کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2587707 1130935 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pharmacokinetics of melamine in pigs following intravenous administration
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
Pharmacokinetics of melamine in pigs following intravenous administration
چکیده انگلیسی

Melamine-contaminated pet food was recently added as a supplement to livestock feed. There is little or no information concerning the pharmacokinetics of melamine in livestock, and the aim of this study was to obtain pharmacokinetic parameters for this contaminant in pigs. Melamine was administered intravenously to five weanling pigs at a dose of 6.13 mg/kg and plasma samples were collected over 24 h, extracted for melamine, and then analyzed by HPLC–UV. The data was shown to best fit a one-compartment model with melamine’s half-life of 4.04 (±0.37) h, clearance of 0.11 (±0.01) L/h/kg, and volume of distribution of 0.61 (±0.04) L/kg. These data are comparable to the only mammalian study in rats and suggests that melamine is readily cleared by the kidney and there is unlikely to be significant tissue binding. Further tissue residue studies are required to assess the depletion kinetics of this contaminant in the pig which will determine whether residue levels in the kidney should be of public health concern if pigs were exposed to a similar dose.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 46, Issue 3, March 2008, Pages 1196–1200
نویسندگان
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