Cyclin-dependent kinase 5 is a calmodulin-binding protein that associates with puromycin-sensitive aminopeptidase in the nucleus of Dictyostelium

► Cdk5 is a calmodulin-binding protein in Dictyostelium. ► Calmodulin localizes to the nucleus in Dictyostelium. ► Cdk5 and PsaA interact with CaM in Dictyostelium nuclei. ► Cdk5 contains a calmodulin-binding domain. ► Calmodulin regulates the nucleocytoplasmic transport of Cdk5.