کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2503569 1557431 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Optimization and evaluation of thermoresponsive diclofenac sodium ophthalmic in situ gels
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Optimization and evaluation of thermoresponsive diclofenac sodium ophthalmic in situ gels
چکیده انگلیسی

This work was conducted to optimize and evaluate Pluronic F127-based thermoresponsive diclofenac sodium ophthalmic in situ gels (DS in situ gel). They were prepared by cold method and investigated their physicochemical properties i.e., pH, flow ability, sol–gel transition temperature, gelling capacity and rheological properties. An optimized formulation was selected and investigated its physicochemical properties before and after autoclaving, eye irritation potency in SIRC cells and rabbits. In vivo ophthalmic absorption was performed in rabbits. It was found that physicochemical properties of DS in situ gels were affected by formulation compositions. Increment of Pluronic F127 content decreased sol–gel transition temperature of the products while increase in Pluronic F68 concentration tended to increase sol–gel transition temperature. In this study, Carbopol 940 did not affect sol–gel transition temperature but it affected transparency, pH, and gelling capacity of the products. The optimized formulation exhibited sol–gel transition at 32.6 ± 1.1 °C with pseudoplastic flow behavior. It was lost diclofenac sodium content during autoclaving. However, it was accepted as safe for ophthalmic use and could increase diclofenac sodium bioavailability in aqueous humor significantly. In conclusion, the optimized DS in situ gel had potential for using as an alternative to the conventional diclofenac sodium eye drop. However, autoclaving was not a suitable sterilization method for this product.

Pluronic F127-based thermoresponsive diclofenac sodium ophthalmic in situ gels could improve ophthalmic bioavailability of diclofenac sodium with simple instillation into eyes.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 411, Issues 1–2, 15 June 2011, Pages 128–135
نویسندگان
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