Stimulus control by 5-methoxy-N,N-dimethyltryptamine in wild-type and CYP2D6-humanized mice

► 5-Methoxy-N,N-dimethyltryptamine is a naturally-occurring hallucinogen. ► CYP2D6-humanized mice have increased levels of bufotenine following 5-MeO-DMT. ► Wild type and Tg-CYP2D6 mice did not differ in rate of acquisition of stimulus control. ► 5-MeO-DMT did not generalize to bufotenine and only partially to acetylbufotenine. ► Harmaline, a mono amine oxidase inhibitor, enhanced the stimulus effects of 5-MeO-DMT.