Keywords: میمون cynomolgus; Cardiomyocyte; Cynomolgus monkey; In vitro cytotoxicity; Microarray; Doxorubicin; Endoplasmic reticulum stress; IPA; Ingenuity Pathway Analysis; GO; Gene Ontology; hiPSC-CM; human pluripotent stem cell-derived cardiomyocyte; ER; endoplasmic reticulum;
مقالات ISI میمون cynomolgus (ترجمه نشده)
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Keywords: میمون cynomolgus; Farletuzumab; Folate receptor alpha; Cynomolgus monkey; Embryo-fetal development;
Keywords: میمون cynomolgus; PEGylation; Islet transplantation; Instant blood-mediated inflammatory reaction (IBMIRs); Cynomolgus monkey;
Keywords: میمون cynomolgus; Cocaine; Ethanol; Second-order schedules; Conditioned stimuli; Cynomolgus monkey;
Keywords: میمون cynomolgus; BBB; blood-brain barrier; BSA; bovine serum albumin; cAMP; cyclic adenosine monophosphate; CGRP; calcitonin gene-related peptide; CHO; Chinese hamster ovary; CLR; calcitonin receptor-like receptor; CNS; central nervous system; DAB; 3,3â²-diaminobenzidi
Keywords: میمون cynomolgus; Aβ, amyloid-β peptide; AD, Alzheimer disease; APP, amyloid-β precursor protein; GSL, glycosphingolipid; CSF, cerebrospinal fluid; N2a, neuro2a; EGCase, endoglycoceramidaseExosome; Amyloid-β peptide; Alzheimer’s disease; Cynomolgus monkey; APP transgenic m
Keywords: میمون cynomolgus; Cardiovascular safety pharmacology; Cynomolgus monkey; ECG; Heart rate; Jacketed external telemetry; Methods; Social housing;
Keywords: میمون cynomolgus; Learning ability; Memory; Wisconsin General Testing Apparatus; Cynomolgus monkey; Juvenile toxicity studies; WGTA; Wisconsin General Testing Apparatus; TCDD; 2,3,7,8-Tetrachlorodibenzo-p-dioxin; NHP; Nonhuman primate;
Keywords: میمون cynomolgus; Selective Progesterone Receptor Modulator; Cynomolgus monkey; Ulipristal acetate; Toxicity; PAEC;
Keywords: میمون cynomolgus; Cynomolgus monkey; Rhesus monkey; Flavin-containing monooxygenase; Liver;
RNA-seq analysis of the transcriptome of the liver of cynomolgus monkeys with type 2 diabetes
Keywords: میمون cynomolgus; T2DM; type 2 diabetes mellitus; DEGs; differentially expressed genes; FDR; false discovery rate; SD; standard diet; HFD; high-fat diet; OGTT; oral glucose tolerance test; HOMA-IR; homeostatic model assessment of insulin resistance; KEGG; Kyoto Encyclopedi
Molecular and functional characterization of UDP-glucuronosyltransferase 1A in cynomolgus macaques
Keywords: میمون cynomolgus; Cynomolgus monkey; Drug metabolism; Gene; Genome; UDP-glucuronosyltransferases;
Minimal physiologically-based pharmacokinetic model to investigate the effect of pH dependent FcRn affinity and the endothelial endocytosis on the pharmacokinetics of anti-VEGF humanized IgG1 antibody in cynomolgus monkey
Keywords: میمون cynomolgus; AIC; Akaike Information Criterion; ATA; anti-therapeutic antibody; AUC; area under the curve; CLe; antibody clearance in endothelial space; CDP; Complex Dedrick Plot; CV; coefficient of variations; FR; recycling fraction of IgG; F1; modulation factor of m
Nonclinical assessments of the potential biosimilar PF-06439535 and bevacizumab
Keywords: میمون cynomolgus; Bevacizumab; PF-06439535; Biosimilar; Vascular endothelial growth factor; Nonclinical; Cynomolgus monkey; Sprague Dawley rat; ADA; antidrug antibody; AUC; area under the serum concentration-time curve; AUC0-72; area under the serum concentration-time
Localization of zinc transporters in the spinal cord of cynomolgus monkey
Keywords: میمون cynomolgus; Zinc homeostasis; Zinc transporter; Spinal cord; Cynomolgus monkey; Immunohistochemistry;
Biodistribution and safety of a live attenuated tetravalent dengue vaccine in the cynomolgus monkey
Keywords: میمون cynomolgus; Live attenuated vaccine; Dengue; Cynomolgus monkey; Toxicity; Biodistribution; Shedding; CYD-TDV; live attenuated tetravalent dengue vaccine; DENV; dengue virus; DF; dengue fever; DHF; dengue hemorrhagic fever; DSS; dengue shock syndrome; ELISA; enzyme-li
Perspectives on using a multiplex human kidney safety biomarker panel to detect cisplatin-induced tubular toxicity in male and female Cynomolgus monkeys
Keywords: میمون cynomolgus; AKI; acute kidney injury; ALB; albumin; α1M; alpha 1 microglobulin; αGST; alpha glutathione S-transferase; β2M; beta 2 microglobulin; BUN; blood urea nitrogen; CALB; calbindin D28k; CLU; clusterin; Cr; creatinine; CYS C; cystatin C; DIKI; drug-induced
Utility of non-human primates in drug development: Comparison of non-human primate and human drug-metabolizing cytochrome P450 enzymes
Keywords: میمون cynomolgus; Common marmoset; Cynomolgus monkey; P450 2C9; P450 2C19; Warfarin;
Functional neurotoxicity evaluation of noribogaine using video-EEG in cynomolgus monkeys
Keywords: میمون cynomolgus; Noribogaine; Electroencephalography; EEG; Cynomolgus monkey; Pentylenetetrazol;
Precise and accurate assay of pregnenolone and five other neurosteroids in monkey brain tissue by LC–MS/MS
Keywords: میمون cynomolgus; Liquid chromatography–tandem mass spectrometry; Cynomolgus monkey; Neurosteroids; Girard T reagent
Induction of systemic and mucosal immunity and maintenance of its memory against influenza A virus by nasal vaccination using a new mucosal adjuvant SF-10 derived from pulmonary surfactant in young cynomolgus monkeys
Keywords: میمون cynomolgus; APC; antigen presenting cell; CVP; carboxyvinyl polymer; DPPC; 1,2-dipalmitoyl-phosphatidylcholine; ELISA; enzyme-linked immunosorbent assay; GMP; good manufacturing practices; HI; hemagglutination inhibition; IAV; influenza A virus; OD; optical density;
Slow R-warfarin 7-hydroxylation mediated by P450 2C19 genetic variants in cynomolgus monkeys in vivo
Keywords: میمون cynomolgus; AUC; area under the plasma concentration vs. time curve; CL; total body clearance; P450; general term for cytochrome P450 (EC 1.14.14.1); t1/2; elimination half-life; V; volume of distribution; Cynomolgus monkey; CYP2C19; Genotyping; Stereoselectivity; S-
Dehydroepiandrosterone sulfate, a useful endogenous probe for evaluation of drug–drug interaction on hepatic organic anion transporting polypeptide (OATP) in cynomolgus monkeys
Keywords: میمون cynomolgus; Drug–drug interaction; Organic anion-transporting polypeptide (OATP); Dehydroepiandrosterone sulfate; Endogenous probe; Rifampicin; Cynomolgus monkey
Increased oligomerization and phosphorylation of α-synuclein are associated with decreased activity of glucocerebrosidase and protein phosphatase 2A in aging monkey brains
Keywords: میمون cynomolgus; α-Synuclein; Parkinson's disease; Dementia with Lewy bodies; Glucocerebrosidase; Cynomolgus monkey; Aging;
Assessment of ixekizumab, an interleukin-17A monoclonal antibody, for potential effects on reproduction and development, including immune system function, in cynomolgus monkeys
Keywords: میمون cynomolgus; Cynomolgus monkey; Embryo-fetal; Fertility; Ixekizumab; Pre-postnatal; Toxicity;
Age-associated changes of cerebrospinal fluid amyloid-β and tau in cynomolgus monkeys
Keywords: میمون cynomolgus; β-amyloid; p-Tau; Cynomolgus monkey; Age; CSF;
Altered social interactions in male juvenile cynomolgus monkeys prenatally exposed to bisphenol A
Keywords: میمون cynomolgus; Bisphenol A; Cynomolgus monkey; Social behavior; Sexual differentiation
CYP2C19 polymorphisms account for inter-individual variability of drug metabolism in cynomolgus macaques
Keywords: میمون cynomolgus; Cynomolgus monkey; Cytochrome P450; Genetic polymorphisms; Liver;
Original articleMeasurement of hyper- and hypotension during repeated dose toxicity studies in either freely moving or physically restrained cynomolgus monkeys
Keywords: میمون cynomolgus; Cardiovascular; Hypertension; Hypotension; HDO; Cynomolgus monkey; JET; Telemetry; Method; Safety pharmacology; Hemodynamic;
Appraisal of state-of-the-artPreclinical QT safety assessment: Cross-species comparisons and human translation from an industry consortium
Keywords: میمون cynomolgus; Biomarker; Cynomolgus monkey; Dog; Guinea pig; Marmoset; Methods; Minipig; Moxifloxacin; Preclinical-clinical concordance; QT rate-correction;
Mechanisms of allergy and clinical immunologyThymic stromal lymphopoietin receptor blockade reduces allergic inflammation in a cynomolgus monkey model of asthma
Keywords: میمون cynomolgus; Thymic stromal lymphopoietin; dendritic cells; allergen challenge; cynomolgus monkey; gene expression profiling; eosinophilia; TH2 inflammation; AHR; Airway hyperresponsiveness; BAL; Bronchoalveolar lavage; DC; Dendritic cell; IC50; Inhibitory concentrati
Effect of an investigational CYP17A1 inhibitor, orteronel (TAK-700), on estrogen- and corticoid-synthesis pathways in hypophysectomized female rats and on the serum estradiol levels in female cynomolgus monkeys
Keywords: میمون cynomolgus; Orteronel; 17,20-Lyase; Estradiol; Progesterone; Rat; Cynomolgus monkey;
Systematic identification and characterization of glutathione S-transferases in cynomolgus macaque
Keywords: میمون cynomolgus; Cynomolgus monkey; Rhesus monkey; Glutathione S-transferase; Tissue expression;
Cynomolgus monkey induced pluripotent stem cells established by using exogenous genes derived from the same monkey species
Keywords: میمون cynomolgus; Induced pluripotent stem cells; Cynomolgus monkey; Cynomolgus monkey genes; Non-human primate; Medical research
The LIF receptor antagonist PEGLA is effectively delivered to the uterine endometrium and blocks LIF activity in cynomolgus monkeys
Keywords: میمون cynomolgus; Leukemia inhibitory factor receptor; Uterus; Endometrium; Cynomolgus monkey
Monkey liver cytochrome P450 2C19 is involved in R- and S-warfarin 7-hydroxylation
Keywords: میمون cynomolgus; P450; general term for cytochrome P450 (EC 1.14.14.1); Cynomolgus monkey; Human; CYP2C19; CYP2C9; Stereoselectivity;
Sebaceous Gland Metaplasia in the Oesophagus of a Cynomolgus Monkey (Macaca fascicularis)
Keywords: میمون cynomolgus; cynomolgus monkey; oesophagus; sebaceous gland metaplasia;
Lipofuscin can be eliminated from the retinal pigment epithelium of monkeys
Keywords: میمون cynomolgus; Lipofuscin; Age-related macular degeneration; Retinal pigment epithelium; Cynomolgus monkey; Electron microscopy;
Quantified tracking and monitoring of diazepam treated socially housed cynomolgus monkeys
Keywords: میمون cynomolgus; Quantitative; Behaviour; Cynomolgus monkey; Locomotor activity; Group-housed nonhuman primates; Video-tracking; Long-tailed macaque; Automation of patterns of moving; COG; centre of gravity; FOB; functional observation battery; NCEs; new chemical entities
Functional assessment of sexual maturity in male macaques (Macaca fascicularis)
Keywords: میمون cynomolgus; Semen; Ejaculate; Spermatogenesis; Testis histology; Cynomolgus monkey; Long-tailed macaque; Puberty; Maturity;
Vitrification and transfer of cynomolgus monkey (Macaca fascicularis) embryos fertilized by intracytoplasmic sperm injection
Keywords: میمون cynomolgus; Cynomolgus monkey; ICSI; Vitrification; Polypropylene strip; Cryopreservation
Use of mixed-effect models and tolerance limits to evaluate control cynomolgus monkey body weight change and variability during preclinical toxicology studies
Keywords: میمون cynomolgus; Cynomolgus monkey; Body weight; Mixed-effect modelling
Lymphocyte Depletion and Repopulation in Peripheral Blood and Small Intestine of Cynomolgus Monkeys After Alemtuzumab Treatment
Keywords: میمون cynomolgus; alemtuzumab; cynomolgus monkey; intestine; lymphocyte depletion; repopulation
Spontaneous transformation of adult mesenchymal stem cells from cynomolgus macaques in vitro
Keywords: میمون cynomolgus; Cynomolgus monkey; Mesenchymal stem cells; Transformation; Ex vivo expansion; Safety
Periventricular Leucomalacia (PVL)-like Lesions in Two Neonatal Cynomolgus Monkeys (Macaca fascicularis)
Keywords: میمون cynomolgus; cynomolgus monkey; histopathology; immunohistochemistry; periventricular leucomalacia
A multiple-dose toxicity study of tanezumab in cynomolgus monkeys
Keywords: میمون cynomolgus; Anti-drug antibody; Cynomolgus monkey; Nerve growth factor; Pharmacokinetics; Tanezumab; Toxicity;
Pharmacokinetic–pharmacodynamic modelling of the effect of Moxifloxacin on QTc prolongation in telemetered cynomolgus monkeys
Keywords: میمون cynomolgus; Dofetilide; Cynomolgus monkey; Moxifloxacin; PKPD; QTc; QT interval
Addressing species specific metabolism and solubility issues in a quinoline series of oral PDE4 inhibitors
Keywords: میمون cynomolgus; PDE4; COPD; Quinoline; Cinnoline; Cynomolgus monkey; PK
Evaluation of a generic immunoassay with drug tolerance to detect immune complexes in serum samples from cynomolgus monkeys after administration of human antibodies
Keywords: میمون cynomolgus; Anti-drug antibody; Immune complex; Drug interference; Cynomolgus monkey; Immunogenicity
Regional Distribution of Cytochrome P450 mRNA Expression in the Liver and Small Intestine of Cynomolgus Monkeys
Keywords: میمون cynomolgus; cytochrome P450; cynomolgus monkey; mRNA expression; liver; small intestine