Keywords: موش های انسانی; IgE; mast cells; anaphylaxis; humanized mice; tryptase; peanut allergy; APC; Antigen-presenting cell; HSC; Hematopoietic stem cell; huNSG; Humanized nonobese diabetic severe combined immunodeficient common gamma chain-deficient stem cell factor; NOD; No
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Keywords: موش های انسانی; Humanized mice; Leukemia; Lymphopenia; Mixed-lineage leukemia fusion gene; Recipient leukocyte infusion
Keywords: موش های انسانی; WHO; World Health Organization; TNF; tumor necrosis factor; IL; interleukin; HSC; hematopoietic stem cell; NSG; NOD/SCID/γcâ/â; NK; natural killer; DC; dendritic cell; TCR; T cell receptor; DTH; delayed type hypersensitivity; HLA; human leukocyte ant
Keywords: موش های انسانی; Mast cell; humanized mice; NSG; NSG-SGM3; passive cutaneous anaphylaxis; PCA; passive systemic anaphylaxis; PSA; BLT; Bone marrow, Liver, Thymus; chIgE-anti-NP; Chimeric human IgE-anti-hapten 4-hydroxy-3 nitrophenacetyl antibody; HSC; Hematopoietic stem c
Keywords: موش های انسانی; HIV; HTLV; Humanized mice; Pathogenesis; Latency; Gene therapy; Animal models; SCID mouse;
Keywords: موش های انسانی; Spinal cord injury; Humanized mice; Inflammation; Neuroimmunology; Macrophages; Lymphocytes; Functional recovery; Stem cells; Hematopoiesis;
Keywords: موش های انسانی; Gut microbiome; Rheumatoid arthritis; Collagen-induced arthritis; Humanized mice;
Keywords: موش های انسانی; Infectious mononucleosis; Dendritic cells; T cells; NK cells; Lymphoproliferative disease; Humanized mice
A CYP2B6-humanized mouse model and its potential applications
Keywords: موش های انسانی; CYP2B6; Liver; Drug metabolism; Xenobiotic toxicity; Knockout mice; Humanized mice; WT; wild-type; CYPs; cytochromes P450; CAR; constitutive androstane receptor; PXR; pregnane X receptor; GR; glucocorticoid receptor; PB; phenobarbital; and DEX; dexamethas
Species differences in drug glucuronidation: Humanized UDP-glucuronosyltransferase 1 mice and their application for predicting drug glucuronidation and drug-induced toxicity in humans
Keywords: موش های انسانی; UDP-glucuronosyltransferase; Glucuronidation; Species difference; Humanized mice; Drug metabolism; Toxicity;
The natural compound silvestrol inhibits hepatitis E virus (HEV) replication in vitro and in vivo
Keywords: موش های انسانی; Hepatitis E virus (HEV); Silvestrol; Antiviral activity; Host target; Replication; Humanized mice;
Increased ethanol drinking in “humanized” mice expressing the mu opioid receptor A118G polymorphism are mediated through sex-specific mechanisms
Keywords: موش های انسانی; ANOVA; analysis of variance; BECs; blood ethanol concentrations; CPP; conditioned place preference; DID; rinking-in-the-dark; ICSS; intracranial self stimulation; IP; intraperitoneal; LORR; loss of righting reflex; MOR; mu-opioid receptor; Oprm1; mu-opioi
A novel orally available small molecule that inhibits hepatitis B virus expression
Keywords: موش های انسانی; RG7834; HBV; HBsAg; Viral gene expression; Humanized mice;
Transmission of hepatitis E virus infection to human-liver chimeric FRG mice using patient plasma
Keywords: موش های انسانی; Viral hepatitis; Hepatitis E virus; Transmission; Animal model; Humanized mice; FAH; Blood transfusion;
A novel in vivo model for predicting myelotoxicity of chemotherapeutic agents using IL-3/GM-CSF transgenic humanized mice
Keywords: موش های انسانی; MTD; maximum tolerated doses; CFU-GM; colony-forming unit granulocyte/macrophage; NOG; NOD/Shi-scid IL2rγnull; HSC; hematopoietic stem cell; Myelotoxicity; Anticancer drugs; Humanized mice;
Animal models of HBV infection
Keywords: موش های انسانی; Animal models; HBV-related viruses; Hepadnaviruses; Humanized mice; Antiviral therapy; Immunopathogenesis; HBV; hepatitis B virus; cccDNA; covalently closed circular DNA; pgRNA; pregenomic RNA; DHBV; duck hepatitis B virus; WHV; woodchuck hepatitis virus;
Recapitulation of treatment response patterns in a novel humanized mouse model for chronic hepatitis B virus infection
Keywords: موش های انسانی; Hepatitis B virus (HBV); Humanized mice; Antivirals; Genome engineering;
B cells influence sex specificity of arthritis via myeloid suppressors and chemokines in humanized mice
Keywords: موش های انسانی; Rheumatoid arthritis; Rituximab; Humanized mice; Collagen-induced arthritis; Myeloid suppressor cells; T regulatory;
Human innate responses and adjuvant activity of TLR ligands in vivo in mice reconstituted with a human immune system
Keywords: موش های انسانی; TLR ligands; Adjuvant; Humanized mice; Human innate response; CD40-targeting HIV vaccine; Cytotoxic T cells; LN; lymph node; mDC; myeloid dendritic cell; MPLA; monophosphoryl lipid A; pDC; plasmacytoid dendritic cell; TLR-Ls; Toll-like receptor ligands;
Simple and reliable genotyping protocol for mouse PrkdcSCID mutation
Keywords: موش های انسانی; SCID; NSG; Humanized mice; RFLP; Genotyping;
Research paperRapid identification and expression of human TCRs in retrogenic mice
Keywords: موش های انسانی; TCR; T cell receptor; HLA; human leukocyte antigen; hu-Rg; humanized retrogenic; T1D; type 1 diabetes; NOD; non-obese diabetic mouse; PCR; polymerase chain reaction; T cell receptor; TCR; PCR; Single cell; Human; Humanized mice;
No SEVI-mediated enhancement of rectal HIV-1 transmission of HIV-1 in two humanized mouse cohorts
Keywords: موش های انسانی; HIV; Transmission; Semen-derived enhancer of viral infection; SEVI; Amyloid; Humanized mice;
Targeting dendritic cells in humanized mice receiving adoptive T cells via monoclonal antibodies fused to Flu epitopes
Keywords: موش های انسانی; DCs; dendritic cells; c; conventional; p; plasmacytoid; HPCs; CD34+ hematopoietic stem cells; FluM1; influenza M1 protein; FACS; fluorescent activated cell sorting; PBMCs; peripheral blood mononuclear cells; mAb; monoclonal antibody; APCs; antigen present
Species differences in the pharmacokinetics of cefadroxil as determined in wildtype and humanized PepT1 mice
Keywords: موش های انسانی; Species differences; Pharmacokinetics; Cefadroxil; Humanized mice; PEPT1
The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes
Keywords: موش های انسانی; NOD; Type 1 diabetes; Gut microbiota; B cells; Humanized mice;
Recent advances in RNAi-based strategies for therapy and prevention of HIV-1/AIDS
Keywords: موش های انسانی; RNAi; si/shRNA; AgoshRNA; shRNA-miR; CCR5; HIV-1; Lentiviral vector; Humanized mice
The mixed lineage kinase-3 inhibitor URMC-099 improves therapeutic outcomes for long-acting antiretroviral therapy
Keywords: موش های انسانی; HIV-1; Long-acting nanoformulations; URMC-099; Humanized mice; Phagolysosome; Rab proteins;
Visualization of the human CD4+ T-cell response in humanized HLA-DR4-expressing NOD/Shi-scid/γcnull (NOG) mice by retrogenic expression of the human TCR gene
Keywords: موش های انسانی; TCR; Humanized mice; NOG mice; HLA-DR4; Th1;
Development of human B cells and antibodies following human hematopoietic stem cell transplantation to Rag2â/âγcâ/â mice
Keywords: موش های انسانی; Adaptive immunity; B cells; Human antibodies; Human immunity; Humanized mice; RAG-hu mice;
Humanized mice dually challenged with R5 and X4 HIV-1 show preferential R5 viremia and restricted X4 infection of CCR5+CD4+ T cells
Keywords: موش های انسانی; HIV; Humanized mice; CD4+ T cells; CCR5;
Evaluation of the efficiency of human immune system reconstitution in NSG mice and NSG mice containing a human HLA.A2 transgene using hematopoietic stem cells purified from different sources
Keywords: موش های انسانی; Humanized mice; Hematopoietic stem cells; HLA-A2 transgene
Expression of hepatic cytochrome P450s and UDP-glucuronosyltransferases in PXR and CAR double humanized mice treated with rifampicin
Keywords: موش های انسانی; Nuclear receptor; Humanized mice; Rifampicin; Cytochrome P450; UDP-glucuronosyltransferase;
Mechanisms of allergy and clinical immunologyActivated glycoprotein A repetitions predominant (GARP)-expressing regulatory T cells inhibit allergen-induced intestinal inflammation in humanized mice
Keywords: موش های انسانی; Humanized mice; IgE; allergen; regulatory T cells; colon; inflammation; DC; Dendritic cell; GARP; Glycoprotein AÂ repetitions predominant; IMDM; Iscove modified Dulbecco medium; NOD; Nonobese diabetic; SCID; Severe combined immunodeficiency; Treg; Regulat
Analysis of human innate immune responses to PRINT fabricated nanoparticles with cross validation using a humanized mouse model
Keywords: موش های انسانی; PRINT; Nanoparticles; PEGylation; Humanized mice; Monocytes; Complement; Toxicity;
The use of BLT humanized mice to investigate the immune reconstitution of the gastrointestinal tract
Keywords: موش های انسانی; Humanized mice; BLT; GALT; NOD/SCID; NSG; NOG
Humanized NOD-SCID IL2rg–/– mice as a preclinical model for cancer research and its potential use for individualized cancer therapies
Keywords: موش های انسانی; Tumor model; Xenograft; Preclinical model; Humanized mice; NOD-SCID-IL2rg–/– mice; Immunodeficient mice
Research ArticleImmune cell responses are not required to induce substantial hepatitis B virus antigen decline during pegylated interferon-alpha administration
Keywords: موش های انسانی; cccDNA; HBsAg; HBeAg; Interferon stimulated genes; Hepatocyte responsiveness; Humanized mice;
Cellular sources of pathogenic and protective TNF and experimental strategies based on utilization of TNF humanized mice
Keywords: موش های انسانی; TNF; Cytokine; Anti-TNF therapy; Humanized mice; Colitis
Visualizing hepatitis C virus infection in humanized mice
Keywords: موش های انسانی; Hepatitis C virus; Viral hepatitis; Animal model; Humanized mice; Imaging
Research ArticleThe entry inhibitor Myrcludex-B efficiently blocks intrahepatic virus spreading in humanized mice previously infected with hepatitis B virus
Keywords: موش های انسانی; IFN; interferon; HBV; hepatitis B virus; pgRNA; pregenomic RNA; cccDNA; covalently closed circular DNA; rcDNA; relaxed circular DNA; HBV; uPA; Humanized mice; Entry inhibitor; cccDNA;
Barriers of hepatitis C virus interspecies transmission
Keywords: موش های انسانی; Hepatitis C virus; Animal models; Humanized mice; Species tropism; Drug development; Vaccine development; Pathogenesis
Liver X receptor agonist inhibits HIV-1 replication and prevents HIV-induced reduction of plasma HDL in humanized mouse model of HIV infection
Keywords: موش های انسانی; HIV-1; Humanized mice; Atherosclerosis; Pathogenesis; Liver X receptor agonist;
A transgenic Plasmodium falciparum NF54 strain that expresses GFP–luciferase throughout the parasite life cycle
Keywords: موش های انسانی; Malaria; Plasmodium falciparum; NF54; Luciferase; Humanized mice
Humanized mice: Current states and perspectives
Keywords: موش های انسانی; Humanized mice; Lymphocyte function; HLA; Sirpa
Mucosal HIV-1 transmission and prevention strategies in BLT humanized mice
Keywords: موش های انسانی; humanized mice; BLT; HIV-1 prevention; efficacy evaluation; microbicides; PrEP
Comprehensive evaluation of leukocyte lineage derived from human hematopoietic cells in humanized mice
Keywords: موش های انسانی; Humanized mice; Leukocyte lineage; Hematopoietic stem cell; Cell transplantation; NOG mice
Androgen receptor gene polymorphisms and alterations in prostate cancer: Of humanized mice and men
Keywords: موش های انسانی; Androgen receptor; Polyglutamine tract; AR gain-of-function mutations; Humanized mice; Mouse prostate cancer models; Therapy selection;
Using mouse models to study function of transcriptional factors in T cell development
Keywords: موش های انسانی; Genetic modified mice; Humanized mice; Lymphopoiesis; T cell development; Bcl11b;
Mechanisms of allergy and clinical immunologyReduction of total IgE by targeted coengagement of IgE B-cell receptor and FcγRIIb with Fc-engineered antibody
Keywords: موش های انسانی; Allergy; asthma; FcεRI; FcγRIIb; humanized mice; IgE; inhibitory receptor; omalizumab; plasma cell; therapeutic antibody; BCR; B-cell receptor; FcγR; Receptor for antibody Fc; HuSCID; Human PBMC-engrafted SCID mouse; ITIM; Immunoreceptor tyrosine-based
Stimulus control by 5-methoxy-N,N-dimethyltryptamine in wild-type and CYP2D6-humanized mice
Keywords: موش های انسانی; Drug-induced stimulus control; Harmaline; 5-methoxy-N,N-dimethyltryptamine; Drug interaction; CYP2D6; Humanized mice;