دانلود مقالات ISI درباره BSEP، پمپ صادرات نمک صفرا + ترجمه فارسی

تغییر فعالیت حمل و نقل داروهای کبد انسان و بیان آن توسط میعانات سیگار

Alteration of human hepatic drug transporter activity and expression by cigarette smoke condensate

Keywords: BSEP، پمپ صادرات نمک صفرا; ABC, ATP-binding cassette; AhR, aryl hydrocarbon receptor; ALDH3A1, aldehyde deshydrogenase 3A1; BCRP, breast cancer resistance protein; BSEP, bile salt export pump; BSP, bromosulfophtalein; CCK8, cholecystokinin octapeptide sulphated; CF, carboxy-2.7-dic

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

اثرات متابولیک جذب روده و دوچرخه سواری انتروژیپاتیک اسیدهای صفراوی

Metabolic effects of intestinal absorption and enterohepatic cycling of bile acids

Keywords: BSEP، پمپ صادرات نمک صفرا; Bile acids; Liver; Intestine; Transporters; Lipid metabolism; Energy homeostasisACCII, acetyl-CoA carboxylase 2; APO, apolipoproteins; ASBT, apical sodium-dependent bile acid transporter; BSEP, bile salt export pump; CYP7A1, cholesterol 7α-hydroxylase; DI

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

نئوپلاسم های کبدی در کودکان: تمرکز بر تشخیص افتراقی

Hepatic neoplasms in children: A focus on differential diagnosis

Keywords: BSEP، پمپ صادرات نمک صفرا; AFP, Alfa-fetoprotein; BSEP, Bile salt export pump; CT, Computer tomography; DIC, Disseminated intravascular coagulation; FNH, Focal nodular hyperplasia; HBL, Hepatoblastoma; HCA, Hepatocellular adenoma; HCC, Hepatocellular carcinoma; HNF1a, Hepatocyte nu

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

پیشرفت در سم شناسی محاسباتی

Progress in computational toxicology

Keywords: BSEP، پمپ صادرات نمک صفرا; ANN, artificial neural networks; BSEP, bile salt export pump; DILI, drug-induced liver injury; ECFC_6, extended connectivity functional class fingerprints of maximum diameter 6; hERG, human ether-a-go-go-related gene; HIAT, hepatocyte imaging assay techno

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2014 سفارش ترجمه

اضافه کردن دگزامتازون باعث ایجاد ترکیب اسید صفراوی با القاء CYP8B1 در کشت های اولیه هپاتوسیت های انسانی می شود

Addition of Dexamethasone Alters the Bile Acid Composition by Inducing CYP8B1 in Primary Cultures of Human Hepatocytes

Keywords: BSEP، پمپ صادرات نمک صفرا; BSEP, bile salt export pump; CA, cholic acid; CDCA, chenodeoxycholic acid; CYP7A1, cholesterol 7α-hydroxylase; CYP8B1, sterol 12α-hydroxylase; CYP27A1, sterol 27α-hydroxylase; FXR, farnesoid X receptor; G6Pase, glucose-6-phosphatase; GR, glucocorticoid re

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Investigation on bile acid receptor regulators. Discovery of cholanoic acid derivatives with dual G-protein coupled bile acid receptor 1 (GPBAR1) antagonistic and farnesoid X receptor (FXR) modulatory activity

Keywords: BSEP، پمپ صادرات نمک صفرا; BSEP, bile salt export pump; CDCA, chenodeoxycholic acid; CRE, cAMP response element; CREB, cAMP-response element binding protein; DMT-MM, 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; 6-ECDCA/OCA, 6-ethylchenodeoxycholic acid/obetic

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Up-regulation of BSEP and MRP2 by Calculus Bovis administration in 17α-ethynylestradiol-induced cholestasis: Involvement of PI3K/Akt signaling pathway

Keywords: BSEP، پمپ صادرات نمک صفرا; ALT, alanine aminotransferase; ALP, alkaline phosphatase; GGT, gamma glutamyltransferase; TBIL, total bilirubin; CB, Calculus Bovis; EE, 17α-ethynylestradiol; BSEP, bile salt export pump; MRP2, multidrug resistance-associated protein 2; MRP4, multidrug re

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Physiological and pathophysiological factors affecting the expression and activity of the drug transporter MRP2 in intestine. Impact on its function as membrane barrier

Keywords: BSEP، پمپ صادرات نمک صفرا; 5′UTR, 5′ untranslated region; ABC, ATP-binding cassette; AP-1, activator protein-1; ATF-2, activating transcription factor-2; BCRP, breast cancer resistance protein; BDL, bile duct ligation; BSEP, bile salt export pump; CAR, constitutive androstane recep

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro

Keywords: BSEP، پمپ صادرات نمک صفرا; 1H NMR, proton nuclear magnetic resonance imaging; BSEP, Bile Salt Export Pump; CAR, constitutive androstane receptor; CsA, Cyclosporin A; DEG, differentially expressed gene; ER, endoplasmic reticulum; FC, fold change; FDR, False Discovery Rate; FXR, farn

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Liver transcript analysis reveals aberrant splicing due to silent and intronic variations in the ABCB11 gene

Keywords: BSEP، پمپ صادرات نمک صفرا; ABCB11, ATP-binding cassette, sub-family B (MDR/TAP), member 11; BSEP, bile salt export pump; PFIC2, progressive familial intrahepatic cholestasis type 2; SNPs, single-nucleotide polymorphisms; ESE, exonic splicing enhancer; WT, wild type; ss, splice site

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Alpha-naphthylisothiocyanate modulates hepatobiliary transporters in sandwich-cultured rat hepatocytes

Keywords: BSEP، پمپ صادرات نمک صفرا; SCRH, sandwich-cultured rat hepatocytes; ANIT, alpha-naphthylisothiocyanate; Mrp, multidrug resistance-associated protein; Bsep, bile salt export pump; Ntcp, sodium/taurocholate cotransporting polypeptide; Oatp, organic anion transporting polypeptide; BEI

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Integrative cross-omics analysis in primary mouse hepatocytes unravels mechanisms of cyclosporin A-induced hepatotoxicity

Keywords: BSEP، پمپ صادرات نمک صفرا; 1H-NMR, proton nuclear magnetic resonance imaging; AOP, adverse outcome pathway; BSEP, bile salt export pump; CsA, cyclosporin A; DEG, differentially expressed gene; ER, endoplasmic reticulum; FC, fold change; FDR, false discovery rate; MDR1, multidrug re

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor

Keywords: BSEP، پمپ صادرات نمک صفرا; HTS, high-throughput screen; FXR, farnesoid X receptor; NRs, nuclear receptors; Cyp7A1, cytochrome 7A1; BAs, bile acids; BSEP, bile salt export pump; SAR, structure–activity relationship; LBD, ligand-binding domain

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2014 سفارش ترجمه

ATP-dependent transport of statins by human and rat MRP2/Mrp2

Keywords: BSEP، پمپ صادرات نمک صفرا; MRP2, multidrug resistance associated protein 2; BCRP, breast cancer resistance pump; BSEP, bile salt export pump; OATP1B1, organic anion transporting polypeptide 1B1; CDF, 5(6)-carboxy-2′,7′-dichlorofluorescein; DDIs, drug–drug interactions; Ki, inhibiti

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

The adverse outcome pathway concept: A pragmatic tool in toxicology

Keywords: BSEP، پمپ صادرات نمک صفرا; 5′-NT, 5′-nucleotidase; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AO(P)(s), adverse outcome (pathway(s)); AST, aspartate aminotransferase; BSEP, bile salt export pump; CAR, constitutive androstane receptor; CD36, fatty acid translocase; Ch

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Nuclear receptors, bile acids and cholesterol homeostasis series – Bile acids and pregnancy

Keywords: BSEP، پمپ صادرات نمک صفرا; BSEP, bile salt export pump; CA, cholic acid; CDCA, chenodeoxycholic acid; DCA, deoxycholic acid; FXR, farnesoid X receptor; ICP, intrahepatic cholestasis of pregnancy; LCA, lithocholic acid; NTCP, Na+-taurocholate cotransporting polypeptide; UDCA, ursode

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Genetic variation in the mouse model of Niemann Pick C1 affects female, as well as male, adiposity, and hepatic bile transporters but has indeterminate effects on caveolae

Keywords: BSEP، پمپ صادرات نمک صفرا; BSEP, bile salt export pump; ECL, enhanced chemiluminescence; GLUT4, glucose transporter 4; KO, knockout; Mrp, multidrug resistant protein; NAFLD, non-alcoholic fatty liver disease; Npc1, mouse Niemann–Pick C1 gene or protein; NPC1, Niemann–Pick C1 type d

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

ABC transporters, CYP1A and GSTα gene transcription patterns in developing stages of the Nile tilapia (Oreochromis niloticus)

Keywords: BSEP، پمپ صادرات نمک صفرا; ABC, Adenosine tris-phosphate binding cassette; ANOVA, Analysis of variance; ATP, Adenosine tris-phosphate; BSEP, bile salt export pump; BWSF, Biodegradated water-soluble fraction; cDNA, Complementary deoxyribonucleic acid; CYP1A, Cytochrome P450 1A; DNA,

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Comparison of Culture Media for Bile Acid Transport Studies in Primary Human Hepatocytes

Keywords: BSEP، پمپ صادرات نمک صفرا; primary human hepatocytes; bile acid transport; NTCP; BSEP; dexamethasoneDMEM, Dulbecco's Modified Eagle Medium; NTCP, sodium taurocholate cotransporting polypeptide; BSEP, bile salt export pump; OATP, organic anion-transporting polypeptide; MRP2, multidr

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Endogenous bile acid disposition in rat and human sandwich-cultured hepatocytes

Keywords: BSEP، پمپ صادرات نمک صفرا; BA, bile acids; BSEP, bile salt export pump; BEI, biliary excretion index; CTL, control; CYP450, cytochrome P450; DMSO, dimethyl sulfoxide; DMEM, Dulbecco's modified Eagle medium; EDTA, ethylenediaminetetraacetic acid; GCDCA, glycochenodeoxycholic acid; G

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Preclinical experimental models of drug metabolism and disposition in drug discovery and development

Keywords: BSEP، پمپ صادرات نمک صفرا; ADME, absorption, distribution, metabolism and excretion; AO, aldehyde oxidases; AUC, area under the plasma concentration–time course curve; BCRP, breast cancer resistance protein; BDC, bile-duct cannulation; BSEP, bile salt export pump; CYP, cytochrome P

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

Molecular mechanism for the involvement of nuclear receptor FXR in HBV-associated hepatocellular carcinoma

Keywords: BSEP، پمپ صادرات نمک صفرا; BSEP, bile salt export pump; CA, cholic acid; DBD, DNA-binding domain; DCA, deoxycholic acid; CDCA, chenodeoxycholic acid; CYP7A1, cholesterol 7α-hydroxylase; CYP8B1, cytochrome P450 sterol 12α-hydroxylase; FGF19/15, fibroblast growth factor 19/15; FXR, F

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Novel strategies for microdose studies using non-radiolabeled compounds

Keywords: BSEP، پمپ صادرات نمک صفرا; ADME, absorption, distribution, metabolism and excretion; AMS, accelerator mass spectrometry; AUC, area under the plasma concentration–time curve; BSEP, bile salt export pump; Cmax, maximum plasma concentration; CYP, cytochrome P450; DIN, drug interaction

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

PXR Prevents Cholesterol Gallstone Disease by Regulating Biosynthesis and Transport of Bile Salts

Keywords: BSEP، پمپ صادرات نمک صفرا; Fgf15; PCN; Nuclear Receptor; Gene Regulation; Transgenic MiceAbc, ATP binding cassette; Asbt, apical sodium-dependent bile acid transporter; Bsep, bile salt export pump; CAR, constitutive androstane receptor; CGD, cholesterol gallstone disease; CSI, chol

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Biliary efflux transporters involved in the clearance of rosuvastatin in sandwich culture of primary rat hepatocytes

Keywords: BSEP، پمپ صادرات نمک صفرا; Bsep, bile salt export pump; BEI, biliary efflux index; Bcrp, breast cancer resistance protein; ES, estrone-3-sulfate; HBSS, Hank’s balanced salt solution; Clbile,intClbile,int, intrinsic biliary clearance; Mrp2, multidrug resistance associated protein 2;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

The effect of dimerumic acid on LPS-induced downregulation of Mrp2 in the rat

Keywords: BSEP، پمپ صادرات نمک صفرا; Bsep, bile salt export pump; Mrp2, multidrug resistance-associated protein 2; GSH, glutathione; LPS, lipopolysaccharide; EA, ethacrynic acid; DMA, dimerumic acid; ALT, alanine aminotransferase; NO, nitric oxide; CrM, crude membrane; ZO-1, zonal occuldin-1

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Risk Factors for Idiosyncratic Drug-Induced Liver Injury

Keywords: BSEP، پمپ صادرات نمک صفرا; HLA; Amoxicillin-Clavulanate; Hy's Law; DILIanti-TB, antituberculosis; BSEP, bile salt export pump; DILI, drug-induced liver injury; IL, interleukin; MnSOD, manganese superoxide dismutase; MRP, multidrug resistance protein; NAT2, N-acetyltransferase 2; OR

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2010 سفارش ترجمه

Ku proteins function as corepressors to regulate farnesoid X receptor-mediated gene expression

Keywords: BSEP، پمپ صادرات نمک صفرا; AF-1, activation function-1; AF-2, activation function-2; BSEP, bile salt export pump; CDCA, chenodeoxycholic acid; DBD, DNA-binding domain; DNA-PK, DNA-dependent protein kinase; DNA-PKcs, DNA-dependent protein kinase catalytic subunit; FBS, fetal bovine

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Coordinate regulation of human drug-metabolizing enzymes, and conjugate transporters by the Ah receptor, pregnane X receptor and constitutive androstane receptor

Keywords: BSEP، پمپ صادرات نمک صفرا; AHR, aryl hydrocarbon receptor; ARE, antioxidant response element; BaP, benzo[a]pyrene; BCRP, breast cancer resistance protein; BSEP, bile salt export pump; CAR, constitutive androstane receptor; FXR, farsenoid X receptor; GR, glucocorticoid receptor; LXR

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

Localization of the Sodium-Taurocholate cotransporting polypeptide in membrane rafts and modulation of its activity by cholesterol in vitro

Keywords: BSEP، پمپ صادرات نمک صفرا; BS, bile salts; BSEP, bile salt export pump; Cav-1, caveolin-1; MR, membrane rafts; HEK 293, Human embryonic kidney 293; MCD, Methyl-β-Cyclodextrin; Ntcp, Sodium-Taurocholate Cotransporting PolypeptideBile acid; Caveolin; Lipid microdomain; Lipid raft; Me

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

Mutations in Bile Salt Export Pump (ABCB11) in Two Children with Progressive Familial Intrahepatic Cholestasis and Cholangiocarcinoma

Keywords: BSEP، پمپ صادرات نمک صفرا; BSEP, Bile salt export pump; FAB-MS, Fast atom bombardment ionization-mass spectrometry; MRP2, Multidrug resistance-associated protein 2; SγGT, Serum concentration of gamma-glutamyl transpeptidase activity

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2007 سفارش ترجمه

The human hepatoma HepaRG cells: A highly differentiated model for studies of liver metabolism and toxicity of xenobiotics

Keywords: BSEP، پمپ صادرات نمک صفرا; AhR, aryl hydrocarbon receptor; BSEP, bile salt export pump; CAR, constitutive androstane receptor; CYP, cytochrome P450; DMSO, dimethylsulfoxide; GST, glutathione transferase; MRP, multidrug-resistance associated protein; NTCP, Na+-taurocholate co-transp

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه

Effects of genetic backgrounds on hyperbilirubinemia in radixin-deficient mice due to different expression levels of Mrp3

Keywords: BSEP، پمپ صادرات نمک صفرا; ERM, ezrin/radixin/moesin; mAb, monoclonal antibody; pAb, polyclonal antibody; Mrp, multidrug resistance protein; Rdx, radixin; Bsep, bile salt export pump; P-gps, P-glycoprotein; EMB, early mixed background; LMB, late mixed backgroundERM; Mrp2; Mrp3; Hyp

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2007 سفارش ترجمه

Novel cationic and neutral glycocholic acid and polyamine conjugates able to inhibit transporters involved in hepatic and intestinal bile acid uptake

Keywords: BSEP، پمپ صادرات نمک صفرا; ASBT/Asbt, apical sodium-dependent bile salt transporter; BSEP, Bile salt export pump; NTCP/Ntcp, Na-taurocholate-cotransporting polypeptide; OATP, Organic anion-transporting polypeptide; OST, Organic solute transporterASBT; Enterohepatic circulation; Ile

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2007 سفارش ترجمه

Liver-homing of purified glucose oxidase: A novel in vivo model of physiological hepatic oxidative stress (H2O2)

Keywords: BSEP، پمپ صادرات نمک صفرا; AST, aspartate aminotransferase; ALT, alanine aminotransferase AP-alkaline phosphatase; BSEP, bile salt export pump; GGT, γ-glutamyltranspeptidase; GOX, glucose oxidase; GSH, reduced glutathione; GSSG, oxidized glutathione; HO1, heme oxygenase 1; LDH, lac

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2007 سفارش ترجمه

Expression in Human Trophoblast and Choriocarcinoma Cell Lines, BeWo, Jeg-3 and JAr of Genes Involved in the Hepatobiliary-like Excretory Function of the Placenta

Keywords: BSEP، پمپ صادرات نمک صفرا; ABC proteins; Bile acid; Carrier; Liver; Nuclear receptors; OATP; PregnancyBCRP, breast cancer resistance protein; BSEP, bile salt export pump; E217βG, estradiol 17β-d-glucuronide; hCC, human choriocarcinoma cells; hTr, human primary trophoblasts; MDR, mu

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2007 سفارش ترجمه

Inhibition of the intestinal absorption of bile acids using cationic derivatives: Mechanism and repercussions

Keywords: BSEP، پمپ صادرات نمک صفرا; ASBT; Enterohepatic circulation; Ileum; Intestine; Liver; Polyamine; TransportASBT, apical sodium-dependent bile acid transporter; BAPA, bile acid-polyamine derivative; BSEP, bile salt export pump; CDCA, chenodeoxycholic acid; GC, glycocholic acid; NTCP,

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2007 سفارش ترجمه

Regulation of hepatic bile acid transporters Ntcp and Bsep expression

Keywords: BSEP، پمپ صادرات نمک صفرا; bDNA, branched DNA signal amplification assay; Bsep, bile salt export pump; DHT, 5α-dihydrotestosterone; E2, 17β-estadiol; GHRH, growth hormone releasing hormone; GNX, gonadectomy; HX, hypophysectomy; Ntcp, sodium-taurocholate cotransporting polypeptideNt

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2007 سفارش ترجمه

Potential role of trans-inhibition of the bile salt export pump by progesterone metabolites in the etiopathogenesis of intrahepatic cholestasis of pregnancy

Keywords: BSEP، پمپ صادرات نمک صفرا; ABC proteins; Cholestasis; Estradiol; Pregnancy; TransportAHP, asymptomatic hypercholanemia of pregnancy; BAs, bile acids; BSEP, bile salt export pump; CA, cholic acid; CDCA, chenodeoxycholic acid; CES1, human carboxylesterase-1; CsA, cyclosporin A; E217β

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2006 سفارش ترجمه

Nuclear bile acid receptor FXR as pharmacological target: Are we there yet?

Keywords: BSEP، پمپ صادرات نمک صفرا; ABC, ATP binding cassette transporter; ASBT, apical sodium dependent bile acid transporter; BSEP, bile salt export pump; CA, cholic acid; CDCA, chenodeoxycholic acid; CGD, cholesterol gallstone disease; CYP7A1, cholesterol 7α-hydroxylase; DCA, deoxycholic

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2006 سفارش ترجمه