence With and Adherence to Biologics for Rheumatoid Arthritis: A Systematic Review
Keywords: بیولوژیک; adherence; biologics; persistence; rheumatoid arthritis
The risk of infection and malignancy with tumor necrosis factor antagonists in adults with psoriatic disease: A systematic review and meta-analysis of randomized controlled trials
Keywords: بیولوژیک; biologics; cancer; infection; malignancy; meta-analysis; psoriasis; psoriatic arthritis; safety; tumor necrosis factor-alfaCI, confidence interval; DMARD, disease-modifying antirheumatic drug; IRR, incidence rate ratio; NMSC, nonmelanoma skin cancer; OR,
Cutaneous lupus erythematosus: Update of therapeutic options : Part II
Keywords: بیولوژیک; biologics; dapsone; lupus erythematosus; methotrexate; mycophenolate mofetil; retinoids; second-line treatment; skinACLE, acute cutaneous lupus erythematosus; CHLE, chilblain lupus erythematosus; CLE, cutaneous lupus erythematosus; DILE, drug-induced lupu
The Italian Society of Gastroenterology (SIGE) and the Italian Group for the study of Inflammatory Bowel Disease (IG-IBD) Clinical Practice Guidelines: The use of tumor necrosis factor-alpha antagonist therapy in Inflammatory Bowel Disease
Keywords: بیولوژیک; Biologics; Guidelines; Inflammatory Bowel Disease; Tumor necrosis factor-alpha antagonist
Systemic Therapy With Conventional and Novel Immunomodulatory Agents for Ocular Inflammatory Disease
Keywords: بیولوژیک; immunomodulatory therapy; antimetabolites; alkylating agents; biologics; uveitis; scleritis; keratitis; pemphigoid
Guidelines of care for the management of psoriasis and psoriatic arthritis : Section 6. Guidelines of care for the treatment of psoriasis and psoriatic arthritis: Case-based presentations and evidence-based conclusions
Keywords: بیولوژیک; adalimumab; alefacept; biologics; case studies; clinical guidelines for psoriasis; combination therapy; comorbidities; dermatology; etanercept; gaps in knowledge; gaps in research; golimumab; guidelines; inflammation; infliximab; methotrexate; narrowband;
Biologics — beyond the joints
Keywords: بیولوژیک; Biologics; Rheumatoid arthritis; Ankylosing spondylitis; Inflammatory bowel disease; Psoriasis; Uveitis; Atherosclerosis; Cardiovascular disease
Drug-induced lupus: An update
Keywords: بیولوژیک; SLE, Systemic lupus erythematosus; DIL, Drug-induced lupus; TNF, Tumor necrosis factor; RA, Rheumatoid arthritisDrug-induced lupus; SLE; Anti-TNF; Autoimmunity; Biologics
Effect of Bacterial Exposure on Acellular Human Dermis in a Rat Ventral Hernia Model
Keywords: بیولوژیک; acellular human dermis; bacterial contamination; inflammation; ingrowth; shear strength; biologics
Innovative Uses of Rituximab in Dermatology
Keywords: بیولوژیک; Biologics; Rituximab; Dermatology;
Alopecia areata update : Part II. Treatment
Keywords: بیولوژیک; biologics; corticosteroids; immunotherapy; intralesional; minoxidil; phototherapyAA, alopecia areata; AT, alopecia totalis; AU, alopecia universalis; DNCB, dinitrochlorobenzene; DPCP, diphenylcyclopropenone; IFN-γ, interferon gamma; IL, interleukin; ILCS,
Biologic Drugs for the Treatment of Hidradenitis Suppurativa: An Evidence-Based Review
Keywords: بیولوژیک; Hidradenitis suppurativa; Biologics; Nodules; Abscesses;
Biologics in Foot and Ankle Surgery
Keywords: بیولوژیک; Foot and ankle surgery; Biologics; Bone morphogenetic proteins; Bone healing;
Sustained progression-free survival with weekly paclitaxel and bevacizumab in recurrent ovarian cancer
Keywords: بیولوژیک; Ovarian cancer; Chemotherapy; Biologics; Monoclonal antibodies
Continued development of an empirical function for predicting and rationalizing protein-protein binding affinities
Keywords: بیولوژیک; Protein-protein recognition; Binding affinity; Free energy; Alanine scanning mutagenesis; Hot spot; Peptide therapeutics; Biologics; Computational;
The economics of treatment in early rheumatoid arthritis
Keywords: بیولوژیک; economics; productivity; cost-effectiveness; DMARDs; biologics;
Are biologics safe in the treatment of atopic dermatitis? A review with a focus on immediate hypersensitivity reactions
Keywords: بیولوژیک; atopic dermatitis; biologics; immediate hypersensitivity reactionsAD, atopic dermatitis; EASI, Eczema Area and Severity Index; IL, interleukin; TNF, tumor necrosis factor
Managing patients with chronic severe asthma: Rise to the challenge
Keywords: بیولوژیک; Chronic severe asthma; Steroid-refractoriness; Differential diagnosis; Pharmacotherapy; Biologics; Immunomodulators
Abdominal Wall Reconstruction Using Biological Tissue Grafts
Keywords: بیولوژیک; biological tissue grafts; biologics; abdominal wall defects; cross-link; decellularization; hernia; porcine dermis; porcine small intestine submucosa; fetal bovine dermis; human dermis;
Reducing risk, improving outcomes: Bioengineering less immunogenic protein therapeutics
Keywords: بیولوژیک; Anti-drug-antibodies (ADA); Protein therapeutic; Biologics; Immunogenicity; T-cell dependent immunogenicity; Biologics; T cell; Regulatory T cell; Treg
Evaluation and Management of Psoriasis: An Internist's Guide
Keywords: بیولوژیک; Psoriasis; Plaque; Immunopathogenesis; Biologics; Metabolic syndrome;
Effect of anti-tumor necrosis factor-α therapies on body mass index in patients with psoriasis
Keywords: بیولوژیک; TNF-α; Biologics; Psoriasis; Weight gain
The autoimmunologist: geoepidemiology, a new center of gravity, and prime time for autoimmunity
Keywords: بیولوژیک; Autoimmunology; Center of Excellence; Biologics; Female predominance
Anti-CD20 (rituximab) treatment improves atopic eczema
Keywords: بیولوژیک; Atopic dermatitis; B cells; biologics; cytokines; inflammation; rituximab; T cellsAE, Atopic eczema; EASI, Eczema area and severity index; ECP, Eosinophil cationic protein
Emerging Technologies in Spine Surgery
Keywords: بیولوژیک; emerging spine technology; minimally invasive spine surgery; disc nucleus replacement; biologics
Arthroscopic Replacement of Massive, Irreparable Rotator Cuff Tears Using a GraftJacket Allograft: Technique and Preliminary Results
Keywords: بیولوژیک; Rotator cuff; GraftJacket; Biologics; Shoulder arthroscopy;
Novel therapeutic options in the inflammatory bowel disease world
Keywords: بیولوژیک; Biologics; Children; Crohn's disease; Helminthes; Inflammatory bowel disease; Leukocyte apheresis; Probiotics; Stem cell transplantation; Ulcerative colitis
Overview of the clinical application of regenerative medicine products in Japan
Keywords: بیولوژیک; Regenerative medicine; Biologics; Regulatory guideline; Interview survey
Issues Related to Clinical Trials of Oral and Biologic Disease-Modifying Agents for Sjögren's Syndrome
Keywords: بیولوژیک; Sjögren's; Clinical trials; DMARD; Biologics; Outcome; Study design
Adult-onset Still disease
Keywords: بیولوژیک; anakinra; autoinflammatory syndrome; biologics; ferritin; glycosylated ferritin; inflammatory arthritides; Still disease
Primary Sjogren’s Syndrome: Current and Prospective Therapies
Keywords: بیولوژیک; primary Sjogren’s syndrome; sicca syndrome; dry eye; dry mouth; treatment; biologics; anti-TNF-α; rituximab; lymphoma15S-HETE, 15S-hydroxyeicosatetraenoic acid; ANA, antinuclear antibody; AQP, aquaporin; BAFF, B-cell activating factor; BCR, B-cell recepto
Duration of chronic toxicity studies for biotechnology-derived pharmaceuticals: Is 6 months still appropriate?
Keywords: بیولوژیک; Biologics; Chronic toxicity; Duration; Preclinical; Protein therapeutics; Chronic
Specific detection of residual CHO host cell DNA by real-time PCR
Keywords: بیولوژیک; Chinese hamster ovary; Genomic DNA; Real-time PCR; Biologics; SYBR GreenCHO, Chinese hamster ovary; PCR, polymerase chain reaction; qRTPCR, quantitative real-time polymerase chain reaction
Progression-free survival as an end-point in clinical trials of biotherapeutic agents
Keywords: بیولوژیک; Anticancer agents; Biologics; Drug approval; Drug registration; End-point; Progression-free survival; Surrogate; Targeted agents;
Drug safety evaluation through biomarker analysis—A toxicity study in the cynomolgus monkey using an antibody-cytotoxic conjugate against ovarian cancer
Keywords: بیولوژیک; Predictive toxicity; Biologics; Immunoconjugate; Antibody; Toxin; MTD; Biomarker; Toxicokinetics; Safety evaluation; Toxicology
Considerations for the sensible use of rodent models of inflammatory disease in predicting efficacy of new biological therapeutics in the clinic
Keywords: بیولوژیک; Rheumatoid arthritis; Multiple sclerosis; Asthma; Animal models; Inflammation; Biologics
Immunobiologics in the treatment of psoriasis
Keywords: بیولوژیک; T cell; TNF-alpha; Psoriasis; Inflammation; Biologics; Skin disease;
Systemic lupus erythematosus: modern strategies for management – a moving target
Keywords: بیولوژیک; biologics; cyclophosphamide; monoclonal antibodies; mycophenolate mofetil; systemic lupus erythematosus
Animal experimentation in Japan: Regulatory processes and application for microbiological studies
Keywords: بیولوژیک; Expériences sur des animaux; Animaux d’expérience; Système de gestion; Recherches et développement microbiologiques; BiosécuritéAnimal experimentation; Laboratory animals; Management system; Microbiological research and development; Biologics
Leflunomide combined with conventional disease-modifying antirheumatic drugs or biologics in patients with rheumatoid arthritis
Keywords: بیولوژیک; Rheumatoid arthritis; Leflunomide; Biologics; Drug therapy; combination;
Gene therapy for patients with rheumatoid arthritis
Keywords: بیولوژیک; Rheumatoid arthritis; Cytokines; Vectors; Experimental models; Biologics
Therapeutic Options for Resistant Lupus Nephritis
Keywords: بیولوژیک; glomerulonephritis; lupus erythematosus; modalities; biologics; immunomodulatorySLE, systemic lupus erythematosus; ACR, American College of Rheumatology; NIH, National Institutes of Health; CYC, cyclophosphamide; GnRH, gonadotropin-releasing hormone; HSCT
Biologics in development for rheumatoid arthritis: Relevance to osteoarthritis
Keywords: بیولوژیک; Osteoarthritis; Cartilage; Structure modification; Biomarkers; DMOADs; Cytokines; Biologics