Keywords: AC-42; 4-(4-Butyl-1-piperidinyl)-1-(2-methylphenyl)-1-butanone hydrochloride; ACh; acetylcholine; AM; allosteric modulator; BQCA; Benzyl quinolone carboxylic acid; ECL; extracellular loop; FRET; Förster resonance energy transfer; F-V curve; Function -
مقالات ISI (ترجمه نشده)
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Keywords: ACh; acetylcholine; β-Arr; beta arrestin; BETP; 2-(ethylsulfinyl)-4-[3-(phenylmethoxy)phenyl]-6-(trifluoromethyl)-pyrimidine; BQCA; benzyl quinolone carboxylic acid; cAMP; cyclic adenosine 3â²5â²-monophosphate; CaSR; calcium-sensing receptor; CB1; cann
The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease
Keywords: 7-Methoxytacrine; Acetylcholinesterase; Acetylcholinesterase inhibitor; Butyrylcholinesterase; Alzheimer's disease; BQCA; Multi-target directed ligands; Positive allosteric modulator of muscarinic receptor; Tacrine;
Probing the binding site of novel selective positive allosteric modulators at the M1 muscarinic acetylcholine receptor
Keywords: ACh; acetylcholine; mAChR; muscarinic acetylcholine receptor; GPCR; G protein-coupled receptor; AD; Alzheimer's disease; PAM; positive allosteric modulator; NAM; negative allosteric modulator; TM; transmembrane domain; ECL; extracellular loop; CHO; Chin
Development of allosteric modulators of GPCRs for treatment of CNS disorders
Keywords: 5MPEP; 5-methyl-6-(phenylethynyl)-pyridine; 6-OHDA; 6-hydroxydopamine; 7TMR; seven transmembrane receptor; 77-LH-28-1; 1-[3-(4-butyl-1-piperidinyl)propyl]-3,4-dihydro-2(1H)-quinolinone; AC-42; 4-n-butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine; ACh
Behavioural pharmacologyUsing cholinergic M1 receptor positive allosteric modulators to improve memory via enhancement of brain cholinergic communication
Keywords: Memory; Muscarinic receptor; M1 positive allosteric modulator; BQCA; (Rat);
Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): The development of ML169, an MLPCN probe
Keywords: Muscarinic; Acetylcholine; Positive allosteric modulator (PAM); ML169; BQCA; Alzheimer’s disease; MLPCN
Research reportA new automated method to assess the rat recognition memory: Validation of the method
Keywords: Rat; Memory; Object recognition; Y-maze; Scopolamine; Natural forgetting; BQCA;