Keywords: سیکلین وابسته به کیناز 5; AD; Alzheimer's disease; PPs; polyphenols; EGCG; epigallocatechin gallate; NFTs; neurofibrillary tangles; ACh; acetylcholine; Aβ; amyloid-beta; APP; amyloid precursor protein; PS-1; presenilin-1; PS-2; presenilin-2; AChE; acetylcholine esterase; Cdk5;
مقالات ISI سیکلین وابسته به کیناز 5 (ترجمه نشده)
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Keywords: سیکلین وابسته به کیناز 5; AD; Alzheimer Disease; DS; Down Syndrome; Aβ; amyloid-β; HSA21; Chromosome 21; APP; Amyloid precursor protein; BACE1/2; β-site APP cleaving enzyme 1/2; βCTF; β carboxyl-terminal fragment; PSEN1; presenilin 1; APPL1; adaptor protein containing pleckst
Keywords: سیکلین وابسته به کیناز 5; Ache; acetylcholinesterase; AD; Alzheimer's disease; Adra2a, Adra2b, Adra1b; adrenoceptor alpha 2a, alpha 2b, beta 1; Akt1; Akt serine/threonine protein kinase 1/protein kinase B; ApoE; apolipoprotein E; Bche; butyrylcholinesterase; BDNF; brain derived ne
Keywords: سیکلین وابسته به کیناز 5; AC; adenylate cyclase; Actn4; α-Actinin-4; ARF6; ADP-ribosylation factor 6; ATD; amino terminal domain; CAIN; calcineurin inhibitor protein; CaM; calmodulin; CaMKII; Ca2+/calmodulin-dependent protein kinase II; Cbln1; cerebellin 1 precursor; CC; coiled-c
Keywords: سیکلین وابسته به کیناز 5; CDK5; Cyclin-dependent kinase 5; CRMP2; Collapsin response mediator protein 2; DMSO; dimethylsulfoxide; DIV; Days in vitro; Cyclin-dependent kinase 5; Collapsin response mediator protein 2; Sevoflurane; Dendrite; Cortical neurons;
Keywords: سیکلین وابسته به کیناز 5; 5-HT; 5-hydroxytryptamine; 5-HTT; 5-hydroxytryptamine transporter; AC; adenylyl cyclase; AD; Alzheimer's disease; Akt; protein kinase B; AMPAR; α-amino-3-hydroxy-5-mthhyl-4-isoxazolepropionic acid receptor; apCAM; Aplysia cell adhesion molecules; ASD;
Keywords: سیکلین وابسته به کیناز 5; Aβ; beta-amyloid peptide; AAV; adeno-associated virus; ABAD; amyloid-beta-binding alcohol dehydrogenase; AD; Alzheimer's disease; ALP; autophagy-lysosome pathways; Apaf-1; apoptic protease-activating factor 1; APP; amyloid precursor protein; AICD; APP in
Keywords: سیکلین وابسته به کیناز 5; Traumatic brain injury; Chronic traumatic encephalopathy; Tauopathy; Concussion; Repetitive head injury; 2-AG; 2-arachidonoylglycerol; 3-NT; 3-nitrotyrosine; 4-HNE; 4-hydroxynonenal; Ach; acetylcholine; AChEI; acetylcholine esterase inhibitor; AD; Alzheim
Keywords: سیکلین وابسته به کیناز 5; Cyclin-dependent kinase 5; Hippocampus; Lipopolysaccharide; Systemic inflammation; NeuroinflammationAIF, apoptosis inducing factor; Cdk5, cyclin-dependent kinase 5; COX-2, cyclooxygenase 2; cPLA2, calcium-dependent phospholipase A2; Egr-1, early growth re
Keywords: سیکلین وابسته به کیناز 5; 2DE; two-dimensional gel electrophoresis; ACN; acetonitrile; AP-2; adaptor-related protein-2; AP2b1; AP-2 complex subunit beta; Cdk5; cyclin-dependent kinase 5; CLO; clozapine; CRMPs; collapsin response mediator protein family, dihydropyrimidinase-related
Keywords: سیکلین وابسته به کیناز 5; BBB; blood-brain barrier; Bcl-2; B-cell lymphoma 2; Cdk5; cyclin-dependent kinase 5; DCX; doublecortin; GSK3; glycogen synthase kinase 3; MCAO; middle cerebral artery occlusion/reperfusion; NF-κB; nuclear factor-kappa B; SalA; salvianolic acid A; β-cate
Keywords: سیکلین وابسته به کیناز 5; AC; adenylyl cyclase; AKT; protein kinase B; AMPK; AMP-activated protein kinase; AnR; androgen receptor; ARF6; ADP ribosylation factor 6; CaMK; Ca2+-calmodulin dependent kinase; CaMKK; CaMK kinase; cAMP; cyclic adenosine 3â²,5â²-monophosphate; CDK5; cyc
Keywords: سیکلین وابسته به کیناز 5; Cyclin-dependent kinase 5; Isoflurane; Apoptosis; Learning and memory; Neurotoxicity; Hippocampus; Calpain; Ca2+-activated protease; CDK5; Cyclin-dependent kinase 5; DIV; Day in vitro; DN CDK5; Dominant-Negative cyclin-dependent kinase 5; FCM; Flow cytom
Keywords: سیکلین وابسته به کیناز 5; AD; Alzheimer's disease; Aβ; amyloid beta; CDK5; cyclin-dependent kinase 5; CNS; central nervous system; COX; cyclooxygenase; CRP; C-reactive protein; FADD; Fas-Associated protein with Death Domain; GSK3; glycogen synthase kinase-3; IFN-γ; interferon-γ
Keywords: سیکلین وابسته به کیناز 5; Aβ; amyloid-β; AD; Alzheimer's disease; ALP; autophagy-lysosome pathway; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ApoER2; apolipoprotein E receptor 2; APP; Aβ precursor protein; BDNF; brain-derived neurotrophic factor; CSF; cere
Keywords: سیکلین وابسته به کیناز 5; Parkinson's disease; Alpha-synuclein; Cyclin-dependent kinase 5; Phosphorylation; p35; Calpain;
Keywords: سیکلین وابسته به کیناز 5; 7,8-DHF; 7,8-dihydroxyflavone; Aβ; amyloid beta; AchE; acetylcholine-esterase; ABCA1; ATP-binding cassette transporter 1; APP; amyloid precursor protein; Akt; protein kinase B; ApoE; apolipoprotein E; AAV/Aβ; adeno-associated viral vector carrying Aβ c
Evaluation of the association of single nucleotide polymorphisms in DDP4 and CDK5RAP2 genes with rheumatoid arthritis susceptibility in Iranian population
Keywords: سیکلین وابسته به کیناز 5; RA; rheumatoid arthritis; SNP; single nucleotide polymorphism; GWAS; genome-wide association study; HLA; human leukocyte antigen; DPP4; dipeptidyl peptidase-4; CD26; cluster of differentiation 26; CDK-5; Cyclin-dependent kinase 5; CDK5RAP2; Cyclin-depende
Phosphorylation of synaptic GTPase-activating protein (synGAP) by polo-like kinase (Plk2) alters the ratio of its GAP activity toward HRas, Rap1 and Rap2 GTPases
Keywords: سیکلین وابسته به کیناز 5; Synaptic plasticity; Synaptic scaling; Postsynaptic density; Synaptic GTPase activating protein (synGAP); Cyclin-dependent kinase 5 (CDK5); Polo-like kinase 2 (Plk2); synGAP; synaptic GTPase activating protein; r-synGAP; soluble recombinant synGAP fragmen
cPKCγ alleviates ischemic injury through modulating synapsin Ia/b phosphorylation in neurons of mice
Keywords: سیکلین وابسته به کیناز 5; cPKCγ; conventional protein kinase Cγ; MCAO; middle cerebral artery occlusion; HPC; hypoxic preconditioning; OGD; oxygen glucose deprivation; TTC; 2, 3, 5-triphenyltetrazolium chloride; PKA; protein kinase A; CaMKI/IV; calcium/calmodulin-dependent prote
Cyclin-dependent kinase 5 controls vasculogenic mimicry formation in non-small cell lung cancer via the FAK-AKT signaling pathway
Keywords: سیکلین وابسته به کیناز 5; Vasculogenic mimicry; Cyclin-dependent kinase 5; Non-small cell lung cancer; Tumor plasticity; FAK; CDK5; Cyclin-dependent kinase 5; NSCLC; non-small cell lung cancer; VM; vasculogenic mimicry;
Structural basis for differential activities of enantiomeric PPARγ agonists: Binding of S35 to the alternate site
Keywords: سیکلین وابسته به کیناز 5; PPAR; peroxisome proliferator-activated receptor; LBD; ligand-binding domain; LBP; ligand-binding pocket; TZD; thiazolidinedione; Cdk5; cyclin-dependent kinase 5; SRC-1; steroid receptor coactivator-1; r.m.s.; root-mean-square; Crystal structure; Alternat
TFP5 is comparable to mild hypothermia in improving neurological outcomes in early-stage ischemic stroke of adult rats
Keywords: سیکلین وابسته به کیناز 5; AD; Alzheimer's disease; BBB; blood-brain barrier; CDK5; cyclin-dependent kinase 5; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; IHC; immunohistochemistry; MAP; mean artery pressure; MCAO; middle cerebral artery occlusion; MH; mild hypothermia; MM
Muscarinic acetylcholine M4 receptors play a critical role in oxotremorine-induced DARPP-32 phosphorylation at threonine 75 in isolated medium spiny neurons
Keywords: سیکلین وابسته به کیناز 5; Basal ganglia circuitry; Dopamine and cAMP-regulated phosphoprotein (DARPP-32); Dopamine receptor; Medium spiny neuron (MSN); Muscarinic acetylcholine receptor 4 (M4); ACh; acetylcholine; APO; apomorphine; CDK5; cyclin-dependent kinase 5; CREB; cAMP respo
Fyn regulates multipolar-bipolar transition and neurite morphogenesis of migrating neurons in the developing neocortex
Keywords: سیکلین وابسته به کیناز 5; Cdk5; cyclin-dependent kinase 5; CP; cortical plate; EGFP; enhanced green fluorescent protein; FAK; focal adhesion kinase; IZ; intermediate zone; MZ; marginal zone; PB; phosphate buffer; PFA; paraformaldehyde; RNAi; RNA interference; SFKs; Src family kina
CDK5 inhibitors prevent astroglial apoptosis and reactive astrogliosis by regulating PKA and DRP1 phosphorylations in the rat hippocampus
Keywords: سیکلین وابسته به کیناز 5; SE; status epilepticus; MFN1; mitofusin 1; MFN2; mitofusin 2; OPA1; optic atrophy 1; DRP1; dynamin-related protein 1; Fis-1; fission related protein-1; MFF; mitochondrial fission factor; CDK5; cyclin-dependent kinase 5; PKA; protein kinase A; AIF; apoptot
Dexibuprofen prevents neurodegeneration and cognitive decline in APPswe/PS1dE9 through multiple signaling pathways
Keywords: سیکلین وابسته به کیناز 5; AD; Alzheimer's disease; Aβ; Amyloid beta; APP; Amyloid precursor protein; NFTs; Neurofibrillary tangles; BACE1; β-secretase 1; TNF-α; Tumor necrosis factor; iNOS; Inducible nitric oxide synthase; NSAIDs; Non-steroidal anti-inflammatory drugs; PPARγ;
Acute stress regulates phosphorylation of N-methyl-d-aspartate receptor GluN2B at S1284 in hippocampus
Keywords: سیکلین وابسته به کیناز 5; AMPAR; a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; Cdk5; Cyclin-dependent kinase 5; EDTA; ethylenediaminetetraacetic acid; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; NMDAR; N-methyl-D-aspartate receptor; PSD; postsynapti
Cyclin-dependent kinase 5 contributes to endoplasmic reticulum stress induced podocyte apoptosis via promoting MEKK1 phosphorylation at Ser280 in diabetic nephropathy
Keywords: سیکلین وابسته به کیناز 5; Cyclin-dependent kinase 5; Podocyte; Diabetic nephropathy; Endoplasmic reticulum stress; Apoptosis;
Calpain-2/p35-p25/Cdk5 pathway is involved in the neuronal apoptosis induced by polybrominated diphenyl ether-153
Keywords: سیکلین وابسته به کیناز 5; Polybrominated diphenyl ether-153; Calpain; P25; P35; Cyclin-dependent kinase 5; Neuronal apoptosis;
TREMs in Alzheimer's disease: Genetic and clinical investigations
Keywords: سیکلین وابسته به کیناز 5; AD; Alzheimer's disease; TREM; Triggering receptor expressed on myeloid cells; TREML; TREM like transcript; NHD; Nasu-Hakola disease; NFTs; neurofibrillary tangles; p-tau; hyperphosphorylated tau; GWAS; genome-wide association studies; sTREM2; soluble f
Disruption of neuronal nitric oxide synthase dimerization contributes to the development of Alzheimer’s disease: Involvement of cyclin-dependent kinase 5-mediated phosphorylation of neuronal nitric oxide synthase at Ser293
Keywords: سیکلین وابسته به کیناز 5; Alzheimer’s disease; Neuronal nitric oxide synthase; Dimerization; Cyclin-dependent kinase 5; p25; PhosphorylationAD, Alzheimer’s disease; CDK5, cyclin-dependent kinase 5; NO, nitric oxide; eNOS, endothelial nitric oxide synthase; nNOS, neuronal nitric ox
Cdk5/p25 specific inhibitory peptide TFP5 rescues the loss of dopaminergic neurons in a sub-acute MPTP induced PD mouse model
Keywords: سیکلین وابسته به کیناز 5; Parkinson's disease; MPTP; Cyclin-dependent kinase 5; TFP5; Dopaminergic neurons; MEF2;
Clozapine induces chloride channel-4 expression through PKA activation and modulates CDK5 expression in SH-SY5Y and U87 cells
Keywords: سیکلین وابسته به کیناز 5; CDK5, cyclin-dependent kinase 5; CLC-4, chloride channel-4; CREB, cAMP response element-binding protein; NGF, nerve growth factor; PKA, protein kinase AChloride channel-4; Clozapine; Cyclin-dependent kinase 5; SH-SY5Y; U87
Reduced phosphorylation of synapsin I in the hippocampus of Engrailed-2 knockout mice, a model for autism spectrum disorders
Keywords: سیکلین وابسته به کیناز 5; ASD; autism spectrum disorders; CA1/CA2/CA3; hippocampal pyramidal cell layers; Cdk5; cyclin-dependent kinase 5; En2; Engrailed-2; ERK; extracellular-regulated kinase; GABA; γ-aminobutyric acid; GCL; granule cell layer; mf; mossy fibers; MWM; Morris wate
GSK3β-activation is a point of convergence for HIV-1 and opiate-mediated interactive neurotoxicity
Keywords: سیکلین وابسته به کیناز 5; CNS; central nervous system; HIV-1; human immunodeficiency virus-1; HAND; HIV-1-associated neurocognitive disorders; cART; combination antiretroviral therapy; Tat; trans-activator of transcription; gp120; glycoprotein 120; GSK3β; glycogen synthase kinase
L312, a novel PPARγ ligand with potent anti-diabetic activity by selective regulation
Keywords: سیکلین وابسته به کیناز 5; BAT; Brown adipose tissue; CBP; cAMP responsive element binding protein (CREBP) binding protein; CDK5; Cyclin-dependent kinase 5; EC50; half-maximal effective concentration; FFA; Free fatty acids; HOMA-IR; HOMA of insulin resistance; ITT; Insulin toleranc
Translational implications of the β-cell epigenome in diabetes mellitus
Keywords: سیکلین وابسته به کیناز 5; Arx; arista-less-related homeobox protein; CDK5; cyclin-dependent kinase 5; CpG; Cytosine-phosphodiester-bond-guanine; DM; diabetes mellitus; EZH2; enhancer of zeste homolog 2; GLP-1; glucagonlike peptide 1; GWAS; genomewide association study; H3-K4; Lys-
Development of new highly potent imidazo[1,2-b]pyridazines targeting Toxoplasma gondii calcium-dependent protein kinase 1
Keywords: سیکلین وابسته به کیناز 5; Imidazo[1,2-b]pyridazine; Anti-apicomplexan; Toxoplasma gondii; Toxoplasma gondii calcium-dependent protein kinase 1; IC50; 50% inhibitory concentration; EC50; 50% effective concentration; CC50; 50% cytotoxic concentration; SAR; structure-activity relatio
Valproic acid downregulates Cdk5 activity via the transcription of the p35 mRNA
Keywords: سیکلین وابسته به کیناز 5; Cdk5; cyclin-dependent kinase 5; GABA; γ-aminobutyric acid; HDAC; histone deacetylase; MG132; benzyloxycarnonyl-leucyl-leucyl-leucinal; TSA; trichostatin A; VPA; valproic acid; VPM; valpromide; Cdk5; Valproic acid; Transcription; p35; Autism; HDAC;
Haloperidol-induced Nur77 expression in striatopallidal neurons is under the control of protein phosphatase 1 regulation by DARPP-32
Keywords: سیکلین وابسته به کیناز 5; Striatum; Dopamine; Orphan nuclear receptors; Antipsychotics; A2AR; adenosine 2A receptor; CDK5; cyclin-dependent kinase 5; DAPI; 4â²,6â²-Diamidino-2-phenylindole; DARPP-32; dopamine- and cAMP-regulated phosphoprotein of 32Â kDa; D1R, D2R, and D3R; dopa
Intrathecal administration of roscovitine prevents remifentanil-induced postoperative hyperalgesia and decreases the phosphorylation of N-methyl-d-aspartate receptor and metabotropic glutamate receptor 5 in spinal cord
Keywords: سیکلین وابسته به کیناز 5; Opioid-induced hyperalgesia; Remifentanil; Cyclin-dependent kinase 5; N-methyl-d-aspartate receptor; Metabotropic glutamate receptor 5
CDK5-mediated phosphorylation and autophagy of RKIP regulate neuronal death in Parkinson's disease
Keywords: سیکلین وابسته به کیناز 5; Chaperone-mediated autophagy; Cyclin-dependent kinase 5; Parkinson's disease; Protein phosphorylation; Raf kinase inhibitor protein;
Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice
Keywords: سیکلین وابسته به کیناز 5; Cdk5; cyclin-dependent kinase 5; FTDP-17; frontal temporal dementias with Parkinsonism linked to chromosome 17; GSK-3β; glycogen synthase kinase 3β; MAPK (Erk1/2); mitogen-activated protein kinase; SAPK; stress-activated protein kinase; Environmental ne
Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review
Keywords: سیکلین وابسته به کیناز 5; PPAR gamma; Nuclear receptor; Natural product; Nutrition; Diabetes; 9-(S)-HODE; (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid; AF-2; activation function-2; CAP; c-Cbl-associated protein; Cdk5; cyclin-dependent kinase 5; DCM; dichloromethane; DIO; diet
Valproic acid increases NO production via the SH-PTP1-CDK5-eNOS-Ser116 signaling cascade in endothelial cells and mice
Keywords: سیکلین وابسته به کیناز 5; eNOS; endothelial nitric oxide synthase; CDK5; cyclin-dependent kinase 5; JNK; c-Jun N-terminal kinase; Abl; Abelson kinase; SH-PTP; SH2 domain-containing protein tyrosine phosphatase; VPA; valproic acid; HDAC; histone deacetylase; HUVEC; human umbilical
Cdk5 regulates Rap1 activity
Keywords: سیکلین وابسته به کیناز 5; Signal transduction; Cyclin-dependent kinase 5; Rap1; C3G; Neurones;
Cyclin-dependent kinase 5 is a calmodulin-binding protein that associates with puromycin-sensitive aminopeptidase in the nucleus of Dictyostelium
Keywords: سیکلین وابسته به کیناز 5; CaM; calmodulin; Ca2Â +; calcium; CaMBP; CaM-binding protein; CaMBD; CaM-binding domain; Cdk5; cyclin-dependent kinase 5; PsaA; puromycin-sensitive aminopeptidase A; GFP; green fluorescent protein; NLS; nuclear localization sequence; Cyclin-dependent kina
The serotonin receptor 7 promotes neurite outgrowth via ERK and Cdk5 signaling pathways
Keywords: سیکلین وابسته به کیناز 5; 5-HTR7; Cytoskeletal proteins; MAP1B; Neurite outgrowth; Neuronal primary cultures; 5-HT; 5-hydroxytryptamine; 5-HTR7; serotonin receptor 7; ADHD; attention deficit hyperactivity disorder; Cdk5; cyclin-dependent kinase 5; CHX; cycloheximide; CTX; cortex;
The Expression of Intermediate Filament Protein Nestin and Its Association With Cyclin-dependent Kinase 5 in the Glomeruli of Rats With Diabetic Nephropathy
Keywords: سیکلین وابسته به کیناز 5; Nestin; Cyclin-dependent kinase 5; Diabetic nephropathy; Roscovitine; Vimentin