کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1374342 981917 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
(+)-Arisugacin A—Computational evidence of a dual binding site covalent inhibitor of acetylcholinesterase
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
(+)-Arisugacin A—Computational evidence of a dual binding site covalent inhibitor of acetylcholinesterase
چکیده انگلیسی

A computation docking study of the highly potent, non-nitrogen containing, acetylcholinesterase inhibitor (+)-arisugacin A is presented. The model suggests that (+)-arisugacin A is a dual binding site covalent inhibitor of AChE. These findings are examined in the context of Alzheimer’s disease-modifying therapeutic design. (+)-Arisugacin A’s revealed mode of action is unique, and may serve as a basis for the development of AD therapeutics capable of treating the symptomatic aspects of AD, while being neuroprotective with long term efficacy.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 9, 1 May 2011, Pages 2687–2691
نویسندگان
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