Keywords: CPT، camptothecin; ADR, adriamycin; AQCOM, alginate-Q-CMCS-organic montmorillonite; bFGF, basic fibroblast growth gactor; BSA, bovine serum albumin; BMSCs, bone marrow stromal cells; CPT, camptothecin; CMC, critical micelle concentration; CMCS, carboxymethyl chitosan; O-CMC
مقالات ISI CPT، camptothecin (ترجمه نشده)
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Human topoisomerase IB is a target of a thiosemicarbazone copper(II) complex
Keywords: CPT، camptothecin; Human DNA topoisomerase IB; Thiosemicarbazone; Copper(II) complex; Catalytic inhibitor; Molecular docking; Cytotoxicitytopo IB, human topoisomerase IB; complex (1), [Cu(PyCT4BrPh)Cl]; CPT, camptothecin
Combination treatment with Rhizoma Paridis and Rhizoma Curcuma longa extracts and 10-hydroxycamptothecin enhances the antitumor effect in H22 tumor model by increasing the plasma concentration
Keywords: CPT، camptothecin; HCPT, 10-hydroxycamptothecin; LH, prescription of Rhizoma Paridis and Rhizoma Curcuma longa; DJ, the part between duodenum and jejunum; F, permeation flux; Papp, apparent permeability; CPT, camptothecin; HPLC-FLD, high-performance liquid chromatography wi
Synthesis and biological evaluation of quinazolin-4(3H)-one derivatives bearing dithiocarbamate side chain at C2-position as potential antitumor agents
Keywords: CPT، camptothecin; Quinazolin-4(3H)-one; Dithiocarbamate; Synthesis; Antiproliferative activity; G2/M arrest; Spindle assembly checkpoint5-FU, 5-fluorouracil; ATR, attenuated total reflection; BubR1, Bub1-related protein kinase; CPT, camptothecin; 7,8-DHF, 7,8-dihydrofolate
Synthesis and biological evaluation of new fluorinated and chlorinated indenoisoquinoline topoisomerase I poisons
Keywords: CPT، camptothecin; CPT, camptothecin; Top1, topoisomerase IB; TDP1, tyrosyl-DNA phosphodiesterase 1; TDP2, tyrosyl-DNA phosphodiesterase 2; PAGE, polyacrylamide gel electrophoresis; SDS, sodium dodecyl sulfateTopoisomerase I; Indenoisoquinoline; Anticancer; Cytotoxicity; Ty
A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to Chemotherapy
Keywords: CPT، camptothecin; BLM, Bloom Syndrome; CPT, camptothecin; DNA2, DNA2 nuclease/helicase; DSB, double-strand break; EMSA, electrophoretic mobility shift assay; EXO1, exonuclesae 1; FA, Fanconi anemia; FEN1, flap endonuclease 1; HDR, homology direct repair; HTS, high throughp
DNA repair defects ascribed to pby1 are caused by disruption of Holliday junction resolvase Mus81-Mms4
Keywords: CPT، camptothecin; YKO, yeast knockout; P body, cytoplasmic processing body; SSL, synthetic sick/syntheticlethal; SGD, Saccharomyces genome database; MMS, methyl methanesulfonate; HU, hydroxyurea; CPT, camptothecin; DRYGIN, data repository of yeast genetic interactionsSacch
Mutation of Gly717Phe in human topoisomerase 1B has an effect on enzymatic function, reactivity to the camptothecin anticancer drug and on the linker domain orientation
Keywords: CPT، camptothecin; hTop1B, human topoisomerase 1B; CPT, camptothecin; TPT, topotecan; DMSO, dimethyl sulfoxide; EDTA, ethylenediaminetetraacetic acid; EGTA, ethylene glycol tetraacetic acid; DTT, dithiothreitol; BSA, bovine serine albumin; TBE, tris-borate-EDTA; PMSF, pheny
Characterization of 9-nitrocamptothecin-in-cyclodextrin-in-liposomes modified with transferrin for the treating of tumor
Keywords: CPT، camptothecin; BCA, bicinchoninic acid; CD, cyclodextrin; CPT, camptothecin; DCL, drug-in-cyclodextrin-in-liposome; DSPC, 1,2-distearoyl-sn-glycero-3-phosphatidylcholine; DSPE-PEG2000, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-(carbonyl-methoxypolyethyleneglycol
Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B
Keywords: CPT، camptothecin; 6-4PP, 6-4 photoproduct; BMC, bone marrow cell; Cdk, cyclin-dependent kinase; CPD, cyclopyrimidine dimer; CPT, camptothecin; CRBN, Cereblon; CRL4, cullin RING ligase; CS, Cockayne syndrome; CSN, COP9 signalosome; CUL4A, cullin 4A; CUL4B, cullin 4B; DCAF,
Determination of irinotecan and its metabolite SN-38 in rabbit plasma and tumors using a validated method of tandem mass spectrometry coupled with liquid chromatography
Keywords: CPT، camptothecin; CPT, camptothecin; CPT-11, irinotecan; CV, coefficient of variation; IS, internal standard; LLE, liquid-liquid extraction; MRM, multiple reaction monitoring; SD, standard deviationIrinotecan; SN-38; Camptothecin; Rabbit; VX2 tumor; LC–MS/MS
UVA generated free radicals in irinotecan (CPT-11) in the presence of copper ions
Keywords: CPT، camptothecin; ACN, acetonitrile; CPT, camptothecin; CPT-11, irinotecan; DIPPMPO, 5-(diisopropoxy-phosphoryl)-5-methyl-1-pyrroline N-oxide; DPPH, 2,2-diphenyl-1-picrylhydrazyl; DMPO, 5,5-dimethyl-1-pyrroline N-oxide; DMSO, dimethylsulfoxide; DNA, deoxyribonucleic acid;
Nanotoxicology applied to solid lipid nanoparticles and nanostructured lipid carriers – A systematic review of in vitro data
Keywords: CPT، camptothecin; Chol, cholesterol; COM, Compritol™ 888 ATO; CP, cetyl palmitate; CPC, cetylpyrimidium chloride; CPT, camptothecin; CTAB, cetyltrimethylammonium bromide, hexadecyltrimethylammonium bromide; CysA, Cyclosporine A; DOPE, dioleoylphosphatidyl ethanolamine; DOT
Increased Cdc7 expression is a marker of oral squamous cell carcinoma and overexpression of Cdc7 contributes to the resistance to DNA-damaging agents
Keywords: CPT، camptothecin; DDK, Dbf4-dependent kinase; DDR, DNA damage response; OSCC, oral squamous cell carcinoma; IHC, immunohistochemistry; HU, hydroxyurea; CPT, camptothecin; CI, confidence interval; HR, hazard ratios; TUNEL, terminal deoxynucleotidyl transferase-mediated dUTP
Oxo-heterocyclic fused naphthalimides as antitumor agents: Synthesis and biological evaluation
Keywords: CPT، camptothecin; Oxo-heterocyclic; Naphthalimides; Antitumor agents; Topo I; Topo II; DNA intercalationCD, circular dichroism; CPT, camptothecin; ctDNA, calf thymus DNA; kDNA, kinetoplast DNA; SAR, structure–activity relationship
Evodiamine, a dual catalytic inhibitor of type I and II topoisomerases, exhibits enhanced inhibition against camptothecin resistant cells
Keywords: CPT، camptothecin; CPT, camptothecin; DMSO, dimethylsulphoxide; EtBr, ethidium bromide; m-AMSA, amsacrine; MTT, 3-(4,5-dimethyl thiazol-2yl)-2,5-diphemyltetrazolium bromide; Nck, nicked; Rel, relaxed; Sc, supercoiled; Topo I, topoisomerase I; Topo II, topoisomerase IIEvodia
Alternatively spliced tissue factor and full-length tissue factor protect cardiomyocytes against TNF-α-induced apoptosis
Keywords: CPT، camptothecin; asTF, alternatively spliced TF; AV, annexin-V; Bad, Bcl-2-antagonist of cell death; Bax, Bcl-2-associated X; Bcl-2, B-cell lymphoma 2; Bcl-xL, B-cell lymphoma-extra large; CPT, Camptothecin; Clk, Cdc2-like kinases; cRGD, cyclic arginine–glycine–aspartate
Genotoxic stress modulates CDC25C phosphatase alternative splicing in human breast cancer cell lines
Keywords: CPT، camptothecin; CDC25 phosphatases; Alternative splicing; Genotoxic stress; Breast cancer cellsATM, ataxia telangiectasia-mutated; ATR, ATM- and Rad3-related; CDC25, cell division cycle 25; CDK, cyclin-dependent kinase; CPT, camptothecin; DAPI, 4′,6-diamidino-2-phenylind
Hypoxia modulates the effect of dihydroartemisinin on endothelial cells
Keywords: CPT، camptothecin; BSO, buthionine sulfoximine; CPT, camptothecin; DCF-DA, dihydrodichlorofluorescein diacetate; DeoxyDHA, dihydrodeoxyartemisinin; DHA, dihydroartemisinin; EC, endothelial cell; GSH, glutathione; HIF-1α, hypoxia inducible factor; HMEC-1, human microvascular
Sodium salicylate is a novel catalytic inhibitor of human DNA topoisomerase II alpha
Keywords: CPT، camptothecin; 5-IDNR, 5-iminodaunorubicin; ASA, acetylsalicylic acid; ATM, ataxia telangiectasia mutated; COX-2, cyclooxygenase-2; CPT, camptothecin; DEM, diethyl maleate; DSB, double-stranded break; ICE, in vivo complex of enzyme; IR, ionizing radiation; kDNA, kinetop
Role of senataxin in DNA damage and telomeric stability
Keywords: CPT، camptothecin; AOA, ataxia with oculomotor apraxia; ChIP, chromatin immunoprecipitation; CPT, camptothecin; LCLs, lymphoblastoid cell lines; MMC, mitomycin C; Q-FISH, quantitative-FISH; RT, room temperature; SETX, senataxinAOA2; SETX; Helicase domain; DNA damage; Telome
Kinetic modelling of the role of the aldehyde dehydrogenase enzyme and the breast cancer resistance protein in drug resistance and transport
Keywords: CPT، camptothecin; Efflux pump; Drug kinetics; Topotecan; Aldehyde dehydrogenase; Structural identifiability; Parameter estimationALDH, aldehyde dehydrogenase; BRCP, breast cancer resistance protein; CPT, camptothecin; DNA, deoxyribonucleic acid; dsDNA, double-stranded DNA;
Phenylbutyrate inhibits homologous recombination induced by camptothecin and methyl methanesulfonate
Keywords: CPT، camptothecin; CPT, camptothecin; Top1, topoisomerase I; HDAC, histone deacetylase; PBA, sodium phenylbutyrate; HR, homologous recombination; RPA, replication protein A; HAT, histone acetyltransferase; YPD, yeast extract-peptone-dextrose; SC, synthetic complete; TSA, tr
Schizosaccharomyces pombe Mms1 channels repair of perturbed replication into Rhp51 independent homologous recombination
Keywords: CPT، camptothecin; BER, base excision repair; ChIP, chromatin immunoprecipitation; CPT, camptothecin; D loop, displacement loop; DSB, double strand break; FPC, fork protection complex; HR, homologous recombination; HU, hydroxyurea; IR, ionizing radiation; MMS, methyl methan
COX-2 inhibitors block chemotherapeutic agent-induced apoptosis prior to commitment in hematopoietic cancer cells
Keywords: CPT، camptothecin; Bak, Bcl-2 homologous antagonist killer; Bax, Bcl-2-associated X protein; Bcl-2, B-cell lymphoma 2; Bcl-Xl, B-cell lymphoma-extra large; CPT, camptothecin; CISP, cisplatin; COX-2, cyclooxygenase-2; CTR-1, copper transporter 1; CYT, cytarabine; DMC, 2,5-di
Combination of arsenic trioxide and BCNU synergistically triggers redox-mediated autophagic cell death in human solid tumors
Keywords: CPT، camptothecin; APL, acute promyelocytic leukemia; AVO, acidic vesicular organelles; BCNU, N,N′-bis(2-chloroethyl)-N-nitrosourea; BSO, l-buthionine sulfoximine; CPT, camptothecin; DHA, docosahexaenoic acid; 5-FU, 5-fluorouracil; GR, glutathione reductase; GSH, reduced gl
Prodrug-based intracellular delivery of anticancer agents
Keywords: CPT، camptothecin; 5-FdU, 5-fluoro-2′-deoxyuridine; Ag, Antigen; ApoE, Apolipolipoprotein E; AraC, 1-β-d-Arabinofuranosylcytosine (cytarabine); BE, Benzyl elimination; CALI, NAc-gamma calicheamycin; CPP, Cell-penetrating peptide; CPT, Camptothecin; DAUN, Daunorubicin; dFdC,
Squalene protects against oxidative DNA damage in MCF10A human mammary epithelial cells but not in MCF7 and MDA-MB-231 human breast cancer cells
Keywords: CPT، camptothecin; AAPH, 2,2′-azobis (2-methylpropionamidine) dihydrochloride; ABTS, 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid); CPT, camptothecin; DCFH-DA, 2′,7′-dichlorofluorescein diacetate; DMSO, dimethyl sulfoxide; DPPH, 2,2-diphenyl-1-picrylhydrazyl; EDTA,
An unusual DNA binding compound, S23906, induces mitotic catastrophe in cultured human cells
Keywords: CPT، camptothecin; CPT, camptothecin; CDDP, cisplatin; Cdk1, cyclin-dependent kinase 1; Chk1, checkpoint kinase 1Cytotoxic drug; Cyclin-dependent kinases; Cdk1; DNA damage response; Checkpoint kinase 1; Histone γ-H2AX; Checkpoint adaptation
Divergent cellular phenotypes of human and mouse cells lacking the Werner syndrome RecQ helicase
Keywords: CPT، camptothecin; CFE, colony-forming efficiency; cis-Pt, cis-diammineplatinum(II)dichloride; CPT, camptothecin; WS, Werner syndrome; MearF, mouse ear fibroblastsWerner syndrome; RecQ helicase; Mouse model; Progeroid syndrome; Genetic instability
Down-regulation of adenine nucleotide translocase 3 and its role in camptothecin-induced apoptosis in human hepatoma QGY7703 cells
Keywords: CPT، camptothecin; ANT, adenine nucleotide translocase; CPT, camptothecin; MPTP, mitochondrial permeability transition pore; ΔΨm, mitochondrial membrane potentialCamptothecin; Adenine nucleotide translocase 3; Apoptosis; Hepatoma QGY7703 cell; Mitochondrial permeability tra
Cytotoxicity and TOP1-targeting activity of 8- and 9-amino derivatives of 5-butyl- and 5-(2-N,N-dimethylamino)ethyl-5H-dibenzo[c,h][1,6]naphthyridin-6-ones
Keywords: CPT، camptothecin; Topoisomerase I-targeting agents; 5H-Dibenzo[c,h][1,6]naphthyridin-6-ones; Cytotoxicity; Multidrug resistanceTOP1, topoisomerase I; CPT, camptothecin
De novo ceramide synthesis is responsible for the anti-tumor properties of camptothecin and doxorubicin in follicular thyroid carcinoma
Keywords: CPT، camptothecin; CPT, camptothecin; DOX, doxorubicin; FB1, fumonisin B1; FTC, follicular thyroid carcinoma; GCS, glucosylceramide synthase; LASS, longevity assurance homolog; PDMP, phenyl-2-decanoylamino-3-morpholino-1-propanol; SMase, sphingomyelinase; TSP-1, thrombospon
Nanoparticle-based targeted drug delivery
Keywords: CPT، camptothecin; BBB, blood–brain barrier; CPT, camptothecin; DT-A, diphtheria toxin suicide gene; DOX, doxorubicin; EPR, enhanced permeability and retention; PEO-PPO, ethylene oxide–propylene oxide block copolymer; C60, fullerenes; GBM, glioblastoma multiforme; GCS, gluc
Dual inhibition of topoisomerase I and tubulin polymerization by BPR0Y007, a novel cytotoxic agent
Keywords: CPT، camptothecin; Top I, topoisomerase I; CPT, camptothecin; PLDBs, protein-linked DNA breaksTopoisomerase I; Tubulin; Dual inhibitor
Frequent Inactivation of Axon Guidance Molecule RGMA in Human Colon Cancer Through Genetic and Epigenetic Mechanisms
Keywords: CPT، camptothecin; 5aza-dC, 5-aza-2′-deoxycytidine; BMP, bone morphogenetic protein; bp, base pair; CPT, camptothecin; CRC, colorectal cancer; DAPI, 4′,6-diamidino-2-phenylindole; DCC, deleted-in-colorectal cancer; LOH, loss of heterozygosity; MSP, methylation-specific poly
Delocalization of nucleolar poly(ADP-ribose) polymerase-1 to the nucleoplasm and its novel link to cellular sensitivity to DNA damage
Keywords: CPT، camptothecin; PARP-1, poly(ADP-ribose) polymerase-1; AIF, apoptosis induction factor; MNNG, N-methyl-N′-nitro-N-nitrosoguanidin; CPT, camptothecin; Topo I, topoisomerase I; PI, propidium iodidePARP-1; DNA damage; The nucleolus
Modulation of nucleobindin-1 and nucleobindin-2 by caspases
Keywords: CPT، camptothecin; CPT, camptothecin; NUCB1, nucleobindin-1; NUCB2, nucleobindin-2; TNT, coupled in vitro transcription and translationCaspase substrates; Nucleobindin-1 (NUCB1); Nucleobindin-2 (NUCB2); EF-hand motif; Ca2+-binding proteins; Cleavage of functional domain
Development and validation of a reverse-phase HPLC with fluorescence detector method for simultaneous determination of CZ48 and its active metabolite camptothecin in mouse plasma
Keywords: CPT، camptothecin; CPT, camptothecin; CZ48, C20-propionate ester of camptothecin; Cmax, maximum plasma drug concentration following a single dose; Tmax, time to Cmax; Ke, the elimination rate constants; AUC0–t, area under the plasma drug concentration–time curve from time z
From bench to drug: Human seizure modeling using Drosophila
Keywords: CPT، camptothecin; AED, antiepileptic drug; BS, bang-sensitive Drosophila mutant; CNS, central nervous system; CPT, camptothecin; DLM, dorsal longitudinal muscle; ECS, electroconvulsive shock; ECT, electroconvulsive shock treatment; HF, high-frequency; PSI, peripherally syn
Hyperphosphorylation of RNA Polymerase II in Response to Topoisomerase I Cleavage Complexes and Its Association with Transcription- and BRCA1-dependent Degradation of Topoisomerase I
Keywords: CPT، camptothecin; APD, aphidicolin; Cdk, cyclin-dependent kinase; CPT, camptothecin; CSK, cytoskeleton; CTD, carboxy-terminal domain; DRB, 5,6-dichlorobenzimidazole 1-β-d-ribofuranoside; FLV, flavopiridol; Pol II, RNA polymerase II; Pol IIa, hypophosphorylated Pol II; Pol
Bloom's syndrome workshop focuses on the functional specificities of RecQ helicases
Keywords: CPT، camptothecin; ALT, alternative lengthening of telomeres; BS, Bloom's syndrome; CPT, camptothecin; dsDNA, double-stranded DNA; DSB, double-strand break; ES cells, embryonic stem cells; G4, G quartet; G4P, G4 DNA-forming potential; HR, homologous recombination; HU, hydro
Gene tagging and gene replacement using recombinase-mediated cassette exchange in Schizosaccharomyces pombe
Keywords: CPT، camptothecin; 5-FOA, 5-fluoroorotic Acid; MCS, multiple cloning site; CPT, Camptothecin; YE, yeast extract; EMM, Edinburgh minimal media; PCR, polymerase chain reaction; kb, kilobase(s) or 1000 bp; S., Schizosaccharomyces.Cre recombination; Intron; RMCE; Epitope tag; C
γ-Secretase Inhibitors Enhance Taxane-Induced Mitotic Arrest and Apoptosis in Colon Cancer Cells
Keywords: CPT، camptothecin; APC, adenomatous polyposis coli; cdk, cyclin-dependent kinase; CPT, camptothecin; DAPT, N-[N-(3,5-difluorophenacetyl-l-alanyl)-S-phenylglycine]-t-butyl ester; FBS, fetal bovine serum; 5-FU, 5-fluorouracil; NICD, Notch intracellular domain; RT-PCR, reverse
Signal transduction events in aluminum-induced cell death in tomato suspension cells
Keywords: CPT، camptothecin; Aluminum; Antioxidants; Ethylene; Phospholipid signalling; Programmed cell death; TomatoAA, ascorbic acid; ACC, 1-aminocyclopropane-1-carboxylic acid; Al, aluminum; AVG, aminoethoxy vinylglycine; CPT, camptothecin; DAG, diacylglycerol; FDA, fluorescein di
Vasoactive intestinal peptide–camptothecin conjugates inhibit the proliferation of breast cancer cells
Keywords: CPT، camptothecin; VIP, vasoactive intestinal peptide; CPT, camptothecin; PACAP, pituitary adenylate cyclase activating polypeptide; (A-NL-K)VIP, (Ala2,8.9.19.24.25.27, Nle17, Lys28) VIP; Ki, inhibitory constant; L2, N-(N-methyl-amino-ethyl)-glycine carbamate; IP, inositol
Mutation of a Conserved Active Site Residue Converts Tyrosyl-DNA Phosphodiesterase I into a DNA Topoisomerase I-dependent Poison
Keywords: CPT، camptothecin; Tdp1, tyrosyl-DNA phosphodiesterase; Top1, topoisomerase I; CPT, camptothecin; 3′PG, 3′phosphoglycolate; SCAN1, spinocerebellar ataxia with axonal neuropathy; MAD, multiple anomalous dispersion; ssDNA, single-strand DNAcamptothecin; DNA topoisomerase I; e
Circadian regulation of mouse topoisomerase I gene expression by glucocorticoid hormones
Keywords: CPT، camptothecin; Topo I, topoisomerase I; CPT, camptothecin; CORT, corticosterone; CPT-11, 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin; ICR, Institute of Cancer Research; RU486, 11β-(4-dimethyl-amino)phenyl-17β-hydroxy-17-(1-propynyl)estra-4,9-dien-3
Involvement of ethylene and lipid signalling in cadmium-induced programmed cell death in tomato suspension cells
Keywords: CPT، camptothecin; Antioxidants; Cadmium; Calcium; Ethylene; Lycopersicon esculentum Mill.; Phospholipids; Programmed cell death; Tomato cell cultureAA, ascorbic acid; AVG, aminoethoxy vinylglycine; CPT, camptothecin; DEVD-CMK, Asp-Glu-Val-Asp-chloromethylketone; DPI, diphe
Chemotherapy induces an increase in coenzyme Q10 levels in cancer cell lines
Keywords: CPT، camptothecin; 4AB, 4-aminobenzoate; BHA, butylated hydroxianisole; CPT, camptothecin; CoQ, coenzyme Q10; COX, cytochrome c oxidase; H2DCF-DA, carboxy-2′,7′-dichlorodihydrofluorescein diacetate; ETOP, etoposide; DOXO, doxorubicin; IOD, integrated optical density; LOV, l