Keywords: CLP، پیوند زده و مچ پا; Mast cells; Stem cell factor (SCF); c-KIT; IgE; FcεRIAHR, airway hyperresponsiveness; BAL, bronchoalveolar lavage; BMCMC, bone marrow-derived cultured mast cell; CLP, cecal ligation and puncture; CPA, carboxypeptidase; DT, diphtheria toxin; DTR, diphtheri
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Metabolic changes at the early stage of sepsis induced by cecal ligation and puncture in rats and the interventional effects of Huang-Lian-Jie-Du-Tang
Keywords: CLP، پیوند زده و مچ پا; CLP, cecal ligation and puncture; HLJDT, Huang-Lian-Jie-Du-Tang; LC–Q-TOF-MS, liquid chromatography/quadrupole time-of-flight mass spectrometry; MVA, multivariate analytical; PLS-DA, partial least-squares discriminant analysis; OPLS, orthogonal partial le
Suppressive effects of polyozellin on TGFBIp-mediated septic responses in human endothelial cells and mice
Keywords: CLP، پیوند زده و مچ پا; Polyozellin; TGFBIp; Sepsis; Severe inflammation; MiceALT, alanine transaminase; AST, aspartate transaminase; BUN, blood urea nitrogen; CAM, cell adhesion molecule; CLP, cecal ligation and puncture; HUVEC, human umbilical vein endothelial cell; LPS, lipop
Pomegranate protects liver against cecal ligation and puncture-induced oxidative stress and inflammation in rats through TLR4/NF‐κB pathway inhibition
Keywords: CLP، پیوند زده و مچ پا; CLP, cecal ligation and puncture; GSH, reduced glutathione; LDH, lactate dehydrogenase; MDA, malondialdehyde; MPO, myeloperoxidase; κB, nuclear factor-κB; SOD, superoxide dismutase; TLR, toll-like receptor-4, tumor necrosis factor-αAcute liver injury; Cec
A cardioprotective insight of the cystathionine γ-lyase/hydrogen sulfide pathway
Keywords: CLP، پیوند زده و مچ پا; Akt, protein kinase B; BCA, brachiocephalic artery; CAM, chorioallantoic membrane; CAT, cysteine aminotransferase; CBS, cystathionine β-lyase; CLP, cecal ligation and puncture; CSE, cystathionine γ-lyase; CSE KO, CSE knock out; CTO, chronic total occlusio
Ascorbic acid reduces HMGB1 secretion in lipopolysaccharide-activated RAW 264.7 cells and improves survival rate in septic mice by activation of Nrf2/HO-1 signals
Keywords: CLP، پیوند زده و مچ پا; Sepsis; Heme oxygenase; HMGB1; Phosphatidylinositol-3-kinase; Nrf-2AscA, Ascorbic acid; ALT, Alanine aminotransferase; ARE, Antioxidant response element; AST, Aspartate Aminotransferase; CLP, Cecal ligation and puncture; CO, Carbon monoxide; ELISA, Enzyme
Autophagy in lung disease pathogenesis and therapeutics
Keywords: CLP، پیوند زده و مچ پا; ALI, acute lung injury; AMPK, 5′-adenosine monophosphate-regulated kinase; ATG, autophagy related protein; CF, cystic fibrosis; CFTR, cystic fibrosis transmembrane conductance regulator; CLP, cecal ligation and puncture; COPD, chronic obstructive pulmonar
Molecular hydrogen protects mice against polymicrobial sepsis by ameliorating endothelial dysfunction via an Nrf2/HO-1 signaling pathway
Keywords: CLP، پیوند زده و مچ پا; CLP, cecal ligation and puncture; DMEM, Dulbecco modified eagle medium; DMSO, cimethylsulfoxide; H2, hydrogen; HMGB1, high-mobility group box 1 protein; HO-1, heme oxygenase-1; HUVEC, human umbilical vein endothelial cell; ICAM, intercellular cell adhesio
Vascular barrier protective effects of baicalin, baicalein and wogonin in vitro and in vivo
Keywords: CLP، پیوند زده و مچ پا; HMGB1, high mobility group box 1; LPS, lipopolysaccharide; BCL, baicalin; BCN, baicalein; WGN, wogonin; CLP, cecal ligation and puncture; RAGE, receptor for advanced glycation end products; TLR, toll like receptor; ELISA, enzyme-linked immunosorbent assay
MBD2 regulates TH17 differentiation and experimental autoimmune encephalomyelitis by controlling the homeostasis of T-bet/Hlx axis
Keywords: CLP، پیوند زده و مچ پا; EAE; Epigenetic; Methylation; MBD2; TH17; T-betBMDCs, bone marrow-derived DCs; CFU, colony-forming units; ChIP, chromatin immunoprecipitation; CLP, cecal ligation and puncture; DCs, dendritic cells; EAE, experimental autoimmune encephalomyelitis; EMSA, el
Early adverse changes in liver microvascular circulation during experimental septic shock are not linked to an absolute nitric oxide deficit
Keywords: CLP، پیوند زده و مچ پا; NO, nitric oxide; NOS, nitric oxide synthase; CLP, cecal ligation and puncture; RT-PCR, real-time polymerase chain reaction; mRNA, messenger RNA
Inhibitory effects of epi-sesamin on HMGB1-induced vascular barrier disruptive responses in vitro and in vivo
Keywords: CLP، پیوند زده و مچ پا; HMGB1, high mobility group box 1; LPS, lipopolysaccharide; ESM, Epi-sesamin; SM, sesamin; CLP, cecal ligation and puncture; RAGE, receptor for advanced glycation end products; TLR, toll like receptor; ELISA, enzyme-linked immunosorbent assay; CAM, cell ad
Effects of a peripheral cholinesterase inhibitor on cytokine production and autonomic nervous activity in a rat model of sepsis
Keywords: CLP، پیوند زده و مچ پا; HRV, heart rate variability; CLP, cecal ligation and puncture; LPS, lipopolysaccharide; TP, total power; HF, high-frequency power; TNF, tumor necrosis factor; IL, interleukin; HMGB-1, high mobility group box 1 protein; ELISA, enzyme-linked immunosorbent a
Therapeutic benefits of the group B3 vitamin nicotinamide in mice with lethal endotoxemia and polymicrobial sepsis
Keywords: CLP، پیوند زده و مچ پا; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BUN, blood urea nitrogen; CLP, cecal ligation and puncture; d-Gal, d-galactosamine; ELISA, enzyme-linked immunosorbent assays; ERK, extracellular signal-regulated kinases; IkB, inhibitor of k
Interleukin-1β causes long-term potentiation deficiency in a mouse model of septic encephalopathy
Keywords: CLP، پیوند زده و مچ پا; blood brain barrier; cecal ligation and puncture; hippocampus; interleukin-1; long-term potentiation; septic encephalopathyACSF, artificial cerebral spinal fluid; BBB, blood brain barrier; CLP, cecal ligation and puncture; EDTA, ethylenediaminetetraacetic
Heterotrimeric Gαi proteins are regulated by lipopolysaccharide and are anti-inflammatory in endotoxemia and polymicrobial sepsis
Keywords: CLP، پیوند زده و مچ پا; ANOVA, analysis of variance; CLP, cecal ligation and puncture; FCS, fetal calf serum; GPCR, G protein coupled receptors; IL, interleukin; LPS, lipopolysaccharide; MP-7, Mastoparan; MPO, myeloperoxidase; PTx, pertussis toxin; TLR, Toll-like receptor; TNF,
Chitosan oligosaccharides protect mice from LPS challenge by attenuation of inflammation and oxidative stress
Keywords: CLP، پیوند زده و مچ پا; ALT, Alanine transferase; AST, Aspartate transaminase; CAT, Catalase; CLP, Cecal ligation and puncture; COS, Chitosan oligosaccharides; CRE, Creatinine; GSH, Glutathione; LPS, Lipopolysaccharide; MDA, Malondialdehyde; MPO, MyeloperoxidaseSepsis; Lipopolys
β1-Adrenergic receptor-mediated HO-1 induction, via PI3K and p38 MAPK, by isoproterenol in RAW 264.7 cells leads to inhibition of HMGB1 release in LPS-activated RAW 264.7 cells and increases in survival rate of CLP-induced septic mice
Keywords: CLP، پیوند زده و مچ پا; β-AR, beta adrenergic receptor; CLP, cecal ligation and puncture; CO, carbon monoxide; HMGB1, high mobility group box 1; HO-1, heme oxygenase-1; ISO, isoproterenol; LPS, lipopolysaccharides; MAPK, mitogen-activated protein kinase; Nrf2, nuclear factor-ery
EGCG stimulates autophagy and reduces cytoplasmic HMGB1 levels in endotoxin-stimulated macrophages
Keywords: CLP، پیوند زده و مچ پا; CLP, cecal ligation and puncture; EGCG, (−)-epigallocatechin-3-gallate; HMGB1, high mobility group box 1; LC3, microtubule-associated protein1 light chain 3; LPS, lipopolysaccharide
Benznidazole blocks NF-κB activation but not AP-1 through inhibition of IKK
Keywords: CLP، پیوند زده و مچ پا; BZL, benznidazole; CLP, cecal ligation and puncture; IKK, IκB kinase; LTA, lipoteichoic acid; OpZym, opsonized zymosan; ROS, reactive oxygen speciesImmunomodulation; Anti-inflammatory; NF-κB; Chagas’ disease
Tiger shrimp (Penaeus monodon) penaeidin possesses cytokine features to promote integrin-mediated granulocyte and semi-granulocyte adhesion
Keywords: CLP، پیوند زده و مچ پا; Penaeidin; Antimicrobial peptide; Cytokine; Cell adhesion; siRNA; ImmunomodulantAMPs, Antimicrobial peptides; RGDS, Arg-Gly-Asp-Ser; RGES, Arg-Gly-Glu-Ser; CAMs, cell adhesion molecules; CLP, cecal ligation and puncture; Con-A, Concanavalin A; CRD, cystei
Blocking central leukotrienes synthesis affects vasopressin release during sepsis
Keywords: CLP، پیوند زده و مچ پا; cecal ligation and puncture; plasma; neurohypophysis; hypothalamus; LTC4 synthaseAVP, arginine vasopressin; CLP, cecal ligation and puncture; cys-LTs, cysteinyl leukotrienes; DMSO, dimethyl sulfoxide; ECL, enhanced chemiluminescence; FLAP, 5-lipoxygenase-
A systematic review of experimental treatments for mitochondrial dysfunction in sepsis and multiple organ dysfunction syndrome
Keywords: CLP، پیوند زده و مچ پا; Bcl, B cell leukemia; CLP, cecal ligation and puncture; CsA, cyclosporin A; DFX, deferroxamine; ETF, electron-transferring flavoprotein; ETS, electron transport system; IL, interleukin; iNOS, inducible nitric oxide synthase; LPS, lipopolysaccharide; MPT,
Role of Toll-like receptor responses for sepsis pathogenesis
Keywords: CLP، پیوند زده و مچ پا; Gene polymorphism; Innate immunity; Sepsis; Toll-like receptors; Type-I interferonsAP-1, activator protein 1; CASP, colon ascendens peritonitis; CLP, cecal ligation and puncture; IFN, interferon; IκB, inhibitory factor κB; IKK, IκB kinase; IL, interleukin
Effects of i.c.v. administration of interleukin-1 on sleep and body temperature of interleukin-6-deficient mice
Keywords: CLP، پیوند زده و مچ پا; cytokine; fever; rodent; knockout; neuroimmunology; CNSANOVA, analyses of variance; CLP, cecal ligation and puncture; EEG, electroencephalogram; IL, interleukin; KO, knockout; LPS, lipopolysaccharide; muIL-1β, murine interleukin-1β; NREM, non-rapid eye mo
Beneficial Versus Detrimental Effects of Neutrophils Are Determined by the Nature of the Insult
Keywords: CLP، پیوند زده و مچ پا; ALI, acute lung injury; BAL, bronchoalveolar lavage fluid; CBA, cytometric bead assay; CLP, cecal ligation and puncture; HEM, hemorrhagic shock; IFN, interferon; IL, interleukin; KC, keratinocyte-derived chemokine; LPS, lipopolysaccharide; MCR, monocyte c
Heat shock response and acute lung injury
Keywords: CLP، پیوند زده و مچ پا; CLP, cecal ligation and puncture; ER, endoplasmic reticulum; HO, heme oxygenase; HSFs, heat shock factors; Hsp, heat shock protein; IKK, IκB kinase; IL, interleukin; I/R, ischemia–reperfusion; MAPK, mitogen-activated protein kinase; MKP-1, mitogen-activat
Mast cells in allergy: Innate instructors of adaptive responses
Keywords: CLP، پیوند زده و مچ پا; Adaptive immunity; Allergy; Cytokines; Innate immunity; Mast cells; T cells; Toll-like receptorsBMMCs, bone marrow-derived mast cells; CLP, cecal ligation and puncture; ERK, extracellular signal-regulated kinase; FcεRI, high-affinity receptor for the carb
Inhibition of Mitochondrial Permeability Transition Prevents Sepsis-Induced Myocardial Dysfunction and Mortality
Keywords: CLP، پیوند زده و مچ پا; BALF, bronchoalveolar lavage fluid; Bcl, B-cell leukemia; CLP, cecal ligation and puncture; CsA, cyclosporine A; Δψm, mitochondrial transmembrane potential; MPO, myeloperoxidase; NIM811, N-methyl-4-isoleucine cyclosporine; RCR, respiratory control ratio;