The Role of Cyclooxygenase-2 in Colorectal Carcinogenesis
Keywords: Cancer; COX-2; Invasion; Proliferation; Prostaglandin;
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Early life stress and later peer distress on depressive behavior in adolescent female rats: Effects of a novel intervention on GABA and D2 receptors
Keywords: BLA; basolateral amygdala; CON; control, animal facility reared control group; COX-2; cyclodeoxygenase-2; COX-2I; cyclodeoxygenase-2 inhibitor; DMSO; dimethyl sulfoxide; D2; dopamine type 2 receptor; D3; dopamine type 3 receptor; DR; dorsal raphe nucleus;
Immunomodulatory effects of xanthan gum in LPS-stimulated RAW 264.7 macrophages
Keywords: Xanthan gum (PubChem CID7107); Nitric oxide (PubChem CID145068); XG; xanthan gum; SEM; scanning electron microscopy; LPS; lipopolysaccharide; TLR4; Toll-like receptor 4; IL-1; βinterleukin-1β; IL-6; interleukin-6; TNF-α; tumor necrosis factor α; iNOS;
Pathological α-synuclein exacerbates the progression of Parkinson's disease through microglial activation
Keywords: AKT; protein kinase B; AP-1; activator protein-1; BV-2; immortalized murine microglia cell line; CD11b; cluster of differentiation 11b; CD36; cluster of differentiation 36; CD44; cluster of differentiation 44; CD68; cluster of differentiation 68; CNS; cen
Bifidobacterium adolescentis IM38 ameliorates high-fat diet-induced colitis in mice by inhibiting NF-κB activation and lipopolysaccharide production by gut microbiota
Keywords: Bifidobacterium adolescentis; Gut microbiota; Lipopolysaccharide; Colitis; Obesity; NF-κB activation; ANOVA; one-way analysis of variance; CFU; colony-forming unit; COX-2; cyclooxygenase-2; ELISA; enzyme-linked immunosorbent assay; ERK; extracellular sig
Lipidomics in translational research and the clinical significance of lipid-based biomarkers
Keywords: 5-HETE; 5-hydroxyicosatetraenoic acid; 12-HETE; 12-hydroxyicosatetraenoic acid; 15-HETE; 15-hydroxyicosatetraenoic acid; aa; diacyl; ae; acyl-alkyl; ACs; acylcarnitines; ACOG; The American College of Obstetricians and Gynecologists; AD; Alzheimer's dise
Trans-chalcone added in topical formulation inhibits skin inflammation and oxidative stress in a model of ultraviolet B radiation skin damage in hairless mice
Keywords: ABTS; 2,2â²-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid); COX-2; Cyclooxygenase-2; FRAP; Ferric reducing antioxidant power; Gpx; Glutathione peroxidase; Gr; Glutathione reductase; GSH; Reduced glutathione; HO-1; Heme oxygenase-1; LPO; Lipid peroxid
Nrf2 signaling pathway: Pivotal roles in inflammation
Keywords: ARE; antioxidant response element; CBP; cAMP-response-element-binding protein binding protein; COX-2; cyclooxygenase 2; Gclc; glutamate cysteine ligase catalytic subunit; Gclm; glutamate cysteine ligase regulatory subunit; GSH; glutathione; HO-1; heme oxy
Inhibition of proinflammatory mediators by coumaroyl lupendioic acid, a new lupane-type triterpene from Careya arborea, on inflammation-induced animal model
Keywords: NO; nitric oxide; MPO; myeloperoxidase; PGE2; prostaglandin E2; COX; cycloxygenase; TNF; tumor necrosis factor; IL; interleukin; NF-ҡB; nuclear factor-kappa beta; Coumaroyl lupendioic acid; Carrageenan; Betulinic acid; PGE2; COX-2; TNF-α; NF-ҡB;
Prostaglandin E2 Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice
Keywords: Inflammation; Tumorigenesis; Villus Regeneration; Mouse Model; ANKRD1; ankyrin repeat domain 1; APC; adenomatous polyposis coli; ChIP; chromatin immunoprecipitation; COX-2; cyclooxygenase 2; CREB; cyclic adenosine monophosphate response element binding pr
Src-family tyrosine kinases and the Ca2Â + signal
Keywords: 5-HT6; serotonin receptor 6; A23187; 5-(methylamino)-2-({(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl}methyl)-1,3-benzoxazole-4-carboxylic acid; ADPR; ADP-ribose; AMPA; α-amino-3-hydr
Is osseointegration inflammation-triggered?
Keywords: Implant; Inflammatory response; Regeneration; COX-2; PGE2; MMP-9; Angiogenesis;
Ozone-induced damage in 3D-Skin Model is prevented by topical vitamin C and vitamin E compound mixtures application
Keywords: O3; ozone; MIXs; antioxidant mixtures; RHE; reconstructed human epidermis; OS; oxidative stress; ROS; reactive oxygen species; HNE; 4-hydroxy2-nonenal; HNE-PA; 4-hydroxy2-nonenal protein adducts; ELISA; enzyme-linked immunosorbent assay; NF-κB; nuclear f
Prostaglandin E Receptor EP4 expression, survival and pattern of recurrence in locally advanced NSCLC
Keywords: Nonsmall cell lung cancer; EP4 receptor; COX-2; Stage 3; Prognosis; Treatment;
Hydrolysis of lipoproteins by sPLA2's enhances mitogenesis and eicosanoid release from vascular smooth muscle cells: Diverse activity of sPLA2's IIA, V and X
Keywords: ALDH; aldehyde dehydrogenase; COX-2; cyclooxygenase-2; DHA; docosahexaenoic acid; DNA; deoxyribonucleic acid; EPA; eicosapentaenoic acid; ESI; electrospray ionization; GroPCho; glycerophosphocholine; GSH; glutathione; HDL; high density lipoprotein; HNE; 4
A randomized controlled trial of the effects of n-3 fatty acids on resolvins in chronic kidney disease
Keywords: Resolvins; Fish oil; Inflammation resolution; Renal disease; EPA; eicosapentaenoic acid; DHA; docosahexaenoic acid; LC-MS/MS; liquid chromatography-tandem mass spectrometry; 18-HEPE; 18R/S-hydroxy-5Z, 8Z, 11Z, 14Z, 16E-eicosapentaenoic acid; 17-HDHA;
NSAIDs diclofenac, indomethacin, and meloxicam highly upregulate expression of ICAM-1 and COX-2 induced by X-irradiation in human endothelial cells
Keywords: Radiation; COX inhibitor; COX-2; ICAM-1; Endothelial cells; NSAIDs; COX; Cyclooxygenase; DMSO; dimethyl sulfoxide; HUVEC; human umbilical vein endothelial cell; IC80; the concentration that inhibit 80% of activity; ICAM-1; intercellular adhesion molecule-
15-O-Acetyl-3-O-benzoylcharaciol and helioscopinolide A, two diterpenes isolated from Euphorbia helioscopia suppress microglia activation
Keywords: Euphorbia helioscopia; Microglia; Cytokine; iNOS; COX-2; NF-κB;
Zeranol induces COX-2 expression through TRPC-3 activation in the placental cells JEG-3
Keywords: Zeranol; TRP; COX-2; Placental cells;
Polyphenols from Cymbopogon citratus leaves as topical anti-inflammatory agents
Keywords: COX-2; cyclooxygenase-2; iNOS; inducible nitric oxide synthase; NF-κB; nuclear factor kappa B; IKKβ; inhibitor of nuclear factor kappa-B kinase subunit beta; HPLC; high-performance liquid chromatography; PDA; photo-diode array; ESI/MSn; electro-spray io
PRGF exerts more potent proliferative and anti-inflammatory effects than autologous serum on a cell culture inflammatory model
Keywords: Plasma rich in growth factors; Dry eye; Platelet-rich plasma; GVHD; Autologous serum; Eye drops; Inflammation; GVHD; Graft Versus Host Disease; oGVHD; ocular Graft Versus Host Disease; IL; interleukin; TNF-α; tumor necrosis factor-α; COX-2; Cyclooxygena
The role of TWEAK/Fn14 signaling in the MPTP-model of Parkinson's disease
Keywords: COX-2; cycoloxygenase-2; DOPAC; 3,4-dihydrophenylacetic acid; FN14; fibroblast growth factor-inducible 14; HPLC; high-performance liquid chromatography; HRP; horseradish peroxidase; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; NF-κB; nuclear facto
Research articleInsulin on activation of autophagy with integrins and syndecans against MPP+-induced α-synuclein neurotoxicity
Keywords: α-Syn, SNCA; α-synuclein; Cox-2; cyclooxygenase-2; ILK; integrin-linked kinase; ITGAV; integrin αV; ITGB3; integrin β3; LDH; lactate dehydrogenase; MAP1LC3; microtubule-associated protein 1 light chain 3; MPP+; 1-Methyl-4-phenyl pyridinium; SDC1; synd
Simultaneous quantification of PGI2 and TXA2 metabolites in plasma and urine in NO-deficient mice by a novel UHPLC/MS/MS method
Keywords: PGI2; prostacyclin; TXA2; thromboxane A2; IP; PGI receptor; TP; TX receptor; PLA2; phospholipase A2; PGIS; prostacyclin synthase; TXS; thromboxane A synthase; UHPLC/MS/MS; ultra high-performance liquid chromatography coupled to mass spectrometry; TXB2; th
The expression of prostaglandin-E2 and its receptor in the oviduct of Chinese brown frog (Rana dybowskii)
Keywords: COX-1; COX-2; PGE2; EP4; Oviduct; Rana dybowskii
Suppressing Cyclooxygenase-2 Prevents nonalcoholic and inhibits apoptosis of hepatocytes that are involved in the Akt/p53 signal pathway
Keywords: COX-2; Celecoxib; Nonalcoholic steatohepatitis; Apoptosis; Akt; p53;
Effects of pro-inflammatory cytokines, lipopolysaccharide and COX-2 mediators on human colonic neuromuscular function and epithelial permeability
Keywords: Colitis; COX-2; Epithelial permeability; Interleukin 17; Prostaglandins; Prostaglandin ethanolamides;
The role of IL-18 in type 1 diabetic nephropathy: The problem and future treatment
Keywords: COX-2; cyclooxygenase-2; DN; diabetic nephropathy; ICAM-1; intracellular adhesion molecule-1; IL-18BP; IL-18 binding protein; IRAKs; IL-1R-associated kinases; MAPK; mitogen-activated protein kinase; MCP-1; monocyte chemotactic protein-1; MyD99; myeloid di
Calcitonin gene-related peptide contributes to peripheral nerve injury-induced mechanical hypersensitivity through CCL5 and p38 pathways
Keywords: ANOVA; analysis of variance; CatS; cathepsin S; cDMEM; complete Dulbecco's Modified Eagle Media; CGRP; calcitonin gene-related peptide; COX-2; cyclooxygenase 2; ELISA; enzyme-linked immunosorbent assay; ERK; extracellular signal-regulated kinase; IACUC; I
Kinetics and molecular docking studies of fucosterol and fucoxanthin, BACE1 inhibitors from brown algae Undaria pinnatifida and Ecklonia stolonifera
Keywords: BACE1; Alzheimer's disease; Docking analysis; Enzyme kinetic; Fucosterol; Fucoxanthin; AD; Alzheimer's disease; APP; amyloid precursor protein; Aβ; β-amyloid; BACE1; β site amyloid precursor protein cleaving enzyme 1; BBB; blood-brain barrier; COX-2;
Indomethacin based new triazolothiadiazine derivatives: Synthesis, evaluation of their anticancer effects on T98 human glioma cell line related to COX-2 inhibition and docking studies
Keywords: Triazole; Triazolothiadiazine; Glioma; Anticancer; Apoptosis; COX-2
Low-salt diet increases NO bioavailability and COX-2 vasoconstrictor prostanoid production in spontaneously hypertensive rats
Keywords: Low-salt diet; Hypertension; Endothelium; Vascular reactivity; COX-2; Reactive oxygen species;
Up-regulation of HB-EGF by the COX-2/PGE2 signaling associates with the cisplatin resistance and tumor recurrence of advanced HNSCC
Keywords: HNSCC; HB-EGF; COX-2; PGE2; Cisplatin
Sophoraflavanone G from Sophora alopecuroides inhibits lipopolysaccharide-induced inflammation in RAW264.7 cells by targeting PI3K/Akt, JAK/STAT and Nrf2/HO-1 pathways
Keywords: SG; Sophoraflavanone G; LPS; lipopolysaccharide; NO; nitric oxide; PGE2; prostaglandin E2; iNOS; inducible nitric oxide synthase; COX-2; cyclooxygenase-2; TNF-α; tumor necrosis factor-α; IL-6; interleukin-6; IL-1β; interleukin-1β; PI3K; phosphoinositi
TNF-α stimulates colonic myofibroblast migration via COX-2 and Hsp27
Keywords: TNF-α; Migration; COX-2; Myofibroblast; Hsp27
Briarenolides M-T, new briarane diterpenoids from a Formosan octocoral Briareum sp.
Keywords: Briarane; Briarenolide; Briareum; Anti-inflammatory; iNOS; COX-2;
Sphingosine-1-phosphate induces COX-2 expression and PGE2 production in human granulosa cells through a S1P1/3-mediated YAP signaling
Keywords: S1P; COX-2; PGE2; YAP; Granulosa cells;
Evaluation of the anti-inflammatory action of curcumin analog (DM1): Effect on iNOS and COX-2 gene expression and autophagy pathways
Keywords: DM1; Curcumin analog; Peritonitis; Edema; Anti-inflammatory; iNOS; COX-2; Autophagy
Naringin protects ultraviolet B-induced skin damage by regulating p38 MAPK signal pathway
Keywords: UVB; Naringin; COX-2; p38
Research articleFree radical scavenging and COX-2 inhibition by simple colon metabolites of polyphenols: A theoretical approach
Keywords: 3-Hydroxyphenylacetic acid; 4-Hydroxyphenylpropionic acid; Free radical scavenging; DFT; COX-2; Docking;
Photothermal therapeutic effect of PEGylated gold nano-semicubes in chemically-induced skin cancer in mice
Keywords: PEGylated gold nano-semicubes; Skin cancer; TNF-α; COX-2; VEGF; Nitric oxide;
Voluntary exercise blocks Western diet-induced gene expression of the chemokines CXCL10 and CCL2 in the prefrontal cortex
Keywords: CREB; cAMP response element binding protein; CNS; central nervous system; CCL2; chemokine (C-C Motif) ligand 2; CCR2; chemokine (C-C Motif) receptor 2; CTRL; control; CXCL10; C-X-C motif chemokine 10; COX-2; cyclooxygenase 2; EPM; elevated plus maze; EX R
Aplysia kurodai-derived glycosaminoglycans increase the phagocytic ability of macrophages via the activation of AMP-activated protein kinase and cytoskeletal reorganization in RAW264.7 cells
Keywords: AMPK; Aplysia; Glycosaminoglycans; Inflammation; Macrophage; Phagocytosis; AICAR (PubChem CID: 46780289); Compound C (PubChem CID: 11524144); Nocodazole (PubChem CID: 4122); Cytochalasin D (PubChem CID: 5458428); MTT (PubChem CID: 64965); AICAR; 5-aminoim
Phospholipase D1 modulates protein kinase C-epsilon in retinal pigment epithelium cells during inflammatory response
Keywords: COX-2; cyclooxygenase 2; DAG; diacylglycerol; ERK; extracellular signal-regulated kinase; HRP; horseradish peroxidase; LPS; lipopolysaccharide; LPPs; lipid phosphate phosphatases; MEF; membrane-enriched fraction; PA; phosphatidic acid; PC; phosphatidylcho
Cardioprotective actions of curcumin on the pathogenic NFAT/COX-2/prostaglandin E2 pathway induced during Trypanosoma cruzi infection
Keywords: Curcumin; Trypanosoma cruzi; Cardiomyocyte; Cyclooxygenase type 2; Prostaglandin E2; b-type natriuretic peptide; [Ca2+]i; intracellular calcium concentration; BNP; b-type natriuretic peptide; COX-2; cyclooxygenase type 2; Cur; curcumin; dnNFAT; dominant n
Anti-neuroinflammatory effect of Sophoraflavanone G from Sophora alopecuroides in LPS-activated BV2 microglia by MAPK, JAK/STAT and Nrf2/HO-1 signaling pathways
Keywords: Sophoraflavanone G; Neuroinflammation; BV2; LPS; SG; Sophoraflavanone G; LPS; lipopolysaccharide; NO; nitric oxide; PGE2; prostaglandin E2; iNOS; inducible nitric oxide synthase; COX-2; cyclooxygenase-2; TNF-α; tumor necrosis factor-α; IL-6; interleukin
A new steroidal saponin, furotrilliumoside from Trillium tschonoskii inhibits lipopolysaccharide-induced inflammation in Raw264.7 cells by targeting PI3K/Akt, MARK and Nrf2/HO-1 pathways
Keywords: FT; furotrilliumoside; LPS; lipopolysaccharide; NO; nitric oxide; iNOS; inducible nitric oxide synthase; COX-2; cyclooxygenase-2; TNF-α; tumor necrosis factor-α; IL-6; interleukin-6; IL-1β; interleukin-1β; PI3K; phosphoinositide-3-kinase; MARK; mitoge
Iridoid glycosides from the flowers of Gentiana macrophylla Pall. ameliorate collagen-induced arthritis in rats
Keywords: RA; rheumatoid arthritis; DMARDs; disease-modifying anti-rheumatic drugs; NSAIDs; non-steroidal anti-inflammatory drugs; GMI; iridoid glycosides from Gentiana macrophylla Pall.; COX-2; cyclooxygenase-2; iNOS; inducible nitric oxide; IL-1β; interleukin-1Î
Role of histamine H4 receptor ligands in bleomycin-induced pulmonary fibrosis
Keywords: COX-2; cyclooxygenase-2; H4R; histamine H4 receptor; 8OHdG; 8-hydroxy-2⿲-deoxyguanosine; JNJ7777120; 1-[(5-chloro-1H-indol-2yl)carbonyl]-4methylpiperazine; MPO; myeloperoxidase; PGE2; prostaglandin E2; ROS; reactive oxygen species; TBARS; thiobarbituric
The role of epsilon PKC in acute and chronic diseases: Possible pharmacological implications of its modulators
Keywords: PKC; protein kinase C; IPC; ischemic pre conditioning; RACK; receptor for activated C-kinase; DAG; diacylglycerol; beta COP; coatomer subunit beta; CHOK1; chinese hamster ovary K1; CVD; cardiovascular disease; mKATP; ATP-sensitive mitochondrial potassium