Keywords: کربنیل ردوکتاز; AKR; aldo-keto reductase; AOX1; aldehyde oxidase 1; 11β-HSD; 11β-hydroxysteroid dehydrogenase; CBR; carbonyl reductase; CYP; cytochrome P450; EDTA; ethylenediamine-N,N,N',N'-tetraacetic acid; G-6-P; glucose-6-phosphate; G-6-PDH; glucose-6-phosphate
مقالات ISI کربنیل ردوکتاز (ترجمه نشده)
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Keywords: کربنیل ردوکتاز; Carbonyl reductase; Asymmetric reduction; Two steps screening methodology; (S)-3-(Dimethylamino)-1-(2-Thienyl)-1-propanol;
Keywords: کربنیل ردوکتاز; 4-Oxodecanoic acid; 5-Oxodecanoic acid; (R)-γ-Decalactone; (R)-δ-Decalactone; Carbonyl reductase; Asymmetric reduction;
Keywords: کربنیل ردوکتاز; carbonyl reductase 1; tissue distribution; liver; intestine; kidney; LC-MS/MS; protein quantification; proteomics; CBR; carbonyl reductase; DDI; drug-drug interactions; DMF; dimethylformamide; fm; fraction metabolized; IDA; information-dependent acquisiti
Keywords: کربنیل ردوکتاز; Carbonyl reductase; Glucose dehydrogenase; Chiral intermediate of ezetimibe; Dual-enzyme coupled system; Aqueous-organic solvent system;
Keywords: کربنیل ردوکتاز; Tiaprofenic acid; Carbonyl reducing enzymes (CREs); AKR; Short-chain dehydrogenase/reductase; Carbonyl reductase; Reductive drug metabolism;
Keywords: کربنیل ردوکتاز; 3-BC; 3-benzylidene camphor; 4-MBC; 4-methylbenzylidene camphor; Aβ; amyloid-β; ABAD; Aβ-binding alcohol dehydrogenase; AD; Alzheimer's disease; AI; aromatase inhibitor; AKR; aldo-keto reductase; AME; apparent mineralocorticoid excess; AR; androgen r
Keywords: کربنیل ردوکتاز; Asymmetric reduction; Carbonyl reductase; Ethyl (S)-4-chloro-3-hydroxybutanoate; Substrate to catalyst ratio
Keywords: کربنیل ردوکتاز; Carbonyl reductase; Enantiorecognition; Computational design; OPBE; Improved enantioselectivity;
Keywords: کربنیل ردوکتاز; Doxorubicin; Glutathione deficiency; Pharmacogenetics; Cardiotoxicity; Carbonyl reductase
Keywords: کربنیل ردوکتاز; QCT (Q0); quinocetone; Q1; 1-desoxyquinocetone; Q2; dideoxyquinocetone; Q3; carbonyl-reduced metabolites of 1-deoxyquinocetone; Q4; carbonyl- and double-bond-reduced metabolites of 1-deoxyquinocetone; Q5; carbonyl-reduced metabolites of dideoxyquinocetone
Keywords: کربنیل ردوکتاز; AKR; Carbonyl reducing enzymes; Carbonyl reductase; Fenofibric acid; Reductive drug metabolism; Short-chain dehydrogenase/reductaseAKR, aldo-keto reductase; CLint, internal clearance; CREs, carbonyl reducing enzymes; SDR, short-chain dehydrogenase/reducta
Chemoenzymatic approaches to the synthesis of the (1S,2R)-isomer of benzyl 2-hydroxycyclohexanecarboxylate
Keywords: کربنیل ردوکتاز; Whole-cell yeast biocatalyst; Carbonyl reductase; Reduction; Cyclic β-oxoester;
Attempt to simultaneously generate three chiral centers in 4-hydroxyisoleucine with microbial carbonyl reductases
Keywords: کربنیل ردوکتاز; 4-Hydroxyisoleucine; Stereoisomer; Carbonyl reductase; Kinetic resolution; Asymmetric biosynthesis;
Biosynthesis of tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate by carbonyl reductase from Rhodosporidium toruloides in mono and biphasic media
Keywords: کربنیل ردوکتاز; tert-butyl (S)-6-chloro-5-hydroxy-3-oxohexanoate; tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate; Carbonyl reductase; Biphasic reaction system;
Synthesis of enantiomerically enriched drug precursors and an insect pheromone via reduction of ketones using commercially available carbonyl reductase screening kit “Chiralscreen® OH”
Keywords: کربنیل ردوکتاز; “Chiralscreen® OH”; Carbonyl reductase; Enzyme library; Asymmetric reduction;
Facilitation of 9,10-phenanthrenequinone-elicited neuroblastoma cell apoptosis by NAD(P)H:quinone oxidoreductase 1
Keywords: کربنیل ردوکتاز; 9,10-Phenanthrenequinone; Neuroblastoma cell; Apoptosis; Reactive oxygen species; Antioxidant property; NAD(P)H:quinone oxidoreductase 1; AKR; aldo-keto reductase; AMC; 7-amido-4-methylcoumarin; ATM; ataxia telangiectasia mutated kinase; BSO; dl-buthionin
Semi-rational engineering of carbonyl reductase YueD for efficient biosynthesis of halogenated alcohols with in situ cofactor regeneration
Keywords: کربنیل ردوکتاز; Carbonyl reductase; Protein engineering; Halogenated chiral alcohol; Cofactor recycling; Co-substrate;
Efficient synthesis of a (S)-fluoxetine intermediate using carbonyl reductase coupled with glucose dehydrogenase
Keywords: کربنیل ردوکتاز; Carbonyl reductase; Glucose dehydrogenase; Bio-production; (S)-3-chloro-1-phenyl-1-propanol; (S)-fluoxetine;
Improvement of carbonyl reductase activity for the bioproduction of tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate
Keywords: کربنیل ردوکتاز; Carbonyl reductase; Directed evolution; Tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate; Single-batch reaction;
Short communicationEfficient bioreductive production of (R)-N-Boc-3-hydroxypiperidine by a carbonyl reductase
Keywords: کربنیل ردوکتاز; (R)-N-Boc-3-hydroxypiperidine; Carbonyl reductase; Asymmetric reduction; Cofactor-recycling system;
Improvement of operational stability of Ogataea minuta carbonyl reductase for chiral alcohol production
Keywords: کربنیل ردوکتاز; Carbonyl reductase; Directed evolution; Thermal stability; Organic-solvent tolerance; Ogataea minuta;
Human carbonyl reductase 1 participating in intestinal first-pass drug metabolism is inhibited by fatty acids and acyl-CoAs
Keywords: کربنیل ردوکتاز; CBR; carbonyl reductase; SDR; short-chain dehydrogenase/reductase; CYP; cytochrome P450; AKR; aldo-keto reductase; DOX; doxorubicin; FA; fatty acid; ONE; 4-oxo-2-nonenal; 13h; 8-hydroxy-2-imino-2H-chromene-3-carboxylic acid (2-chlorophenyl)amide; DHRS4; d
Research paperEnhancement of ethyl (S)-4-chloro-3-hydroxybutanoate production at high substrate concentration by in situ resin adsorption
Keywords: کربنیل ردوکتاز; Ethyl (S)-4-chloro-3-hydroxybutanoate; Carbonyl reductase; Asymmetric reduction; Product inhibition; Resin adsorption;
Regular articleChiral diol t-butyl 6-cyano-(3R,5R)-dihydroxylhexanoate synthesis catalyzed by immobilized cells of carbonyl reductase and glucose dehydrogenase co-expression E. coli
Keywords: کربنیل ردوکتاز; t-Butyl 6-cyano-(3R,5R)-dihydroxyhexanoate; Cell immobilization; Carbonyl reductase; Bioreduction;
Research paperHighly efficient bioreduction of 2-hydroxyacetophenone to (S)- and (R)-1-phenyl-1,2-ethanediol by two substrate tolerance carbonyl reductases with cofactor regeneration
Keywords: کربنیل ردوکتاز; Highly enantioselective; Carbonyl reductase; 2-Hydroxyacetophenone; Chiral 1-phenyl-1,2-ethanediol; Cofactor regeneration;
Development of a practical biocatalytic process for (S)-N-Boc-3-hydroxypiperidine synthesis
Keywords: کربنیل ردوکتاز; (S)-N-Boc-3-hydroxypiperidine; Carbonyl reductase; Asymmetric reduction; Biphasic system;
Efficient bioreductive production of (S)-N-Boc-3-hydroxypiperidine using ketoreductase ChKRED03
Keywords: کربنیل ردوکتاز; (S)-N-Boc-3-hydroxypiperidine (PubChem CID: 1514399); N-Boc-piperidin-3-one (PubChem CID: 2756825); Carbonyl reductase; Ketoreductase; Asymmetric reduction; Ibrutinib; Chiral alcohol; Biocatalysis;
Transcriptional regulation of the canine carbonyl reductase 1 gene (cbr1) by the specificity protein 1 (Sp1)
Keywords: کربنیل ردوکتاز; 5â²-UTR; 5â² untranslated region; ACTB; beta-actin; AKRs; aldo-keto reductases; ALOX-5; Arachidonate 5-lipoxygenase; CBR; carbonyl reductase; CHF; congestive heart failure; ChIP; chromatin immunoprecipitation; DMEM; Dulbecco's Modified Eagle Medium; DMS
Highly efficient synthesis of ethyl (S)-4-chloro-3-hydroxybutanoate by a novel carbonyl reductase from Yarrowia lipolytica and using mannitol or sorbitol as cosubstrate
Keywords: کربنیل ردوکتاز; Biocatalysis; Carbonyl reductase; Enzyme production; Ethyl (S)-4-chloro-3-hydroxybutanoate; Optimisation; Bioconversion;
Biosynthesis of optically pure chiral alcohols by a substrate coupled and biphasic system with a short-chain dehydrogenase from Streptomyces griseus
Keywords: کربنیل ردوکتاز; SDRs; short-chain dehydrogenases/reductases superfamily; CR; carbonyl reductase; SgCR; carbonyl reductase from Streptomyces griseus; COBE; ethyl 4-chloro-3-oxobutanoate; (S)-CHBE; (S)-4-chloro-3-hydroxybutanoate; IPT; gisopropyl β-d-1-thiogalactopy-ranos
The elusive endogenous adipogenic PPARγ agonists: Lining up the suspects
Keywords: کربنیل ردوکتاز; NO; nitric oxide; NO2; dioxide radical; O2; superoxide; ONO2â; Â peroxynitrite; 15-dPGJ2; 15-deoxy-Î12,14-prostaglandin J2; AA; arachidonic acid; ADH; alcohol dehydrogenase; AF-1; ligand-independent activation function; AF-2; ligand-dependent activatio
Enzymatic preparation of t-butyl-6-cyano-(3R, 5R)-dihydroxyhexanoate by a whole-cell biocatalyst co-expressing carbonyl reductase and glucose dehydrogenase
Keywords: کربنیل ردوکتاز; Carbonyl reductase; Glucose dehydrogenase; Nicotinamide cofactor; Whole-cell biocatalysis; Statin side chains
Efficient synthesis of (R)-2-chloro-1-phenylethol using a yeast carbonyl reductase with broad substrate spectrum and 2-propanol as cosubstrate
Keywords: کربنیل ردوکتاز; Biocatalysis; Carbonyl reductase; Enzyme production; (R)-2-Chloro-1-phenylethol; Optimisation; Bioconversion;
Cloning, expression, and characterization of an anti-Prelog stereospecific carbonyl reductase from Gluconobacter oxydans DSM2343
Keywords: کربنیل ردوکتاز; Carbonyl reductase; Asymmetric reduction; Anti-Prelog rule; Molecular modeling
NADP+-dependent dehydrogenase activity of carbonyl reductase on glutathionylhydroxynonanal as a new pathway for hydroxynonenal detoxification
Keywords: کربنیل ردوکتاز; 4-Hydroxy-2-nonenal; 3-Glutathionyl-4-hydroxynonanal; Carbonyl reductase; Hydroxynonenal detoxification; Free radicals
1-Heteroaryl-3-phenoxypropan-2-ones as inhibitors of cytosolic phospholipase A2α and fatty acid amide hydrolase: Effect of the replacement of the ether oxygen with sulfur and nitrogen moieties on enzyme inhibition and metabolic stability
Keywords: کربنیل ردوکتاز; Cytosolic phospholipase A2α; Fatty acid amide hydrolase; Indole-5-carboxylic acid; Benzotriazole; Inhibitors; Metabolic stability; Cytochrome P450; Carbonyl reductase; Short chain dehydrogenase/reductase; Aldo-keto reductase;
Structure-activity relationship of flavonoids as potent inhibitors of carbonyl reductase 1 (CBR1)
Keywords: کربنیل ردوکتاز; CBR; carbonyl reductase; DOX; doxorubicin; Hydroxy-PP; 3-(1-tert-butyl-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenol; SAR; structure-activity relationship; S-Tetralol; (S)-(+)-1,2,3,4-tetrahydro-1-naphthol; Acacetin (PubChem CID: 5280442); Apigenin (P
Highly enantioselective double reduction of phenylglyoxal to (R)-1-phenyl-1,2-ethanediol by one NADPH-dependent yeast carbonyl reductase with a broad substrate profile
Keywords: کربنیل ردوکتاز; Carbonyl reductase; Bioreduction; Reduction of α-oxoaldehyde; Chiral alcohol;
Purification and characterization of a new carbonyl reductase from Leifsonia xyli HS0904 involved in stereoselective reduction of 3,5-bis(trifluoromethyl) acetophenone
Keywords: کربنیل ردوکتاز; Carbonyl reductase; Leifsonia xyli; (R)-3,5-bis(trifluoromethyl) phenyl ethanol; Purification; Characterization; Asymmetric reduction; BTAP; 3,5-bis(trifluoromethyl) acetophenone; BTPE; 3,5-bis(trifluoromethyl)phenyl ethanol; ee; enantiometric excess; Vma
Scalable biocatalytic synthesis of optically pure ethyl (R)-2-hydroxy-4-phenylbutyrate using a recombinant E. coli with high catalyst yield
Keywords: کربنیل ردوکتاز; Asymmetric reduction; Coexpression; Carbonyl reductase; (R)-2-hydroxy-4-phenylbutanoate; Biocatalysis;
Investigations on the metabolic stability of cytosolic phospholipase A2α inhibitors with 1-indolylpropan-2-one structure
Keywords: کربنیل ردوکتاز; cPLA2α; cytosolic phospholipase A2α; CYP450; cytochrome P450; SDR; short-chain dehydrogenase/reductase; AKR; aldo-keto-reductase; HPLC; high performance liquid chromatography; MS; mass spectrometry; ESI; electrospray ionization; NMR; nuclear magnetic
Production of (3S)-acetoin from diacetyl by using stereoselective NADPH-dependent carbonyl reductase and glucose dehydrogenase
Keywords: کربنیل ردوکتاز; (3S)-Acetoin; Diacetyl; Carbonyl reductase; Glucose dehydrogenase; Cofactor regeneration
Pleurotus ostreatus as a source of enoate reductase
Keywords: کربنیل ردوکتاز; Pleurotus ostreatus; Bioreduction; α,β-unsaturated aryl ketone; Enoate reductase; Carbonyl reductase
Design of an activity and stability improved carbonyl reductase from Candida parapsilosis
Keywords: کربنیل ردوکتاز; Carbonyl reductase; Dimer interface; Stability; Activity
Preparation of pharmaceutical important fluorinated 1-arylethanols using isolated enzymes
Keywords: کربنیل ردوکتاز; Alcohol dehydrogenase; Asymmetric reduction; Biocatalysis; Carbonyl reductase; Enantioselective; Fluorinated molecules
Carbonyl reductase mRNA abundance and enzymatic activity as potential biomarkers of oxidative stress in marine fish
Keywords: کربنیل ردوکتاز; Carbonyl reductase; Biomarker; Biomonitoring; Eelpout; Oxidative stress; AhR-agonists
Two-Enzyme Coexpressed Recombinant Strain for Asymmetric Synthesis of Ethyl (R)-2-Hydroxy-4-phenylbutyrate
Keywords: کربنیل ردوکتاز; carbonyl reductase; glucose dehydrogenase; coexpression; (R)-2-hydroxy-4-phenylbutyrate; asymmetric reduction
Improved production of (R)-1-phenyl-1,2-ethanediol using Candida parapsilosis (R)-carbonyl reductase expressed in Pichia pastoris
Keywords: کربنیل ردوکتاز; MDR; medium-chain dehydrogenases/reductases; MD; minimal dextrose medium; MM; methanol medium; PED; (R)-1-phenyl-1,2-ethanediol; rcr; (R)-specific carbonyl reductase gene; RCR; (R)-specific carbonyl reductase; TCA; trichloroaceticacid; Carbonyl reductase;
Highly efficient synthesis of chiral alcohols with a novel NADH-dependent reductase from Streptomyces coelicolor
Keywords: کربنیل ردوکتاز; Carbonyl reductase; Streptomyces coelicolor; Asymmetric reduction; Ethyl (S)-4-chloro-3-hydroxybutanoate; NADH regeneration;