کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3416132 1225003 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Enhanced resistance to Salmonella enterica serovar Typhimurium infection in mice after coumarin treatment
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Enhanced resistance to Salmonella enterica serovar Typhimurium infection in mice after coumarin treatment
چکیده انگلیسی

Coumarin and its derivatives are naturally occurring substances with multiple biological activities. Here we demonstrate that prophylactic peroral administration of coumarin or 7-hydroxycoumarin (7-OHC) enhances resistance to subsequent lethal Salmonella enterica Serovar Typhimurium infection in mice. 7-OHC decreased bacterial load in liver and spleen, and enhanced phagocytosis and bacterial killing by macrophages when applied in vitro and in vivo. 7-OHC treatment induced significant NO release in peritoneal macrophage cultures. The observed protective effect correlated with the induction of Th1-associated cytokines, such as IL-12, IFN-γ, and TNF-α. These data demonstrate a clear immunomodulatory potential of coumarins which might have important therapeutic implications to enhance resistance to infection.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbes and Infection - Volume 9, Issue 1, January 2007, Pages 7–14
نویسندگان
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