BRCA1 and BRCA2 mutation predictions using the BRCAPRO and Myriad models in Korean ovarian cancer patients
Keywords: BRCA1; BRCA2; Risk models; BRCAPRO; Myriad BRCA risk calculator;
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Multigene panels in Ashkenazi Jewish patients yield high rates of actionable mutations in multiple non-BRCA cancer-associated genes
Keywords: Multigene panels; BRCA1; BRCA2; Ashkenazi Jewish; Cancer genetics;
Higher antitumor activity of trabectedin in germline BRCA2 carriers with advanced breast cancer as compared to BRCA1 carriers: A subset analysis of a dedicated phase II trial
Keywords: Trabectedin; Lurbinectedin; Breast cancer; BRCA1; BRCA2;
ESR1 single nucleotide polymorphism rs1062577 (c.*3804TÂ >Â A) alters the susceptibility of breast cancer risk in Iranian population
Keywords: ATM; ataxia-telangiectasia mutated; BRCA1; BReast CAncer gene 1; BRCA2; BReast CAncer gene 2; CHECK2; checkpoint kinase 2; ER; estrogen receptor; ESR1; estrogen receptor 1; HER2; human epidermal growth factor 2; PR; progesterone receptor; PTEN; phosphatas
Mainstreaming cancer genetics: A model integrating germline BRCA testing into routine ovarian cancer clinics
Keywords: BRCA1; BRCA2; Genetic testing; Mainstreaming; Ovarian cancer;
¿CÃMO PUEDO MODIFICAR MI RIESGO A DESARROLLAR CÁNCER, CUANDO SOY PORTADOR DE UNA MUTACIÃN?
Keywords: BRCA1; BRCA2; SÃndrome de Lynch; SÃndrome hereditario de mama y ovario; manejo; vigilancia; BRCA1; BRCA2; Lynch syndrome; Hereditary breast and ovary syndrome; treatment; surveillance;
Prolonged exposure to particulate chromate inhibits RAD51 nuclear import mediator proteins
Keywords: Nuclear import; Particulate chromium (VI); RAD51C; BRCA2; RAD51 cytoplasmic accumulation;
Original ResearchRisk of uterine cancer for BRCA1 and BRCA2 mutation carriers
Keywords: Uterine cancer; Endometrial cancer; BRCA1; BRCA2; Risk-reducing surgery; Oophorectomy;
Original ArticleRecurrent large genomic rearrangements in BRCA1 and BRCA2 in an Irish case series
Keywords: BRCA1; BRCA2; large genomic rearrangement; hereditary breast and ovarian cancer;
Original ResearchOnline self-test identifies women at high familial breast cancer risk in population-based breast cancer screening without inducing anxiety or distress
Keywords: Breast cancer; Population screening; BRCA1; BRCA2; Hereditary; Risk; Familial risk assessment; Genetic counselling; Distress; Prevention;
The impact of the IGF-1 system of cancer cells on radiation response - An in vitro study
Keywords: IGF-1R; insulin-like growth factor 1 receptor; SF; surviving fractions; IGF-1R/KR; kinase-deficient IGF-1R; Caco-2-KR4; IGF-1R/KR clone number 4; IRS-1; insulin receptor substrate 1; HRR; homologous recombination repair; NHEJ; non-homologous end joining;
BRCA mutation genetic testing implications in the United States
Keywords: BRCA1; BRCA2; Genetic testing; Timing; Hereditary breast cancer; Prophylactic mastectomy; Prophylactic oophorectomy; PARP inhibitors; Platinums;
ReviewLinking uterine serous carcinoma to BRCA1/2-associated cancer syndrome: A meta-analysis and case report
Keywords: Uterine serous carcinoma; BRCA1; BRCA2; Germline mutation; Meta-analysis;
Oncogenética de los cánceres pélvicos
Keywords: Predisposición genética; Cáncer de ovario; Cáncer de útero; BRCA1; BRCA2; SÃndrome de Lynch;
Faulty BRCA1, BRCA2 genes: how poor is the prognosis?
Keywords: BRCA1; BRCA2; Breast cancer; Genetics; Probability; Risk;
The zebrafish kidney mutant zeppelin reveals that brca2/fancd1 is essential for pronephros development
Keywords: AO; acridine orange; brca2; breast cancer 2, early onset, also known as fancd1; cRNA; capped RNA; DAPT; N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester; dpf; days post fertilization; ESRD; end stage renal disease; FISH; fluorescent i
Zebularine induces replication-dependent double-strand breaks which are preferentially repaired by homologous recombination
Keywords: Zebularine; Homologous recombination; Replication; DNA damage; BRCA2; XRCC1;
Changes in gene expression variability reveal a stable synthetic lethal interaction network in BRCA2âovarian cancers
Keywords: SLI(s); synthetic lethal interaction(s); TCGA; the Cancer Genome Atlas; HR; Homologous recombination; SD; standard deviation; CV; coefficient of variation; IPA; Ingenuity Pathway Analysis; Synthetic lethal interactions; BRCA2; Ovarian cancer; Gene express
Guidance Statement On BRCA1/2 Tumor Testing in Ovarian Cancer Patients
Keywords: Ovarian cancer; BRCA1; BRCA2; Tumor testing;
Biallelic Inactivation of BRCA2 in Platinum-sensitive Metastatic Castration-resistant Prostate Cancer
Keywords: BRCA2; Platinum; Carboplatin; Prostate cancer; mCRPC; DNA repair;
Genetic characterization of early onset ovarian carcinoma
Keywords: Inherited; Young; Ovarian; Carcinoma; BRCA1; BRCA2;
Prevalencia mutacional de los genes BRCA1 y BRCA2 en pacientes con cáncer de mama y ovario atendidos en el Área de Salud de La Ribera (Comunidad Valenciana, España)
Keywords: Cáncer de mama hereditario; BRCA1; BRCA2; prevalencia alélica; clÃnico-patologÃa; Hereditary Breast Cancer; BRCA1; BRCA2; allelic prevalence; clinic-pathology;
Treatment of infertility does not increase the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation
Keywords: BRCA1; BRCA2; infertility; in vitro fertilization; ovarian cancer;
Evaluation of germline BRCA1 and BRCA2 mutations in a multi-ethnic Asian cohort of ovarian cancer patients
Keywords: BRCA1; BRCA2; Ovarian cancer; Predictor of mutation; Asian; Malaysia;
Original ArticleIn silico, in vitro and case-control analyses as an effective combination for analyzing BRCA1 and BRCA2 unclassified variants in a population-based sample
Keywords: BRCA1; BRCA2; variants of unknown significance; cDNA; splicing; cancer genetic counseling;
Original ArticlePrevalence of Hispanic BRCA1 and BRCA2 mutations among hereditary breast and ovarian cancer patients from Brazil reveals differences among Latin American populations
Keywords: Hereditary breast and ovarian cancer; BRCA1; BRCA2;
Ten-year survival after epithelial ovarian cancer is not associated with BRCA mutation status
Keywords: Ovarian cancer; BRCA1; BRCA2; Long-term survival
BRCA2-positive spinal intramedullary ovarian metastatic disease: case report
Keywords: BRCA2; Intramedullary; Metastatic; Ovarian cancer; Spine; Surgery
Paradoxical roles of cyclin D1 in DNA stability
Keywords: Cell cycle; Cancer; Cyclin D1; BRCA2; RAD51; Homologous recombination
Current PerspectiveCurrent perspectives on recommendations for BRCA genetic testing in ovarian cancer patients
Keywords: Ovarian cancer; BRCA1; BRCA2; PARPi; Guidelines; Genetic testing;
64Cu-ATSM therapy targets regions with activated DNA repair and enrichment of CD133+ cells in an HT-29 tumor model: Sensitization with a nucleic acid antimetabolite
Keywords: 64Cu-ATSM; DNA repair; Nucleic acid antimetabolite; Hypoxia; Internal radiotherapy; 18FDG; [18F]-fluorodeoxyglucose; 5-FU; 5-fluorouracil; 64Cu-ATSM; 64Cu-diacetyl-bis (N4-methylthiosemicarbazone); 6-TG; 6-thioguanine; ANOVA; analysis of variance; ASB9; a
PARP inhibitor combination therapy
Keywords: PARP inhibitor; Drug combinations; BRCA1; BRCA2;
Long non-coding RNA: A newly deciphered “code” in prostate cancer
Keywords: Androgen receptor; LNCaP; Biomarker; PCa; prostate cancer; ncRNA; non-coding RNAs; lncRNA; long ncRNA; miRNA; microRNA; snRNA; small nuclear RNA; siRNA; small interfering RNA; tRNA; transfer RNA; rRNA; ribosomal RNA; PCA3; PCa antigen 3; PIN; prostatic in
Fanconi anemia with biallelic FANCD1/BRCA2 mutations - Case report of a family with three affected children
Keywords: Fanconi anemia; FANCD1; BRCA2; Wilms tumor; Medulloblastoma; Leukemia;
Le point sur la prédisposition génétique pour le cancer de la prostate
Keywords: Cancer de prostate; Dépistage; Génétique; Héréditaire; Prédisposition; Susceptibilité; Prostate cancer; Genetic predisposition; Hereditary; Susceptibility; BRCA2; HOXB13;
Effects of aluminium chloride and aluminium chlorohydrate on DNA repair in MCF10A immortalised non-transformed human breast epithelial cells
Keywords: Aluminium chloride; Aluminium chlorohydrate; Antiperspirant; BRCA1; BRCA2; Breast cancer; DNA repair; MCF10A cells;
A novel BRCA2 in frame deletion in a Tunisian woman with early onset sporadic breast cancer
Keywords: Sporadic breast cancer; BRCA2; Mutation screening; In frame deletionCancer du sein sporadique; BRCA2; Recherche de mutation; Délétion en phase
Preemptive Bone Marrow Transplantation for FANCD1/BRCA2
Keywords: Preemptive transplantation; Fanconi anemia; BRCA2; Markov model; Decision analysis
BRCA mutation carriers show normal ovarian response in in vitro fertilization cycles
Keywords: BRCA1; BRCA2; ovarian reserve; IVF; fertility preservation
Hereditary predisposition to ovarian cancer, looking beyond BRCA1/BRCA2
Keywords: Hereditary; BRCA1; BRCA2; Multi-gene; Next-generation sequencing; Lynch syndrome;
Effect of BRCA Mutations on Metastatic Relapse and Cause-specific Survival After Radical Treatment for Localised Prostate Cancer
Keywords: BRCA1; BRCA2; Homologous repair; Prognostic factor; Prostate cancer; Prostatectomy; Radiotherapy;
Two decades beyond BRCA1/2: Homologous recombination, hereditary cancer risk and a target for ovarian cancer therapy
Keywords: BRCA1; BRCA2; Homologous recombination; PARP inhibitor synthetic lethality; Genetic testing;
Increased in vitro and in vivo sensitivity of BRCA2-associated pancreatic cancer to the poly(ADP-ribose) polymerase-1/2 inhibitor BMN 673
Keywords: Pancreatic ductal adenocarcinoma; BRCA2; DNA repair; BMN 673; Personalized medicine
The role of the prostate cancer gene 3 urine test in addition to serum prostate-specific antigen level in prostate cancer screening among breast cancer, early-onset gene mutation carriers
Keywords: PSA; prostate cancer gene 3; PCA3; BRCA2; marker; diagnostic value;
Gene analysis techniques and susceptibility gene discovery in non-BRCA1/BRCA2 familial breast cancer
Keywords: Genetic predisposition to disease; Sequence analysis; Genetics; Breast neoplasm; BRCA1; BRCA2
Screening for common mutations in BRCA1 and BRCA2 genes: interest in genetic testing of Tunisian families with breast and/or ovarian cancer
Keywords: BRCA1; BRCA2; genetic testing; hereditary breast; ovarian cancer; targeted approach; Tunisia;
Analysis of BRCA2 loss of heterozygosity in tumor tissue using droplet digital polymerase chain reaction
Keywords: Droplet digital PCR; LOH; Familial breast cancer; BRCA2; VUS
Central European BRCA2 mutation carriers: Birth cohort status correlates with onset of breast cancer
Keywords: BRCA2; Hereditary breast and ovarian cancer; Breast cancer risk; Penetrance of BRCA2
Risk reducing mastectomy, breast reconstruction and patient satisfaction in Norwegian BRCA1/2 mutation carriers
Keywords: BRCA1; BRCA2; Risk-reducing mastectomy; ReconstructionTRAM, transverse rectus abdominal myocutaneous flap; DIEP, deep inferior epigastric perforator flap; SGAP, superior gluteal artery perforator flap
A preliminary Quality Control (QC) for next generation sequencing (NGS) library evaluation turns out to be a very useful tool for a rapid detection of BRCA1/2 deleterious mutations
Keywords: NGS, next generation sequencing; GS, Gene Scan; QC, Quality Control; MPS, massive parallel sequencing; MLPA, multiplex ligation-dependent probe amplification; MAQ, multiplex amplicon quantificationBRCA1; BRCA2; Frameshift mutations; NGS; Breast cancer