کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6265638 | 1614160 | 2009 | 6 صفحه PDF | دانلود رایگان |

The post-treatment effects of the selective cyclooxygenase (COX)-2 inhibitor, valdecoxib, were investigated in a rat model of temporary focal ischemia. Valdecoxib reduced basal brain prostaglandin E2 concentrations at dosages that did not affect serum thromboxane B2, consistent with a selective COX-2 effect. Temporary focal cerebral ischemia was produced in rats by middle cerebral artery occlusion for 90Â min. There was increased expression of COX-2 protein detected by Western blot and immunocytochemistry within neurons in the ischemic cortex at 4 and 24Â h after ischemia. Rats were treated with vehicle or valdecoxib 15Â min before or 1.5, 3 and 6Â h after cerebral ischemia. Rats were sacrificed and brain infarction volume determined 24Â h after ischemia. Valdecoxib treatment was associated with a decrease in infarction volume when administered 15Â min before, and 1.5 or 3Â h but not 6Â h after cerebral ischemia. There were no differences in physiological parameters during the procedure. Valdecoxib administered at 1.5Â h after ischemia significantly reduced the concentrations of prostaglandin E2 in ischemic penumbral cortex as compared to the vehicle-treated group and contralateral non-ischemic cortex. These results suggest that COX-2 inhibition with valdecoxib is effective when initiated both before and after middle cerebral artery occlusion.
Journal: Brain Research - Volume 1279, 7 July 2009, Pages 168-173