Multiple Global Suppressors of Protein Stability Defects Facilitate the Evolution of Extended-Spectrum TEM β-Lactamases
Keywords: CFU، واحدهای تشکیل دهنده کلنی; antibiotic resistance; global suppressor; β-lactamase; protein evolution; protein stabilityESBL, extended-spectrum β-lactamase; IRT, inhibitor-resistant TEM; CFU, colony-forming units