
Determination of irinotecan and its metabolite SN-38 in rabbit plasma and tumors using a validated method of tandem mass spectrometry coupled with liquid chromatography
Keywords: CPT, camptothecin; CPT-11, irinotecan; CV, coefficient of variation; IS, internal standard; LLE, liquid-liquid extraction; MRM, multiple reaction monitoring; SD, standard deviationIrinotecan; SN-38; Camptothecin; Rabbit; VX2 tumor; LC–MS/MS