Compounds from the insect Blaps japanensis with COX-1 and COX-2 inhibitory activities
Keywords: Blaps japanensis; Insects; N-Acetyldopamine dimers; COX-1; COX-2;
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The CC-genotype of the cyclooxygenase-2 gene associates with decreased risk of nasopharyngeal carcinoma in a Tunisian population
Keywords: Nasopharyngeal carcinoma; Cox-2; T8473 C polymorphism; AssociationCancer du nasopharynx; Cyclooxygénase-2; Polymorphisme T8473 C; Association
Two cinnamoyloctopamine antioxidants from garlic skin attenuates oxidative stress and liver pathology in rats with non-alcoholic steatohepatitis
Keywords: Nonalcoholic steatohepatitis; Garlic skin; N-trans-Feruloyloctopamine; Antioxidant; Hepatic oxidative stress; COX-2;
Anti-inflammatory action of Justicia acuminatissima leaves
Keywords: Justicia; Inflammation; Nitric oxide; COX-2
COX-2 gene promoter DNA methylation status in eutopic and ectopic endometrium of Egyptian women with endometriosis
Keywords: COX-2; cyclooxygenase-2; PGs; prostaglandins; MS-PCR; methylation specific polymerase chain reaction; NF-kB; nuclear factor-Kappa beta; NF-IL6; nuclear factor for interleukin-6 expression; CRE; cyclic AMP response element; Endometriosis; DNA hypomethylati
Malloapelta B suppresses LPS-induced NF-κB activation and NF-κB-regulated target gene products
Keywords: NF-κB; nuclear factor-κB; IκBα; inhibitor of NF-κB alpha; AP-1; activator protein-1; IKK; IκB kinase; LPS; lipopolysaccharide; TNF-α; tumor necrosis factor-α; IL-6; interleukin 6; IL-1β; interleukin 1β; COX-2; cyclooxygenase-2; iNOS; inducible n
Alteration of delta-6-desaturase (FADS2), secretory phospholipase-A2 (sPLA2) enzymes by Hot-nature diet with co-supplemented hemp seed, evening primrose oils intervention in multiple sclerosis patients
Keywords: AA; arachidonic acid; ALA; alpha- linolenic acid; BBB; blood-brain barrier; CNS; central nervous system; COX-2; cyclooxygenase-2; D6D (FADS2); delta -6-desaturase; D5D (FADS1); delta -5-desaturase; DGLA; dihomo-gammalinolenic acid; DHA; docosa-hexanoic
Schistosome infection-derived Hepatic Stellate Cells are cellular source of prostaglandin D2: Role in TGF-β-stimulated VEGF production
Keywords: COX-2; Cyclooxygenase-2; cysLT; cysteinyl-leukotriene; GM-CSF; Granulocyte-macrophage colony-stimulating factor; GR-HSCs; Hepatic Stellate Cells derived from liver granulomas of S. mansoni infected mice; HPGDS; Hematopoietic Prostaglandin D synthase; HSCs
Tormentic acid reduces inflammation in BV-2 microglia by activating the liver X receptor alpha
Keywords: MTT; 3-(4,5-dimethylthiazol-2-y1)-2,5-diphenyltetrazolium bromide; IL-1β; interleukin 1beta; CNS; central nervous system; COX-2; Cyclooxygenase-2; ELISA; enzyme-linked immunosorbent assays; HRP; horseradish peroxidase-conjugated; LPS; lipopolysaccharide;
Mitochondrial ROS govern the LPS-induced pro-inflammatory response in microglia cells by regulating MAPK and NF-κB pathways
Keywords: cDNA; complementary DNA; Cox-2; cyclooxygenase-2; DMEM; Dulbecco's modified Eagle's medium; ERK; extracellular signal-regulated kinase; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; IL; interleukin; iNOS; inducible nitric oxide synthase; IκB; nuclear
Optical imaging of COX-2: Studies on an autofluorescent 2,3-diaryl-substituted indole-based cyclooxygenase-2 inhibitor
Keywords: Fluorescence; Luminescence; Phorbol myristate ester-induced COX-2 expression; Melanoma-associated inflammation; Rodent melanoma xenograft model; COX-2; cyclooxygenase-2; DMSO; dimethyl sulfoxide; FWHM; full width at half maximum; TPA; 12-O-Tetradecanoylph
N-adamantyl-4-methylthiazol-2-amine suppresses lipopolysaccharide-induced brain inflammation by regulating NF-κB signaling in mice
Keywords: Neuroinflammation; Thiazole derivative; NF-κB; INOS; COX-2
Activating PTEN by COX-2 inhibitors antagonizes radiation-induced AKT activation contributing to radiosensitization
Keywords: Radiation; PTEN; AKT; COX-2; Celecoxib; Valdecoxib;
Identification of evodiamine as the bioactive compound in evodia (Evodia rutaecarpa Benth.) fruit extract that activates human peroxisome proliferator-activated receptor gamma (PPARγ)
Keywords: COX-2; cyclooxygenase-2; ERK; extracellular signal-regulated kinase; EGFR; epidermal growth factor receptor; FABP1; human fatty acid binding protein 1; HMGCS2; 3-hydroxy-3-methylglutaryl-CoA synthase 2; HPRT1; hypoxanthine phosphoribosyltransferase; LBD;
Evidence of different mediators of central inflammation in dysfunctional and inflammatory pain - Interleukin-8 in fibromyalgia and interleukin-1 β in rheumatoid arthritis
Keywords: HRV; heart rate variability; RA; rheumatoid arthritis; FM; fibromyalgia; CSF; cerebrospinal fluid; IL; interleukin; IL-1Ra; interleukin 1 receptor antagonist; TNF; tumor necrosis factor; CCL-2; chemokine (C-C motif) ligand 2; BDNF; brain-derived neurotr
Diverse roles of LPA signaling in the intestinal epithelium
Keywords: LPA; lysophosphatidic acid; IEC; intestinal epithelial cell; IBD; inflammatory bowel disease; CRC; colorectal cancer; PA; phosphatidic acid; PLA; phospholipase A; ATX; autotaxin; YAMC; young adult mouse colonic epithelium; MSIE; mouse small intestinal epi
Selenium deficiency sensitizes the skin for UVB-induced oxidative damage and inflammation which involved the activation of p38 MAPK signaling
Keywords: CAT; catalase; COX-2; cyclooxygenase-2; DCFH-DA; 2â², 7â²-dichlorodihydrofluorescein diacetate; ERK; extracellular signal regulated kinase; GPx; glutathione peroxidase; GSH; glutathione; GST; glutathione S-transferase; IL-1β; interleukin-1beta; iNOS; i
Blackberry extract inhibits UVB-induced oxidative damage and inflammation through MAP kinases and NF-κB signaling pathways in SKH-1 mice skin
Keywords: Blackberry extract; Ultraviolet radiation; Inflammation; COX-2; NF-κB;
Modulation of the xenobiotic transformation system and inflammatory response by ochratoxin A exposure using a co-culture system of Caco-2 and HepG2 cells
Keywords: CYP450; NAT2; COX-2; LOX-5; MRP2; TEER measurement;
Cancer-promoting effect of capsaicin on DMBA/TPA-induced skin tumorigenesis by modulating inflammation, Erk and p38 in mice
Keywords: Capsaicin; DMBA/TPA; Skin inflammation; Tumorigenesis; COX-2; iNOS;
Ethanol enhances arsenic-induced cyclooxygenase-2 expression via both NFAT and NF-κB signalings in colorectal cancer cells
Keywords: Arsenic; Ethanol; COX-2; NFAT; NF-κB;
MicroRNA-146a reduces IL-1 dependent inflammatory responses in the intervertebral disc
Keywords: ADAMTS; a disintergrin and metalloproteinase with thrombospondin motifs; ANOVA; analysis of variance; COX-2; cyclooxygenase-2; Ct; threshold cycle; DAB; 3, 3â²-diaminobenzidine; DMEM; Dulbecco's modified eagle medium; IHC; immunohistochemical; EGFR; epid
ReviewChemoprevention targets for tobacco-related head and neck cancer: Past lessons and future directions
Keywords: Chemoprevention; Head and neck cancer; Oral premalignant lesion; Retinoid; COX-2; EGFR; Phytochemical; Green tea; Sulforaphane;
Research ArticleHepatitis C virus-mediated Aurora B kinase inhibition modulates inflammatory pathway and viral infectivity
Keywords: HCV; hepatitis C virus; HCC; hepatocellular carcinoma; AURKB; Aurora B kinase; PP2; protein phosphatase 2; Chk1; checkpoint kinase 1; NF-κB; nuclear factor-κB; COX-2; cyclooxygenase-2; Hepatitis C; Inflammation; NF-κB; COX-2; Histone modifications;
Isomeric methoxy analogs of nimesulide for development of brain cyclooxygense-2 (COX-2)-targeted imaging agents: Synthesis, in vitro COX-2-inhibitory potency, and cellular transport properties
Keywords: Nimesulide; Methoxy substituted analog; COX-2; Caco-2 cells
Docosahexaenoic acid ester of phloridzin inhibit lipopolysaccharide-induced inflammation in THP-1 differentiated macrophages
Keywords: Phloridzin; Docosahexaenoic acid; Inflammation; Cytokines; COX-2; TNF-α;
Statins meditate anti-atherosclerotic action in smooth muscle cells by peroxisome proliferator-activated receptor-γ activation
Keywords: Statin; PPARγ; COX-2; Smooth muscle cell; Atherosclerosis
Diplacone and mimulone ameliorate dextran sulfate sodium-induced colitis in rats
Keywords: Diplacone (PubChem CID: 14539948); Mimulone (PubChem CID: 5716903); Sulfasalazine (PubChem CID: 5353980); CAT; catalase; CD; Crohn's Disease; COX-2; cyclooxygenase-2; DSS; dextran sulfate sodium; IBD; Inflammatory Bowel Disease; LPS; lipopolysaccharide; M
Sargaquinoic acid attenuates inflammatory responses by regulating NF-κB and Nrf2 pathways in lipopolysaccharide-stimulated RAW 264.7 cells
Keywords: Akt; protein kinase B; BSA; bovine serum albumin; COX-2; cyclooxygenase 2; DAPI; 4,6â²-diamidino-2-phenylindole; DCF-DA; 4,6â²-diamidino-2-phenylindole; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; ECL; enhanced chemiluminescence;
Telmisartan mediates anti-inflammatory and not cognitive function through PPAR-γ agonism via SARM and MyD88 signaling
Keywords: AP-1; activator protein-1; ANOVA; analysis of variance; AT1; angiotensin II receptor 1; BBB; blood brain barrier; C; control; CaCl2; calcium chloride; CMC; carboxy methyl cellulose; CSF; cerebrospinal fluid; JNK/c-Jun; c-Jun N-terminal kinases; COX-2; cyc
TNF-α stimulates MMP-3 production via PGE2 signalling through the NF-kB and p38 MAPK pathway in a murine cementoblast cell line
Keywords: Cementoblasts; TNF-α; MMP-3; Cox-2; PGE2
The aryl hydrocarbon receptor (AhR) mediates resistance to apoptosis induced in breast cancer cells
Keywords: AhR; aryl hydrocarbon receptor; ER; estrogen receptor; TCDD; 2,3,7,8-tetrachlorodibenzo-p-dioxin; MNF; 3â²methyl-4â²nitroflavone; COX-2; cyclooxygenase-2; IDO; indoleamine 2, 3-dioxygenase; Kyn; kynurenine; MNF; 3â²methoxy-4â²nitroflavone; TGFα; tran
Synovial TRPV1 is upregulated by 17-β-estradiol and involved in allodynia of inflamed temporomandibular joints in female rats
Keywords: Estradiol; Synoviocytes ;TRPV1; NGF; COX-2; TMD; temporomandibular disorders; NGF; nerve growth factor; TRPV1; transient receptor potential vanilloid 1; TMJ; temporomandibular joints; CFA; complete Freund's adjuvant; HSP 25; heat shock protein 25; LPS; li
Research PaperIncreasing levels of the endocannabinoid 2-AG is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease
Keywords: 2-AG; 2-arachidonoylglycerol; BOS; base of support; CB; cannabinoid; CE; coefficient of error; CV; coefficient of variance; COX-2; cyclo-oxygenase-2; DOPAC; 3,4-dihydrophenylacetic acid; ECS; endocannabinoid system; FAAH; fatty acid amide hydrolase; HPLC;
Anti-inflammatory effect of desoxo-narchinol-A isolated from Nardostachys jatamansi against lipopolysaccharide
Keywords: COX-2; cyclooxygenase-2; DN; desoxo-narchinol-A; ELISA; enzyme-linked immunosorbent assay; ERK; extracellular signal-regulated kinase; EtOAc; ethyl acetate; FBS; fetal bovine serum; H&E; hematoxylin and eosin; HPRT; hypoxanthine guanine phosphoribosyl-tra
Activation of Nrf2/HO-1signaling pathway involves the anti-inflammatory activity of magnolol in Porphyromonas gingivalis lipopolysaccharide-stimulated mouse RAW 264.7 macrophages
Keywords: LPS; lipopolysaccharide; P. gingivalis; Porphyromonas gingivalis; HO-1; heme oxygenase-1; ROS; reactive oxygen species; RANKL; receptor activator of nuclear factor-κB (RANKL); NF-Îb; nuclear factor-kappa B; Nrf-2; nuclear factor-erythroid 2-related fact
VIP induces NF-κB1-nuclear localisation through different signalling pathways in human tumour and non-tumour prostate cells
Keywords: VIP; vasoactive intestinal peptide; EPAC; cAMP/exchange protein directly activated by cAMP; NF-κB; nuclear factor-κB; PKA; cAMP-dependent protein kinase; ERK; extracellular-signal regulated kinase; PI3-K; phosphoinositide 3-kinase; GEF; PKA-independent
Hepatitis C virus NS3 protein enhances cancer cell invasion by activating matrix metalloproteinase-9 and cyclooxygenase-2 through ERK/p38/NF-κB signal cascade
Keywords: AP-1; activation protein-1; CMA; cell matrix adhesion; COX-2; cyclooxygenase-2; ECM; extracellular matrix; ELISA; enzyme-linked immunosorbent assay; EMSA; electrophoretic mobility shift assay; ERK; extracellular signal-regulated kinase; HBV; hepatitis B v
Reactive oxygen species induce Cox-2 expression via TAK1 activation in synovial fibroblast cells
Keywords: COX, cyclooxygenase; HA, hyaluronic acid; NAC, N-acetyl cysteamine; OA, osteoarthritis; PGs, prostaglandins; RA, rheumatoid arthritis; ROS, reactive oxygen species; SFs, synovial fibroblast cellsReactive oxygen species; Cox-2; TAK1; Synovial tissues; OA m
Low level of trans-10, cis-12 conjugated linoleic acid decreases adiposity and increases browning independent of inflammatory signaling in overweight Sv129 mice
Keywords: AUC; area under the curve; BAT; brown adipose tissue; 10,12 CLA; trans-10, cis-12 conjugated linoleic acid; Cidea; cell death-induced DNA fragmentation factor-a-like effector A; Cox8b; cytochrome c oxidase subunit VIII b; COX-2; cyclooxygenase-2; CPT; car
Nonenzymatic lipid mediators, neuroprostanes, exert the antiarrhythmic properties of docosahexaenoic acid
Keywords: 4(RS)-4-F4t-NeuroP; 4(RS)-4-F4t-neuroprostane; Ï3 PUFA; Ï3 polyunsaturated fatty acid; AAP; antiarrhythmic properties; COX-2; cyclooxygenase; CYP450; cytochrome P450; DHA; docosahexaenoic acid; DNP; carbonylated RyR; ECG; electrocardiograms; EF; ejectio
COX-2 inhibitors from the leaves of Pellacalyx saccardianus Scortech (Rhizophoraceae)
Keywords: Pellacalyx saccardianus; Rhizophoraceae; Diarylheptanoid alkaloid; Phytochemicals; Anti-inflammatory activity; COX-2;
Co-administration of subtherapeutic diazepam enhances neuroprotective effect of COX-2 inhibitor, NS-398, after lithium pilocarpine-induced status epilepticus
Keywords: COX-2; cyclooxygenase-2; EEG; electroencephalogram; PGE2; prostaglandin E2; SE; status epilepticus; cyclooxygenase-2 (COX-2); inflammation; neuroprotection;
Oral administration of aflatoxin G1 induces chronic alveolar inflammation associated with lung tumorigenesis
Keywords: Aflatoxin G1; Chronic inflammation; Lung tumorigenesis; Alveolar type II cell; COX-2; Oxidative stress
PDE5 inhibitors as therapeutics for heart disease, diabetes and cancer
Keywords: A1AR; adenosine A1 receptor; ABC transporters; ATP-binding cassette; ABCB1/P-gp/MDR1; P-glycoprotein; ABCG2/BCRP; breast cancer resistant protein; Ang-1; angiopoietin 1; ASCs; Adipose stem cells; Bcl-2; B-cell lymphoma 2; Bcl-xL; B-cell lymphoma extra-lar
Activation of MEK/ERK pathways through NF-κB activation is involved in interleukin-1β-induced cyclooxygenease-2 expression in canine dermal fibroblasts
Keywords: NF-κB; ERK1/2; IL-1β; COX-2; Prostaglandin E2; Canine dermal fibroblasts;
Protective effect of (±)α-tocopherol on brominated diphenyl ether-47-stimulated prostaglandin pathways in human extravillous trophoblasts in vitro
Keywords: BDE-47; brominated diphenyl ether-47; carboxy-H2DCF-DA; 6-carboxy dichlorodihydrofluorescein diacetate; COX-2; cyclooxygenase-2; cPGES; cytosolic prostaglandin E synthase; DCF; dichlorofluorescein; cDCF; carboxydichlorofluorescein; DMSO; dimethyl sulfoxid
Anti-inflammatory sesquiterpenes from Costus speciosus rhizomes
Keywords: ANOVA; analysis of variance; COX-2; cyclooxygenase-2; CNS; central nervous system; COSY; Correlation Spectroscopy; DMEM; Dulbecco's Modified Eagle's Medium; EDTA; ethylenediaminetetraacetate; FBS; fetal bovine serum; HMBC; heteronuclear multiple bond corr
Herb-drug interactions between Scutellariae Radix and mefenamic acid: Simultaneous investigation of pharmacokinetics, anti-inflammatory effect and gastric damage in rats
Keywords: ANOVA; one-way analysis of variance; AUC0ââ; area under the curve from zero to infinity; AUC0â24 [ex vivo PGE2]; area under the curve from zero to last time point (24Â h) of the ex vivo prostaglandin E2 production; COX-2; cyclooxygenase-2; CLtotal;
Synthesis and biological evaluation of phenyl-1H-1,2,3-triazole derivatives as anti-inflammatory agents
Keywords: Diclofenac; Anti-inflammatory drug; NSAID; QSAR; In silico docking; COX-2