Keywords: بازدارنده COX-2; Prostate cancer; Brachytherapy; COX-2 inhibitor; Urinary morbidity; Frequency volume chart; Randomized controlled trial;
مقالات ISI بازدارنده COX-2 (ترجمه نشده)
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Keywords: بازدارنده COX-2; Metformin; COX-2 inhibitor; Obesity; Adipose tissue inflammation; Insulin resistance; Fatty liver
Keywords: بازدارنده COX-2; Celecoxib; COX-2 inhibitor; Potassium channel; Sodium channel; Calcium channel;
Keywords: بازدارنده COX-2; Prostaglandin; Stomach; Side Effects; Treatment; AP; proportion attributable to interaction; ATC; Anatomical Therapeutic Chemical; CI; confidence interval; COX-2 inhibitor; cyclooxygenase-2 selective inhibitor; EHR; electronic health record; GPA; gastropr
Effect of Fluconazole on the Pharmacokinetic Properties of Imrecoxib, a Novel NSAID: A Single-center, Open-label, Self-controlled Study in Healthy Chinese Male Volunteers
Keywords: بازدارنده COX-2; COX-2 inhibitor; drug interaction; fluconazole; imrecoxib; pharmacokinetics; NASID;
Design and biological evaluation of novel hybrids of 1, 5-diarylpyrazole and Chrysin for selective COX-2 inhibition
Keywords: بازدارنده COX-2; Pyrazole; Chysin; COX-2 inhibitor; Antiproliferative; Docking;
Design, synthesis and biological evaluation of novel ferrocene-pyrazole derivatives containing nitric oxide donors as COX-2 inhibitors for cancer therapy
Keywords: بازدارنده COX-2; Pyrazole; Ferrocene; COX-2 inhibitor; NO-Releasing; Anticancer;
Unexpected formation of 1-[4-chloromethylphenyl]-5-[4-(methylsulfonyl)benzyl]-1H-tetrazole and 1-[4-chloromethylphenyl]-5-[4-(aminosulfonyl)phenyl]-1H-tetrazole: Crystal structure, bioassay screening and molecular docking studies
Keywords: بازدارنده COX-2; Tetrazoles; COX-2 inhibitor; Molecular docking; Silicon tetrachloride; Alcohol chlorination; Functional group transformation;
Identification of COX-2 inhibitors via structure-based virtual screening and molecular dynamics simulation
Keywords: بازدارنده COX-2; COX-2 inhibitor; Virtual screening; Molecular dynamic; PASS; ADMET;
Salubrinal and robenacoxib treatment after global cerebral ischemia. Exploring the interactions between ER stress and inflammation
Keywords: بازدارنده COX-2; COX-2 inhibitor; Salubrinal; Blood-brain barrier; Microglia; Inflammation; ER stress;
Research reportAcute effects of aceclofenac, COX-2 inhibitor, on penicillin-induced epileptiform activity
Keywords: بازدارنده COX-2; Aceclofenac; COX-2 inhibitor; Proconvulsant; Epileptiform activity; Acute;
Structural insight into the inhibition of carbonic anhydrase by the COX-2-selective inhibitor polmacoxib (CG100649)
Keywords: بازدارنده COX-2; Polmacoxib; COX-2 inhibitor; CA I; CA II; Crystal structure;
Synthesis and crystal structure of N-[(dimethylamino)methylidene]-4-[1-(4-nitrophenyl)-1H-tetrazol-5-yl]-benzenesulfonamide: Molecular docking and bioassay studies as cyclooxygenase-2 inhibitor
Keywords: بازدارنده COX-2; 1,5-Diaryl tetrazole; COX-2 inhibitor; Molecular docking; Crystal structure; 1,5-Diaryl amide; [(Dimethylamino)methylene]aminosulfonyl
Coumarin sulfonamides derivatives as potent and selective COX-2 inhibitors with efficacy in suppressing cancer proliferation and metastasis
Keywords: بازدارنده COX-2; Coumarin; Sulfonamides; COX-2 inhibitor; Anticancer; Docking simulation
In vivo and in vitro anti-inflammatory effects of Zao-Jiao-Ci (the spine of Gleditsia sinensis Lam.) aqueous extract and its mechanisms of action
Keywords: بازدارنده COX-2; Gleditsia sinensis Lam.; Anti-inflammation; Anti-oxidative; Carrageenan-induced paw edema; COX-2 inhibitor
Molecular characterization, biological activity, and in silico study of 2-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-6-methoxy-4H-chromen-4-one as a novel selective COX-2 inhibitor
Keywords: بازدارنده COX-2; Chromone; Single-crystal XRD; Prostaglandin E2; COX-2 inhibitor; Docking simulation
Pharmacokinetic, Pharmacodynamic, and Safety/Tolerability Profiles of CG100649, a Novel COX-2 Inhibitor: Results of a Phase I, Randomized, Multiple-dose Study in Healthy Korean Men and Women
Keywords: بازدارنده COX-2; carbonic anhydrase; COX-2 inhibitor; NSIADs; prostacyclin; thromboxane;
Enhanced water-soluble derivative of PC407 as a novel potential COX-2 inhibitor injectable formulation
Keywords: بازدارنده COX-2; COX-2 inhibitor; Prodrug; Solubility; Injectable formulation
Pharmacokinetic profiles of the novel COX-2 selective inhibitor cimicoxib in dogs
Keywords: بازدارنده COX-2; Cimicoxib; Pharmacokinetics; Fasted; Fed; COX-2 inhibitor
Effect of cyclooxygenase (COX)-2 inhibition on mouse renal interstitial fibrosis
Keywords: بازدارنده COX-2; Meloxicam (PubChem CID: 54677470)Unilateral ureteral obstruction (UUO); COX-2 inhibitor; Fibrosis; Heat shock protein (HSP) 47; Type IV collagen
Assessment of Common Nonsteroidal Anti-Inflammatory Medications by Whole Blood Aggregometry: A Clinical Evaluation for the Perioperative Setting
Keywords: بازدارنده COX-2; COX-1 inhibitor; COX-2 inhibitor; Nonsteroidal anti-inflammatory; Perioperative risk; Surgical bleeding; Whole blood platelet aggregometryAA, Arachidonic acid; ADP, Adenosine diphosphate; ASA, Aspirin; Col, Collagen; COX, Cyclooxygenase; DDAVP, Desmopress
Inhibition of prostaglandin E2 production by synthetic minor prenylated chalcones and flavonoids: Synthesis, biological activity, crystal structure, and in silico evaluation
Keywords: بازدارنده COX-2; KGGSHPHZXATMIK-UHFFFAOYSA-N; CDPURQCKXKHMIZ-UHFFFAOYSA-N; FCMITIPRVNTWRD-JXMROGBWSA-N; LSXKKBWGLFMMGT-VMPITWQZSA-N; GXAPOUBMDSDMBB-JJFYIABZSA-N; CVHKPRDYBSIPGB-VIZOYTHASA-N; Prenylated chalcone; Minor flavonoids; Single-crystal XRD; Prostaglandin E2; COX-
The SK-N-AS human neuroblastoma cell line develops osteolytic bone metastases with increased angiogenesis and COX-2 expression
Keywords: بازدارنده COX-2; Osteoclasts; Receptor activator of NF-κB ligand; Vascular endothelial growth factor-A; Microvessel density; Adrenal gland; COX-2 inhibitor
Effects of Ketoconazole on the Pharmacokinetic Properties of CG100649, A Novel NSAID: A Randomized, Open-Label Crossover Study in Healthy Korean Male Volunteers
Keywords: بازدارنده COX-2; CG100649; COX-2 inhibitor; drug interaction; ketoconazole; pharmacokinetic;
A prospective, randomized, double-blind, multicenter comparative study on the safety and efficacy of Celecoxib and GCSB-5, dried extracts of six herbs, for the treatment of osteoarthritis of knee joint
Keywords: بازدارنده COX-2; ADR; adverse drug reaction; AE; adverse events; COX-1; cyclooxygenase-1; COX-2 inhibitor; cyclooxygenase-2 inhibitor; FDA; Food and Drug Administration; GEE; generalized estimating equation; ITT; intention to Treat; IL-1beta; inteleukin-1β; K/L; Kellgren
Antiproliferative effect of two novel COX-2 inhibitors on human keratinocytes
Keywords: بازدارنده COX-2; COX-2 inhibitor; 1,5-Diarylpyrrole-3-alkopyrrole-3-alkoxyethyl ethers; Cyclin D1; p21;
Synthesis and biological evaluation of some novel resveratrol amide derivatives as potential anti-tumor agents
Keywords: بازدارنده COX-2; Resveratrol derivatives; COX-2 inhibitor; Anti-tumor; Molecular docking
Pharmacokinetics of intravenous and intramuscular parecoxib in healthy Beagles
Keywords: بازدارنده COX-2; Parecoxib; Valdecoxib; Plasma; HPLC-FL; Dog; COX-2 inhibitor;
Effect of celecoxib add-on treatment on symptoms and serum IL-6 concentrations in patients with major depressive disorder: Randomized double-blind placebo-controlled study
Keywords: بازدارنده COX-2; Add-on; Celecoxib; COX-2 inhibitor; IL-6; Major depressive disorder; Sertraline
Radiosynthesis of a 18F-labeled 2,3-diarylsubstituted indole via McMurry coupling for functional characterization of cyclooxygenase-2 (COX-2) in vitro and in vivo
Keywords: بازدارنده COX-2; Cyclooxygenase-2; COX-2 inhibitor; 18F-radiolabeling; McMurry cyclization; Positron emission tomography;
From COX-2 inhibitor nimesulide to potent anti-cancer agent: Synthesis, in vitro, in vivo and pharmacokinetic evaluation
Keywords: بازدارنده COX-2; COX-2 inhibitor; Nimesulide; Anti-cancer; Xenograft; Pharmacokinetics
Effect of celecoxib on benign prostatic hyperplasia: Results of a preliminary study
Keywords: بازدارنده COX-2; benign prostatic hyperplasia; celecoxib; COX-2 inhibitor; terazosin
Structure-based parallel medicinal chemistry approach to improve metabolic stability of benzopyran COX-2 inhibitors
Keywords: بازدارنده COX-2; Cyclooxygenase; COX-2 inhibitor; Benzopyran; Structure-based design; Parallel solid phase synthesis; Structure–activity relationship; Computer-assisted molecular modeling; Free energy perturbation; Metabolic stability
Inhibition of cyclooxygenase-2 promotes the stimulatory action of adenosine A3 receptor agonist on hematopoiesis in sublethally γ-irradiated mice
Keywords: بازدارنده COX-2; Hematopoiesis; COX-2 inhibitor; Adenosine A3 receptor agonistCOX-1, cyclooxygenase-1; COX-2, cyclooxygenase-2; NSAIDs, non-steroidal anti-inflammatory drugs; GM-CFC, granulocyte/macrophage colony-forming cells (hematopoietic progenitor cells for granulocy
A double prodrug system for colon targeting of benzenesulfonamide COX-2 inhibitors
Keywords: بازدارنده COX-2; COX-2 inhibitor; Colon cancer; Celecoxib; Azoreductase; Cyclization
The inhibitory effect of celecoxib and rosiglitazone on experimental endometriosis
Keywords: بازدارنده COX-2; Apoptosis; cell proliferation; COX-2 inhibitor; endometriosis; PPARγ agonist;
Benefits of Prolonged Postoperative Cyclooxygenase-2 Inhibitor Administration on Total Knee Arthroplasty Recovery : A Double-Blind, Placebo-Controlled Study
Keywords: بازدارنده COX-2; celecoxib; COX-2 inhibitor; total knee arthroplasty; postoperative pain; narcotic use
Inducible COX-2 dominates over COX-1 in prostacyclin biosynthesis: Mechanisms of COX-2 inhibitor risk to heart disease
Keywords: بازدارنده COX-2; Cyclooxygenase-1 (COX-1); COX-2; COX-2 inhibitor; Arachidonic acid (AA); Prostacyclin or prostaglandin I2 (PGI2); PGI2 synthase (PGIS) and FRET;
Selective inhibition of cyclooxygenase-2 suppresses metastatic disease without affecting primary tumor growth in a murine model of Ewing sarcoma
Keywords: بازدارنده COX-2; Antiangiogenesis; Lung metastases; COX-2 inhibitor; mTOR inhibitor; Ewing sarcoma
Phase II Trial of Neoadjuvant Exemestane in Combination With Celecoxib in Postmenopausal Women Who Have Breast Cancer
Keywords: بازدارنده COX-2; Celecoxib; COX-2 inhibitor; Estrogen receptor; Exemestane; Ki-67; Neoadjuvant
Accelerated gene transfer through a polysorbitol-based transporter mechanism
Keywords: بازدارنده COX-2; Gene transfer; Polysorbitol; Transporter; COX-2 inhibitor; Accelerated transfection
The novel benzopyran class of selective cyclooxygenase-2 inhibitors-part I: The first clinical candidate
Keywords: بازدارنده COX-2; Cyclooxygenase; COX-2 inhibitor; Clinical candidate; Benzopyran; Half-life; Plasma protein bound; X-ray crystal structure
The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: The second clinical candidate having a shorter and favorable human half-life
Keywords: بازدارنده COX-2; Cyclooxygenase; COX-2 inhibitor; Clinical candidate; Benzopyran; Half-life; Plasma protein bound; Microsomal; X-ray crystal structure
A selective cyclooxygenase-2 inhibitor suppresses the growth of endometriosis with an antiangiogenic effect in a rat model
Keywords: بازدارنده COX-2; Angiogenesis; COX-2 inhibitor; endometriosis; PGE2; vascularization; VEGF
Hyperesthesia one year after breast augmentation surgery increases the odds for persisting pain at four years: A prospective four-year follow-up study
Keywords: بازدارنده COX-2; Persistent postoperative pain; Sensory changes; Hyperesthesia; Hypoesthesia; Glucocorticoid; COX-2 inhibitor; Odds ratio; Risk factors; Cosmetic surgery; Breast surgery; Augmentation mammoplasty
Mechanism of Kv2.1 channel inhibition by a selective COX-2 inhibitor SC-791—modification of gating
Keywords: بازدارنده COX-2; Potassium channel; COX-2 inhibitor; SC-791
Targeting the prostaglandin E2 EP1 receptor and cyclooxygenase-2 in the amygdala kindling model in mice
Keywords: بازدارنده COX-2; Amygdala kindling; COX-2 inhibitor; EP1 receptor; Prostaglandin E2; Temporal lobe epilepsy
Celecoxib blocks cardiac Kv1.5, Kv4.3 and Kv7.1 (KCNQ1) channels: Effects on cardiac action potentials
Keywords: بازدارنده COX-2; Voltage-gated potassium channel; Kv1.5; Kv4.3; Kv2.1; Kv7.1; COX-2 inhibitor; Celecoxib; Pharmacology
Research ReportProlonged opportunity for neuroprotection in experimental stroke with selective blockade of cyclooxygenase-2 activity
Keywords: بازدارنده COX-2; COX; cyclooxygenase; PG; prostaglandin; TX; thromboxane; MCAO; middle cerebral artery occlusion; CCA; common carotid artery; ICA; internal carotid artery; Cerebral ischemia; Therapeutic window; Clinical significance; Valdecoxib; COX-2 inhibitor;
In vitro and in vivo inhibitory effect evaluation of cyclooxygenase-2 inhibitors, antisense cyclooxygenase-2 cDNA, and their combination on the growth of human bladder cancer cells
Keywords: بازدارنده COX-2; COX-2 antisense cDNA; COX-2 inhibitor; Therapeutic effect