دانلود مقالات ISI درباره Braf + ترجمه فارسی

A Nexus Consisting of Beta-Catenin and Stat3 Attenuates BRAF Inhibitor Efficacy and Mediates Acquired Resistance to Vemurafenib

Keywords: β-catenin; Melanoma; BRAF; Stat3; Resistance; Vemurafenib

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2016 سفارش ترجمه

New insight into the role of metabolic reprogramming in melanoma cells harboring BRAF mutations

Keywords: ATP; adenosine triphosphate; BRAF; serine/threonine-protein kinase B-Raf; cAMP; cyclic adenosine monophosphate; CDK4; cyclin-dependent kinases 4; CREB; cAMP response element binding protein; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxi

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2016 سفارش ترجمه

Regulation of BRAF protein stability by a negative feedback loop involving the MEK-ERK pathway but not the FBXW7 tumour suppressor

Keywords: C. elegans; Caenorhabditis elegans; MEK; mitogen-activated protein kinase kinase; ERK; extracellular signal-regulated kinase; CPD; CDC4 phosphodegron; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethylsulphoxide; MEFs; mouse embryonic fibroblasts; A

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2016 سفارش ترجمه

RIG-I inhibits the MAPK-dependent proliferation of BRAF mutant melanoma cells via MKP-1

Keywords: RIG-I; MAPK; MKP-1/DUSP1; BRAF; Melanoma; Proliferation;

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2016 سفارش ترجمه

An overview of chemical inhibitors of the Nrf2-ARE signaling pathway and their potential applications in cancer therapy

Keywords: AA; Ascorbic acid; AEM1; ARE expression modulator 1; AEG1; Astrocyte elevated gene-1; Akt; Protein kinase B; AMPK; AMP-activated protein kinase; APL; Acute promyelocytic leukemia; ARE; Antioxidant response element; ATO; Arsenic trioxide; Bach; BTB and CNC

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2016 سفارش ترجمه

Vemurafenib resistance increases melanoma invasiveness and modulates the tumor microenvironment by MMP-2 upregulation

Keywords: BRAF; v-Raf murine sarcoma viral oncogene homolog B; MAPK; mitogen-activated protein kinases; MMP; matrix metalloproteinase; ECM; extracellular matrix; IL-8; interleukin 8; EGFR; epidermal growth factor receptor; TIMP-2; metallopeptidase-2 or tissue inhib

دانلود رایگان متن کامل مقاله ISI 55 صفحه سال انتشار : 2016 سفارش ترجمه

The genus Boschniakia in China: An ethnopharmacological and phytochemical review

Keywords: 5-FU; 5-Fluorouracil; β-AP; β-amiloid peptide; AD; Alzheimer disease; ALT; Alanine aminotransferase; ASC; antidepressants sensitive catalepsy; AST; Aspartate Transaminase; BC; human breast cancer; Bcl-2; B-cell lymphoma-2; bFGF; Basic fibroblast growth

دانلود رایگان متن کامل مقاله ISI 55 صفحه سال انتشار : 2016 سفارش ترجمه

Hairy cell leukemia: Past, present and future

Keywords: Hairy cell leukemia; BRAF; Vemurafenib;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2015 سفارش ترجمه

Detection of BRAF-V600E and V600K in melanoma circulating tumour cells by droplet digital PCR

Keywords: BRAF; v-Raf murine sarcoma viral oncogene homolog B; CTCs; circulating tumour cells; ddPCR; droplet digital PCR; castPCR; competitive allele-specific TaqMan; WGA; whole genome amplification; Circulating tumour cells; Melanoma; BRAF; Droplet digital PCR; c

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2015 سفارش ترجمه

BRAF V600E mutations: a series of case reports in patients with non–small cell lung cancer

Keywords: BRAF; non-small cell lung cancer; driver mutations; V600E; adenocarcinoma

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2015 سفارش ترجمه

Oncogenic KIAA1549-BRAF fusion with activation of the MAPK/ERK pathway in pediatric oligodendrogliomas

Keywords: KIAA1549; BRAF; pediatric oligodendroglioma; MAPK/ERK

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Clinical characteristics associated with BRAF, NRAS and KIT mutations in Japanese melanoma patients

Keywords: CSD; chronic sun-induced damage; Melanoma; BRAF; NRAS; KIT; Mitogen-activated protein kinase (MAPK); Japanese;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Activating mutations in the RAS/mitogen-activated protein kinase signaling pathway in sporadic trichoblastoma and syringocystadenoma papilliferum

Keywords: HRAS; KRAS; BRAF; Trichoblastoma; Syringocystadenoma papilliferum

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Multiple proliferation-survival signalling pathways are simultaneously active in BRAF V600E mutated thyroid carcinomas

Keywords: Thyroid carcinoma; BRAF; cell signalling pathway; ERK; AKT

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Genetic profiling of advanced radioactive iodine-resistant differentiated thyroid cancer and correlation with axitinib efficacy

Keywords: Axitinib; Advanced differentiated thyroid cancer; BRAF; RAS; VEGFR; PIK3CA

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

KRAS, NRAS, BRAF mutations and high counts of poorly differentiated clusters of neoplastic cells in colorectal cancer: observational analysis of 175 cases

Keywords: BRAF; colorectal cancer; KRAS; NRAS; poorly differentiated clusters;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

ReviewDysplastic nevus: Fact and fiction

Keywords: B-K mole syndrome; BRAF; common nevus; congenital melanocytic nevus; cyclin-dependent kinase inhibitor 2A (CDKN2A); dysplastic nevus; familial atypical multiple-mole melanoma; melanoma; p16, p53; CMN; congenital melanocytic nevus; CN; common nevus; DN; dy

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Síndrome cardiofaciocutáneo, un trastorno relacionado con el síndrome de Noonan: hallazgos clínicos y moleculares en 11 pacientes

Keywords: Síndrome de Noonan; Síndrome cardiofaciocutáneo; Síndrome LEOPARD; Estenosis pulmonar valvular; Miocardiopatía hipertrófica; Vía RAS-MAPK; Rasopatía; PTPN11; BRAF; MAP2K1; Correlación genotipo-fenotipo; Noonan syndrome; Cardiofaciocutaneous syndr

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Cardiofaciocutaneous syndrome, a Noonan syndrome related disorder: Clinical and molecular findings in 11 patients

Keywords: Noonan syndrome; Cardiofaciocutaneous syndrome; LEOPARD syndrome; Pulmonary valve stenosis; Hypertrophic cardiomyopathy; RAS-MAPK pathway; Rasopathy; PTPN11; BRAF; MAP2K1; Genotype–phenotype correlationSíndrome de Noonan; Síndrome cardiofaciocutáneo; Sínd

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Prospective immunohistochemical analysis of BRAF V600E mutation in melanoma

Keywords: BRAF; Macrophages; Melanoma; Pigment; Prospective; Sentinel node; V600

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Is diagnosing cardio-facio-cutaneous (CFC) syndrome still a challenge? Delineation of the phenotype in 15 Polish patients with proven mutations, including novel mutations in the BRAF gene

Keywords: Cardio-facio-cutaneous syndrome; CFC; BRAF; MEK1; MEK2; KRAS; Genotype–phenotype; Novel mutation

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

BRAF p.Val600Glu (V600E) mutation detection in thyroid fine needle aspiration cell block samples: a feasibility study

Keywords: BRAF; fine needle aspiration; immunohistochemistry; papillary thyroid carcinoma; thyroid cytopathology;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Lymph node metastases of melanoma: challenges for BRAF mutation detection

Keywords: Melanoma; BRAF; Lymph node; Tumor cellularity; Mutant allele-specific imbalance;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Targeted Therapy for Patients with BRAF-Mutant Lung Cancer Results from the European EURAF Cohort

Keywords: Lung cancer; Targeted therapy; BRAF; Vemurafenib; Dabrafenib;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Double stranded promoter region of BRAF undergoes to structural rearrangement in nearly physiological conditions

Keywords: BRAF; G-quadruplex; i-motif; Oncogene

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

BRAF Alterations as Therapeutic Targets in Non-Small-Cell Lung Cancer

Keywords: BRAF; V600E; MEK; Vemurafenib; Dabrafenib; Trametinib; Non-small-cell lung cancer;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

FOLFIRI and Cetuximab Every Second Week for First-Line Treatment of KRAS Wild-Type Metastatic Colorectal Cancer According to Phosphatase and Tensin Homolog Expression: A Phase II Study

Keywords: Anti-EGFR antibody; BRAF; MET; Phosphatase and tensin homolog; PIK3CA

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

PACMEL: A phase 1 dose escalation trial of trametinib (GSK1120212) in combination with paclitaxel

Keywords: Melanoma; MEK; BRAF; Trametinib; Trial; Phase 1;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Acquired BRAF inhibitor resistance: A multicenter meta-analysis of the spectrum and frequencies, clinical behaviour, and phenotypic associations of resistance mechanisms

Keywords: BRAF; Vemurafenib; Dabrafenib; Resistance; Acquired; MAPK; NRAS; Splice; MEK1; Meta-analysis

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Low Grade Serous Ovarian Carcinoma: From the molecular characterization to the best therapeutic strategy

Keywords: Ovarian cancer; Low-Grade Serous; KRAS; BRAF; Chemoresistance; MEK-inhibitors;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Combined BRAF and MEK inhibition for the treatment of BRAF-mutated metastatic melanoma

Keywords: Melanoma; BRAF; MEK; Vemurafenib; Dabrafenib; Trametinib

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

BRAFV600E induces ABCB1/P-glycoprotein expression and drug resistance in B-cells via AP-1 activation

Keywords: BRAF; Vemurafenib; B-cell; ABCB1; P-glycoprotein; Leukemia; Lymphoma;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

HER2 expression and markers of phosphoinositide-3-kinase pathway activation define a favorable subgroup of metastatic pulmonary adenocarcinomas

Keywords: ADCa; denocarcinoma of the lung; ALKa; naplastic lymphoma kinase; (p)AKT; (phospho-)protein kinase B; bpb; ase pair; BRAF; V-Raf murine sarcoma viral oncogene homolog B; (C/F/D)ISH; (chromogenic/fluorescence/dual color) in-situ hybridization; cMETh; epato

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Profiling of Oncogenic Driver Events in Lung Adenocarcinoma Revealed MET Mutation as Independent Prognostic Factor

Keywords: Lung cancer; EGFR; KRAS; ALK; HER2; BRAF; MET; ROS1; RIT1; TTF-1 lung adenocarcinoma; NRAS; Driver mutations; Oncogenic driver mutation; East Asian lung cancer; MET amplification; Targeted therapy; Genetic marker; Biomarker; Molecular classification lung

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

MicroRNA-126 suppresses proliferation of undifferentiated (BRAFV600E and BRAFWT) thyroid carcinoma through targeting PIK3R2 gene and repressing PI3K-AKT proliferation-survival signalling pathway

Keywords: miR-126; Undifferentiated thyroid carcinoma; BRAF; PIK3R2

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Implementation of a companion diagnostic in the clinical laboratory: The BRAF example in melanoma

Keywords: IVD; in vitro diagnostics; BRAF; V-RAF murine sarcoma viral oncogene homolog B1; SSCP; single-stranded conformation polymorphism analysis; dHPLC; denaturing high performance liquid chromatography; HRMA; high resolution melting analysis; LDTs; Laboratory D

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Differential effects of MAPK pathway inhibitors on migration and invasiveness of BRAFV600E mutant thyroid cancer cells in 2D and 3D culture

Keywords: Thyroid; Cancer; BRAF; MEK; U0126; PLX4720; Migration; 3D

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Microvessel density, lymphovascular density, and lymphovascular invasion in primary cutaneous melanoma—correlation with histopathologic prognosticators and BRAF status

Keywords: Primary cutaneous melanoma; Microvessel density; Lymphovascular density; Lymphovascular invasion; Histopathologic prognosticators; BRAF

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

The DNA methylation landscape of human melanoma

Keywords: DNA methylation; Melanoma; Melanocytes; Polycomb; H3K27me3; BRAF

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Update on immunohistochemistry to identify colorectal tumours with deficient DNA mismatch repair function

Keywords: BRAF; EpCAM; immunohistochemistry; Lynch syndrome; Lynch-like syndrome; mismatch repair

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

ReviewPharmacogenomics and targeted therapy of cancer: Focusing on non-small cell lung cancer

Keywords: ALDH; aldehyde dehydrogenase; ALK; anaplastic lymphoma kinase; BRAF; v-Raf murine sarcoma viral oncogene homolog B1; CSC; cancer stem cell; EGFR; epidermal growth factor receptor; EGFR-TKIs; EGFR tyrosine kinase inhibitors; EGFRvIII; EGFR variant III; EML

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Dual NRASQ61R and BRAFV600E mutation-specific immunohistochemistry completes molecular screening in melanoma samples in a routine practice

Keywords: Melanoma; BRAF; NRAS; Immunohistochemistry; Molecular analysis

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Prevalence of RAS mutations and individual variation patterns among patients with metastatic colorectal cancer: A pooled analysis of randomised controlled trials

Keywords: Panitumumab; mCRC; RAS prevalence; KRAS; NRAS; BRAF;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Melanocytic nevi excised during B-Raf proto-oncogene (BRAF) inhibitor therapy: A study of 19 lesions from 10 patients

Keywords: B-Raf proto-oncogene inhibition; CD4; CD8; melanocytic nevi; phosphorylated extracellular signal-regulated kinase; phosphorylated protein kinase B; AKT; protein kinase B; BRAF; B-Raf proto-oncogene; MAPK; mitogen-activated protein kinase; NRAS; neuroblast

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Embryonal Fyn-associated substrate (EFS) and CASS4: The lesser-known CAS protein family members

Keywords: 5-HT; 5-hydroxytryptamine, serotonin; A549; non-small cell lung cancer cell line; AD; Alzheimer's disease; ADPKD; autosomal dominant polycystic kidney disease; Aire; autoimmune regulator; AP-1; activator protein 1; APP; amyloid precursor protein; AREB6; Z

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Beyond EGFR and ALK inhibition: Unravelling and exploiting novel genetic alterations in advanced non small-cell lung cancer

Keywords: Non-small cell lung cancer; Oncogenic drivers; EGFR; ALK; KRA; BRAF; HER2; PI3KCA; DDR2; ROS1

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

The immune-related role of BRAF in melanoma

Keywords: BRAF; NRAS; Melanoma; Immune phenotype;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Mammalian cell transient expression, non-affinity purification, and characterization of human recombinant IGFBP7, an IGF-1 targeting therapeutic protein

Keywords: BRAF; B-Raf; CAG; chicken β-actin; CHO; Chinese hamster ovary; CV; column volume; EBV; Epstein-Barr virus; Fer L; ferritin composite light chain; GFP; green fluorescent protein; Grp 78; glucose-regulated protein 78; HEK 293E cell; human embryonic kidne

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

RAF-1 promotes survival of thyroid cancer cells harboring RET/PTC1 rearrangement independently of ERK activation

Keywords: Thyroid cancer; RAF-1; BRAF; RET/PTC1; PI3K-AKT; ERKAKT, V-AKT murine thymoma viral oncogene; ATC, anaplastic thyroid cancer; BRAF, V-RAF murine sarcoma viral oncogene homolog B; BrdU, 5-bromo-2-deoxyuridine; ERK, Extracellular-signal-regulated kinase; FI

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Séries thématiques « Maladies pulmonaires rares »Coordonnée par D. MontaniManifestations pulmonaires de l'histiocytose langerhansiennePulmonary manifestations of Langerhans cell histiocytosis

Keywords: Cellules dendritiques; Pneumopathies infiltrantes kystiques; Tomodensitométrie haute résolution; BRAF; MAP kinases; Dendritic cells; Diffuse cystic lung disease; High-resolution computed tomography; BRAF; MAP kinases;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2015 سفارش ترجمه