کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3941055 1253602 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
CYP17 and CYP19 gene polymorphisms in women affected with endometriosis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
CYP17 and CYP19 gene polymorphisms in women affected with endometriosis
چکیده انگلیسی

ObjectiveTo investigate whether CYP17 T>C polymorphism and polymorphisms C1558T and Val80 of CYP19 are related to endometriosis.DesignClinical study.Patient(s)Women affected with endometriosis (n = 104) and control group (n = 86). The diagnosis of endometriosis was confirmed by the histologic examination of the endometriotic lesions.Result(s)In patients affected with endometriosis, we observed that AA and CC genotypes were significantly represented in Val80 and C1558T polymorphisms of CYP19.Conclusion(s)The molecular mechanisms that underlie the development of endometriosis are unclear. Both environmental and genetic factors are involved in the pathogenesis of the disease. The inheritable susceptibility to endometriosis justifies the growing interest in identifying genes and/or genetic polymorphisms that predispose women to an increased risk of developing endometriosis. The identification of single-nucleotide polymorphism (SNP), probably linked to endometriosis, could help to explain its pathogenesis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fertility and Sterility - Volume 92, Issue 5, November 2009, Pages 1532–1535
نویسندگان
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