CYP17 and CYP2C19 gene polymorphisms in patients with endometriosis
Keywords: CYP2C19; CYP17; cytochrome P450; endometriosis; gene polymorphism
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Steroid profiles in ovarian follicular fluid in women with and without polycystic ovary syndrome, analyzed by liquid chromatography-tandem mass spectrometry
Keywords: Polycystic ovary syndrome; PCOS; follicular fluid; LC-MS/MS; mass spectrometry; steroid hormones; androgens; estrogens; CYP17; CYP19
Chemopreventive actions by enterolactone and 13 VIOXX®-related lactone derivatives in H295R human adrenocortical carcinoma cells
Keywords: CYP17; Chemoprevention; Lactone derivatives; Sex steroidogenesis; H295R
Mice lacking Mrp1 have reduced testicular steroid hormone levels and alterations in steroid biosynthetic enzymes
Keywords: Multidrug resistance-associated protein 1; ATP-binding cassette; Testosterone; Androstenedione; Testes; Cyp17; 17β-Hydroxysteroid dehydrogenase
A single amino acid residue, Ala 105, confers 16α-hydroxylase activity to human cytochrome P450 17α-hydroxylase/17,20 lyase
Keywords: Cytochrome P450c17; CYP17; 16-Hydroxyprogesterone; 17-Hydroxyprogesterone; Homology model
Molecular Modeling on Inhibitor Complexes and Active-Site Dynamics of Cytochrome P450 C17, a Target for Prostate Cancer Therapy
Keywords: CYP17, cytochrome P450 C17; 17α-OH, 17α-hydroxylase; PDB, Protein Data Bank; RMSF, root-mean-square fluctuationP450; CYP17; prostate cancer; homology model; inhibitor modeling
CYP17 and CYP19 gene polymorphisms in women affected with endometriosis
Keywords: Endometriosis; CYP17; CYP19; single-nucleotide polymorphisms (SNPs)
Dehydroepiandrosterone formation is independent of cytochrome P450 17α-hydroxylase/17, 20 lyase activity in the mouse brain
Keywords: Androgen; Neurosteroids; CYP17; Steroidogenesis; Transgenic mice
CYP17 causes hypocortisolism in the South African Angora goat
Keywords: Cytochrome P450 17α-hydroxylase/17,20-lyase; CYP17; Angora goat; Hypocortisolism;
Complex assembly on the human CYP17 promoter
Keywords: CYP17; p54nrb; GCN5; SRC-1; cAMP; Steroidogenic factor-1;
CYP11A1 and CYP17 promoter polymorphisms associate with hyperandrogenemia in polycystic ovary syndrome
Keywords: CYP11A1; CYP17; PCOS; hyperandrogenemia
Sex determination in amphibians
Keywords: GSD; ESD; Sex chromosome; Sex steroids; Sex reversal; CYP19; CYP17; SF1; Foxl2; Rana rugosa; Amphibians
Cloning a new cytochrome P450 isoform (CYP356A1) from oyster Crassostrea gigas
Keywords: Cytochrome P450; Pacific oyster; Crassostrea gigas; Biotransformation enzymes; CYP356A1; CYP17
A polymorphism of the CYP17 gene related to sex steroid metabolism is associated with female-to-male but not male-to-female transsexualism
Keywords: Transsexualism; gender; sex steroids; polymorphism; CYP17
Shorter CAG repeats in androgen receptor and non-GG genotypes in prostate-specific antigen loci are associated with decreased risk of benign prostatic hyperplasia and prostate cancer
Keywords: Polymorphism; Androgen receptor; CAG repeats; PSA; Prostate cancer; SRD5A2; CYP17
Cultured Bovine Trophoblast Cells Differentially Express Genes Encoding Key Steroid Synthesis Enzymes
Keywords: Trophoblasts; Cell culture; Hsd3b; Cyp17; Cyp19; Csh1; Cytokeratin; Vimentin; Dolichos biflorus agglutinin; DBA; qPCR
Immunohistochemical detection and biological activities of CYP17 (P450c17) in the indifferent gonad of the frog Rana rugosa
Keywords: CYP17; Immunohistochemistry; Enzymatic activity; Real-time RT-PCR; FISH; Gonad; Sex differentiation; Frog
Elevated expression of P450c17 (CYP17) during testicular formation in the frog
Keywords: CYP17; CYP11A1; 3β-HSD, CYP19; RT-PCR; In situ hybridization; Sex reversal; Rana rugosa; Amphibians
Synthesis of novel C17 steroidal carbamates: Studies on CYP17 action, androgen receptor binding and function, and prostate cancer cell growth
Keywords: 1,1′-Carbonylbis(2-methylimidazole); CYP17; Prostate cancer; Androgen receptor; PC cell lines; Steroids
Steroidogenic factor-1 is a sphingolipid binding protein
Keywords: Steroidogenic factor-1; CYP17; Sphingosine; cAMP; Adrenocorticotropin
CYP17 and COMT gene polymorphisms can influence bone directly, or indirectly through their effects on endogenous sex steroids, in postmenopausal Japanese women
Keywords: Gene polymorphism; Sex steroids; Bone density; CYP17; COMT
Suppression of fetal testicular cytochrome P450 17 by maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: A mechanism involving an initial effect on gonadotropin synthesis in the pituitary
Keywords: 2,3,7,8-Tetrachlorodibenzo-p-dioxin; Dioxins; Cytochrome P450 17; CYP17; Fetus; Testis; Pituitary; Luteinizing hormone
Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors
Keywords: Indazole; CYP17; Prostate cancer; Androgen receptor; PC cell lines
A novel compound heterozygous mutation of K494_V495 deletion plus R496L and D487_F489 deletion in extreme C-terminus of cytochrome P450c17 causes 17α-hydroxylase deficiency
Keywords: Congenital adrenal hyperplasia; 17α-Hydroxylase deficiency; CYP17; Mutation
Association of the polymorphisms of genes involved in androgen metabolism and signaling pathways with familial prostate cancer risk in a Japanese population
Keywords: AR CAG repeat; Single nucleotide polymorphisms; Genetic susceptibility; Risk factors; Genotyping; Genomic DNA; SRD5A2; UGT2B15; CYP17; PSA promoter; 5α-Reductase; Genetic polymorphism; Prostate cancer; Family history
In vitro effects of brominated flame retardants and metabolites on CYP17 catalytic activity: A novel mechanism of action?
Keywords: Brominated flame retardants (BFRs); Polybrominated diphenyl ethers (PBDEs); Hydroxylated PBDEs (OH-PBDEs); Methoxylated PBDEs (CH3O-PBDEs); CYP17; Dehydroepiandrosterone (DHEA); H295R human adrenocortical carcinoma cells
CYP17- and CYP11B-dependent steroid hydroxylases as drug development targets
Keywords: CYP11B1; CYP11B2; CYP17; Hypertension; Heart fibrosis; Prostate cancerACE, angiotensin-converting enzyme; ADME, absorption, distribution, metabolism, and excretion; AdR, adrenodoxin reductase; Adx, adrenodoxin; AGS (CAH), Adrenogenital syndrome (congenita
Estrogen receptor α dinucleotide repeat and cytochrome P450c17α gene polymorphisms are associated with susceptibility to endometriosis
Keywords: Cytochrome P450c17; CYP17; dinucleotide repeat polymorphism; endometriosis; estrogen receptor; single nucleotide polymorphism;
Inhibition of tyrosine phosphorylation blocks hormone-stimulated calcium influx in an insect steroidogenic gland
Keywords: [Ca2+]; calcium ion concentration; cAMP; adenosine 3â²,5â²-cyclic monophosphate; CYP17; 17-alpha-hydroxylase,17,20-lyase; DHEA(S); dehydroepiandrosterone sulfate; DMSO; dimethylsulfoxide; ERK; extracellular signal-regulated kinase; GDPβS; guanosine-5â
Novel mutation of the CYP17 gene in two unrelated patients with combined 17α-hydroxylase/17,20-lyase deficiency: Demonstration of absent enzyme activity by expressing the mutant CYP17 gene and by three-dimensional modeling
Keywords: CYP17; P450c17; 17-Hydroxylase/17,20-lyase deficiency; Myelolipoma; Congenital adrenal hyperplasia;