دانلود مقالات ISI درباره C max، حداکثر غلظت + ترجمه فارسی

فلاونوئیدها در رابط غذا: آیا یک شاخص درمانی در تقاضا است؟

Flavonoids at the pharma-nutrition interface: Is a therapeutic index in demand?

Keywords: C max، حداکثر غلظت; Flavonoids; Pharma-nutrition; Recommended daily allowance; Therapeutic indexADI, acceptable daily intake; AhR, aryl hydrocarbon receptor; AP-1, activation protein-1; AUC, area under the concentration–time curve; Cmax, maximum concentration; CVD, cardiovas

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

مدلسازی فیزیولوژیکی مبتنی بر فارماکوکینتیک از نحوه قرارگیری و درگیریهای متابولیسم داروی آتورواستاتین و متابولیتهای آن

Physiologically based pharmacokinetic modeling of disposition and drug–drug interactions for atorvastatin and its metabolites

Keywords: C max، حداکثر غلظت; AUC, area under the concentration–time curve; CL, clearance; Cmax, maximum concentration; CYP, cytochrome P450; DDI, drug–drug interaction; F, bioavailability; HMG–CoA, 3-hydroxy-3-methylglutaryl–coenzyme A; Jmax, maximum rate of transporter-mediated effl

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

پودر خشک شده اسپری نانو آمورف برای بهبود زیست پذیری خوراکی آن از روی آن است

Nano-amorphous spray dried powder to improve oral bioavailability of itraconazole

Keywords: C max، حداکثر غلظت; AUC, Area under the curve; API, Active pharmaceutical ingredient; Cmax, Maximum concentration; DE, Dextrose equivalent; DoE, Design of experiment; PXRD, Powder x-ray diffraction; PLM, Polarized light microscopy; Tg, Glass transition temperature; Tmax, Tim

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

درمان های بیولوژیک در بیماری التهابی روده

Biologic therapies in inflammatory bowel disease

Keywords: C max، حداکثر غلظت; ADA, antidrug antibodies; ADM, adalimumab; AUC, area under the curve; CD, Crohn's disease; CI, confidence interval; Cmax, maximum concentration; Ctrough, trough concentration; CZP, certolizumab pegol; GLM, golimumab; HR, hazard ratio; IBD, inflammatory bo

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2014 سفارش ترجمه

Self-nanoemulsifying particles of coenzyme Q10 with improved nutraceutical potential

Keywords: C max، حداکثر غلظت; ALT, alanine aminotransferase; ANOVA, analysis of variance; AST, aspartate aminotransferase; β-NADH, nicotinamide adenine dinucleotide; CCl4, carbon tetrachloride; Cmax, maximum concentration; CoQ10, coenzyme Q10; DLS, dynamic light scattering; DSC, diffe

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Robust expansion of dendritic cells in vivo by hydrodynamic FLT3L-FC gene transfer

Keywords: C max، حداکثر غلظت; AUC, area under curve; cDC, conventional DC; Cmax, maximum concentration; DC, dendritic cell; EC50, half-maximal effective concentration; FLT3L, Fms-like tyrosine kinase 3-ligand; HDT, hydrodynamic gene transfer; t1/2, half-life; PD, pharmacodynamics; pDC

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

3-Methoxynaltrexone is not a selective antagonist for the acute psychomotor stimulating effects of heroin and 6-monoacetylmorphine in mice

Keywords: C max، حداکثر غلظت; 3-MeONtx, 3-methoxynaltrexone; 6-MAM, 6-monoacetylmorphine; Cmax, maximum concentration; i.p., intraperitoneal; LOD, limit of detection; LC–MS/MS, liquid chromatography–tandem mass spectrometry; M6G, morphine-6-glucuronide; NTX, naltrexone; s.c., subcutan

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Ospemifene: A first-in-class, non-hormonal selective estrogen receptor modulator approved for the treatment of dyspareunia associated with vulvar and vaginal atrophy

Keywords: C max، حداکثر غلظت; AUC, area under the concentration-time curve; brdU, bromodeoxyuridine; Cmax, maximum concentration; DCIS, ductal carcinoma in situ; DMBA, dimethylbenzanthracene; EE, ethinyl estradiol; ERE, estrogen response element; HRT, hormone replacement therapy; LBD,

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Development of novel solid dispersion of tranilast using amphiphilic block copolymer for improved oral bioavailability

Keywords: C max، حداکثر غلظت; ANOVA, analysis of variance; ASD, amorphous solid dispersion; AUC, area under the curve of blood concentration vs. time; BA, bioavailability; BCS, biopharmaceutics classification system; BMA, butyl methacrylate; Cmax, maximum concentration; CSD, crystalli

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Characterization of vaniprevir, a hepatitis C virus NS3/4A protease inhibitor, in patients with HCV genotype 1 infection: Safety, antiviral activity, resistance, and pharmacokinetics

Keywords: C max، حداکثر غلظت; AE, adverse event; AUC, area under the concentration-time curve; bid, twice daily; BMI, body mass index; BUN, blood urea nitrogen; CI, confidence interval; Cmax, maximum concentration; Ctrough, trough concentration; CRU, clinical research unit; DAA, direc

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Systemic in vitro and in vivo evaluation for determining the feasibility of making an amorphous solid dispersion of a B-Raf (rapidly accelerated fibrosarcoma) inhibitor

Keywords: C max، حداکثر غلظت; AUC, area under the concentration-timer profile; CL, clearance; Cmax, maximum concentration; Cp, isobaric heat capacity; DSC, differential scanning calorimetry; F, bioavailability; HPLC, High Performance Liquid Chromatography; Tg, glass transition tempera

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Melamine in prenatal and postnatal organs in rats

Keywords: C max، حداکثر غلظت; ACN, acetonitrile; AUC, area under the curve; AUMC, predicted area under the first moment curve divided by the predicted AUC; Cl/F, apparent oral clearance; Cmax, maximum concentration; FDA, The US Food and Drug Administration; GFR, glomerular filtration

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Review of the histamine system and the clinical effects of H1 antagonists: Basis for a new model for understanding the effects of insomnia medications

Keywords: C max، حداکثر غلظت; Insomnia; Antihistamines; Histamine; PharmacologyBWSQ, benzodiazepine withdrawal symptom questionnaire; Cmax, maximum concentration; DSCT, digit symbol copying test; DSST, digit symbol substitution test; GABA, gamma amino butyric acid; GPCRs, G-protein co

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Novel formulation strategies for enhancing oral delivery of methoxyflavones in Kaempferia parviflora by SMEDDS or complexation with 2-hydroxypropyl-β-cyclodextrin

Keywords: C max، حداکثر غلظت; AUC, area under the curve; β-CD, β-cyclodextrin; CD, cyclodextrin; Cmax, maximum concentration; DGME, diethylene glycol monoethyl ether; DMF, 5,7-dimethoxyflavone; DSC, differential scanning calorimetry; F, oral bioavailability; 2-HP-β-CD, 2-hydroxypropyl

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Effect of olanzapine orally disintegrating tablet versus oral standard tablet on body weight in patients with schizophrenia: a randomized open-label trial

Keywords: C max، حداکثر غلظت; OST, oral standard tablet; ODT, orally disintegrating tablet; Cmax, maximum concentration; Tmax, time of maximum concentration; AUC, area under the curve; HbA1c, hemoglobinA1c; HDL, high-density lipoprotein; PANSS, Positive and Negative Syndrome Scale; GA

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Novel solid self-emulsifying drug delivery system of coenzyme Q10 with improved photochemical and pharmacokinetic behaviors

Keywords: C max، حداکثر غلظت; ANOVA, analysis of variance; ATP, adenosine triphosphate; AUC0–24, area under the curve of blood concentration vs. time from t = 0 to t = 24 after oral administration; BA, bioavailability; Cmax, maximum concentration; CoQ9, coenzyme Q9; CoQ10, coenzyme Q1

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Dry powder insufflation of crystalline and amorphous voriconazole formulations produced by thin film freezing to mice

Keywords: C max، حداکثر غلظت; VRC, voriconazole; TFF, thin film freezing; IPA, invasive pulmonary aspergillosis; AUC, area under the curve; Cmax, maximum concentration; DPI, dry powder inhaler; PVP, polyvinylpyrrolidone; HPMC, hydroxypropyl methylcellulose; SEM, scanning electron micr

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Mechanisms underlying food–drug interactions: Inhibition of intestinal metabolism and transport

Keywords: C max، حداکثر غلظت; APAP, acetaminophen; AUC, area under the curve; BG, bergamottin; bid, two times a day; Cmax, maximum concentration; CBJ, cranberry juice; CYP, cytochrome P450; DDI, drug–drug interaction; DHB, 6′,7′-dihydroxybergamottin; FDA, Food and Drug Administration;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2012 سفارش ترجمه

Optimization and evaluation of thermoresponsive diclofenac sodium ophthalmic in situ gels

Keywords: C max، حداکثر غلظت; AUC, area under curve; °C, degree Celsius; Cmax, maximum concentration; cm, centimeter; CO2, carbon dioxide; DS in situ gel, thermoresponsive diclofenac sodium ophthalmic* in situ gel; F127, Pluronic F127; F68, Pluronic F68; g, gram; G′, storage modulus;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Randomised, cross-over, comparative bioavailability trial of matrix type transdermal drug delivery system (TDDS) of carvedilol and hydrochlorothiazide combination in healthy human volunteers: A pilot study

Keywords: C max، حداکثر غلظت; ALT, Serum Alanine Amino Transferase; AST, Serum Aspartate Amino Transferase; AUC(0 − t), Area under the Concentration–Time Curve (zero to time t); BMI, Body Mass Index; CCH-3, Optimised Transdermal Formulation; Cmax, Maximum Concentration; CRV, Carvedilo

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Synthesis and pharmacokinetic evaluation of novel N-acyl-cordycepin derivatives with a normal alkyl chain

Keywords: C max، حداکثر غلظت; Cordycepin; N-acyl modification; PharmacokineticsADA, Adenosine deaminase; Cmax, Maximum concentration; AUC, Area under concentration–time curve; Tmax, Time of maximum concentration; t1/2, Half-life; Cn, Carbon number of alkyl chain in derivative

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Controlled application and scheduled removal of nanoparticle based chemotherapeutics (CARL) will reduce dose limiting adverse events in anticancer chemotherapy

Keywords: C max، حداکثر غلظت; Cmax, Maximum concentration; DDS, Nanoscale particle based drug delivery system; EPR-effect, Enhanced permeation and retention effect; LDL, Low-density lipoprotein; PLD, Pegylated liposomal doxorubicin; PPE, Palmar-plantar erythrodysesthesia; t1/2, half l

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

A different kinetic profile of ochratoxin A in mature male rats

Keywords: C max، حداکثر غلظت; Ochratoxin A; Toxicokinetic population approach; Male and female F344 rats; Age; Plasma; Simulation−2LL, −2 × log (likelihood); BEN, Balkan Endemic Nephropathy; CMAX, maximum concentration; CMAXobs, maximum observed concentration; CV(%), coefficient of va

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

A randomized, double-blind trial on the bioavailability of two CoQ10 formulations

Keywords: C max، حداکثر غلظت; AE, adverse event; ALT, alanine transaminase; AST, aspartate aminotransferase; AUC, area under the concentration–time curve; BUN, blood urea nitrogen; CBC, complete blood count; CHF, coronary heart failure; Cl, chloride; Cmax, maximum concentration; CoQ10

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

Long Acting Testosterone Undecanoate Therapy in Men With Hypogonadism: Results of a Pharmacokinetic Clinical Study

Keywords: C max، حداکثر غلظت; testis; hypogonadism; testosterone; pharmacokinetics; injections; intramuscularAE, adverse event; BMI, body mass index; Cavg, mean concentration; Cmax, maximum concentration; Cmin, minimum concentration; FDA, Food and Drug Administration; M-PGA, male pati

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Exposure of infants to budesonide through breast milk of asthmatic mothers

Keywords: C max، حداکثر غلظت; Pulmicort; budesonide; asthma; breast milkAUC, Area under the curve; Cav, Average steady-state concentration; Cmax, Maximum concentration; ICS, Inhaled corticosteroid; LC-APCI-MS/MS, Liquid chromatography and atmospheric pressure chemical ionization tande

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه

Kinetic difference of baicalin in rat blood and cerebral nuclei after intravenous administration of Scutellariae Radix extract

Keywords: C max، حداکثر غلظت; TCM, traditional Chinese medicine; Glu, Glutamic acid; Asp, Apartic acid; CNS, central nervous system; BBB, blood brain barrier; HPLC-EC, high performance liquid chromatography-electrochemistry (detector); Cmax, maximum concentration; Tpeak, time to reach

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2006 سفارش ترجمه

Understanding intestinal cysteamine bitartrate absorption

Keywords: C max، حداکثر غلظت; AOC, Area over the curve; Cmax, Maximum concentration; GI, Gastrointestinal; HSD, Honestly significant difference test; REML, Restricted maximum likelihood; SI, Small intestine

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2006 سفارش ترجمه

Safety studies on epigallocatechin gallate (EGCG) preparations. Part 1: Genotoxicity

Keywords: C max، حداکثر غلظت; ADRS, adapted relative survival; AUC, area under the curve; Cmax, maximum concentration; EGCG, epigallocatechin gallate; NCE, normochromatic erythrocytes; PCE, polychromatic erythrocytes; TFT, 5-trifluorothymidineTeavigo™; Epigallocatechin gallate; Genoto

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه

Safety studies on epigallocatechin gallate (EGCG) preparations. Part 3: Teratogenicity and reproductive toxicity studies in rats

Keywords: C max، حداکثر غلظت; AUC, area under the curve; Cmax, maximum concentration; EGCG, epigallocatechin gallate; NOAEL, no-observed adverse effect levelTeavigo™; Epigallocatechin gallate; Reproductive toxicity; Teratogenicity

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

An up-date review on individualized dosage adjustment of calcineurin inhibitors in organ transplant patients

Keywords: C max، حداکثر غلظت; ABC, ATP-binding cassette; AUC, area under the concentration–time curve; BID, twice a day; C0, predose trough concentration; C2, 2 hr after administration; CAR, constitutive androstane receptor; C/D, concentration/oral dose; Cmax, maximum concentration; C

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2006 سفارش ترجمه