کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2595568 1562344 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The adverse outcome pathway concept: A pragmatic tool in toxicology
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
The adverse outcome pathway concept: A pragmatic tool in toxicology
چکیده انگلیسی

Adverse outcome pathways (AOPs) are novel tools in toxicology and human risk assessment with broad potential. AOPs are designed to provide a clear-cut mechanistic representation of critical toxicological effects that span over different layers of biological organization. AOPs share a common structure consisting of a molecular initiating event, a series of intermediate steps and key events, and an adverse outcome. Development of AOPs ideally complies with OECD guidelines. This also holds true for AOP evaluation, which includes consideration of the Bradford Hill criteria for weight-of-evidence assessment and meeting a set of key questions defined by the OECD. Elaborate AOP frameworks have yet been proposed for chemical-induced skin sensitization, cholestasis, liver fibrosis and liver steatosis. These newly postulated AOPs can serve a number of ubiquitous purposes, including the establishment of (quantitative) structure–activity relationships, the development of novel in vitro toxicity screening tests and the elaboration of prioritization strategies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology - Volume 312, 4 October 2013, Pages 158–165
نویسندگان
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