Keywords: 4- Shogaol (PubChem CID: 9794897); 6- Shogaol (PubChem CID: 5281794); Apigenin (PubChem CID: 5280443); Berberine (PubChem CID: 2353); Bergamottin (PubChem CID: 5471349); Caffeic acid (PubChem CID: 689043)Capsaicin (PubChem CID: 1548943); Cardamonin (PubCh
مقالات ISI (ترجمه نشده)
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Keywords: â¢OH; hydroxyl radical; 2,2-BP; 2,2-bipyridyl; ABC; ATP-binding cassette; AIF; apoptosis-inducing factor; AMPK; AMP-activated protein kinase; AMPKK; AMPK kinase; ANT; adenine nucleotide translocase; AP-1; activator protein 1; Apaf-1; protease activating
Keywords: Cancer; Therapeutics; Chemotherapy; Hormonal therapy; Targeted therapy; Gene therapy; Death receptors; c-FLIP
Nogo-B (Reticulon-4B) functions as a negative regulator of the apoptotic pathway through the interaction with c-FLIP in colorectal cancer cells
Keywords: si-RNA; small interfering RNA; STS; staurosporine; FasL; Fas ligand; c-FLIP; cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitor protein; IHC; immunohistochemistry; CRC; colorectal cancer; ER; endoplasmic reticulum; PERK; protein kinase RNA-like
Original ArticleRocaglamide breaks TRAIL-resistance in human multiple myeloma and acute T-cell leukemia in vivo in a mouse xenogtraft model
Keywords: TRAIL; Rocaglamide; Apoptosis; c-FLIP; Myeloma; Leukemia;
Original ArticleFn14·TRAIL fusion protein is oligomerized by TWEAK into a superefficient TRAIL analog
Keywords: Fn14·TRAIL; Fusion protein; TWEAK; Apoptosis; Oligomerization; TRAIL; TNF-related apoptosis-inducing ligand; TWEAK; tumor necrosis factor-like weak inducer of apoptosis; Fn14; fibroblast growth factor-inducible 14-kDa protein; c-FLIP; cellular Fas-associ
MiR-126 reverses drug resistance to TRAIL through inhibiting the expression of c-FLIP in cervical cancer
Keywords: TRAIL; TNF-related apoptosis-inducing ligand; Hela-TR; TRAIL-resistant Hela; SiHa-TR; TRAIL-resistant SiHa; C-FLIP; CASP8 and FADD like apoptosis regulator; TNF-α; tumor necrosis factor-α; FasL; Fas ligand; MiR-126; microRNA-126; 3â² UTR; 3â²-untransl
Simvastatin pretreatment reduces caspase-9 and RIPK1 protein activity in rat cardiac allograft ischemia-reperfusion
Keywords: APC; antigen-presenting cell; c-FLIP; cellular FLICE-inhibitory protein; DAMP; damage-associated molecular pattern; EC; endothelial cell; IRI; ischemia/reperfusion injury; LDH; lactate dehydrogenase; PGD; primary graft dysfunction; RIPK1/3; receptor-inter
A novel role of c-FLIP protein in regulation of ER stress response
Keywords: Mouse embryonic fibroblast; Endoplasmic reticulum stress; UPR; Apoptosis; c-FLIP;
Jaceosidin induces apoptosis through Bax activation and down-regulation of Mcl-1 and c-FLIP expression in human renal carcinoma Caki cells
Keywords: Jaceosidin; Apoptosis; Bax; c-FLIP; Mcl-1; Renal cancer;
Research ArticleCleaved c-FLIP mediates the antiviral effect of TNF-α against hepatitis B virus by dysregulating hepatocyte nuclear factors
Keywords: HBV; hepatitis B virus; HCC; hepatocellular carcinoma; CTLs; cytotoxic T lymphocytes; IFN-γ; interferon-gamma; TNF-α; tumor necrosis factor-alpha; c-FLIP; cellular FLICE-inhibitory protein; DEDs; death effector domains; DISC; death-inducing signaling co
The overriding of TRAIL resistance by the histone deacetylase inhibitor MS-275 involves c-myc up-regulation in cutaneous, uveal, and mucosal melanoma
Keywords: Histone deacetylase inhibitors; MS-275; TRAIL; c-myc; c-FLIP; Melanoma; Apoptosis
Angiotensin II-induced mouse hippocampal neuronal HT22 cell apoptosis was inhibited by propofol: Role of neuronal nitric oxide synthase and metallothinonein-3
Keywords: Ang II; angiotensin II; APAF-1; apoptotic protease activating factor-1; AT1R; angiotensin type 1 receptor; AT2R; angiotensin type 2 receptor; Bcl-2; B-cell lymphoma-2; BID; BH3-interacting domain; cIAP-1; cellular inhibitor of apoptosis protein-1; c-FLIP;
Restoration of TRAIL-induced apoptosis in resistant human pancreatic cancer cells by a novel FAK inhibitor, PH11
Keywords: Pancreatic cancer cell lines; TRAIL; FAK inhibitor; c-FLIP; PI3K/AKT pathway
Conservation of structure and function in vertebrate c-FLIP proteins despite rapid evolutionary change
Keywords: CARD; caspase-recruitment domain; CASc; Caspase, interleukin-1 β converting enzyme homologs; c-FLIP; cellular FLICE-like inhibitory protein; CHX; cycloheximide; DED; death effector domain; EGFP; enhanced green fluorescent protein; FADD; Fas-associated de
Class I-specific histone deacetylase inhibitor MS-275 overrides TRAIL-resistance in melanoma cells by downregulating c-FLIP
Keywords: HDACis; Apoptosis; TRAIL; c-FLIP; Cutaneous melanoma; Uveal melanoma;
Dicoumarol sensitizes renal cell carcinoma Caki cells to TRAIL-induced apoptosis through down-regulation of Bcl-2, Mcl-1 and c-FLIP in a NQO1-independent manner
Keywords: Dicoumarol; TRAIL; Bcl-2; Mcl-1; c-FLIP; NQO1;
Histone deacetylase inhibitor (HDACI) mechanisms of action: Emerging insights
Keywords: HDAC inhibitor; DNA damage response; DNA repair; Cell cycle checkpoints; Apoptosis; Rational combinations; ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; APAF-1; apoptotic protease activating factor 1; ASK1; apoptosis signal-regulating ki
Thymoquinone attenuates liver fibrosis via PI3K and TLR4 signaling pathways in activated hepatic stellate cells
Keywords: Akt; serine/threonine kinase-protein kinase B; ALT; alanine aminotransferase; AST; aspartate aminotransferase; α-SMA; α-smooth muscle actin; c-FLIP; cellular FLIP; d-GlaN; d-galactosamine; ECM; extracellular matrix; HSCs; hepatic stellate cells; LPS; li
Sensitization of TRAIL-induced apoptosis in human hepatocellular carcinoma HepG2 cells by phytochemicals
Keywords: TRAIL; Indole-3-carbinol; Epigallocatechin-3-gallate; Hepatocellular carcinoma; c-FLIP; Death receptors;
Production of Cyr61 protein is modulated by extracellular acidification and PI3K/Akt signaling in prostate carcinoma PC-3 cells
Keywords: NAC; N-acetylcysteine; ECM; extracellular matrix; PI3K; phosphoinositide 3-kinase; SDS; sodium dodecyl sulfate; HRP; horseradish peroxidase; ECL; enhanced chemiluminescence; siRNA; small interfering RNA; PBS; phosphate buffered saline; Akt; serine/threoni
c-FLIP does not correlate with response to immunochemotherapy treatment and outcome of patients with nodal diffuse large B-cell lymphoma
Keywords: Diffuse large B-cell lymphoma; c-FLIP; Apoptosis; Immunohistochemistry; Prognosis
Targeting c-FLIP in cancer
Keywords: c-FLIP; Death receptors; CancerCDDP, cisplatin; VP16, etoposide; 5-FU, 5-fluorouracil; DISC, death-inducing signaling complex; DcR2, TRAIL-R4 or decoy receptor 2; DR5, TRAIL-R1
Cellular FLICE-like inhibitory proteins (c-FLIPs): Fine-tuners of life and death decisions
Keywords: c-FLIP; Death receptor; Apoptosis; Caspase-8; DISC;
Regulation of chemoresistance via alternative messenger RNA splicing
Keywords: Alternative splicing; Drug resistance; Spliceosome; Cyclin D1; c-FLIP
Death Receptor 5 and cellular FLICE-inhibitory protein regulate pemetrexed-induced apoptosis in human lung cancer cells
Keywords: Pemetrexed; DR5; c-FLIP; Apoptosis; CHOP; TRAIL;
Conatumumab (AMG 655) coated nanoparticles for targeted pro-apoptotic drug delivery
Keywords: DR5; c-FLIP; Nanoparticles; Cancer; Caspase pathway; Conatumumab
Research ArticleAblation of c-FLIP in hepatocytes enhances death-receptor mediated apoptosis and toxic liver injury in vivo
Keywords: c-FLIP; CD95; d-Galactosamine/LPS; Concanavalin A; JNK; Bid; Apoptosis; Caspase-8; Liver injury; Cell death; ALT; alanine aminotransferase; c-FLIP; cellular FLICE-inhibitory protein; ConA; concanavalin A; DED; death effector domain; DISC; death-inducing s
Stimulation of Fas signaling down-regulates activity of neutrophils from major trauma patients with SIRS
Keywords: AIS; abbreviated injury scale; ANOVA; one-way analysis of variance; BE; base excess; BocD-fmk; t-butoxycarbonyl-aspartyl(O-methyl)-fluoromethyl ketone; DHR; dihydrorhodamine; ELISA; enzyme-linked immunosorbent assay; FACS; fluorescence-activated cell scan
Knockdown of MADD and c-FLIP overcomes resistance to TRAIL-induced apoptosis in ovarian cancer cells
Keywords: apoptosis; c-FLIP; IG20; MADD; ovarian cancer; shRNA;
Cellular FLICE-inhibitory protein (c-FLIP) signalling: A key regulator of receptor-mediated apoptosis in physiologic context and in cancer
Keywords: c-FLIP; Death-receptors; Apoptosis; Pro-survival signalling; Cancer
The coffee diterpene kahweol sensitizes TRAIL-induced apoptosis in renal carcinoma Caki cells through down-regulation of Bcl-2 and c-FLIP
Keywords: Kahweol; TRAIL; Apoptosis; Caki; Bcl-2; c-FLIP
Transglutaminase 2 expression levels regulate sensitivity to cystamine plus TRAIL-mediated apoptosis
Keywords: TRAIL; Cystamine; c-FLIP; Apoptosis; Transglutaminase 2
Testis atrophy and reduced sperm motility in transgenic mice overexpressing c-FLIPL
Keywords: Apoptosis; c-FLIP; germ cells; spermatogenesis; Stra8; testis atrophy; transgenic mouse
TRAIL and Interferon-α Act Synergistically to Induce Renal Cell Carcinoma Apoptosis
Keywords: kidney; carcinoma, renal cell; TNF-related apoptosis-inducing ligand; interferons; extracellular signal-regulated MAP kinases; c-FLIP; cellular FLIP; cIAP; cellular inhibitor of apoptosis; DAPI; 4,6-diamidino-2-phenylindole; DcR; decoy receptor; DD; death
Liver cancer: From molecular pathogenesis to new therapies
Keywords: DEB; drug-eluting bead; HBV; hepatitis B virus; HCC; hepatocellular carcinoma; HCV; hepatitis C virus; hTERT; human telomerase reverse transcriptase; PDGF; platelet derived growth factor; FAK; focal adhesion kinase; Pyk2; proline-rich tyrosine kinase 2; M
Clonal expansion of HTLV-1 positive CD8+ cells relies on cIAP-2 but not on c-FLIP expression
Keywords: HTLV-1; Apoptosis; Clonal expansion; cIAP-2; c-FLIP;
Genistein enhances proteasomal degradation of the short isoform of FLIP in malignant glioma cells and thereby augments TRAIL-mediated apoptosis
Keywords: TRAIL, tumour necrosis factor-related apoptosis-inducing ligand; IAP, inhibitor of apoptosis proteins; XIAP, X-linked inhibitor of apoptosis protein; ph-Akt, phosphorylated Akt; c-FLIP, FADD-like interleukin-1ß-converting enzyme-inhibitory protein; c-FLIP
Nuclear localization of c-FLIP-L and its regulation of AP-1 activity
Keywords: c-FLIP; Nuclear localization; AP-1; MAPK; T-cell proliferation
KAAD-cyclopamine augmented TRAIL-mediated apoptosis in malignant glioma cells by modulating the intrinsic and extrinsic apoptotic pathway
Keywords: TRAIL; tumor necrosis factor-related apoptosis-inducing ligand; IAP; Inhibitor of apoptosis proteins; DR4; death receptor 4; DR5; death receptor 5; XIAP; X-linked inhibitor of apoptosis protein; ph-Akt; phosphorylated Akt; Glioma; TRAIL/Apo2L; KAAD-cyclop
The XIAP inhibitor Embelin enhances TRAIL-mediated apoptosis in malignant glioma cells by down-regulation of the short isoform of FLIP
Keywords: TRAIL, tumor necrosis factor-related apoptosis-inducing ligand; IAP, inhibitor of apoptosis proteins; DISC, death-inducing signalling complex; ph-Akt, phosphorylated Akt; PKB, proteinkinase B; DR4/DR5, death-receptor 4/5Glioma; TRAIL/Apo2L; c-FLIP; Embeli
Over-expression of Reticulon 3 (RTN3) enhances TRAIL-mediated apoptosis via up-regulation of death receptor 5 (DR5) and down-regulation of c-FLIP
Keywords: RTN3; TRAIL; Apoptosis; DR5; c-FLIP
Inhibition of host cell apoptosis by Eimeria bovis sporozoites
Keywords: Eimeria bovis; Apoptosis; c-IAP1; c-FLIP; Actinomycin D; Cytochalasin B; Colchicin
Down-regulation of AMP-activated protein kinase sensitizes DU145 carcinoma to Fas-induced apoptosis via c-FLIP degradation
Keywords: AMP-activated protein kinase; Fas; c-FLIP; DU145
Myricetin sensitizes malignant glioma cells to TRAIL-mediated apoptosis by down-regulation of the short isoform of FLIP and bcl-2
Keywords: TRAIL, tumour necrosis factor-related apoptosis-inducing ligand; IAP, inhibitor of apoptosis proteins; DISC, death-inducing signalling complex; ph-Akt, phosphorylated Akt; PKB, proteinkinase B; DR4/DR5, death-receptor 4/5Glioma; TRAIL/Apo2L; c-FLIP; bcl-2
Withaferin A sensitizes TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP
Keywords: Withaferin A; ROS; TRAIL; DR5; c-FLIP; CHOP; NF-κB; Free radicals
Epidermal growth factor receptor inhibitors enhance susceptibility to Fas-mediated apoptosis in oral squamous cell carcinoma cells
Keywords: Squamous cell carcinoma; Fas; Apoptosis; EGFR inhibitor; c-FLIP
Ectodomain shedding of TNF receptor 1 induced by protein synthesis inhibitors regulates TNF-α-mediated activation of NF-κB and caspase-8
Keywords: c-FLIP; Cycloheximide; Ectodomain shedding; NF-κB; TNF receptor;
c-FLIP knockdown induces ligand-independent DR5-, FADD-, caspase-8-, and caspase-9-dependent apoptosis in breast cancer cells
Keywords: c-FLIP; Apoptosis; Breast cancer; Small interfering RNA (siRNA); TRAIL receptor 5
Rosiglitazone promotes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP
Keywords: TRAIL; Apoptosis; Rosiglitazone; DR5; Reactive oxygen species; c-FLIP; Free radicals