دانلود مقالات ISI درباره Cl، ترخیص کالا از گمرک + ترجمه فارسی

کاربرد مدلسازی فارماکوکینتیک مبتنی بر فیزیولوژیک در پیشبینی فارماکوکینتیک فرمولاسیون آزادسازی بیتیکلول در انسان

Application of physiologically based pharmacokinetic modeling in the prediction of pharmacokinetics of bicyclol controlled-release formulation in human

Keywords: Cl، ترخیص کالا از گمرک; PBPK, physiologically based pharmacokinetic; IR, immediate-release; CR, controlled-release; PK, pharmacokinetic; API, active pharmaceutical ingredient; CL, clearance; AUC0−t, area under the plasma concentration-time curve from time 0 to the last time poin

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

پاکسازی داخل چرکی و حجم توزیع ترکیبات در خرگوش: در پیش بینی سیلیکا و شبیه سازی های فارماکوکینتیک برای توسعه دارو

Intravitreal clearance and volume of distribution of compounds in rabbits: In silico prediction and pharmacokinetic simulations for drug development

Keywords: Cl، ترخیص کالا از گمرک; BAB, blood-aqueous barrier; BRB, blood-retinal barrier; CL, clearance; CLivt, intravitreal clearance; Css, ivt, steady state drug concentration in the vitreous; CV%, coefficient of variation; E, extraction ratio; Eaqueous humour, extraction ratio from vit

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

مقایسه متابولیسم و وضعیت مواد مخدر مینی پیگ، سگ، میمون و انسان

Comparison of minipig, dog, monkey and human drug metabolism and disposition

Keywords: Cl، ترخیص کالا از گمرک; AUC, area under the plasma concentration versus time curve; (B–A)/(A–B), cross-membrane transport rate, basolateral to apical and reverse; CB, covalent binding; CL, clearance; Cmax, maximal plasma concentration; CYP, cytochrome P450; fu, fraction unbound

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

مدلسازی فیزیولوژیکی مبتنی بر فارماکوکینتیک از نحوه قرارگیری و درگیریهای متابولیسم داروی آتورواستاتین و متابولیتهای آن

Physiologically based pharmacokinetic modeling of disposition and drug–drug interactions for atorvastatin and its metabolites

Keywords: Cl، ترخیص کالا از گمرک; AUC, area under the concentration–time curve; CL, clearance; Cmax, maximum concentration; CYP, cytochrome P450; DDI, drug–drug interaction; F, bioavailability; HMG–CoA, 3-hydroxy-3-methylglutaryl–coenzyme A; Jmax, maximum rate of transporter-mediated effl

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

غلظت کاربامازپین و کاربامازپین 10،11-اپوکساید در خون مادر و بند ناف نوزاد در هنگام تولد: تاثیر مدیریت مشترک اسید و والپروئیک یا داروهای ضدصرع ناشی از آنزیم

Concentrations of carbamazepine and carbamazepine-10,11-epoxide in maternal and umbilical cord blood at birth: Influence of co-administration of valproic acid or enzyme-inducing antiepileptic drugs

Keywords: Cl، ترخیص کالا از گمرک; Carbamazepine; Carbamazepine-10,11-epoxide; Delivery; Therapeutic drug monitoring; Drug–drug interaction; EpilepsyAEDs, antiepileptic drugs; CBZ, carbamazepine; Cl, clearance; CLZ, clonazepam; CYP, cytochrome P450; EURAP, European and International Regist

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

The kidneys play a central role in the clearance of rhGH in rats

Keywords: Cl، ترخیص کالا از گمرک;  − 2LL, minus two times the log-likelihood; bpm, beats per minute; CI, confidence interval; Cl, clearance; COV, covariate; CRF, chronic renal failure; EDTA, ethylenediaminetetraacetic acid; fCl, fractional change in clearance; GH, growth hormone; GHBP, gr

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

Pharmacokinetic properties of tandem d-peptides designed for treatment of Alzheimer's disease

Keywords: Cl، ترخیص کالا از گمرک; %ID, relative injected dose; AD, Alzheimer's disease; AGP, α1-acid glycoprotein; AUC, area under the concentration-time curve; AUMC, area under the moment curve; Aβ, β-amyloid; C, concentration; Cl, clearance; D, dose; dpm, disintegrations per minute; F,

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

C-3 benzoic acid derivatives of C-3 deoxybetulinic acid and deoxybetulin as HIV-1 maturation inhibitors

Keywords: Cl، ترخیص کالا از گمرک; AUC, area under the curve; BA, betulinic acid; BVM, bevirimat; CA, capsid; calcd, calculated; cART, combination antiretroviral therapy; CL, clearance; Cmax, the maximum concentration of a drug in the body after dosing; CMP, counts per minute; CV, confiden

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

Method development for quantification of the environmental neurotoxin annonacin in Rat plasma by UPLC–MS/MS and application to a pharmacokinetic study

Keywords: Cl، ترخیص کالا از گمرک; AAG, Annonaceous acetogenin; amu, atomic mass unit; AUC, area under curve; Cl, clearance; EMA, Eropean Medicines Agency; F, obsapparent bioavailability; IS, internal standard; LLOQ, lower limit of quantification; MF, matrix factor; MQC, medium concentrati

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Pharmacokinetic study of salvianolic acid D after oral and intravenous administration in rats

Keywords: Cl، ترخیص کالا از گمرک; AUC, the area under curve; CI, confidence interval; CL, clearance; Cmax, peak plasma concentration; ECE-1, endothelin converting enzyme 1; ESI, electrospray ionization; IS, internal standard; LLOQ, lower limit of quantification; QC, quality control; R.E.,

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Pyridopyrimidinone inhibitors of HIV-1 RNase H

Keywords: Cl، ترخیص کالا از گمرک; HIV; AIDS; Reverse transcriptase; Integrase; Two-metal binder; EndonucleaseADME, absorption, distribution, metabolism, excretion; AIDS, acquired immunodeficiency syndrome; Cl, clearance; CLND, chemi-luminescent nitrogen detection; DIPEA, diisopropyl ethyl

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Bidirectional placental transfer of Bisphenol A and its main metabolite, Bisphenol A-Glucuronide, in the isolated perfused human placenta

Keywords: Cl، ترخیص کالا از گمرک; BPA, Bisphenol A; BPA-G, Bisphenol A-Glucuronide; BSA, Bovine serum albumin; Cl, clearance; ER, extraction rate; TR, transfer rateBisphenol A; Bisphenol A-Glucuronide; Endocrine disruptor; Human placenta; Fetal exposure

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Low in vitro permeability of the cyanotoxin microcystin-LR across a Caco-2 monolayer: With identification of the limiting factors using modelling

Keywords: Cl، ترخیص کالا از گمرک; Microcystin-LR; Caco-2 monolayer; Apparent permeability; Mathematical modelA, apical; ADME, absorption distribution metabolism excretion; B, basolateral; Ca, apical concentration; Cb, basolateral concentration; Cc, cellular concentration; CL, clearance; C

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Relevance of UDP-glucuronosyltransferase polymorphisms for drug dosing: A quantitative systematic review

Keywords: Cl، ترخیص کالا از گمرک; UDP-glucuronosyltransferases; Pharmacogenetics; Polymorphism; Pharmacogenetics-based dose adjustments; Drug metabolism; UGT1A1A, Adenine; Afr, Africans; As, Asians; AUC, area under the curve; C, Cytosine; Cauc./Cau, Caucasians; Cl, Clearance; ClHet, Clear

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2014 سفارش ترجمه

A preclinical pharmacokinetic modeling approach to the biopharmaceutical characterization of immediate and microsphere-based sustained release pulmonary formulations of rifampicin

Keywords: Cl، ترخیص کالا از گمرک; PLGA microsphere; Cyclodextrin; Pharmacokinetic modeling; Rifampicin; Rat; Lung deliveryEA, ethyl acetate; HPβCD, 2-hydroxypropyl-β-cyclodextrin; PVA, polyvinyl alcohol; RIF, rifampicin; CL, clearance

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Application of knockout mouse models to investigate the influence of FcγR on the pharmacokinetics and anti-platelet effects of MWReg30, a monoclonal anti-GPIIb antibody

Keywords: Cl، ترخیص کالا از گمرک; IgG, immunoglobulin G; FcγR, Fc receptors for IgG; ITP, immune thrombocytopenic purpura; mAbs, monoclonal antibodies; PK, pharmacokinetics; PD, pharmacodynamics; AUC, area under the concentration vs. time profiles; CL, clearance; Vss, volume of distributi

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Systemic in vitro and in vivo evaluation for determining the feasibility of making an amorphous solid dispersion of a B-Raf (rapidly accelerated fibrosarcoma) inhibitor

Keywords: Cl، ترخیص کالا از گمرک; AUC, area under the concentration-timer profile; CL, clearance; Cmax, maximum concentration; Cp, isobaric heat capacity; DSC, differential scanning calorimetry; F, bioavailability; HPLC, High Performance Liquid Chromatography; Tg, glass transition tempera

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Warning against co-administration of 3,4-methylenedioxymethamphetamine (MDMA) with methamphetamine from the perspective of pharmacokinetic and pharmacodynamic evaluations in rat brain

Keywords: Cl، ترخیص کالا از گمرک; ANOVA, analysis of variance; AUC, area under the curve; CL, clearance; DIB-Cl, 4-(4,5-diphenyl-1H-imidazol-2-yl)benzoyl chloride; ECD, electrochemical detection; HPLC, high performance liquid chromatography; MRT, mean residence time; MDA, 3,4-methylenedio

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Pharmacokinetics of aconitine as the targeted marker of Fuzi (Aconitum carmichaeli) following single and multiple oral administrations of Fuzi extracts in rat by UPLC/MS/MS

Keywords: Cl، ترخیص کالا از گمرک; ACN, acetonitrile; ANOVA, analysis of variance; AUC, area under curve; CL, clearance; HPLC, high performance liquid chromatography; IS, internal standard; MRT, mean residence time; MRM, multiple reaction monitoring; QC, quality control; SE, standard error

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Pharmacokinetics of conjugated metabolites in rat plasma after oral administration of tectoridin

Keywords: Cl، ترخیص کالا از گمرک; Te-7G-4′S, tectorigenin-7-O-glucuronide-4′-sulfate; Te-7G, tectorigenin-7-O-glucuronide; Te-7S, tectorigenin-7-O-sulfate; Te-4′S, tectorigenin-4′-O-sulfate; AUC, area under the curve; CL, clearance; ESI, electrospray ionization; F, bioavailability; Cmax,

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Integration of cell biology, pharmacological modeling and statistical analysis: Part I: Cell biology and PK/PD in the Oncology paradigm

Keywords: Cl، ترخیص کالا از گمرک; α, type I error; AUC, area under the plasma concentration versus time curve; AUCM, area under the concentration times time versus time curve; β, type II error; BOR, Best Overall Response; CB, clinical benefit; CL, clearance; Cmax, maximum plasma concentra

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2012 سفارش ترجمه

Prolonged half-life of glycoPEGylated rFVIIa variants compared to native rFVIIa

Keywords: Cl، ترخیص کالا از گمرک; Cl, clearance; T½, half-life; MRT, mean residence time; PEG, polyethylene glycol; rFVIIa, recombinant activated FVII; Vss, volume of distribution in steady staterFVIIa; PEGylation; Preclinical; Pharmacokinetics; Half-life; Clearance

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

High-throughput analysis of standardized pharmacokinetic studies in the rat using sample pooling and UPLC–MS/MS

Keywords: Cl، ترخیص کالا از گمرک; ACN, acetonitrile; AUC, area under the curve; CL, clearance; DMA, dimethylamine; F, bioavailability; LOQ, limit of quantification; PEG400, polyethylene glycol 400; PK, pharmacokinetic; rt, retention time; T1/2, half life; UPLC–MS/MS, ultra performance liq

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Absorption and tissue distribution of a novel carboxymethyldextran after oral administration

Keywords: Cl، ترخیص کالا از گمرک; i.p., Intraperitoneal injection; i.v., Intravenous injection; F, Bioavailability; AUMC, Area under the first moment curve; RGTA, for ReGeneraTing Agent; PK, Pharmacokinetics; Vd, Volume of distribution; AUCCL, Area under curve; CL, Clearance; Cmax, Maximu

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Effect of hypertriglyceridemia on the pharmacokinetics and blood–brain barrier penetration of clozapine and norclozapine following administration to rats

Keywords: Cl، ترخیص کالا از گمرک; AUC, area under curve; LDL, low-density lipoprotein; VLDL, very low-density lipoprotein; BBB, blood–brain barrier; IV, intravenous; CL, clearance; Vss, apparent volume of distribution at steady state; T1/2, half-life; Cmax, maximal concentration; Tmax, ti

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Species differences in methanol and formic acid pharmacokinetics in mice, rabbits and primates

Keywords: Cl، ترخیص کالا از گمرک; ADH, alcohol dehydrogenase; ADH III, formaldehyde dehydrogenase; AO, alcohol oxidase; AUC, area under the plasma concentration–time curve; Cl, clearance; FA, formic acid; FDH, formate dehydrogenase; FID, flame ionization detector; GC, gas chromatography;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

A Phase I Clinical Study of High Dose Ketoconazole Plus Weekly Docetaxel for Metastatic Castration Resistant Prostate Cancer

Keywords: Cl، ترخیص کالا از گمرک; prostatic neoplasms; docetaxel; ketoconazole; drug interactionsABCB1, ATP-binding cassette subfamily B member 1; ALT, alanine transaminase; AST, aspartate transaminase; AUC, area under the curve; bid, twice daily; CL, clearance; CRPC, castration resistant

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Type 1 von Willebrand disease due to reduced von Willebrand factor synthesis and/or survival: observations from a case series

Keywords: Cl، ترخیص کالا از گمرک; CL, clearance; DDAVP, 1-desamino-8-d-arginine vasopressin; ELISA, enzyme-linked immunosorbant assay; FVIII, Factor VIII; HRP, horseradish peroxidase; PBS, phosphate-buffered saline; T1/2el, T1/2 elimination; Vre, velocity of release; VWD, von Willebrand d

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Pharmacokinetics of melamine in pigs following intravenous administration

Keywords: Cl، ترخیص کالا از گمرک; AUC, area under the curve; Cl, clearance; HPLC, high performance liquid chromatography; IV, intravenous; Kel, elimination rate constant; LD, lethal dose; LOQ, limit of quantification; MRT, mean residence time; SPE, solid-phase extraction; T1/2, half-lifeM

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

Snapshot PK: a rapid rodent in vivo preclinical screening approach

Keywords: Cl، ترخیص کالا از گمرک; AUC, area under the plasma concentration time curve; CL, clearance; Vss, volume of distribution at steady-state; T1/2, half-life of elimination; Cmax, maximum plasma concentration; Tmax, time at which Cmax occurs; Clast, the last observed plasma concentra

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Ketoprofen glucuronidation and bile excretion in carbon tetrachloride and alpha-naphthylisothiocyanate induced hepatic injury rats

Keywords: Cl، ترخیص کالا از گمرک; AUC0–∞, total area under the plasma concentration versus time curve; ANIT, alpha-naphthylisothiocyanate; CCl4, carbon tetrachloride; CL, clearance; Km, Michaelis constant; KP, ketoprofen; KPG, ketoprofen glucuronide; MRT, mean residence time; RP-HPLC, rev

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

Bioavailability and absorption analysis of oxytetracycline orally administered to the standardized moulting farmed Pacific white shrimps (Penaeus vannamei)

Keywords: Cl، ترخیص کالا از گمرک; A, coefficient of 1st phase; AUC0∞, area under the curve from zero to infinite time; AUC0t, area under the curve from zero to the last sampling time; B, coefficient of 2nd phase; Ci, drug concentration in compartment i; Cl, Clearance; DIS, DOSE (IS), intr

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2007 سفارش ترجمه

Dynamic profiling of estrogen receptor and epidermal growth factor signaling in the uteri of genistein- and estrogen-treated rats

Keywords: Cl، ترخیص کالا از گمرک; Genistein; Estrogen; EGF signaling; Receptors; Rat uterus; T1/2A and T1/2E, absorption and elimination half-lives; AUC, area under the drug concentration-time curve; CL, clearance; EGFR, epidermal growth factor receptor; EB, estradiol benzoate; ER, estr

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه