کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
26948 | 43988 | 2014 | 14 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: UVA generated free radicals in irinotecan (CPT-11) in the presence of copper ions UVA generated free radicals in irinotecan (CPT-11) in the presence of copper ions](/preview/png/26948.png)
Irinotecan (CPT-11) is an efficient anticancer drug approved for clinical use in the treatment of advanced colorectal cancers. This work is focused on the study of photoinduced processes in irinotecan (CPT-11) both in the presence and absence of Cu(II) ions by means of UV/vis and EPR spectroscopy. Solid-state EPR revealed the solvent dependent coordination between CPT-11 and cupric ions. EPR spin trapping technique, using various spin trapping agents, was applied to monitor the generation of reactive radical species (oxygen- and carbon-centered radicals) in irradiated CPT-11 and CPT-11/CuCl2 systems under the given experimental conditions. We confirmed that the presence of CPT-11 is necessary for the formation of reactive radicals and the photoinduced processes are influenced by the presence of cupric ions. ROS generated upon irradiation of CPT-11 in the presence/absence of copper ions can be regarded as complementary species to the original inhibitory action of the drug on the DNA topoisomerase I.
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Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 290, 15 September 2014, Pages 125–138