Keywords: مهار کننده کولنر; Anthrax; Edema factor; Covalent inhibitor;
مقالات ISI مهار کننده کولنر (ترجمه نشده)
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در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: مهار کننده کولنر; Boc; tert-butyloxycarbonyl; Cbz; carboxybenzyl; CC50; half maximal cytoxicity concentration; EC50; half maximal effective concentration; EDC; N-(3-Dimethylaminopropyl)-Nâ²-ethylcarbodiimide hydrochloride; IBX; 2-iodoxybenzoic acid; Ki; inhibitory constan
Keywords: مهار کننده کولنر; PTP; STEP; Covalent inhibitor; Irreversible; Probe;
Keywords: مهار کننده کولنر; Covalent inhibitor; Targeted covalent inhibitor (TCI); Mechanism-based inhibitor; kinact/Ki; Warhead reactivity; Activity-based protein profiling (ABPP); Click chemistry;
Structure-based design and synthesis of macrocyclic human rhinovirus 3C protease inhibitors
Keywords: مهار کننده کولنر; Rhinovirus 3C protease; Protease inhibition; Covalent inhibitor; Macrocycle; Structure-based drug design; Solid phase synthesis;
Quinone skeleton as a new class of irreversible inhibitors against Staphylococcus aureus sortase A
Keywords: مهار کننده کولنر; SrtA; sortase A; SpA; protein A; HTS; high-throughput screening; FRET; fluorescence resonance energy transfer; IC50; half maximal inhibitory concentration; MTSET; N,N,N-trimethyl-2-(methylsulfonylthio)ethanaminium chloride; ESI-LC-MS; electrospray ionizat
Structure-activity relationships in a new class of non-substrate-like covalent inhibitors of the bacterial glycosyltransferase LgtC
Keywords: مهار کننده کولنر; Glycosyltransferase; Covalent inhibitor; Structure-activity relationship; Bacterial virulence; Serum resistance;
Discovery and optimization of selective FGFR4 inhibitors via scaffold hopping
Keywords: مهار کننده کولنر; Hepatocellular carcinoma; Fibroblast growth factor 19; Fibroblast growth factor receptor 4; Covalent inhibitor; Isoform selective;
Insight into the mode of action and selectivity of PBRM, a covalent steroidal inhibitor of 17β-hydroxysteroid dehydrogenase type 1
Keywords: مهار کننده کولنر; 17β-Hydroxysteroid dehydrogenase; Steroid; Covalent inhibitor; Irreversible inhibitor; Breast cancer; Endometriosis;
Covalent inhibitors of LgtC: A blueprint for the discovery of non-substrate-like inhibitors for bacterial glycosyltransferases
Keywords: مهار کننده کولنر; Covalent inhibitor; Enzyme; Glycosyltransferase; Chemical tool; Virulence factor;
Recent progress on third generation covalent EGFR inhibitors
Keywords: مهار کننده کولنر; EGFR; Covalent inhibitor; T790M; Oncogenic mutation; Lung cancer; NSCLC; SBDD; Drug resistance;
Preparation and evaluation of deconstruction analogues of 7-deoxykalafungin as AKT kinase inhibitors
Keywords: مهار کننده کولنر; Pyranonaphthoquinone lactone; Covalent inhibitor; AKT kinase; Deconstruction analogues; 7-Deoxykalafungin;
Heteroarylureas with spirocyclic diamine cores as inhibitors of fatty acid amide hydrolase
Keywords: مهار کننده کولنر; FAAH; Hydrolase; Covalent inhibitor; Spirocycles;
Crystal structure of cathepsin A, a novel target for the treatment of cardiovascular diseases
Keywords: مهار کننده کولنر; Serine carboxypeptidase; Crystal structure; Heart failure; Drug discovery; Endothelin; Tetrahedral intermediate; Covalent inhibitor;
Benzoquinones as inhibitors of botulinum neurotoxin serotype A
Keywords: مهار کننده کولنر; Benzoquinone; Irreversible inhibitor; Covalent inhibitor; Naphthoquinone; Juglone; Naphthazarin; Botulinum neurotoxin; Fragment-based design; Rational design; Computational docking; Cysteine targeting
Design, synthesis and biological evaluation of FLT3 covalent inhibitors with a resorcylic acid core
Keywords: مهار کننده کولنر; FLT3; Covalent inhibitor; Michael acceptor; Maleimide; Acrylamide; Resorcylic acid lactones;
Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibition
Keywords: مهار کننده کولنر; Cathepsin K; Covalent inhibitor; Molecular complexity; Structure based design; hERG; Pharmacokinetics; Matched molecular pair analysis; MMPA; Synthesis;
(+)-Arisugacin A—Computational evidence of a dual binding site covalent inhibitor of acetylcholinesterase
Keywords: مهار کننده کولنر; Arisugacin A; Acetylcholinesterase inhibitor; Alzheimer’s disease; Dual binding site; Covalent inhibitor
Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening
Keywords: مهار کننده کولنر; Macrophage migration inhibitory factor; MIF; X-ray crystallography; Tautomerase; Virtual screening; Docking; Enzyme inhibition; Covalent inhibitor; Alkylation
5-Aminopyrimidin-2-ylnitriles as Cathepsin K inhibitors
Keywords: مهار کننده کولنر; Cathepsin K; Cheminformatics; Covalent inhibitor; Covalent adduct; Cysteine protease; Electrophilicity; Glutathione; Leatherface; Matched molecular pair analysis; MMPA; MoCoM; Molecular core matching; Molecule editor; SMARTS
Design of selective Cathepsin inhibitors
Keywords: مهار کننده کولنر; Cathepsin; Cathepsin B; Cathepsin K; Cathepsin L; Cathepsin L2; Cathepsin S; Cathepsin V; Cysteine protease; Nitrile; Covalent inhibitor; Selectity; Protein structure; X-ray crystallography; Structure-based design; Hydrogen bonding; Hot spot; Electrostati
Dipeptidyl nitrile inhibitors of Cathepsin L
Keywords: مهار کننده کولنر; Cathepsin; Cathepsin B; Cathepsin K; Cathepsin L; Cathepsin L2; Cathepsin S; Cathepsin V; Cysteine protease; Nitrile; Covalent inhibitor; Selectivity; Protein structure; X-ray crystallography; Structure-based design; Molecular pincer; Conformational lock;
Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH)
Keywords: مهار کننده کولنر; FAAH inhibitor; Fatty acid amide hydrolase; Urea; Activity-based protein profiling; Covalent inhibitor
Isothiazoles as active-site inhibitors of HCV NS5B polymerase
Keywords: مهار کننده کولنر; HCV; NS5B; NS5B inhibitor; HCV NS5B polymerase; HCV NS5B inhibitors; Isothiazole; NS5B active-site inhibitor; Covalent inhibitor