Keywords: برومودومین; Peptide-based probe; Bromodomain; Fluorescent probe; Proximity effect; Peptides;
مقالات ISI برومودومین (ترجمه نشده)
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Keywords: برومودومین; Prostate cancer; BRD BET bromodomain and extra-terminal domain; BRD BET inhibitor; Chromatin structure remodeling; Transcriptional co-activator; Androgen receptor; TF; transcription factor; HAT; histone acetyltransferase; HDAC; histone deacetylase; BRD; b
Keywords: برومودومین; ARV-825 PubChem CID 92044400; BETd-246 PubChem CID 131698640; dBET1 PubChem CID 91799313; I-BET151 PubChem CID 52912189; I-BET762 PubChem CID 46943432; JQ1 PubChem CID 46907787; MS417 PubChem CID 59190723; OTX015 PubChem CID 9936746; THZ1 PubChem CID 7360
Keywords: برومودومین; Bromodomain; Protein folding; Folding intermediate;
Keywords: برومودومین; Epigenetics; Bromodomain; BRD9; Inhibitor; Resistance;
Keywords: برومودومین; Polymeric nanoparticle; Epigenetic inhibitor; Drug delivery; Controlled release; Stimuli-responsive; ADCA; adenocarcinoma; BrD; bromodomain; BRET; bioluminescence resonance energy transfer; DDS; drug delivery system; DLS; dynamic light scattering; DMF; di
Keywords: برومودومین; Epigenetic modifiers; Chromatin; Therapy; Cancer; Histone profiles; ac; acetyl; ATRA; all-trans retinoic acid; BrD; bromodomain; FL; follicular lymphoma; H; histone; HAT; histone acetyltransferase; HDAC; histone deacetylase; HMT; histone methyltransferase
Keywords: برومودومین; Bromodomain; Gene transcription; Small molecule inhibitors;
Heterologous expression of the human polybromo-1 protein in the methylotrophic yeast Pichia pastoris
Keywords: برومودومین; PBRM1; BAF180; Recombinant protein expression; Pichia pastoris; BRD; Bromodomain; BAH; Bromo-adjacent homology domain; HMG; High mobility group; NHEJ; Non-homologous end-joining; PRR; Post-replication repair; AEX; Anion exchange chromatography; GAP; Glyce
Discovery and lead identification of quinazoline-based BRD4 inhibitors
Keywords: برومودومین; BET inhibitor; BRD4; Bromodomain; Quinazoline; Cancer; Inflammation;
Theoretical research in structure characteristics of different inhibitors and differences of binding modes with CBP bromodomain
Keywords: برومودومین; CBP; CREB (cAMP responsive element binding protein) binding protein; BRD; bromodomain; CPI-098; (4R)-4-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one; CPI-703; (4R)-6-(1-tert-butyl-1H-pyrazol-4-yl)-4-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-
Design and synthesis of a biaryl series as inhibitors for the bromodomains of CBP/P300
Keywords: برومودومین; Bromodomain; CBP inhibitor; Volume of distribution; Half-life;
Benefit of Apabetalone on Plasma Proteins in Renal Disease
Keywords: برومودومین; bromodomain; cardiovascular disease; chronic kidney disease; epigenetics; inflammation; proteomics;
Synergistic activity of BET inhibitor BI 894999 with PLK inhibitor volasertib in AML in vitro and in vivo
Keywords: برومودومین; BET inhibitor; Bromodomain; Volasertib; Acute myeloid leukemia; Combination;
Structural dynamics and quantum mechanical aspects of shikonin derivatives as CREBBP bromodomain inhibitors
Keywords: برومودومین; CREBBP; Bromodomain; Molecular dynamics; Propionylshikonin; MM-PBSA; MM-GBSA; QM/MM;
Co-targeting of BET proteins and HDACs as a novel approach to trigger apoptosis in rhabdomyosarcoma cells
Keywords: برومودومین; Apoptosis; Cell death; Mitochondria; HDAC; BET proteins; Rhabdomyosarcoma; JQ1; ARMS; alveolar rhabdomyosarcoma; BRD; bromodomain; BET protein; bromo- and extra-Terminal protein; CI; combination index; ERMS; embryonal rhabdomyosarcoma; EV; empty vector; F
Methylpyrrole inhibitors of BET bromodomains
Keywords: برومودومین; BET proteins; Bromodomain; Fragment screening;
Profiling of human epigenetic regulators using a semi-automated real-time qPCR platform validated by next generation sequencing
Keywords: برومودومین; MSC; Mesenchymal stromal/stem cell; AMSC; Adipose-tissue derived mesenchymal stromal/stem cell; RT-qPCR; Real-time reverse transcriptase quantitative polymerase chain reaction; RNA-seq; RNA sequencing; EpiReg; Epigenetic regulator; HAT; Histone acetyl tra
Design, synthesis and biological evaluation of 7-methylimidazo[1,5-a]pyrazin-8(7H)-one derivatives as BRD4 inhibitors
Keywords: برومودومین; BRD4; Bromodomain; Lysine acetylation; Antitumor;
Knockdown of epigenetic transcriptional co-regulator Brd2a disrupts apoptosis and proper formation of hindbrain and midbrain-hindbrain boundary (MHB) region in zebrafish
Keywords: برومودومین; Bromodomain; Cell death; Cerebellum; Engrailed; Midbrain-hindbrain boundary; Embryonic patterning;
Inhibition of BET proteins and epigenetic signaling as a potential treatment for osteoporosis
Keywords: برومودومین; Osteoporosis; Epigenetic; Bromodomain; Inhibitor; Osteoblast; Osteoclast;
Targeting epigenetic reader and eraser: Rational design, synthesis and in vitro evaluation of dimethylisoxazoles derivatives as BRD4/HDAC dual inhibitors
Keywords: برومودومین; Epigenetic; Protein-protein interactions; Bromodomain; HDAC; Antiproliferative activity;
A phenotypic drug discovery study on thienodiazepine derivatives as inhibitors of T cell proliferation induced by CD28 co-stimulation leads to the discovery of a first bromodomain inhibitor
Keywords: برومودومین; CD28; Phenotypic drug discovery; Chemical biology; BET family; Bromodomain; Immunosuppressant; Anti-cancer
Nonselective inhibition of the epigenetic transcriptional regulator BET induces marked lymphoid and hematopoietic toxicity in mice
Keywords: برومودومین; Toxicology; Bromodomain; Epigenetics; Lymphocytes; Immunology
New insights into the role of the Brdt protein in the regulation of development and spermatogenesis in the mouse
Keywords: برومودومین; Brdt; Spermatogenesis; Infertility; Bromodomain
Epigenetic blockade of neoplastic transformation by bromodomain and extra-terminal (BET) domain protein inhibitor JQ-1
Keywords: برومودومین; Bromodomain; Brd4; JQ-1; Neoplastic transformation; NF-κB;
A role for tuned levels of nucleosome remodeler subunit ACF1 during Drosophila oogenesis
Keywords: برومودومین; Nucleosome remodeling; ISWI ATPase; Germarium; PHD finger; Bromodomain;
Discovery and structure-activity relationship studies of N6-benzoyladenine derivatives as novel BRD4 inhibitors
Keywords: برومودومین; BRD4; Bromodomain; Benzoyladenine; Structure-activity relationship;
The epigenetically active small chemical N-methyl pyrrolidone (NMP) prevents estrogen depletion induced osteoporosis
Keywords: برومودومین; Epigenetic; NMP; Osteoporosis; Bromodomain; BET proteins; Estrogen deficiency;
Bromodomain inhibitors regulate the C9ORF72 locus in ALS
Keywords: برومودومین; C9ORF72; Amyotrophic lateral sclerosis; Repeat expansion; Bromodomain; BET;
The CH2 domain of CBP/p300 is a novel zinc finger
Keywords: برومودومین; CBP; CREB-binding protein; BRD; bromodomain; PHD; plant homeodomain; CH2; cysteine/histidine-rich region 2; HAT; histone acetyl transferase; NMR; nuclear magnetic resonance; HSQC; heteronuclear single-quantum coherence; CD; circular dichroism; CBP; p300;
Developing epigenetic diagnostics and therapeutics for brain disorders
Keywords: برومودومین; bromodomain; epigenomic; exosome; glioma; histone deacetylase; long non-coding RNA; microRNA
Development of live-cell imaging probes for monitoring histone modifications
Keywords: برومودومین; Histac; Imaging; Fluorescence; Histone; Acetylation; Bromodomain;
Brd2 is required for cell cycle exit and neuronal differentiation through the E2F1 pathway in mouse neuroepithelial cells
Keywords: برومودومین; Transgene insertional mutation; Cell cycle exit; Neuronal differentiation; Bromodomain; Brd2; E2F1
The bromodomain interaction module
Keywords: برومودومین; Bromodomain; Lysine acetylation; Sequence specificity;
The first bromodomain of the testis-specific double bromodomain protein Brdt is required for chromocenter organization that is modulated by genetic background
Keywords: برومودومین; Brdt; Bromodomain; Chromocenter; Spermiogenesis; Sirt1
The full-length isoform of the mouse pleckstrin homology domain-interacting protein (PHIP) is required for postnatal growth
Keywords: برومودومین; Insulin substrate; IGF-1 signaling; Postnatal growth; Bromodomain; Gene expression
Structural implications for K5/K12-di-acetylated histone H4 recognition by the second bromodomain of BRD2
Keywords: برومودومین; BET family; Bromodomain; Cell cycle; Chromatin; Crystal structure; Papilloma virus; Transcription
Trypanosoma cruzi bromodomain factor 2 (BDF2) binds to acetylated histones and is accumulated after UV irradiation
Keywords: برومودومین; Trypanosomes; Bromodomain; TcBDF2; Histone H4
Polybromo-1: The chromatin targeting subunit of the PBAF complex
Keywords: برومودومین; Polybromo; BAF180; PBAF; Bromodomain
Regulation of early T cell development by the PHD finger of histone lysine methyltransferase ASH1
Keywords: برومودومین; Histone modification; Chromatin structure; PHD finger; Bromodomain; HDAC complex; TCR gene rearrangement; Thymus; FTOC
Differential binding modes of the bromodomains of CREB-binding protein (CBP) and p300 with acetylated MyoD
Keywords: برومودومین; Acetylated MyoD; Bromodomain; CBP; p300; Binding
Kinetic analysis of acetylation-dependent Pb1 bromodomain-histone interactions
Keywords: برومودومین; Bromodomain; Histone acetylation; Polybromo; Histone code; Kinetics; Protein-protein interactions;
Intracellular delivery of acetyl-histone peptides inhibits native bromodomain–chromatin interactions and impairs mitotic progression
Keywords: برومودومین; FRAP, fluorescence recovery after photobleaching; GFP, green fluorescent protein; PTD, peptide transduction domainPeptide transduction; Acetyl-histone tail; Bromodomain; Brd4; FRAP
The dual bromodomain and WD repeat-containing mouse protein BRWD1 is required for normal spermiogenesis and the oocyte-embryo transition
Keywords: برومودومین; Spermiogenesis; Bromodomain; Chromatin remodeling; Infertility; Mouse;
Polybromo-1-bromodomains bind histone H3 at specific acetyl-lysine positions
Keywords: برومودومین; Bromodomain; Acetyl-lysine; Histone acetylation; Polybromo; Specificity; Histone H3; Histone code
Solution structure of BRD7 bromodomain and its interaction with acetylated peptides from histone H3 and H4
Keywords: برومودومین; BRD7; Bromodomain; Lysine-acetylated; Histone; Solution structure; NMR spectroscopy; Titration; Dissociation constant
A Nucleosome Interaction Module Is Required for Normal Function of Arabidopsis thaliana BRAHMA
Keywords: برومودومین; GST, glutathione-S-transferase; EMSA, electrophoretic mobility-shift assay; 4WJ, four-way junction; WT, wild-typechromatin; bromodomain; swi/snf complex; AT-hook; seed development
Expression, purification and characterization of individual bromodomains from human Polybromo-1
Keywords: برومودومین; Bromodomain; Polybromo; Histone-binding protein
Cloning and developmental expression of WSTF during Xenopus laevis embryogenesis
Keywords: برومودومین; Xenopus laevis; Neural; Williams–Beuren; WSTF; Bromodomain