Risperidone-associated adverse drug reactions and CYP2D6 polymorphisms in a South African cohort
Keywords: Risperidone; Extrapyramidal symptoms; Weight gain; CYP2D6
مقالات ISI (ترجمه نشده)
مقالات زیر هنوز به فارسی ترجمه نشده اند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Paraoxonase 1 and cytochrome P450 polymorphisms in susceptibility to acute organophosphorus poisoning in Egyptians
Keywords: OP, organophosphorus; PON1, paraoxonase 1; CYP, cytochrome P450 monooxygenases; PChE, pseudo-cholinesterase; SNPs, single nucleotide polymorphisms; PCR-RFLP, polymerase chain reaction-restriction fragment length polymorphismParaoxonase 1; CYP2D6; Acute or
Relationship Among Gefitinib Exposure, Polymorphisms of Its Metabolizing Enzymes and Transporters, and Side Effects in Japanese Patients With Non–Small-Cell Lung Cancer
Keywords: ABCG2; CYP2D6; Gefitinib; Hepatotoxicity; Trough concentration
Individualization of tamoxifen therapy: Much more than just CYP2D6 genotyping
Keywords: Tamoxifen; Endoxifen; Pharmacokinetics; Pharmacogenetics; CYP2D6; Therapeutic drug monitoring
Discovery of an 8-methoxytetrahydroisoquinoline derivative as an orally active N-type calcium channel blocker for neuropathic pain without CYP inhibition liability
Keywords: N-type calcium channel; CaV2.2; Pain; CYP2D6; CYP3A4;
Discovery of a 1-isopropyltetrahydroisoquinoline derivative as an orally active N-type calcium channel blocker for neuropathic pain
Keywords: N-type calcium channel; CaV 2.2; Pain; CYP2D6; CYP3A4;
Human pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) after repeated doses taken 4Â h apart Human pharmacology of MDMA after repeated doses taken 4Â h apart
Keywords: MDMA; Ecstasy; Repeated dose; Pharmacologic effects; Pharmacokinetics; CYP2D6;
Significance of the genetic polymorphism of CYP2D6 and NAT2 in patients with inflammatory bowel diseases
Keywords: Inflammatory bowel diseases; CYP2D6; NAT2; Genetic polymorphism
Modulation of CYP2D6 and CYP3A4 metabolic activities by Ferula asafetida resin
Keywords: Asafetida; Dextromethorphan; CYP3A4; CYP2D6; Microsomes; Metabolism; Interaction
Adjusting the dose of tamoxifen in patients with early breast cancer and CYP2D6 poor metabolizer phenotype
Keywords: Breast cancer; CYP2D6; Tamoxifen; Endoxifen; Dose adjustment;
Influence of combinations of drugs that act on the CYP2D6 metabolic pathway in the treatment of major depressive disorder: A population-based study
Keywords: Major depression; CYP2D6; Substrate-substrate; Substrate-inhibitor; Comorbidity
Functional Characterization of Wild-type and 49 CYP2D6 Allelic Variants for N-Desmethyltamoxifen 4-Hydroxylation Activity
Keywords: cytochrome P450; CYP2D6; genetic polymorphisms; tamoxifen; drug metabolism; pharmacogenomics
Development, validation and clinical application of a HPLC-FL method for CYP2D6 phenotyping in South Brazilian breast cancer patients
Keywords: CYP2D6; Phenotyping; Dextromethorphan; Dextrorphan; HPLC-FL; Tamoxifen;
Quantitative assessment of CYP2D6 polymorphisms and risk of Alzheimer's disease: A meta-analysis
Keywords: Alzheimer's disease; CYP2D6; Polymorphism; Phenotype; Meta-analysis
CYP2D6 phenotypes and Parkinson's disease risk: A meta-analysis
Keywords: Parkinson's disease; CYP2D6; Polymorphisms; Meta-analysis; Phenotypes; Metabolizer;
Evaluation of the Pharmacokinetic Interaction Between Ticagrelor and Venlafaxine, a Cytochrome P-450 2D6 Substrate, in Healthy Subjects
Keywords: CYP2D6; drug-drug interaction; pharmacokinetics; ticagrelor; venlafaxine;
Investigating the contribution of CYP2J2 to ritonavir metabolism in vitro and in vivo
Keywords: CYP2J2; CYP2D6; CYP3A4; Time dependent inhibition; Ritonavir; In vivo; SimcypAUC, area under the plasma concentration–time curve; CYP, cytochrome P450 monooxygenase; EM, extensive metabolizer; IM, intermediate metabolizer; HLM, human liver microsomes; PM,
Influence of Duloxetine on the in-vivo pharmacokinetics of Metoprolol in rat model
Keywords: CYP2D6; Duloxetine; Metoprolol; P-glycoprotein; Pharmacokinetics;
Original studyPolymorphisms of CYP2D6 Gene and Gefitinib-Induced Hepatotoxicity
Keywords: CYP2D6; Erlotinib; Gefitinib; Hepatotoxicity; Polymorphisms;
Associate editor: B. TeicherPharmacogenomics of breast cancer therapy: An update
Keywords: Breast cancer; Pharmacogenetics; Chemotherapy; Endocrine therapy; Tamoxifen; Aromatase inhibitor; Single nucleotide polymorphism; CYP2D6;
Novel triple reuptake inhibitors with low risk of CAD associated liabilities: Design, synthesis and biological activities of 4-[(1S)-1-(3,4-dichlorophenyl)-2-methoxyethyl]piperidine and related compounds
Keywords: Monoamine reuptake inhibition; Piperidine compounds; Cationic amphiphilic drug (CAD); CYP2D6; hERG; PLsis; Tail suspension test; Antidepressant;
High prevalence of CYP2D6*41 (G2988A) allele in Saudi Arabians
Keywords: CYP2D6; Polymorphism; Saudi Arabians; Allele frequency
Cytotoxicity, antioxidant activity and an effect on CYP3A4 and CYP2D6 of Mutellina purpurea L. extracts
Keywords: ABTS; 2,2â²-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid); CYP2D6; cytochrome P450, isoenzyme 2D6; CYP3A4; cytochrome P450, isoenzyme 3A4; DMF; dimethylformamide; DMSO; dimethylsulphoxide; FBS; fetal bovine serum; MEM; eagle's minimal essential me
Genetic polymorphism of CYP2D6 gene among Egyptian hypertensive cases
Keywords: CYP2D6; Polymorphism; Hypertension
A poor metabolizer of both CYP2C19 and CYP2D6 identified by mechanistic pharmacokinetic simulation in a fatal drug poisoning case involving venlafaxine
Keywords: CYP2D6; CYP2C19; Venlafaxine; Poor metabolizer; Drug poisoning; Mechanistic pharmacokinetic simulation
Interest and attitudes of patients, cancer physicians, medical students and cancer researchers towards a spectrum of genetic tests relevant to breast cancer patients
Keywords: Breast cancer; BRCA1/2; CYP2D6; Genetic testing; Oncotype DX
Risk of renal cell carcinoma and polymorphism in phase I xenobiotic metabolizing CYP1A1 and CYP2D6 enzymes
Keywords: CYP1A1; CYP2D6; Xenobiotic metabolizing enzyme; Renal cell carcinoma; AJCC cancer stage; Fuhrman's grade
Binding of quinidine radically increases the stability and decreases the flexibility of the cytochrome P450 2D6 active site
Keywords: CYP2D6; Quinidine; Molecular dynamics; Flexibility; Cytochrome P450; High pressure
Cytochrome P450 inhibitory potential of selected Indian spices - possible food drug interaction
Keywords: Indian spices; Cytochrome P450; Standardization; CYP3A4; CYP2D6; CYP2C9; CYP1A2; Food-drug interaction;
Genetic variation in CYP2D6 impacts neural activation during cognitive tasks in humans
Keywords: Cytochrome P450; CYP2D6; Polymorphism; Functional imaging; Working memory; Emotional face watching task; Neurocognition; fMRI;
Significance of genetic polymorphism of CYP2D6 in the pathogenesis of systemic sclerosis
Keywords: genetic polymorphism; oxidation; CYP2D6; systemic sclerosis (SSc)
Pharmacogenetics of anti-estrogen treatment of breast cancer
Keywords: Tamoxifen; Aromatase inhibitor; CYP2D6; CYP19A1; Estrogen receptor; Polymorphisms; Pharmacogenetics
The Pharmacokinetics and Pharmacogenetics of the Antiemetic Cyclizine in Palliative Care Patients
Keywords: Antiemetic; drug concentrations; nausea; CYP2D6
Inter-individual Variability of In Vivo CYP2D6 Activity in Different Genotypes
Keywords: inter-individual variability; CYP2D6; Monte Carlo simulation; physiologically based pharmacokinetics; pharmacogenetics; dextromethorphan; drug discovery;
Effects of Radix Astragali and Radix Rehmanniae, the components of an anti-diabetic foot ulcer herbal formula, on metabolism of model CYP1A2, CYP2C9, CYP2D6, CYP2E1 and CYP3A4 probe substrates in pooled human liver microsomes and specific CYP isoforms
Keywords: Radix Astragali; Radix Rehmanniae; CYP1A2; CYP2C9; CYP2D6; CYP2E1; CYP3A4; Human liver microsomes
Review articleDevelopments in harmine pharmacology - Implications for ayahuasca use and drug-dependence treatment
Keywords: 5-HT; 5-hydroxytryptamine; 5-HIAA; 5-hydroxyindeolacetic acid; BDNF; brain derived neurotrophic factor; ACTH; adrenocorticotropic hormone; CYP2D6; cytochrome P450 2D6; DMT; N,N-dimethyltryptamine; DOPAC; dihydroxyphenylacetic acid; DYRK1A; dual specificit
Influence of CYP2D6 genotype on the disposition of the enantiomers of venlafaxine and its major metabolites in postmortem femoral blood
Keywords: CYP2D6; Enantiomers; Forensic toxicology; Postmortem toxicology; Venlafaxine
Opioid Therapies and Cytochrome P450 Interactions
Keywords: Adverse drug reactions; cytochrome P450; CYP3A4; CYP2D6; drug-drug interactions; inhibitor; inducer; metabolism; prodrug; substrate; opioids
The neuroprotective enzyme CYP2D6 increases in the brain with age and is lower in Parkinson's disease patients
Keywords: CYP2D6; Parkinson's disease; Human brain; Aging; CNS drugs;
Identification of cytochrome P450 2D6 and 2C9 substrates and inhibitors by QSAR analysis
Keywords: CYP; cytochrome P450; CYP2C9; cytochrome P450 subtype 2C9; CYP2D6; cytochrome P450 subtype 2D6; CYP1A2; cytochrome P450 subtype 1A2; CYP2C19; cytochrome P450 subtype 2C19; CYP3A4; cytochrome P450 subtype 3A4; PLR; partial logistic regression; PLS; partial
Influence of pKa on the biotransformation of indene H1-antihistamines by CYP2D6
Keywords: H1 receptor; H1-antihistamine; Histamine; Insomnia; Indene; CYP2D6; Biotransformation; pKa
Stimulus control by 5-methoxy-N,N-dimethyltryptamine in wild-type and CYP2D6-humanized mice
Keywords: Drug-induced stimulus control; Harmaline; 5-methoxy-N,N-dimethyltryptamine; Drug interaction; CYP2D6; Humanized mice;
Cytochrome P450 (CYP2D6) Genotype is Associated with Elevated Systolic Blood Pressure in Preterm Infants after Discharge from the Neonatal Intensive Care Unit
Keywords: BP; Blood pressure; BPD; Bronchopulmonary dysplasia; CYP2D6; Cytochrome P450, family 2, subfamily D, polypeptide 6; ESBP; Elevated systolic blood pressure; NICU; Neonatal intensive care unit; SBP; Systolic blood pressure; SNP; Single nucleotide polymorphi
Consequences of POR mutations and polymorphisms
Keywords: Cytochrome P450; P450 oxidoreductase; CYP3A4; CYP2D6; Steroidogenesis; Enzyme kinetics; Drug metabolism; Pharmacogenetics;
Tamoxifen, cytochrome P450 genes and breast cancer clinical outcomes
Keywords: Tamoxifen; Cytochrome P450; CYP2D6; Breast cancer
Risk assessment of accidental nortriptyline poisoning: The importance of cytochrome P450 for nortriptyline elimination investigated using a population-based pharmacokinetic simulator
Keywords: Nortriptyline; Cytochrome P450; Poisoning; CYP2D6; Computer simulations; PBPK
Cytochrome P450 2D6 Phenotyping in an Elderly Population With Dementia and Response to Galantamine in Dementia: A Pilot Study
Keywords: CYP2D6; dementia; galantamine; pharmacogenetics;
Reversible time-dependent inhibition of cytochrome P450 enzymes by duloxetine and inertness of its thiophene ring towards bioactivation
Keywords: ACN; acetonitrile; APAP; acetaminophen; CYP1A2; cytochrome P450 1A2 enzyme; CYP2B6; cytochrome P450 2B6 enzyme; CYP2C19; cytochrome P450 2C19 enzyme; CYP2D6; cytochrome P450 2D6 enzyme; CYP3A4; cytochrome P450 3A4 enzyme; CYP450; cytochrome P450 enzymes;
Prioritizing Pharmacogenetic Research: A Value of Information Analysis of CYP2D6 Testing to Guide Breast Cancer Treatment
Keywords: CYP2D6; decision modeling; pharmacogenetics; tamoxifen; value of information
A de novo 7.9 Mb deletion in 22q13.2→qter in a boy with autistic features, epilepsy, developmental delay, atopic dermatitis and abnormal immunological findings
Keywords: Array-CGH; 22q13 deletion syndrome; Autism; Epilepsy; Atopic dermatitis; Immune system; SHANK3; NCAPH2; CYP2D6