دانلود مقالات ISI درباره C max، حداکثر غلظت پلاسما + ترجمه فارسی

زیست پذیری از مدوتریمیدین در هشت گوسفند پس از مصرف خوراکی غذا

The bioavailability of medetomidine in eight sheep following oesophageal administration

Keywords: C max، حداکثر غلظت پلاسما; Cmax, maximum plasma concentration; EDTA, ethylenediaminetetraacetic acid; HPLC, high performance liquid chromatography; IU, international unitsSheep; Analgesia; Pain; Oral administration; Medetomidine; Osmotic pump

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

تحویل ترشحی تستوسترون

Transdermal delivery of testosterone

Keywords: C max، حداکثر غلظت پلاسما; AUC, area under the plasma concentration time curve; Cmax, maximum plasma concentration; Css′, time averaged steady state testosterone concentrations; DHT, dihydrotestosterone; DMAC, dimethyl acetamide; DMF, dimethyl formamide; DMSO, dimethyl sulphoxide;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

هیدروژل در برنامه های چشم پزشکی

Hydrogels in ophthalmic applications

Keywords: C max، حداکثر غلظت پلاسما; ADH, adipic dihydrazide; AMD, age-related macular degeneration; cmax, maximum plasma concentration; EDC, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide; EGF, epidermal growth factor; ESHU, poly(ethylene glycol)-poly-(serinol hexamethylene urethane); HA, hy

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

ترکیبات دارویی جامد مبتنی بر فسفولیپید برای افزایش قابلیت زیستی دهان: یک متاآنالیز

Phospholipid-based solid drug formulations for oral bioavailability enhancement: A meta-analysis

Keywords: C max، حداکثر غلظت پلاسما; AUC0 → t, area under the plasma concentration time curve; CI, confidence interval; Cmax, maximum plasma concentration; df, degree of freedom; DMPC, dimyristoyl phosphatidylcholine; DMPG, dimyristoyl phosphatidylglycerol; DSPC, distearyl phosphatidylcholin

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2015 سفارش ترجمه

تحویل اینترناسال داروهای سیستمیک: مولکول های کوچک و بیومکرومولکول ها

Intranasal delivery of systemic-acting drugs: Small-molecules and biomacromolecules

Keywords: C max، حداکثر غلظت پلاسما; ACTH, adrenocorticotropic hormone; ALCRV, alginate microspheres containing carvedilol; AUC, area under the plasma concentration vs. time curve; Cmax, maximum plasma concentration; CMC, carboxymethylcellulose; GLA, glutaraldehyde; GnRH, gonadotropin-releas

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2014 سفارش ترجمه

پیشرفت های اخیر در مهندسی نانو مواد فعال دارویی: قول و چالش

Recent advances in the engineering of nanosized active pharmaceutical ingredients: Promises and challenges

Keywords: C max، حداکثر غلظت پلاسما; AFR, aerosol flow reactor; API, active pharmaceutical ingredient; ASES, aerosol solvent extraction system; AUC, area under the curve; BSA, bovine serum albumin; CQA, critical quality attributes; Cmax, maximum plasma concentration; CSD, colloidal silicon d

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2016 سفارش ترجمه

A HPLC-fluorescence method for the quantification of abiraterone in plasma from patients with metastatic castration-resistant prostate cancer

Keywords: C max، حداکثر غلظت پلاسما; AA, abiraterone acetate; Cmin, steady-state plasma trough concentration; Cmax, maximum plasma concentration; CYP17, cytochrome P450 17α-hydroxylase/17,20-lyase; DMSO, dimethylsulfoxide; FDA, Food and Drug Administration; HPLC, high performance liquid chro

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Increased intestinal P-glycoprotein expression and activity with progression of diabetes and its modulation by epigallocatechin-3-gallate: Evidence from pharmacokinetic studies

Keywords: C max، حداکثر غلظت پلاسما; ABCB1, ATP-binding cassette sub-family B member 1; ATP, Adenosine triphosphate; ATPase, Adenosine triphosphatase; AUC, Area under curve; BSA, Bovine serum albumin; cDNA, Complimentary Deoxyribonucleic Acid; Cmax, Maximum plasma concentration; dNTPS, Deoxy

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Identifying the limits for ellagic acid bioavailability: A crossover pharmacokinetic study in healthy volunteers after consumption of pomegranate extracts

Keywords: C max، حداکثر غلظت پلاسما; AUCall, area under the plasma concentration-time curve from the time of dosing to the time of the last observation; BMI, body mass index; Cmax, maximum plasma concentration; EA, ellagic acid; ET, ellagitannin; MRTlast, mean residence time for a molecule t

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Transdermal delivery of Angiotensin Converting Enzyme inhibitors

Keywords: C max، حداکثر غلظت پلاسما; ACE, Angiotensin Converting Enzyme; Ang, angiotensin; Cmax, maximum plasma concentration; cm2, centimetre squared; DSC, Differential Scanning Calorimetry; DC, direct current; EC, ethylcellulose; EDTA, ethylene diamine tetra acetic acid; FDA, Food and Drug

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Rotigotine: The first new chemical entity for transdermal drug delivery

Keywords: C max، حداکثر غلظت پلاسما; ADME, Absorption Distribution Metabolism Excretion; AUC, area under the plasma concentration time curve; BE, bioequivalence; CGI, Clinical Global Improvement; Cmax, maximum plasma concentration; COMT, catechol-O-methyl transferase; EMA, European Medicines

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Influence of body condition on plasma prednisolone and prednisone concentrations in clinically healthy cats after single oral dose administration

Keywords: C max، حداکثر غلظت پلاسما; Lean body mass; Bioelectrical impedance; Glucocorticoids; Validation; Obesity; PharmacokineticsAUC, area-under-the-curve; BIA, bioelectrical impedance analysis; Cmax, maximum plasma concentration; CV%, coefficient of variation percentage; HPLC, high-perfo

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Quantification of cabazitaxel, its metabolite docetaxel and the determination of the demethylated metabolites RPR112698 and RPR123142 as docetaxel equivalents in human plasma by liquid chromatography–tandem mass spectrometry

Keywords: C max، حداکثر غلظت پلاسما; P-gp, P-glycoprotein; mCRPC, metastasized castration resistant prostate cancer; Cmax, maximum plasma concentration; ACN, acetonitrile; TBME, tert-butyl methyl ether; IS, internal standard; AT-IS, 2′,7-bisacetyltaxol; DOC-IS, docetaxel-d9; ESI, electrospra

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Nimodipine nanocrystals for oral bioavailability improvement: Role of mesenteric lymph transport in the oral absorption

Keywords: C max، حداکثر غلظت پلاسما; NMD, nimodipine; HBSS, Hank's balanced salt solution; TEM, transmission electron microscope; Papp, permeability coefficient; Caco-2, human colon adenocarcinoma cell line; TEER, transepithelial electrical resistance; Cmax, maximum plasma concentration; tma

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Semi-mechanistic physiologically-based pharmacokinetic modeling of clinical glibenclamide pharmacokinetics and drug–drug-interactions

Keywords: C max، حداکثر غلظت پلاسما; DDI, drug–drug interaction; CYP450, cytochrome P450; SU, sulfonylurea; PBPK-model, physiologically-based pharmacokinetic model; Cmax, maximum plasma concentration; AUC, area under the plasma concentration time curve; ADME, absorption, distribution, metabo

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Predicting human exposure of active drug after oral prodrug administration, using a joined in vitro/in silico–in vivo extrapolation and physiologically-based pharmacokinetic modeling approach

Keywords: C max، حداکثر غلظت پلاسما; ADME, absorption, distribution, metabolism and excretion; AUC, area under curve; Cmax, maximum plasma concentration; DGM, desglymidodrine; FaSSIF, fasted-state simulated intestinal fluid; HIF, human intestinal fluid; IVIVE, in vitro–in vivo extrapolation;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Effect of a novel 17,20-lyase inhibitor, orteronel (TAK-700), on androgen synthesis in male rats

Keywords: C max، حداکثر غلظت پلاسما; 17-OHP, 17-hydroxyprogesterone; ACTH, adrenocorticotropic hormone; AUC, area under the plasma concentration time curve; BA, bioavailability; CI, confidence interval; Cmax, maximum plasma concentration; CRPC, castration-resistant prostate cancer; DHEA, deh

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

28-Day safety and tolerability of umeclidinium in combination with vilanterol in COPD: A randomized placebo-controlled trial

Keywords: C max، حداکثر غلظت پلاسما; COPD; LAMA; LABA; Umeclidinium; GSK573719; VilanterolAE, adverse event/s; AUC, area under the curve; bpm, beats per minute; CI, confidence interval; Cmax, maximum plasma concentration; COPD, chronic obstructive pulmonary disease; ECG, electrocardiogram; F

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Safety and pharmacokinetics of multiple doses of aclidinium bromide administered twice daily in healthy volunteers

Keywords: C max، حداکثر غلظت پلاسما; Aclidinium bromide; COPD; Safety; PharmacokineticsAE, adverse event; AUCτ, area under the concentration–time curve during the dosing interval; AUC0–∞, area under the curve for time 0 to infinity; Cmax, maximum plasma concentration; COPD, chronic obstructi

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Drug nanocrystals: In vivo performances

Keywords: C max، حداکثر غلظت پلاسما; AN, aqueous nanosuspension; Apo, apolipoprotein; AUC, area under the blood concentration–time curve; BCS, biopharmaceutics classification system; BMM, bone marrow-derived macrophage; CL, clearance rate; Cmax, maximum plasma concentration; CNV, choroidal n

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

Novel strategies for microdose studies using non-radiolabeled compounds

Keywords: C max، حداکثر غلظت پلاسما; ADME, absorption, distribution, metabolism and excretion; AMS, accelerator mass spectrometry; AUC, area under the plasma concentration–time curve; BSEP, bile salt export pump; Cmax, maximum plasma concentration; CYP, cytochrome P450; DIN, drug interaction

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

The mechanism of action of rivaroxaban – an oral, direct Factor Xa inhibitor – compared with other anticoagulants

Keywords: C max، حداکثر غلظت پلاسما; ACS, acute coronary syndrome; aPTT, activated partial thromboplastin time; AT, antithrombin; AUC, area under the curve; bid, twice daily; Cmax, maximum plasma concentration; CrCl, creatinine clearance; CYP, cytochrome P450; IC50, inhibitory concentration

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Coagulation parameters in patients receiving dabigatran etexilate or rivaroxaban: Two observational studies in patients undergoing total hip or total knee replacement

Keywords: C max، حداکثر غلظت پلاسما; od, omne in die (once daily); PT, Prothrombin Time; aPTT, activated Prothrombin Time; TGT, Thrombin Generation Test; DOACs, Direct Oral AntiCoagulants; Cmax, Maximum plasma concentration; Tmax, Time after administration when Cmax is reachedDabigatran; Riv

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Identification of novel circulating coffee metabolites in human plasma by liquid chromatography–mass spectrometry

Keywords: C max، حداکثر غلظت پلاسما; ACN, acetonitrile; CA, caffeic acid; CE, collision energy; CID, collision induced dissociation; Cmax, maximum plasma concentration; COMT, catechol-O-methyltransferase; CGA, chlorogenic acid; CoA, coumaric acid; CQA, caffeoylquinic acid; CQAL, caffeoylquin

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Nutrient plasma levels achieved during treatment that reduces noise-induced hearing loss

Keywords: C max، حداکثر غلظت پلاسما; ANOVA, analysis of variance; AREDS, Age-Related Eye Disease Study; AUC, area under the concentration time curve; CAP, compound action potential; Cmax, maximum plasma concentration; df, degrees of freedom; DPOAE, distortion product otoacoustic emission; HP

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2011 سفارش ترجمه

Transdermal iontophoresis of dexamethasone sodium phosphate in vitro and in vivo: Effect of experimental parameters and skin type on drug stability and transport kinetics

Keywords: C max، حداکثر غلظت پلاسما; AUC0–inf, area under a curve from time = 0 to time infinity; Cl−, chloride ion; C, concentration; Cmax, maximum plasma concentration; Cp, plasma concentration; CV, coefficient of variation; DEX-P, dexamethasone sodium phosphate; HPLC, high performance liq

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Using transdermal iontophoresis to increase granisetron delivery across skin in vitro and in vivo: Effect of experimental conditions and a comparison with other enhancement strategies

Keywords: C max، حداکثر غلظت پلاسما; ACE, acetaminophen; ACN, acetonitrile; AUC0_inf, area under a curve from time 0 to time infinity; BA, bioavailability; Cmax, maximum plasma concentration; Cp, plasma concentration of granisetron; EM, electromigration; EO, electroosmosis; GST, granisetron;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Predicting safety toleration of pharmaceutical chemical leads: Cytotoxicity correlations to exploratory toxicity studies

Keywords: C max، حداکثر غلظت پلاسما; ADME, absorption, distribution, metabolism and excretion; ATP, adenosine triphosphate; AUC (0–24 h), area under the plasma concentration curve from 0 to 24 h; b.i.d., twice daily; cGMP, cyclic guanosine monophosphate; Cmax, maximum plasma concentration; C

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Drug interactions among the epidermal growth factor receptor inhibitors, other biologics and cytotoxic agents

Keywords: C max، حداکثر غلظت پلاسما; EGFR inhibitors; Combination regimen; Drug interaction; Pharmacokinetics; Pharmacodynamics; Drug sequenceABC, ATP binding cassette; AUC, area under the curve; CR, complete response; Cmax, maximum plasma concentration; EGFR, epidermal growth factor recepto

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Ibuprofen-induced hypersensitivity syndrome

Keywords: C max، حداکثر غلظت پلاسما; ADR, adverse drug reaction; AUC, area under the concentration-time curve; Cmax, maximum plasma concentration; CoA, coenzyme A; COX-1, cyclooxygenase-1; COX-2, cyclooxygenase-2; CYP, cytochrome P450; HSRs, hypersensitivity reactions; NSAID, nonsteroidal an

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2010 سفارش ترجمه

Exploration of 4,4-disubstituted pyrrolidine-1,2-dicarboxamides as potent, orally active Factor Xa inhibitors with extended duration of action

Keywords: C max، حداکثر غلظت پلاسما; FXa, Factor Xa; DTI, direct thrombin inhibitor; Cmax, maximum plasma concentration; Cmin, minimum plasma concentration; Cmax/Cmin, peak-to-trough plasma concentration ratio; PT, prothrombin time; 2 × PT, concentration required to give a doubling of the pr

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

Snapshot PK: a rapid rodent in vivo preclinical screening approach

Keywords: C max، حداکثر غلظت پلاسما; AUC, area under the plasma concentration time curve; CL, clearance; Vss, volume of distribution at steady-state; T1/2, half-life of elimination; Cmax, maximum plasma concentration; Tmax, time at which Cmax occurs; Clast, the last observed plasma concentra

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Advances in lipid nanodispersions for parenteral drug delivery and targeting

Keywords: C max، حداکثر غلظت پلاسما; PEG, polyethylene glycol; CMC, critical micelle concentration; PIT, phase-inversion temperature; PE, phosphatidylethanolamine; MTD, maximum tolerated dose; Cmax, maximum plasma concentration; AUC, area under the plasma concentration–time curve; EPR, enhan

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2008 سفارش ترجمه

Measurement of voriconazole in serum and plasma

Keywords: C max، حداکثر غلظت پلاسما; CYP, cytochrome P-450; Cmax, maximum plasma concentration; AUC, area under the curve; LOD, limit of detection; LOQ, limit of quantitation; SD, standard deviation; CV, coefficient of variation; RT, ambient (room) temperature; EDTA, potassium ethylenediamin

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه